Drosophila melanogaster

4 known processes

Pal (Dmel_CG5472)

Peptidyl-alpha-hydroxyglycine-alpha-amidating lyase

(Aliases: CG5472,anon-WO0149856.5,PAL,Dmel\CG5472)

Pal biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
small molecule metabolic process GO:0044281 305 0.068
defense response GO:0006952 300 0.059
g protein coupled receptor signaling pathway GO:0007186 136 0.056
Fly
organonitrogen compound metabolic process GO:1901564 318 0.056
single organism behavior GO:0044708 391 0.049
Fly
positive regulation of response to stimulus GO:0048584 323 0.046
negative regulation of signaling GO:0023057 219 0.042
response to external biotic stimulus GO:0043207 293 0.041
epithelial cell differentiation GO:0030855 322 0.040
response to other organism GO:0051707 293 0.039
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.038
synaptic transmission GO:0007268 288 0.038
intracellular signal transduction GO:0035556 300 0.037
single organism biosynthetic process GO:0044711 206 0.037
response to biotic stimulus GO:0009607 294 0.037
response to organic substance GO:0010033 284 0.037
Fly
regulation of intracellular signal transduction GO:1902531 236 0.037
organic substance catabolic process GO:1901575 308 0.036
epithelial cell development GO:0002064 274 0.034
adult behavior GO:0030534 137 0.034
Fly
positive regulation of signaling GO:0023056 243 0.033
negative regulation of response to stimulus GO:0048585 258 0.032
immune response activating signal transduction GO:0002757 2 0.031
transcription from rna polymerase ii promoter GO:0006366 368 0.031
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.030
immune response GO:0006955 246 0.030
eye development GO:0001654 323 0.029
neuropeptide signaling pathway GO:0007218 45 0.029
embryo development ending in birth or egg hatching GO:0009792 152 0.028
vesicle mediated transport GO:0016192 381 0.028
cellular catabolic process GO:0044248 372 0.028
organic acid metabolic process GO:0006082 103 0.028
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.027
immune response regulating signaling pathway GO:0002764 2 0.027
negative regulation of immune system process GO:0002683 50 0.027
activation of innate immune response GO:0002218 4 0.027
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.027
establishment of localization in cell GO:0051649 402 0.027
positive regulation of signal transduction GO:0009967 223 0.026
regionalization GO:0003002 416 0.026
determination of adult lifespan GO:0008340 137 0.025
regulation of defense response GO:0031347 102 0.025
negative regulation of cell communication GO:0010648 223 0.025
regulation of response to stress GO:0080134 200 0.025
carboxylic acid metabolic process GO:0019752 92 0.025
carbohydrate derivative metabolic process GO:1901135 217 0.024
cellular amino acid metabolic process GO:0006520 61 0.024
negative regulation of biosynthetic process GO:0009890 277 0.024
aging GO:0007568 143 0.024
response to oxygen containing compound GO:1901700 200 0.024
Fly
regulation of multi organism process GO:0043900 131 0.023
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.023
actin cytoskeleton organization GO:0030036 206 0.023
negative regulation of nucleic acid templated transcription GO:1903507 240 0.023
innate immune response GO:0045087 144 0.023
regulation of response to biotic stimulus GO:0002831 63 0.023
nucleobase containing small molecule metabolic process GO:0055086 174 0.023
mitotic nuclear division GO:0007067 213 0.023
pattern recognition receptor signaling pathway GO:0002221 2 0.023
nucleotide metabolic process GO:0009117 161 0.023
single organism catabolic process GO:0044712 228 0.022
positive regulation of cell communication GO:0010647 250 0.022
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.022
multicellular organismal aging GO:0010259 140 0.022
eye morphogenesis GO:0048592 260 0.022
innate immune response activating signal transduction GO:0002758 2 0.022
response to abiotic stimulus GO:0009628 341 0.022
compound eye development GO:0048749 307 0.022
organonitrogen compound catabolic process GO:1901565 128 0.022
negative regulation of signal transduction GO:0009968 206 0.021
regulation of anatomical structure size GO:0090066 163 0.021
negative regulation of cellular metabolic process GO:0031324 382 0.021
response to light stimulus GO:0009416 124 0.021
negative regulation of rna biosynthetic process GO:1902679 240 0.020
photoreceptor cell development GO:0042461 96 0.020
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.020
negative regulation of gene expression GO:0010629 387 0.020
appendage morphogenesis GO:0035107 397 0.020
regulation of phosphate metabolic process GO:0019220 210 0.020
oxoacid metabolic process GO:0043436 103 0.020
body morphogenesis GO:0010171 2 0.020
lateral inhibition GO:0046331 206 0.019
neurological system process GO:0050877 358 0.019
Fly
organophosphate metabolic process GO:0019637 195 0.019
imaginal disc derived appendage morphogenesis GO:0035114 395 0.019
purine ribonucleotide metabolic process GO:0009150 145 0.019
amine metabolic process GO:0009308 12 0.019
compound eye morphogenesis GO:0001745 249 0.019
cell cycle phase transition GO:0044770 140 0.019
nucleoside phosphate metabolic process GO:0006753 162 0.019
tube development GO:0035295 244 0.019
mitotic cell cycle phase transition GO:0044772 138 0.019
organelle fusion GO:0048284 46 0.019
regulation of phosphorus metabolic process GO:0051174 210 0.018
wing disc morphogenesis GO:0007472 344 0.018
macromolecular complex assembly GO:0065003 256 0.018
regulation of immune response GO:0050776 118 0.018
negative regulation of cellular biosynthetic process GO:0031327 277 0.018
appendage development GO:0048736 401 0.018
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.018
photoreceptor cell differentiation GO:0046530 170 0.018
defense response to other organism GO:0098542 225 0.018
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.018
regulation of mitotic cell cycle GO:0007346 190 0.018
organelle fission GO:0048285 340 0.018
respiratory system development GO:0060541 213 0.018
ribose phosphate metabolic process GO:0019693 145 0.017
negative regulation of multicellular organismal process GO:0051241 142 0.017
regulation of cell cycle GO:0051726 291 0.017
regulation of cellular protein metabolic process GO:0032268 243 0.017
positive regulation of biosynthetic process GO:0009891 316 0.017
ribonucleotide metabolic process GO:0009259 145 0.017
forebrain development GO:0030900 2 0.017
positive regulation of intracellular signal transduction GO:1902533 116 0.017
cell cell signaling involved in cell fate commitment GO:0045168 210 0.017
columnar cuboidal epithelial cell development GO:0002066 249 0.017
locomotory behavior GO:0007626 176 0.017
Fly
mitotic spindle organization GO:0007052 220 0.017
nuclear division GO:0000280 332 0.016
epithelium migration GO:0090132 148 0.016
adult locomotory behavior GO:0008344 76 0.016
Fly
post embryonic appendage morphogenesis GO:0035120 385 0.016
regulation of immune system process GO:0002682 176 0.016
negative regulation of rna metabolic process GO:0051253 251 0.016
phagocytosis GO:0006909 215 0.016
purine containing compound metabolic process GO:0072521 155 0.016
cellular homeostasis GO:0019725 80 0.016
cell proliferation GO:0008283 299 0.016
positive regulation of immune response GO:0050778 63 0.016
endocytosis GO:0006897 310 0.016
catabolic process GO:0009056 409 0.016
regulation of organelle organization GO:0033043 196 0.015
tissue migration GO:0090130 155 0.015
ovarian follicle cell development GO:0030707 248 0.015
purine nucleotide metabolic process GO:0006163 146 0.015
imaginal disc derived wing morphogenesis GO:0007476 337 0.015
response to radiation GO:0009314 155 0.015
protein complex biogenesis GO:0070271 201 0.015
regulation of localization GO:0032879 275 0.015
positive regulation of phosphorus metabolic process GO:0010562 139 0.015
carbohydrate derivative biosynthetic process GO:1901137 85 0.015
positive regulation of macromolecule metabolic process GO:0010604 405 0.015
response to lipopolysaccharide GO:0032496 4 0.015
immune system process GO:0002376 347 0.015
compound eye photoreceptor development GO:0042051 78 0.015
regulation of cell shape GO:0008360 113 0.015
eye photoreceptor cell development GO:0042462 81 0.015
actin filament based process GO:0030029 220 0.014
protein complex assembly GO:0006461 200 0.014
cellular ketone metabolic process GO:0042180 24 0.014
response to organophosphorus GO:0046683 2 0.014
male gamete generation GO:0048232 201 0.014
positive regulation of i kappab kinase nf kappab signaling GO:0043123 1 0.014
regulation of response to external stimulus GO:0032101 115 0.014
neurotransmitter metabolic process GO:0042133 2 0.014
ameboidal type cell migration GO:0001667 151 0.014
single organism cellular localization GO:1902580 180 0.014
regulation of cellular component biogenesis GO:0044087 201 0.014
mapk cascade GO:0000165 107 0.014
positive regulation of cellular biosynthetic process GO:0031328 316 0.014
regulation of innate immune response GO:0045088 71 0.014
regulation of cell morphogenesis GO:0022604 163 0.014
negative regulation of transcription dna templated GO:0045892 237 0.014
regulation of mitotic cell cycle phase transition GO:1901990 130 0.013
regulation of cellular amine metabolic process GO:0033238 3 0.013
organonitrogen compound biosynthetic process GO:1901566 117 0.013
regulation of anatomical structure morphogenesis GO:0022603 242 0.013
membrane organization GO:0061024 112 0.013
negative regulation of developmental process GO:0051093 201 0.013
cellular macromolecule localization GO:0070727 220 0.013
cellular nitrogen compound catabolic process GO:0044270 165 0.013
sensory organ morphogenesis GO:0090596 260 0.013
nucleobase containing compound catabolic process GO:0034655 165 0.013
cuticle development GO:0042335 86 0.013
positive regulation of gene expression GO:0010628 290 0.013
single organism intracellular transport GO:1902582 207 0.013
response to monosaccharide GO:0034284 4 0.013
developmental growth GO:0048589 280 0.013
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.013
cellular response to chemical stimulus GO:0070887 199 0.013
nucleoside triphosphate catabolic process GO:0009143 108 0.013
ribonucleoside triphosphate catabolic process GO:0009203 108 0.013
regulation of immune effector process GO:0002697 52 0.013
sensory perception of chemical stimulus GO:0007606 116 0.013
camera type eye development GO:0043010 4 0.013
regulation of catabolic process GO:0009894 170 0.013
cellular cation homeostasis GO:0030003 38 0.013
embryonic development via the syncytial blastoderm GO:0001700 148 0.013
open tracheal system development GO:0007424 204 0.013
purine nucleoside triphosphate metabolic process GO:0009144 119 0.013
purine nucleoside catabolic process GO:0006152 112 0.013
signal transduction by phosphorylation GO:0023014 107 0.013
salivary gland morphogenesis GO:0007435 145 0.013
cellular amine metabolic process GO:0044106 12 0.013
neuron recognition GO:0008038 101 0.013
purine nucleoside metabolic process GO:0042278 127 0.012
cellular response to dna damage stimulus GO:0006974 223 0.012
negative regulation of cellular component organization GO:0051129 108 0.012
death GO:0016265 284 0.012
purine nucleoside triphosphate catabolic process GO:0009146 108 0.012
heterocycle catabolic process GO:0046700 166 0.012
regulation of cellular catabolic process GO:0031329 157 0.012
segmentation GO:0035282 207 0.012
cell death GO:0008219 279 0.012
negative regulation of intracellular signal transduction GO:1902532 57 0.012
developmental programmed cell death GO:0010623 138 0.012
nucleoside metabolic process GO:0009116 127 0.012
regulation of cellular ketone metabolic process GO:0010565 3 0.012
axonogenesis GO:0007409 290 0.012
response to alcohol GO:0097305 95 0.012
Fly
cell recognition GO:0008037 102 0.012
regulation of catalytic activity GO:0050790 185 0.012
regulation of protein metabolic process GO:0051246 256 0.012
retina morphogenesis in camera type eye GO:0060042 2 0.012
cation transport GO:0006812 110 0.012
ribonucleoside catabolic process GO:0042454 112 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.012
actin filament organization GO:0007015 126 0.012
ribonucleoside metabolic process GO:0009119 127 0.012
neuron projection guidance GO:0097485 241 0.012
larval behavior GO:0030537 42 0.012
Fly
purine ribonucleoside catabolic process GO:0046130 112 0.012
regulation of molecular function GO:0065009 217 0.012
cellular protein modification process GO:0006464 438 0.012
homeostatic process GO:0042592 199 0.011
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.011
regulation of multicellular organismal development GO:2000026 414 0.011
rna processing GO:0006396 147 0.011
cellular response to organic substance GO:0071310 132 0.011
posttranscriptional regulation of gene expression GO:0010608 145 0.011
glycosyl compound metabolic process GO:1901657 127 0.011
ribonucleotide catabolic process GO:0009261 109 0.011
positive regulation of cell motility GO:2000147 3 0.011
defense response to bacterium GO:0042742 178 0.011
nucleoside phosphate catabolic process GO:1901292 110 0.011
organophosphate catabolic process GO:0046434 112 0.011
single organism membrane organization GO:0044802 93 0.011
embryonic pattern specification GO:0009880 174 0.011
positive regulation of phosphate metabolic process GO:0045937 139 0.011
regulation of mapk cascade GO:0043408 92 0.011
purine containing compound catabolic process GO:0072523 112 0.011
taxis GO:0042330 304 0.011
regulation of cell development GO:0060284 215 0.011
axon guidance GO:0007411 233 0.011
guanosine containing compound catabolic process GO:1901069 74 0.011
imaginal disc derived appendage development GO:0048737 399 0.011
protein localization GO:0008104 284 0.011
organic substance transport GO:0071702 257 0.011
response to ecdysone GO:0035075 34 0.011
camera type eye morphogenesis GO:0048593 2 0.011
axis specification GO:0009798 167 0.011
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.011
ovarian follicle cell migration GO:0007297 121 0.011
proteolysis GO:0006508 192 0.011
regulation of cellular amino acid metabolic process GO:0006521 0 0.011
positive regulation of immune system process GO:0002684 68 0.011
response to bacterium GO:0009617 198 0.011
neuroblast proliferation GO:0007405 74 0.011
aromatic compound catabolic process GO:0019439 166 0.011
retina development in camera type eye GO:0060041 4 0.011
developmental maturation GO:0021700 172 0.011
compound eye photoreceptor cell differentiation GO:0001751 140 0.011
cellular response to hexose stimulus GO:0071331 1 0.011
chemosensory behavior GO:0007635 106 0.011
cell division GO:0051301 248 0.011
regulation of nucleotide metabolic process GO:0006140 62 0.011
nucleoside triphosphate metabolic process GO:0009141 120 0.011
regulation of cellular component size GO:0032535 98 0.011
intracellular transport GO:0046907 228 0.010
molting cycle chitin based cuticle GO:0007591 56 0.010
rna localization GO:0006403 115 0.010
chemotaxis GO:0006935 249 0.010
positive regulation of nucleotide metabolic process GO:0045981 55 0.010
synapse organization GO:0050808 196 0.010
regulation of cell cycle process GO:0010564 181 0.010
transmembrane transport GO:0055085 139 0.010
phosphorylation GO:0016310 294 0.010
purine nucleotide catabolic process GO:0006195 109 0.010
cellular response to biotic stimulus GO:0071216 4 0.010
ras protein signal transduction GO:0007265 88 0.010
endomembrane system organization GO:0010256 119 0.010
carbohydrate derivative catabolic process GO:1901136 118 0.010

Pal disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.023
disease of metabolism DOID:0014667 0 0.020
nervous system disease DOID:863 0 0.015
inherited metabolic disorder DOID:655 0 0.013
diabetes mellitus DOID:9351 0 0.011
type 2 diabetes mellitus DOID:9352 0 0.011
carbohydrate metabolism disease DOID:0050013 0 0.011
glucose metabolism disease DOID:4194 0 0.011
acquired metabolic disease DOID:0060158 0 0.011