Drosophila melanogaster

140 known processes

Mpk2 (Dmel_CG5475)

CG5475 gene product from transcript CG5475-RB

(Aliases: DMPK2,Erk2,D-p38,p38A,dMPK2,Dp38,p38a,DmMPK2,Dmel\CG5475,P38,dp38a,dp38,D-p38a,mpk2,CG5475,p38,p38 alpha,D-MPK2,group 2,D-P38a)

Mpk2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of biosynthetic process of antibacterial peptides active against gram positive bacteria GO:0002816 3 0.986
response to oxidative stress GO:0006979 86 0.977
immune system process GO:0002376 347 0.946
negative regulation of cellular metabolic process GO:0031324 382 0.940
Fly
immune response GO:0006955 246 0.929
intracellular signal transduction GO:0035556 300 0.903
regulation of response to biotic stimulus GO:0002831 63 0.885
regulation of anatomical structure morphogenesis GO:0022603 242 0.855
Yeast Mouse
positive regulation of biosynthetic process GO:0009891 316 0.835
Yeast Mouse Worm
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.750
Yeast Mouse Worm
regulation of immune response GO:0050776 118 0.749
regulation of multi organism process GO:0043900 131 0.747
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.741
Yeast Mouse Worm Fly
regulation of immune system process GO:0002682 176 0.725
regulation of immune effector process GO:0002697 52 0.702
positive regulation of gene expression GO:0010628 290 0.702
Yeast Mouse Worm
defense response to other organism GO:0098542 225 0.701
regulation of intracellular signal transduction GO:1902531 236 0.682
Fly
regulation of cellular response to stress GO:0080135 89 0.677
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.675
response to biotic stimulus GO:0009607 294 0.674
positive regulation of rna biosynthetic process GO:1902680 266 0.654
Yeast Mouse Worm
regulation of defense response to virus by host GO:0050691 10 0.653
immune effector process GO:0002252 98 0.640
humoral immune response GO:0006959 117 0.639
lipopolysaccharide mediated signaling pathway GO:0031663 1 0.609
Mouse
positive regulation of cellular biosynthetic process GO:0031328 316 0.603
Yeast Mouse Worm
negative regulation of cell communication GO:0010648 223 0.583
Mouse Fly
memory GO:0007613 94 0.571
regulation of defense response GO:0031347 102 0.568
Fly
positive regulation of immune response GO:0050778 63 0.561
response to abiotic stimulus GO:0009628 341 0.550
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.549
mucosal immune response GO:0002385 10 0.541
negative regulation of response to stimulus GO:0048585 258 0.523
positive regulation of defense response to virus by host GO:0002230 10 0.519
positive regulation of macromolecule metabolic process GO:0010604 405 0.517
Yeast Mouse Worm Fly
innate immune response GO:0045087 144 0.515
Worm Fly
defense response GO:0006952 300 0.503
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.499
Yeast Mouse Worm
phosphorylation GO:0016310 294 0.494
response to external biotic stimulus GO:0043207 293 0.491
regulation of defense response to virus GO:0050688 14 0.473
defense response to bacterium GO:0042742 178 0.470
response to bacterium GO:0009617 198 0.465
response to other organism GO:0051707 293 0.453
neurological system process GO:0050877 358 0.450
defense response to fungus GO:0050832 48 0.443
antimicrobial peptide production GO:0002775 46 0.430
mapk cascade GO:0000165 107 0.429
response to oxygen radical GO:0000305 3 0.427
Worm
negative regulation of cellular biosynthetic process GO:0031327 277 0.417
gene silencing GO:0016458 138 0.409
transcription from rna polymerase ii promoter GO:0006366 368 0.397
Yeast Mouse Worm
homeostatic process GO:0042592 199 0.392
Mouse
negative regulation of biosynthetic process GO:0009890 277 0.391
regulation of cell morphogenesis GO:0022604 163 0.390
cellular response to chemical stimulus GO:0070887 199 0.382
regulation of humoral immune response GO:0002920 51 0.369
adult chitin containing cuticle pigmentation GO:0048085 16 0.361
regulation of antimicrobial humoral response GO:0002759 50 0.358
cellular response to dna damage stimulus GO:0006974 223 0.352
Human Mouse
organonitrogen compound biosynthetic process GO:1901566 117 0.351
cell cycle checkpoint GO:0000075 95 0.341
Mouse
peptide metabolic process GO:0006518 80 0.338
dna damage checkpoint GO:0000077 78 0.331
Mouse
positive regulation of immune system process GO:0002684 68 0.330
Mouse
paracrine signaling GO:0038001 7 0.321
cellular response to reactive oxygen species GO:0034614 14 0.317
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.317
Yeast Mouse Worm
regionalization GO:0003002 416 0.310
positive regulation of rna metabolic process GO:0051254 271 0.301
Yeast Mouse Worm
regulation of mapk cascade GO:0043408 92 0.299
Fly
response to peptidoglycan GO:0032494 2 0.297
antimicrobial humoral response GO:0019730 99 0.293
positive regulation of nucleic acid templated transcription GO:1903508 266 0.293
Yeast Mouse Worm
negative regulation of transcription dna templated GO:0045892 237 0.289
positive regulation of response to stimulus GO:0048584 323 0.289
negative regulation of gene expression GO:0010629 387 0.285
antibacterial humoral response GO:0019731 44 0.284
Fly
defense response to gram negative bacterium GO:0050829 94 0.280
Worm
defense response to virus GO:0051607 23 0.279
regulation of response to stress GO:0080134 200 0.276
synaptic transmission GO:0007268 288 0.274
Fly
dna integrity checkpoint GO:0031570 81 0.272
Mouse
response to inorganic substance GO:0010035 44 0.268
actin filament based process GO:0030029 220 0.267
organ or tissue specific immune response GO:0002251 10 0.264
cellular amide metabolic process GO:0043603 80 0.261
organonitrogen compound metabolic process GO:1901564 318 0.258
connective tissue development GO:0061448 3 0.252
Mouse
positive regulation of transcription dna templated GO:0045893 266 0.251
Yeast Mouse Worm
negative regulation of response to external stimulus GO:0032102 22 0.247
positive regulation of immune effector process GO:0002699 28 0.247
determination of adult lifespan GO:0008340 137 0.243
regulation of response to external stimulus GO:0032101 115 0.240
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.239
Yeast Mouse Worm
regulation of cellular component biogenesis GO:0044087 201 0.239
dna metabolic process GO:0006259 227 0.233
Yeast
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.230
epithelial cell differentiation GO:0030855 322 0.228
Fly
regulation of defense response to bacterium GO:1900424 30 0.228
positive regulation of signaling GO:0023056 243 0.226
cellular response to oxygen containing compound GO:1901701 79 0.226
death GO:0016265 284 0.225
Worm
regulation of multicellular organismal development GO:2000026 414 0.220
regulation of antibacterial peptide biosynthetic process GO:0002808 22 0.214
positive regulation of cell communication GO:0010647 250 0.213
biosynthetic process of antibacterial peptides active against gram negative bacteria GO:0002812 14 0.211
antibacterial peptide production GO:0002778 22 0.210
response to reactive oxygen species GO:0000302 24 0.205
positive regulation of signal transduction GO:0009967 223 0.200
regulation of antibacterial peptide production GO:0002786 22 0.198
regulation of metal ion transport GO:0010959 15 0.197
epidermal cell differentiation GO:0009913 51 0.191
negative regulation of rna biosynthetic process GO:1902679 240 0.188
macromolecular complex assembly GO:0065003 256 0.187
immune response regulating signaling pathway GO:0002764 2 0.186
response to oxygen containing compound GO:1901700 200 0.185
signal transduction by phosphorylation GO:0023014 107 0.185
positive regulation of cellular component biogenesis GO:0044089 80 0.184
response to heat GO:0009408 63 0.179
negative regulation of defense response to bacterium GO:1900425 7 0.176
positive regulation of defense response GO:0031349 59 0.174
apoptotic process GO:0006915 159 0.174
post embryonic appendage morphogenesis GO:0035120 385 0.173
Fly
heart morphogenesis GO:0003007 32 0.168
regulation of cell shape GO:0008360 113 0.168
regulation of jnk cascade GO:0046328 40 0.168
Fly
response to superoxide GO:0000303 3 0.167
Worm
regulation of programmed cell death GO:0043067 152 0.165
regulation of production of molecular mediator of immune response GO:0002700 44 0.164
regulation of stress activated mapk cascade GO:0032872 41 0.164
Fly
biosynthetic process of antibacterial peptides active against gram positive bacteria GO:0002815 3 0.161
response to starvation GO:0042594 97 0.159
positive regulation of defense response to bacterium GO:1900426 23 0.158
aging GO:0007568 143 0.157
amide biosynthetic process GO:0043604 42 0.155
muscle organ development GO:0007517 127 0.153
Mouse
positive regulation of cellular component organization GO:0051130 156 0.152
Mouse
negative regulation of nucleic acid templated transcription GO:1903507 240 0.151
regulation of cell differentiation GO:0045595 302 0.150
Yeast Mouse
regulation of innate immune response GO:0045088 71 0.149
Fly
response to fungus GO:0009620 50 0.145
pattern recognition receptor signaling pathway GO:0002221 2 0.141
vesicle mediated transport GO:0016192 381 0.139
Fly
imaginal disc derived appendage development GO:0048737 399 0.139
Fly
regulation of antimicrobial peptide production GO:0002784 44 0.138
pigmentation GO:0043473 75 0.136
cellular chemical homeostasis GO:0055082 40 0.136
regulation of dna metabolic process GO:0051052 34 0.136
Yeast
antibacterial peptide biosynthetic process GO:0002780 22 0.133
tube development GO:0035295 244 0.133
Fly
cell death GO:0008219 279 0.132
Worm
immune response activating signal transduction GO:0002757 2 0.130
chemical homeostasis GO:0048878 92 0.127
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.127
stress activated protein kinase signaling cascade GO:0031098 55 0.124
Mouse Rat Worm Fly
regulation of cellular amide metabolic process GO:0034248 39 0.123
multicellular organismal aging GO:0010259 140 0.122
dorsal ventral pattern formation GO:0009953 133 0.122
stress activated mapk cascade GO:0051403 52 0.121
Mouse Rat Worm Fly
regulation of cell death GO:0010941 173 0.120
response to nutrient levels GO:0031667 114 0.120
negative regulation of signaling GO:0023057 219 0.120
Mouse Fly
epithelial cell development GO:0002064 274 0.119
Fly
response to organophosphorus GO:0046683 2 0.119
dendrite morphogenesis GO:0048813 199 0.118
carboxylic acid metabolic process GO:0019752 92 0.118
Mouse
response to extracellular stimulus GO:0009991 116 0.117
response to virus GO:0009615 28 0.117
cellular amino acid metabolic process GO:0006520 61 0.116
cellular response to ionizing radiation GO:0071479 15 0.116
Human
skeletal muscle organ development GO:0060538 48 0.115
Mouse
regulation of phosphorylation GO:0042325 147 0.113
Fly
heart development GO:0007507 82 0.109
programmed cell death GO:0012501 257 0.108
Worm
response to lipopolysaccharide GO:0032496 4 0.108
Human Mouse
melanization defense response GO:0035006 45 0.107
Fly
negative regulation of peptidoglycan recognition protein signaling pathway GO:0061060 3 0.107
muscle attachment GO:0016203 36 0.107
organic substance transport GO:0071702 257 0.106
Mouse
regulation of protein kinase activity GO:0045859 51 0.106
Fly
positive regulation of intracellular signal transduction GO:1902533 116 0.106
appendage development GO:0048736 401 0.105
Fly
response to organic substance GO:0010033 284 0.104
Human Mouse Rat Fly
regulation of neuron death GO:1901214 26 0.104
bmp signaling pathway GO:0030509 27 0.104
Fly
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.102
Mouse Fly
peripheral nervous system development GO:0007422 52 0.102
regulation of anatomical structure size GO:0090066 163 0.101
positive regulation of phosphorus metabolic process GO:0010562 139 0.100
Fly
inorganic ion transmembrane transport GO:0098660 73 0.099
localization of cell GO:0051674 257 0.097
Fly
imaginal disc derived appendage morphogenesis GO:0035114 395 0.097
Fly
response to osmotic stress GO:0006970 14 0.096
ion transmembrane transport GO:0034220 122 0.096
regulation of gene expression epigenetic GO:0040029 128 0.096
immune system development GO:0002520 57 0.095
Mouse
catabolic process GO:0009056 409 0.095
Fly
regulation of phosphate metabolic process GO:0019220 210 0.095
Fly
positive regulation of biosynthetic process of antibacterial peptides active against gram positive bacteria GO:0006965 3 0.094
cell motility GO:0048870 251 0.094
Fly
jnk cascade GO:0007254 50 0.093
Fly
nucleobase containing compound catabolic process GO:0034655 165 0.093
negative regulation of multicellular organismal process GO:0051241 142 0.092
organic acid metabolic process GO:0006082 103 0.092
Mouse
negative regulation of rna metabolic process GO:0051253 251 0.092
oxoacid metabolic process GO:0043436 103 0.091
Mouse
positive regulation of molecular function GO:0044093 136 0.091
regulation of developmental pigmentation GO:0048070 24 0.091
response to endogenous stimulus GO:0009719 119 0.090
Mouse Fly
positive regulation of cell size GO:0045793 21 0.089
response to lipid GO:0033993 38 0.089
Human Mouse
chromatin silencing GO:0006342 76 0.088
positive regulation of multicellular organismal process GO:0051240 143 0.087
Human Mouse Fly
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.087
Fly
peptide biosynthetic process GO:0043043 42 0.086
dendrite development GO:0016358 204 0.086
purine containing compound catabolic process GO:0072523 112 0.085
response to temperature stimulus GO:0009266 106 0.085
cellular cation homeostasis GO:0030003 38 0.085
regulation of biosynthetic process of antibacterial peptides active against gram negative bacteria GO:0002813 14 0.085
cellular response to heat GO:0034605 24 0.085
Yeast
response to monosaccharide GO:0034284 4 0.085
Rat
response to hexose GO:0009746 3 0.085
Rat
response to salt stress GO:0009651 11 0.084
Fly
appendage morphogenesis GO:0035107 397 0.084
Fly
response to light stimulus GO:0009416 124 0.083
response to nitrogen compound GO:1901698 90 0.083
Mouse
regulation of blood circulation GO:1903522 21 0.083
developmental maturation GO:0021700 172 0.083
cellular macromolecule localization GO:0070727 220 0.082
Mouse Worm
regulation of catalytic activity GO:0050790 185 0.082
Fly
cell adhesion GO:0007155 136 0.082
negative regulation of intracellular signal transduction GO:1902532 57 0.080
Fly
imaginal disc derived wing morphogenesis GO:0007476 337 0.080
Fly
cation homeostasis GO:0055080 51 0.080
cuticle development GO:0042335 86 0.079
secretion GO:0046903 109 0.079
negative regulation of phosphorus metabolic process GO:0010563 45 0.079
Fly
muscle tissue development GO:0060537 30 0.079
Mouse
positive regulation of phosphate metabolic process GO:0045937 139 0.078
Fly
cognition GO:0050890 141 0.076
protein complex biogenesis GO:0070271 201 0.076
organic hydroxy compound biosynthetic process GO:1901617 21 0.075
regulation of antimicrobial peptide biosynthetic process GO:0002805 38 0.075
endocytosis GO:0006897 310 0.074
Fly
protein phosphorylation GO:0006468 169 0.073
cell migration GO:0016477 238 0.073
Fly
negative regulation of signal transduction GO:0009968 206 0.072
Mouse Fly
digestive tract development GO:0048565 149 0.072
Fly
response to metal ion GO:0010038 23 0.071
regulation of cell development GO:0060284 215 0.070
Mouse
negative regulation of apoptotic process GO:0043066 63 0.068
protein localization GO:0008104 284 0.067
Mouse Worm
regulation of apoptotic process GO:0042981 130 0.067
regulation of stress activated protein kinase signaling cascade GO:0070302 42 0.066
Fly
cellular response to biotic stimulus GO:0071216 4 0.066
Human Mouse
protein localization to nucleus GO:0034504 55 0.066
Mouse Worm
regulation of cell size GO:0008361 63 0.066
maintenance of protein location in cell GO:0032507 26 0.066
wing disc morphogenesis GO:0007472 344 0.066
Fly
regulation of molecular function GO:0065009 217 0.065
Fly
cellular response to lipopolysaccharide GO:0071222 3 0.065
Human Mouse
innate immune response activating signal transduction GO:0002758 2 0.065
regulation of canonical wnt signaling pathway GO:0060828 15 0.065
Mouse
ion homeostasis GO:0050801 55 0.064
production of molecular mediator of immune response GO:0002440 46 0.064
positive regulation of antibacterial peptide production GO:0002803 20 0.064
peptidoglycan recognition protein signaling pathway GO:0061057 16 0.063
muscle fiber development GO:0048747 12 0.063
Mouse
cell projection assembly GO:0030031 94 0.063
salivary gland development GO:0007431 162 0.063
positive regulation of catalytic activity GO:0043085 118 0.062
nuclear division GO:0000280 332 0.062
protein modification process GO:0036211 438 0.061
taxis GO:0042330 304 0.061
Fly
actin cytoskeleton organization GO:0030036 206 0.061
salivary gland morphogenesis GO:0007435 145 0.060
response to glucose GO:0009749 2 0.059
Rat
positive regulation of programmed cell death GO:0043068 62 0.059
cellular response to transforming growth factor beta stimulus GO:0071560 18 0.057
Fly
positive regulation of cell differentiation GO:0045597 64 0.057
Mouse
cellular nitrogen compound catabolic process GO:0044270 165 0.057
antimicrobial peptide biosynthetic process GO:0002777 38 0.057
regulation of heart contraction GO:0008016 21 0.056
hemopoiesis GO:0030097 46 0.056
Mouse
amine metabolic process GO:0009308 12 0.056
regulation of bmp signaling pathway GO:0030510 23 0.055
Fly
apoptotic signaling pathway GO:0097190 27 0.055
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.055
ras protein signal transduction GO:0007265 88 0.055
cell type specific apoptotic process GO:0097285 38 0.055
muscle structure development GO:0061061 224 0.054
Human Mouse
negative regulation of neuron death GO:1901215 18 0.054
positive regulation of nervous system development GO:0051962 69 0.054
ribose phosphate metabolic process GO:0019693 145 0.053
positive regulation of dendrite morphogenesis GO:0050775 9 0.053
regulation of phosphorus metabolic process GO:0051174 210 0.053
Fly
regulation of protein metabolic process GO:0051246 256 0.053
Fly
embryonic organ development GO:0048568 50 0.053
Fly
activation of innate immune response GO:0002218 4 0.052
cellular response to starvation GO:0009267 61 0.052
phagocytosis GO:0006909 215 0.052
Fly
positive regulation of antimicrobial peptide production GO:0002225 28 0.052
regulation of nervous system development GO:0051960 248 0.052
carbohydrate derivative metabolic process GO:1901135 217 0.051
single organism cellular localization GO:1902580 180 0.051
Mouse
cellular response to nutrient levels GO:0031669 62 0.051
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.051
negative regulation of phosphorylation GO:0042326 35 0.050
Fly
forebrain development GO:0030900 2 0.050
regulation of ion transport GO:0043269 39 0.050
cellular response to molecule of bacterial origin GO:0071219 3 0.050
Human Mouse
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.049
negative regulation of defense response GO:0031348 35 0.049
heart contraction GO:0060047 26 0.049
nucleoside catabolic process GO:0009164 112 0.049
axon guidance GO:0007411 233 0.049
Fly
regulation of peptidoglycan recognition protein signaling pathway GO:0061058 4 0.049
neuron projection guidance GO:0097485 241 0.049
Fly
aromatic compound catabolic process GO:0019439 166 0.049
carbohydrate derivative catabolic process GO:1901136 118 0.049
response to organonitrogen compound GO:0010243 75 0.048
Mouse
establishment of tissue polarity GO:0007164 87 0.048
circulatory system process GO:0003013 37 0.048
regulation of steroid metabolic process GO:0019218 2 0.048
gtp catabolic process GO:0006184 72 0.048
regulation of cell substrate adhesion GO:0010810 2 0.048
positive regulation of developmental process GO:0051094 143 0.048
Mouse Fly
multi organism behavior GO:0051705 175 0.047
cellular response to organic substance GO:0071310 132 0.047
Human Mouse Fly
single organism catabolic process GO:0044712 228 0.046
regulation of cellular component size GO:0032535 98 0.046
single organism biosynthetic process GO:0044711 206 0.046
Yeast
substrate adhesion dependent cell spreading GO:0034446 2 0.046
myoblast fusion GO:0007520 43 0.045
Mouse
molting cycle chitin based cuticle GO:0007591 56 0.045
positive regulation of biosynthetic process of antibacterial peptides active against gram negative bacteria GO:0006964 12 0.045
purine nucleotide metabolic process GO:0006163 146 0.045
ribonucleoside triphosphate metabolic process GO:0009199 119 0.045
actin filament based movement GO:0030048 26 0.044
purine nucleoside triphosphate catabolic process GO:0009146 108 0.044
negative regulation of phosphate metabolic process GO:0045936 45 0.044
Fly
regulation of cellular protein metabolic process GO:0032268 243 0.044
Fly
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 4 0.043
multi organism reproductive behavior GO:0044705 121 0.043
neuron recognition GO:0008038 101 0.043
response to organic cyclic compound GO:0014070 89 0.043
small molecule metabolic process GO:0044281 305 0.043
Mouse
skin development GO:0043588 65 0.042
digestive system development GO:0055123 149 0.042
Fly
response to growth factor GO:0070848 31 0.042
Human Fly
cell activation GO:0001775 9 0.042
cellular component assembly involved in morphogenesis GO:0010927 151 0.042
Yeast Fly
regulation of transferase activity GO:0051338 58 0.042
Fly
organonitrogen compound catabolic process GO:1901565 128 0.041
developmental programmed cell death GO:0010623 138 0.041
regulation of cell proliferation GO:0042127 163 0.041
positive regulation of antibacterial peptide biosynthetic process GO:0006963 20 0.041
enzyme linked receptor protein signaling pathway GO:0007167 179 0.041
Human Mouse Fly
male mating behavior GO:0060179 70 0.041
positive regulation of cell migration GO:0030335 2 0.041
purine nucleotide catabolic process GO:0006195 109 0.041
muscle cell differentiation GO:0042692 103 0.040
Human Mouse
organic substance catabolic process GO:1901575 308 0.040
gtp metabolic process GO:0046039 72 0.040
positive regulation of multi organism process GO:0043902 40 0.040
regulation of adult chitin containing cuticle pigmentation GO:0048082 13 0.040
peptidyl amino acid modification GO:0018193 105 0.040
Human Mouse Worm
small gtpase mediated signal transduction GO:0007264 88 0.040
cell cycle dna replication GO:0044786 23 0.039
Yeast
regulation of organelle organization GO:0033043 196 0.039
signal transduction in response to dna damage GO:0042770 3 0.038
Human
regulation of cellular amine metabolic process GO:0033238 3 0.038
negative regulation of gene expression epigenetic GO:0045814 77 0.038
g protein coupled receptor signaling pathway GO:0007186 136 0.037
morphogenesis of an epithelium GO:0002009 276 0.036
Fly
cellular response to endogenous stimulus GO:0071495 80 0.036
Fly
cellular catabolic process GO:0044248 372 0.036
Fly
anatomical structure homeostasis GO:0060249 97 0.036
cellular divalent inorganic cation homeostasis GO:0072503 23 0.036
response to molecule of bacterial origin GO:0002237 7 0.035
Human Mouse
long term memory GO:0007616 62 0.035
axonogenesis GO:0007409 290 0.035
Fly
single organism intracellular transport GO:1902582 207 0.035
Mouse
regulation of ras protein signal transduction GO:0046578 93 0.035
organelle assembly GO:0070925 198 0.034
nucleotide metabolic process GO:0009117 161 0.034
hematopoietic or lymphoid organ development GO:0048534 57 0.034
Mouse
negative regulation of stress activated protein kinase signaling cascade GO:0070303 20 0.034
Fly
positive regulation of antimicrobial humoral response GO:0002760 28 0.034
negative regulation of cell death GO:0060548 81 0.034
ribonucleotide metabolic process GO:0009259 145 0.034
ion transport GO:0006811 145 0.034
cation transmembrane transport GO:0098655 88 0.033
cellular metal ion homeostasis GO:0006875 31 0.033
response to radiation GO:0009314 155 0.033
Human
peptidoglycan catabolic process GO:0009253 3 0.033
purine containing compound metabolic process GO:0072521 155 0.033
myotube cell development GO:0014904 3 0.033
Mouse
oocyte development GO:0048599 124 0.033
mating behavior GO:0007617 106 0.033
response to wounding GO:0009611 94 0.033
Mouse Fly
biological adhesion GO:0022610 138 0.033
reactive oxygen species metabolic process GO:0072593 22 0.033
negative regulation of cellular component organization GO:0051129 108 0.032
developmental pigmentation GO:0048066 68 0.032
positive regulation of antimicrobial peptide biosynthetic process GO:0002807 26 0.032
learning or memory GO:0007611 141 0.032
digestive tract morphogenesis GO:0048546 127 0.032
Fly
cell aging GO:0007569 2 0.031
Human
organic hydroxy compound metabolic process GO:1901615 83 0.031
Fly
response to decreased oxygen levels GO:0036293 58 0.031
positive regulation of protein metabolic process GO:0051247 128 0.031
Fly
positive regulation of humoral immune response GO:0002922 28 0.031
regulation of map kinase activity GO:0043405 17 0.031
Fly
response to hypoxia GO:0001666 53 0.031
somatic muscle development GO:0007525 66 0.031
positive regulation of cell development GO:0010720 61 0.031
ameboidal type cell migration GO:0001667 151 0.030
Fly
nucleocytoplasmic transport GO:0006913 72 0.030
Mouse
purine ribonucleotide metabolic process GO:0009150 145 0.030
purine nucleoside metabolic process GO:0042278 127 0.030
axon development GO:0061564 297 0.030
Fly
regulation of protein modification process GO:0031399 112 0.030
Fly
organic cyclic compound catabolic process GO:1901361 168 0.030
negative regulation of cell differentiation GO:0045596 143 0.030
Yeast
cellular response to extracellular stimulus GO:0031668 64 0.030
circadian rhythm GO:0007623 105 0.030
gland morphogenesis GO:0022612 145 0.030
cellular response to nitrogen compound GO:1901699 51 0.030
extrinsic apoptotic signaling pathway GO:0097191 1 0.029
negative regulation of kinase activity GO:0033673 16 0.029
Fly
striated muscle cell development GO:0055002 50 0.029
Mouse
macromolecule catabolic process GO:0009057 161 0.029
ovarian follicle cell development GO:0030707 248 0.029
Fly
glycosaminoglycan catabolic process GO:0006027 3 0.028
regulation of cell projection organization GO:0031344 92 0.028
positive regulation of apoptotic signaling pathway GO:2001235 4 0.028
visual learning GO:0008542 4 0.028
response to ionizing radiation GO:0010212 32 0.028
Human
metal ion homeostasis GO:0055065 44 0.028
sex determination GO:0007530 18 0.028
regulation of chromosome organization GO:0033044 64 0.028
heterochromatin organization GO:0070828 25 0.028
nuclear dna replication GO:0033260 1 0.028
Yeast
regulation of nucleocytoplasmic transport GO:0046822 35 0.028
Mouse
regulation of neuron differentiation GO:0045664 103 0.028
negative regulation of developmental process GO:0051093 201 0.027
Yeast
regulation of hydrolase activity GO:0051336 97 0.027
jak stat cascade GO:0007259 49 0.027
regulation of wnt signaling pathway GO:0030111 68 0.027
Mouse
glycosyl compound metabolic process GO:1901657 127 0.027
response to hydrogen peroxide GO:0042542 11 0.027
eye development GO:0001654 323 0.027
respiratory system development GO:0060541 213 0.027
heterocycle catabolic process GO:0046700 166 0.027
terminal button organization GO:0072553 19 0.027
Fly
regulation of cellular ketone metabolic process GO:0010565 3 0.027
positive regulation of reactive oxygen species metabolic process GO:2000379 0 0.027
Human
nucleotide catabolic process GO:0009166 109 0.027
cell proliferation GO:0008283 299 0.027
cuticle pigmentation GO:0048067 22 0.026
wound healing GO:0042060 75 0.026
Mouse Fly
purine ribonucleoside catabolic process GO:0046130 112 0.026
purine ribonucleoside metabolic process GO:0046128 127 0.026
central nervous system development GO:0007417 201 0.026
positive regulation of cell motility GO:2000147 3 0.026
intracellular transport GO:0046907 228 0.026
Mouse
cell cell junction organization GO:0045216 55 0.026
regulation of homeostatic process GO:0032844 7 0.026
Mouse
tissue death GO:0016271 102 0.026
divalent inorganic cation homeostasis GO:0072507 29 0.026
regulation of purine nucleotide metabolic process GO:1900542 62 0.025
cellular response to lipid GO:0071396 20 0.025
Human Mouse
nucleoside triphosphate metabolic process GO:0009141 120 0.025
positive regulation of innate immune response GO:0045089 38 0.025
positive regulation of mapk cascade GO:0043410 63 0.025
regulation of cell cycle GO:0051726 291 0.025
Yeast Rat
organophosphate catabolic process GO:0046434 112 0.025
myotube differentiation GO:0014902 46 0.025
Mouse
neuron death GO:0070997 27 0.025
negative regulation of wnt signaling pathway GO:0030178 28 0.024
Mouse
protein complex assembly GO:0006461 200 0.024
response to copper ion GO:0046688 4 0.024
guanosine containing compound metabolic process GO:1901068 74 0.024
regulation of cellular amino acid metabolic process GO:0006521 0 0.024
nuclear transport GO:0051169 72 0.024
Mouse
imaginal disc derived wing margin morphogenesis GO:0008587 41 0.024
negative regulation of programmed cell death GO:0043069 72 0.024
carbohydrate metabolic process GO:0005975 82 0.024
Mouse
ribonucleotide catabolic process GO:0009261 109 0.024
actin filament organization GO:0007015 126 0.024

Mpk2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.074
cancer DOID:162 0 0.024
disease of cellular proliferation DOID:14566 0 0.024
organ system cancer DOID:0050686 0 0.024