Drosophila melanogaster

0 known processes

Dot (Dmel_CG2788)

Dorothy

(Aliases: CG2788,Dmel\CG2788)

Dot biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
carboxylic acid metabolic process GO:0019752 92 0.178
Human Mouse
small molecule metabolic process GO:0044281 305 0.133
Human Mouse
response to abiotic stimulus GO:0009628 341 0.126
organic acid metabolic process GO:0006082 103 0.114
Human Mouse
catabolic process GO:0009056 409 0.099
Human Rat
organonitrogen compound metabolic process GO:1901564 318 0.086
response to oxygen containing compound GO:1901700 200 0.085
Human Rat
cellular catabolic process GO:0044248 372 0.084
Rat
oxoacid metabolic process GO:0043436 103 0.083
Human Mouse
single organism catabolic process GO:0044712 228 0.077
Human Rat
response to organic substance GO:0010033 284 0.072
Human Rat
response to nutrient levels GO:0031667 114 0.069
Rat
response to extracellular stimulus GO:0009991 116 0.058
Rat
steroid catabolic process GO:0006706 1 0.057
Human Rat
secondary metabolic process GO:0019748 75 0.052
Rat
appendage development GO:0048736 401 0.052
developmental growth GO:0048589 280 0.052
organic substance catabolic process GO:1901575 308 0.051
Human Rat
cellular protein modification process GO:0006464 438 0.051
imaginal disc derived appendage morphogenesis GO:0035114 395 0.049
appendage morphogenesis GO:0035107 397 0.049
response to bacterium GO:0009617 198 0.048
Rat
response to endogenous stimulus GO:0009719 119 0.046
Human Rat
embryonic morphogenesis GO:0048598 206 0.046
regionalization GO:0003002 416 0.045
response to temperature stimulus GO:0009266 106 0.045
tissue morphogenesis GO:0048729 297 0.045
estrogen metabolic process GO:0008210 1 0.045
Human Rat
regulation of growth GO:0040008 233 0.044
embryonic development via the syncytial blastoderm GO:0001700 148 0.044
response to nitrogen compound GO:1901698 90 0.043
Rat
transcription from rna polymerase ii promoter GO:0006366 368 0.042
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.041
lipid metabolic process GO:0006629 121 0.041
Human Rat
protein modification process GO:0036211 438 0.041
positive regulation of gene expression GO:0010628 290 0.040
regulation of multicellular organismal development GO:2000026 414 0.040
growth GO:0040007 359 0.039
positive regulation of macromolecule metabolic process GO:0010604 405 0.039
regulation of developmental growth GO:0048638 174 0.039
intracellular signal transduction GO:0035556 300 0.038
response to other organism GO:0051707 293 0.038
Rat
wing disc morphogenesis GO:0007472 344 0.038
response to lipopolysaccharide GO:0032496 4 0.037
Rat
imaginal disc derived wing morphogenesis GO:0007476 337 0.037
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.037
imaginal disc derived appendage development GO:0048737 399 0.037
cell migration GO:0016477 238 0.037
single organism biosynthetic process GO:0044711 206 0.036
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.035
morphogenesis of an epithelium GO:0002009 276 0.035
taxis GO:0042330 304 0.035
regulation of intracellular signal transduction GO:1902531 236 0.034
regulation of cell differentiation GO:0045595 302 0.034
digestive tract development GO:0048565 149 0.034
compound eye morphogenesis GO:0001745 249 0.034
response to biotic stimulus GO:0009607 294 0.033
Rat
death GO:0016265 284 0.033
compound eye development GO:0048749 307 0.033
vesicle mediated transport GO:0016192 381 0.033
tube development GO:0035295 244 0.033
regulation of cell development GO:0060284 215 0.032
cellular response to organic substance GO:0071310 132 0.032
Human Rat
neurological system process GO:0050877 358 0.032
Rat Fly
regulation of cell cycle GO:0051726 291 0.032
tube morphogenesis GO:0035239 191 0.032
homeostatic process GO:0042592 199 0.032
cell death GO:0008219 279 0.032
negative regulation of developmental process GO:0051093 201 0.031
response to external biotic stimulus GO:0043207 293 0.031
Rat
response to organonitrogen compound GO:0010243 75 0.031
Rat
response to organic cyclic compound GO:0014070 89 0.031
Human Rat
cellular response to chemical stimulus GO:0070887 199 0.031
Human Rat
cell motility GO:0048870 251 0.031
organophosphate metabolic process GO:0019637 195 0.031
phagocytosis GO:0006909 215 0.031
epithelial cell development GO:0002064 274 0.031
hormone catabolic process GO:0042447 3 0.031
Human Rat
eye development GO:0001654 323 0.031
endocytosis GO:0006897 310 0.030
regulation of anatomical structure morphogenesis GO:0022603 242 0.030
negative regulation of gene expression GO:0010629 387 0.030
cell proliferation GO:0008283 299 0.030
androgen metabolic process GO:0008209 1 0.030
Human
cellular amino acid metabolic process GO:0006520 61 0.030
organic hydroxy compound metabolic process GO:1901615 83 0.029
organic substance transport GO:0071702 257 0.029
nucleoside phosphate metabolic process GO:0006753 162 0.029
establishment of localization in cell GO:0051649 402 0.029
response to starvation GO:0042594 97 0.028
Rat
single organism behavior GO:0044708 391 0.028
single organism carbohydrate metabolic process GO:0044723 72 0.028
Human Mouse
response to organophosphorus GO:0046683 2 0.028
xenobiotic catabolic process GO:0042178 1 0.028
Rat
axon guidance GO:0007411 233 0.028
positive regulation of multicellular organismal process GO:0051240 143 0.028
programmed cell death GO:0012501 257 0.028
post embryonic appendage morphogenesis GO:0035120 385 0.027
heterocycle catabolic process GO:0046700 166 0.027
Rat
regulation of cellular component biogenesis GO:0044087 201 0.027
carbohydrate metabolic process GO:0005975 82 0.027
Human Mouse
regulation of phosphorus metabolic process GO:0051174 210 0.027
nucleobase containing small molecule metabolic process GO:0055086 174 0.027
positive regulation of cell communication GO:0010647 250 0.027
body morphogenesis GO:0010171 2 0.027
aromatic compound catabolic process GO:0019439 166 0.027
Rat
negative regulation of cell communication GO:0010648 223 0.026
digestive system development GO:0055123 149 0.026
response to hexose GO:0009746 3 0.026
organic cyclic compound catabolic process GO:1901361 168 0.026
Human Rat
digestive tract morphogenesis GO:0048546 127 0.026
actin filament based process GO:0030029 220 0.026
positive regulation of developmental process GO:0051094 143 0.026
columnar cuboidal epithelial cell development GO:0002066 249 0.025
eye morphogenesis GO:0048592 260 0.025
regulation of nervous system development GO:0051960 248 0.025
respiratory system development GO:0060541 213 0.025
sensory organ morphogenesis GO:0090596 260 0.025
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.025
ras protein signal transduction GO:0007265 88 0.025
positive regulation of signaling GO:0023056 243 0.024
regulation of phosphate metabolic process GO:0019220 210 0.024
synaptic transmission GO:0007268 288 0.024
negative regulation of signaling GO:0023057 219 0.023
positive regulation of cellular biosynthetic process GO:0031328 316 0.023
localization of cell GO:0051674 257 0.023
positive regulation of response to stimulus GO:0048584 323 0.023
regulation of cell death GO:0010941 173 0.023
epithelial cell differentiation GO:0030855 322 0.023
response to monosaccharide GO:0034284 4 0.023
positive regulation of biosynthetic process GO:0009891 316 0.023
multi organism behavior GO:0051705 175 0.023
Fly
axonogenesis GO:0007409 290 0.022
organelle fission GO:0048285 340 0.022
benzene containing compound metabolic process GO:0042537 3 0.022
Rat
regulation of programmed cell death GO:0043067 152 0.022
neuron projection guidance GO:0097485 241 0.022
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.022
nucleotide metabolic process GO:0009117 161 0.022
negative regulation of response to stimulus GO:0048585 258 0.022
regulation of anatomical structure size GO:0090066 163 0.021
positive regulation of phosphorus metabolic process GO:0010562 139 0.021
oxidation reduction process GO:0055114 123 0.021
cellular amine metabolic process GO:0044106 12 0.021
small gtpase mediated signal transduction GO:0007264 88 0.021
positive regulation of phosphate metabolic process GO:0045937 139 0.021
enzyme linked receptor protein signaling pathway GO:0007167 179 0.021
amine metabolic process GO:0009308 12 0.021
carbohydrate derivative metabolic process GO:1901135 217 0.021
chemotaxis GO:0006935 249 0.021
tissue death GO:0016271 102 0.020
muscle structure development GO:0061061 224 0.020
negative regulation of cellular metabolic process GO:0031324 382 0.020
cellular lipid metabolic process GO:0044255 83 0.020
compound eye photoreceptor cell differentiation GO:0001751 140 0.020
response to glucose GO:0009749 2 0.020
positive regulation of developmental growth GO:0048639 62 0.020
hormone metabolic process GO:0042445 33 0.020
Human Rat
regulation of catabolic process GO:0009894 170 0.020
regulation of molecular function GO:0065009 217 0.020
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.020
tissue migration GO:0090130 155 0.019
phosphorylation GO:0016310 294 0.019
negative regulation of cell differentiation GO:0045596 143 0.019
chaeta development GO:0022416 97 0.019
single organism intracellular transport GO:1902582 207 0.019
negative regulation of nucleic acid templated transcription GO:1903507 240 0.019
positive regulation of nucleic acid templated transcription GO:1903508 266 0.019
kidney development GO:0001822 3 0.019
positive regulation of transcription dna templated GO:0045893 266 0.019
regulation of cellular protein metabolic process GO:0032268 243 0.019
developmental programmed cell death GO:0010623 138 0.019
leg disc development GO:0035218 92 0.019
regulation of protein metabolic process GO:0051246 256 0.019
embryo development ending in birth or egg hatching GO:0009792 152 0.019
regulation of apoptotic process GO:0042981 130 0.019
apoptotic process GO:0006915 159 0.019
sensory perception GO:0007600 196 0.019
Rat Fly
negative regulation of rna biosynthetic process GO:1902679 240 0.018
nuclear division GO:0000280 332 0.018
dorsal ventral pattern formation GO:0009953 133 0.018
protein localization GO:0008104 284 0.018
negative regulation of cellular biosynthetic process GO:0031327 277 0.018
pyridine containing compound metabolic process GO:0072524 3 0.018
organonitrogen compound catabolic process GO:1901565 128 0.018
regulation of hormone levels GO:0010817 40 0.018
Human Rat
eye photoreceptor cell differentiation GO:0001754 145 0.018
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.018
salivary gland morphogenesis GO:0007435 145 0.018
regulation of cellular ketone metabolic process GO:0010565 3 0.018
cytoplasmic transport GO:0016482 130 0.018
regulation of small gtpase mediated signal transduction GO:0051056 93 0.018
regulation of cell cycle process GO:0010564 181 0.018
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.018
epithelium migration GO:0090132 148 0.018
positive regulation of rna metabolic process GO:0051254 271 0.018
cellular homeostasis GO:0019725 80 0.018
open tracheal system development GO:0007424 204 0.018
negative regulation of cellular component organization GO:0051129 108 0.017
negative regulation of biosynthetic process GO:0009890 277 0.017
cellular ketone metabolic process GO:0042180 24 0.017
monocarboxylic acid metabolic process GO:0032787 29 0.017
Human Mouse
regulation of catalytic activity GO:0050790 185 0.017
positive regulation of rna biosynthetic process GO:1902680 266 0.017
ovarian follicle cell development GO:0030707 248 0.017
gastrulation GO:0007369 70 0.017
forebrain development GO:0030900 2 0.017
camera type eye development GO:0043010 4 0.017
embryonic axis specification GO:0000578 107 0.016
protein complex assembly GO:0006461 200 0.016
cellular nitrogen compound catabolic process GO:0044270 165 0.016
regulation of ras protein signal transduction GO:0046578 93 0.016
regulation of cellular amine metabolic process GO:0033238 3 0.016
purine nucleotide metabolic process GO:0006163 146 0.016
peptidyl amino acid modification GO:0018193 105 0.016
negative regulation of rna metabolic process GO:0051253 251 0.016
imaginal disc derived leg morphogenesis GO:0007480 80 0.016
defense response GO:0006952 300 0.016
Rat
regulation of cell proliferation GO:0042127 163 0.016
negative regulation of signal transduction GO:0009968 206 0.016
stem cell differentiation GO:0048863 117 0.016
ameboidal type cell migration GO:0001667 151 0.016
intracellular transport GO:0046907 228 0.016
chemosensory behavior GO:0007635 106 0.016
protein transport GO:0015031 155 0.016
intracellular protein transmembrane transport GO:0065002 4 0.016
cell cycle phase transition GO:0044770 140 0.016
regulation of phosphorylation GO:0042325 147 0.015
protein phosphorylation GO:0006468 169 0.015
response to wounding GO:0009611 94 0.015
axon development GO:0061564 297 0.015
regulation of neurogenesis GO:0050767 158 0.015
nitrogen compound transport GO:0071705 85 0.015
purine ribonucleotide metabolic process GO:0009150 145 0.015
protein complex biogenesis GO:0070271 201 0.015
histolysis GO:0007559 102 0.015
proteolysis GO:0006508 192 0.015
defense response to bacterium GO:0042742 178 0.015
spindle organization GO:0007051 253 0.015
blastoderm segmentation GO:0007350 159 0.015
positive regulation of catalytic activity GO:0043085 118 0.015
vitamin metabolic process GO:0006766 2 0.014
cellular response to nutrient levels GO:0031669 62 0.014
positive regulation of molecular function GO:0044093 136 0.014
nucleoside metabolic process GO:0009116 127 0.014
regulation of neuron differentiation GO:0045664 103 0.014
aggressive behavior GO:0002118 63 0.014
Fly
developmental growth involved in morphogenesis GO:0060560 65 0.014
ribose phosphate metabolic process GO:0019693 145 0.014
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.014
response to oxygen levels GO:0070482 59 0.014
leg disc morphogenesis GO:0007478 80 0.014
positive regulation of growth GO:0045927 75 0.014
notch signaling pathway GO:0007219 120 0.014
cell division GO:0051301 248 0.014
establishment or maintenance of cell polarity GO:0007163 167 0.014
mitotic cell cycle phase transition GO:0044772 138 0.014
positive regulation of cellular component organization GO:0051130 156 0.014
positive regulation of signal transduction GO:0009967 223 0.014
positive regulation of catabolic process GO:0009896 105 0.013
axis specification GO:0009798 167 0.013
regulation of cellular catabolic process GO:0031329 157 0.013
single organism cellular localization GO:1902580 180 0.013
positive regulation of intracellular signal transduction GO:1902533 116 0.013
purine nucleoside metabolic process GO:0042278 127 0.013
somatic muscle development GO:0007525 66 0.013
gland morphogenesis GO:0022612 145 0.013
sodium dependent phosphate transport GO:0044341 2 0.013
actin filament based movement GO:0030048 26 0.013
negative regulation of transcription dna templated GO:0045892 237 0.013
cellular response to nitrogen compound GO:1901699 51 0.013
Rat
regulation of cellular amino acid metabolic process GO:0006521 0 0.013
embryonic pattern specification GO:0009880 174 0.013
cellular response to endogenous stimulus GO:0071495 80 0.013
Human Rat
pyridine nucleotide metabolic process GO:0019362 2 0.013
cellular response to molecule of bacterial origin GO:0071219 3 0.013
chromatin organization GO:0006325 207 0.013
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.013
organophosphate catabolic process GO:0046434 112 0.013
epithelial tube morphogenesis GO:0060562 88 0.013
cellular response to biotic stimulus GO:0071216 4 0.013
response to ethanol GO:0045471 59 0.013
Rat
pigment metabolic process GO:0042440 84 0.013
photoreceptor cell differentiation GO:0046530 170 0.013
dendrite development GO:0016358 204 0.013
positive regulation of protein metabolic process GO:0051247 128 0.013
epithelial cell migration GO:0010631 148 0.013
olfactory behavior GO:0042048 97 0.012
imaginal disc pattern formation GO:0007447 91 0.012
multicellular organismal aging GO:0010259 140 0.012
macromolecule catabolic process GO:0009057 161 0.012
positive regulation of cell migration GO:0030335 2 0.012
carbohydrate derivative catabolic process GO:1901136 118 0.012
jak stat cascade GO:0007259 49 0.012
cellular macromolecular complex assembly GO:0034622 153 0.012
anterior posterior axis specification GO:0009948 109 0.012
regulation of localization GO:0032879 275 0.012
segmentation GO:0035282 207 0.012
developmental maturation GO:0021700 172 0.012
macromolecular complex assembly GO:0065003 256 0.012
ribonucleotide metabolic process GO:0009259 145 0.012
inter male aggressive behavior GO:0002121 60 0.012
Fly
mitotic nuclear division GO:0007067 213 0.012
cellular response to lipopolysaccharide GO:0071222 3 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.012
salivary gland histolysis GO:0035070 88 0.012
immune system process GO:0002376 347 0.012
intracellular protein transport GO:0006886 104 0.012
regulation of cell morphogenesis GO:0022604 163 0.012
positive regulation of phosphorylation GO:0042327 87 0.012
purine ribonucleoside metabolic process GO:0046128 127 0.012
oxidoreduction coenzyme metabolic process GO:0006733 2 0.012
telencephalon development GO:0021537 2 0.012
cellular protein localization GO:0034613 160 0.012
phosphate ion transport GO:0006817 4 0.012
purine containing compound metabolic process GO:0072521 155 0.012
meiotic cell cycle GO:0051321 171 0.012
g protein coupled receptor signaling pathway GO:0007186 136 0.012
negative regulation of nervous system development GO:0051961 92 0.012
sex differentiation GO:0007548 81 0.012
gastrulation with mouth forming first GO:0001703 36 0.012
response to radiation GO:0009314 155 0.012
exocrine system development GO:0035272 162 0.012
defense response to other organism GO:0098542 225 0.012
cellular response to ethanol GO:0071361 4 0.012
Rat
border follicle cell migration GO:0007298 113 0.012
phenol containing compound metabolic process GO:0018958 57 0.011
negative regulation of cell cycle GO:0045786 116 0.011
cellular response to dna damage stimulus GO:0006974 223 0.011
response to alcohol GO:0097305 95 0.011
Rat
negative regulation of mitotic cell cycle GO:0045930 109 0.011
nucleoside catabolic process GO:0009164 112 0.011
cellular macromolecule localization GO:0070727 220 0.011
rna processing GO:0006396 147 0.011
secretion by cell GO:0032940 101 0.011
glycosyl compound metabolic process GO:1901657 127 0.011
ion transport GO:0006811 145 0.011
mating behavior GO:0007617 106 0.011
male gamete generation GO:0048232 201 0.011
cognition GO:0050890 141 0.011
central nervous system development GO:0007417 201 0.011
negative regulation of multicellular organismal process GO:0051241 142 0.011
dna damage checkpoint GO:0000077 78 0.011
mitotic cell cycle checkpoint GO:0007093 88 0.011
cellular response to hormone stimulus GO:0032870 44 0.011
Human Rat
actin cytoskeleton organization GO:0030036 206 0.011
regulation of cellular localization GO:0060341 136 0.011
response to alkaloid GO:0043279 26 0.011
lipid biosynthetic process GO:0008610 46 0.011
ribonucleotide catabolic process GO:0009261 109 0.011
nucleobase containing compound catabolic process GO:0034655 165 0.011
eggshell formation GO:0030703 105 0.011
regulation of mitotic cell cycle GO:0007346 190 0.011
ribonucleoside metabolic process GO:0009119 127 0.011
positive regulation of programmed cell death GO:0043068 62 0.011
positive regulation of nucleotide metabolic process GO:0045981 55 0.011
mesodermal cell migration GO:0008078 7 0.011
secretion GO:0046903 109 0.011
nucleoside phosphate catabolic process GO:1901292 110 0.011
regulation of mitotic cell cycle phase transition GO:1901990 130 0.011
cellular response to oxygen containing compound GO:1901701 79 0.011
Human Rat
spermatogenesis GO:0007283 200 0.011
eye photoreceptor cell development GO:0042462 81 0.011
regulation of synapse structure and activity GO:0050803 128 0.011
cellular response to extracellular stimulus GO:0031668 64 0.011
establishment of protein localization GO:0045184 163 0.011
purine containing compound catabolic process GO:0072523 112 0.011
negative regulation of cell development GO:0010721 62 0.011
cellular response to starvation GO:0009267 61 0.011
stem cell proliferation GO:0072089 88 0.011
positive regulation of cell motility GO:2000147 3 0.011
rho protein signal transduction GO:0007266 14 0.011
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.011
cholesterol homeostasis GO:0042632 3 0.011
organelle assembly GO:0070925 198 0.011
organonitrogen compound biosynthetic process GO:1901566 117 0.011
cell fate determination GO:0001709 91 0.010
sensory perception of smell GO:0007608 80 0.010
Rat Fly
medium chain fatty acid metabolic process GO:0051791 1 0.010
dendrite morphogenesis GO:0048813 199 0.010
response to ketone GO:1901654 34 0.010
Human Rat
protein transmembrane transport GO:0071806 4 0.010
nicotinamide nucleotide metabolic process GO:0046496 2 0.010
salivary gland development GO:0007431 162 0.010
regulation of tube size open tracheal system GO:0035151 43 0.010
connective tissue development GO:0061448 3 0.010
regulation of organelle organization GO:0033043 196 0.010
purine nucleoside catabolic process GO:0006152 112 0.010
positive regulation of cell death GO:0010942 69 0.010
salivary gland cell autophagic cell death GO:0035071 83 0.010
autophagic cell death GO:0048102 83 0.010
protein localization to organelle GO:0033365 82 0.010
lipid modification GO:0030258 24 0.010
response to hypoxia GO:0001666 53 0.010
positive regulation of cellular catabolic process GO:0031331 95 0.010
autophagy GO:0006914 108 0.010
reproductive structure development GO:0048608 74 0.010

Dot disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.032
disease of metabolism DOID:0014667 0 0.018
nervous system disease DOID:863 0 0.013
inherited metabolic disorder DOID:655 0 0.012
musculoskeletal system disease DOID:17 0 0.010