Drosophila melanogaster

139 known processes

dlp (Dmel_CG32146)

dally-like

(Aliases: D-gpcB,CG17703,Dmel\CG32146,CG5031,CT16138,Dlp,Dally-like,Dly,dly,CG32146)

dlp biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
neuromuscular junction development GO:0007528 149 0.976
segment polarity determination GO:0007367 25 0.952
neuron projection guidance GO:0097485 241 0.868
synapse organization GO:0050808 196 0.812
axon development GO:0061564 297 0.799
axonogenesis GO:0007409 290 0.767
establishment of organelle localization GO:0051656 122 0.763
synaptic vesicle localization GO:0097479 53 0.701
sensory organ morphogenesis GO:0090596 260 0.692
positive regulation of macromolecule metabolic process GO:0010604 405 0.682
wnt signaling pathway GO:0016055 98 0.677
morphogenesis of an epithelium GO:0002009 276 0.665
Zebrafish
organelle localization GO:0051640 148 0.654
regulation of wnt signaling pathway GO:0030111 68 0.646
vesicle localization GO:0051648 55 0.536
establishment of synaptic vesicle localization GO:0097480 50 0.535
establishment of vesicle localization GO:0051650 51 0.506
synaptic vesicle transport GO:0048489 50 0.500
regulation of synapse structure and activity GO:0050803 128 0.496
imaginal disc derived appendage morphogenesis GO:0035114 395 0.480
axon guidance GO:0007411 233 0.477
regulation of synapse organization GO:0050807 110 0.462
regulation of cell differentiation GO:0045595 302 0.434
Mouse Fly
wing disc morphogenesis GO:0007472 344 0.428
dorsal closure GO:0007391 79 0.424
appendage morphogenesis GO:0035107 397 0.406
eye morphogenesis GO:0048592 260 0.391
salivary gland development GO:0007431 162 0.388
regulation of multicellular organismal development GO:2000026 414 0.379
morphogenesis of embryonic epithelium GO:0016331 94 0.359
gene silencing by rna GO:0031047 57 0.337
cellular response to chemical stimulus GO:0070887 199 0.330
Mouse
regulation of neurogenesis GO:0050767 158 0.326
cuticle pattern formation GO:0035017 27 0.315
respiratory system development GO:0060541 213 0.299
motor neuron axon guidance GO:0008045 58 0.297
Fly
phosphorylation GO:0016310 294 0.292
gastrulation with mouth forming first GO:0001703 36 0.277
negative regulation of wnt signaling pathway GO:0030178 28 0.256
synaptic growth at neuromuscular junction GO:0051124 119 0.252
synapse assembly GO:0007416 143 0.230
periodic partitioning GO:0007365 29 0.230
chemotaxis GO:0006935 249 0.227
regulation of nervous system development GO:0051960 248 0.218
skin development GO:0043588 65 0.207
negative regulation of developmental process GO:0051093 201 0.196
Fly
tissue morphogenesis GO:0048729 297 0.184
Zebrafish
synaptic vesicle recycling GO:0036465 28 0.177
single organismal cell cell adhesion GO:0016337 45 0.173
compound eye morphogenesis GO:0001745 249 0.172
embryonic pattern specification GO:0009880 174 0.171
post embryonic appendage morphogenesis GO:0035120 385 0.160
negative regulation of multicellular organismal process GO:0051241 142 0.155
regulation of synapse assembly GO:0051963 94 0.154
synaptic transmission GO:0007268 288 0.150
developmental programmed cell death GO:0010623 138 0.145
localization of cell GO:0051674 257 0.135
Zebrafish
actin filament based process GO:0030029 220 0.134
positive regulation of response to stimulus GO:0048584 323 0.133
dendrite development GO:0016358 204 0.133
Fly
imaginal disc pattern formation GO:0007447 91 0.132
positive regulation of gene expression GO:0010628 290 0.132
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.131
signal transduction by phosphorylation GO:0023014 107 0.131
response to organic substance GO:0010033 284 0.128
Mouse
developmental growth GO:0048589 280 0.127
positive regulation of nervous system development GO:0051962 69 0.125
regulation of decapentaplegic signaling pathway GO:0090097 8 0.125
negative regulation of gene expression GO:0010629 387 0.122
eye development GO:0001654 323 0.122
regulation of neuron projection development GO:0010975 69 0.120
positive regulation of cell development GO:0010720 61 0.117
neuroblast development GO:0014019 13 0.117
transcription from rna polymerase ii promoter GO:0006366 368 0.115
death GO:0016265 284 0.110
lipid metabolic process GO:0006629 121 0.109
imaginal disc derived wing morphogenesis GO:0007476 337 0.109
cortical cytoskeleton organization GO:0030865 29 0.107
apoptotic process GO:0006915 159 0.107
regionalization GO:0003002 416 0.107
synaptic vesicle endocytosis GO:0048488 28 0.106
posttranscriptional gene silencing by rna GO:0035194 45 0.105
embryonic morphogenesis GO:0048598 206 0.103
Zebrafish
compound eye development GO:0048749 307 0.103
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.103
positive regulation of developmental process GO:0051094 143 0.102
Mouse
programmed cell death GO:0012501 257 0.099
segmentation GO:0035282 207 0.099
positive regulation of protein metabolic process GO:0051247 128 0.098
brain development GO:0007420 120 0.095
protein phosphorylation GO:0006468 169 0.094
regulation of programmed cell death GO:0043067 152 0.094
notch signaling pathway GO:0007219 120 0.094
non canonical wnt signaling pathway GO:0035567 8 0.093
negative regulation of synaptic growth at neuromuscular junction GO:0045886 39 0.093
regulation of notch signaling pathway GO:0008593 100 0.092
negative regulation of signaling GO:0023057 219 0.090
gene silencing GO:0016458 138 0.089
open tracheal system development GO:0007424 204 0.089
protein modification process GO:0036211 438 0.089
retinal ganglion cell axon guidance GO:0031290 12 0.087
positive regulation of synapse assembly GO:0051965 29 0.083
regulation of synaptic growth at neuromuscular junction GO:0008582 89 0.083
cell death GO:0008219 279 0.081
positive regulation of multicellular organismal process GO:0051240 143 0.080
Mouse
stem cell division GO:0017145 69 0.078
Fly
gland development GO:0048732 191 0.077
positive regulation of catabolic process GO:0009896 105 0.077
mapk cascade GO:0000165 107 0.076
positive regulation of cellular component organization GO:0051130 156 0.073
taxis GO:0042330 304 0.072
posttranscriptional regulation of gene expression GO:0010608 145 0.071
developmental pigmentation GO:0048066 68 0.071
negative regulation of cell communication GO:0010648 223 0.069
response to oxidative stress GO:0006979 86 0.068
dorsal ventral pattern formation GO:0009953 133 0.067
negative regulation of response to stimulus GO:0048585 258 0.067
appendage development GO:0048736 401 0.066
regulation of canonical wnt signaling pathway GO:0060828 15 0.066
negative regulation of signal transduction GO:0009968 206 0.065
central nervous system development GO:0007417 201 0.064
positive regulation of rna metabolic process GO:0051254 271 0.064
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.063
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.062
positive regulation of rna biosynthetic process GO:1902680 266 0.061
positive regulation of cellular protein metabolic process GO:0032270 118 0.060
stress activated protein kinase signaling cascade GO:0031098 55 0.059
positive regulation of programmed cell death GO:0043068 62 0.059
positive regulation of nucleic acid templated transcription GO:1903508 266 0.059
embryonic development via the syncytial blastoderm GO:0001700 148 0.058
regulation of synaptic transmission GO:0050804 69 0.057
epidermal cell differentiation GO:0009913 51 0.056
regulation of cell death GO:0010941 173 0.056
tissue death GO:0016271 102 0.054
actin cytoskeleton organization GO:0030036 206 0.054
positive regulation of cellular biosynthetic process GO:0031328 316 0.054
head development GO:0060322 135 0.053
eggshell formation GO:0030703 105 0.052
negative regulation of programmed cell death GO:0043069 72 0.052
regulation of cellular component biogenesis GO:0044087 201 0.052
epithelial cell differentiation GO:0030855 322 0.052
retina development in camera type eye GO:0060041 4 0.051
gastrulation GO:0007369 70 0.051
Zebrafish
single organism biosynthetic process GO:0044711 206 0.050
establishment or maintenance of cell polarity GO:0007163 167 0.048
Zebrafish
morphogenesis of an epithelial bud GO:0060572 3 0.048
regulation of receptor activity GO:0010469 10 0.048
regulation of cell projection organization GO:0031344 92 0.048
organophosphate metabolic process GO:0019637 195 0.047
epidermis development GO:0008544 65 0.047
positive regulation of synaptic growth at neuromuscular junction GO:0045887 26 0.046
terminal button organization GO:0072553 19 0.045
regulation of protein metabolic process GO:0051246 256 0.044
regulation of phosphorus metabolic process GO:0051174 210 0.044
regulation of protein localization GO:0032880 76 0.043
posttranscriptional gene silencing GO:0016441 46 0.043
imaginal disc derived appendage development GO:0048737 399 0.042
negative regulation of smoothened signaling pathway GO:0045879 16 0.042
negative regulation of cellular metabolic process GO:0031324 382 0.042
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 19 0.042
establishment of cell polarity GO:0030010 40 0.041
Zebrafish
regulation of cell development GO:0060284 215 0.041
neuron projection extension GO:1990138 32 0.040
apoptotic process involved in morphogenesis GO:0060561 3 0.040
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.039
regulation of neuron differentiation GO:0045664 103 0.039
positive regulation of signaling GO:0023056 243 0.039
regulation of mapk cascade GO:0043408 92 0.039
positive regulation of jun kinase activity GO:0043507 4 0.038
positive regulation of proteolysis GO:0045862 52 0.038
single organism cellular localization GO:1902580 180 0.038
neuroblast proliferation GO:0007405 74 0.037
forebrain development GO:0030900 2 0.037
defense response to bacterium GO:0042742 178 0.036
regulation of stress activated mapk cascade GO:0032872 41 0.036
regulation of developmental pigmentation GO:0048070 24 0.035
intracellular signal transduction GO:0035556 300 0.035
positive regulation of cell death GO:0010942 69 0.035
small molecule metabolic process GO:0044281 305 0.035
Human
canonical wnt signaling pathway GO:0060070 21 0.034
positive regulation of transcription dna templated GO:0045893 266 0.034
negative regulation of notch signaling pathway GO:0045746 41 0.034
regulation of vesicle mediated transport GO:0060627 59 0.034
regulation of response to external stimulus GO:0032101 115 0.034
gene silencing by mirna GO:0035195 22 0.033
regulation of protein modification process GO:0031399 112 0.033
glycosaminoglycan biosynthetic process GO:0006024 7 0.033
gastrulation involving germ band extension GO:0010004 36 0.033
positive regulation of proteasomal protein catabolic process GO:1901800 20 0.033
regulation of cellular catabolic process GO:0031329 157 0.032
positive regulation of signal transduction GO:0009967 223 0.032
regulation of terminal button organization GO:2000331 11 0.032
cell adhesion GO:0007155 136 0.032
response to superoxide GO:0000303 3 0.032
pigmentation GO:0043473 75 0.032
regulation of cell fate specification GO:0042659 27 0.032
negative regulation of cell death GO:0060548 81 0.031
camera type eye development GO:0043010 4 0.031
exocrine system development GO:0035272 162 0.031
catabolic process GO:0009056 409 0.030
Human
regulation of reproductive process GO:2000241 54 0.030
negative regulation of heart induction GO:1901320 3 0.030
protein complex assembly GO:0006461 200 0.030
macromolecule catabolic process GO:0009057 161 0.030
Human
neuron recognition GO:0008038 101 0.030
stress activated mapk cascade GO:0051403 52 0.030
specification of organ identity GO:0010092 3 0.029
regulation of small gtpase mediated signal transduction GO:0051056 93 0.029
response to growth factor GO:0070848 31 0.029
Mouse
negative regulation of developmental growth GO:0048640 64 0.029
regulation of anatomical structure morphogenesis GO:0022603 242 0.029
developmental maturation GO:0021700 172 0.029
spindle localization GO:0051653 22 0.029
regulation of cellular protein metabolic process GO:0032268 243 0.028
regulation of catabolic process GO:0009894 170 0.028
negative regulation of fibroblast growth factor receptor signaling pathway GO:0040037 2 0.028
Mouse
cellular protein modification process GO:0006464 438 0.028
salivary gland morphogenesis GO:0007435 145 0.028
developmental growth involved in morphogenesis GO:0060560 65 0.028
Zebrafish
response to biotic stimulus GO:0009607 294 0.028
establishment of spindle localization GO:0051293 22 0.027
regulation of dendrite development GO:0050773 37 0.027
tube development GO:0035295 244 0.027
Zebrafish
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.027
Fly
positive regulation of cell projection organization GO:0031346 29 0.026
regulation of cell morphogenesis GO:0022604 163 0.026
negative regulation of canonical wnt signaling pathway GO:0090090 6 0.026
digestive tract morphogenesis GO:0048546 127 0.025
Zebrafish
protein modification by small protein conjugation GO:0032446 79 0.025
proteolysis GO:0006508 192 0.025
regulation of receptor mediated endocytosis GO:0048259 9 0.025
cell surface receptor signaling pathway involved in heart development GO:0061311 3 0.024
salivary gland cell autophagic cell death GO:0035071 83 0.024
positive regulation of epithelial cell differentiation GO:0030858 1 0.024
regulation of protein phosphorylation GO:0001932 64 0.024
neuron fate specification GO:0048665 12 0.023
negative regulation of cellular component organization GO:0051129 108 0.023
positive regulation of cell differentiation GO:0045597 64 0.023
Mouse
positive regulation of apoptotic process GO:0043065 47 0.023
cell fate specification GO:0001708 71 0.023
positive regulation of cellular catabolic process GO:0031331 95 0.022
cellular response to extracellular stimulus GO:0031668 64 0.022
cuticle development GO:0042335 86 0.022
establishment of spindle orientation GO:0051294 18 0.022
positive regulation of neuron differentiation GO:0045666 26 0.022
biological adhesion GO:0022610 138 0.022
regulation of ras protein signal transduction GO:0046578 93 0.022
single organism cell adhesion GO:0098602 47 0.022
axon extension GO:0048675 32 0.022
epithelial tube morphogenesis GO:0060562 88 0.021
transmembrane transport GO:0055085 139 0.021
regulation of molecular function GO:0065009 217 0.021
salivary gland histolysis GO:0035070 88 0.021
embryonic organ development GO:0048568 50 0.021
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 24 0.021
neuron fate determination GO:0048664 1 0.020
macromolecular complex assembly GO:0065003 256 0.020
kidney development GO:0001822 3 0.020
detection of external stimulus GO:0009581 66 0.020
female meiotic division GO:0007143 70 0.020
defense response to gram negative bacterium GO:0050829 94 0.020
positive regulation of retinal cell programmed cell death GO:0046670 9 0.020
regulation of jun kinase activity GO:0043506 8 0.019
cellular macromolecule catabolic process GO:0044265 136 0.019
Human
regulation of jnk cascade GO:0046328 40 0.019
response to wounding GO:0009611 94 0.019
axon cargo transport GO:0008088 29 0.019
positive regulation of secretion GO:0051047 22 0.019
regulation of intracellular protein transport GO:0033157 46 0.018
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.018
regulation of heart induction GO:0090381 3 0.018
negative regulation of heart induction by canonical wnt signaling pathway GO:0003136 3 0.018
cell maturation GO:0048469 144 0.017
neural retina development GO:0003407 4 0.017
ectodermal placode development GO:0071696 4 0.017
regulation of hydrolase activity GO:0051336 97 0.017
autophagic cell death GO:0048102 83 0.017
spemann organizer formation GO:0060061 1 0.017
regulation of cell junction assembly GO:1901888 2 0.017
positive regulation of neurogenesis GO:0050769 41 0.017
response to abiotic stimulus GO:0009628 341 0.017
spinal cord dorsal ventral patterning GO:0021513 1 0.017
positive regulation of phosphate metabolic process GO:0045937 139 0.017
regulation of glutamate receptor signaling pathway GO:1900449 1 0.017
molting cycle GO:0042303 56 0.017
regulation of protein localization to nucleus GO:1900180 29 0.017
wound healing spreading of epidermal cells GO:0035313 1 0.017
positive regulation of biosynthetic process GO:0009891 316 0.017
establishment of mitotic spindle localization GO:0040001 17 0.017
positive regulation of protein transport GO:0051222 37 0.016
ectodermal placode morphogenesis GO:0071697 4 0.016
synaptic target recognition GO:0008039 45 0.016
blastoderm segmentation GO:0007350 159 0.016
histolysis GO:0007559 102 0.016
regulation of compound eye pigmentation GO:0048076 7 0.016
convergent extension GO:0060026 2 0.016
Zebrafish
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.016
regulation of dna dependent dna replication GO:0090329 6 0.016
epithelial cell development GO:0002064 274 0.016
negative regulation of nervous system development GO:0051961 92 0.016
negative regulation of multi organism process GO:0043901 29 0.016
establishment of mitotic spindle orientation GO:0000132 13 0.016
intracellular transport GO:0046907 228 0.016
regulation of phosphatase activity GO:0010921 3 0.016
neurotransmitter gated ion channel clustering GO:0072578 2 0.016
wnt signaling pathway planar cell polarity pathway GO:0060071 6 0.015
regulation of intracellular signal transduction GO:1902531 236 0.015
somatic stem cell division GO:0048103 37 0.015
regulation of transferase activity GO:0051338 58 0.015
response to bacterium GO:0009617 198 0.015
regulation of phosphate metabolic process GO:0019220 210 0.015
organonitrogen compound metabolic process GO:1901564 318 0.015
positive regulation of cell communication GO:0010647 250 0.015
response to external biotic stimulus GO:0043207 293 0.015
positive regulation of cellular component biogenesis GO:0044089 80 0.015
regulation of epithelial cell differentiation GO:0030856 4 0.015
positive regulation of compound eye retinal cell programmed cell death GO:0046672 9 0.014
embryo development ending in birth or egg hatching GO:0009792 152 0.014
Zebrafish
morphogenesis of a branching structure GO:0001763 45 0.014
response to nutrient levels GO:0031667 114 0.014
regulation of protein catabolic process GO:0042176 55 0.014
digestive tract development GO:0048565 149 0.014
Zebrafish
wing disc pattern formation GO:0035222 66 0.014
immune response activating signal transduction GO:0002757 2 0.014
tube morphogenesis GO:0035239 191 0.014
Zebrafish
imaginal disc derived leg morphogenesis GO:0007480 80 0.014
Fly
regulation of cytoplasmic transport GO:1903649 47 0.014
positive regulation of molecular function GO:0044093 136 0.013
regulation of dna metabolic process GO:0051052 34 0.013
carbohydrate derivative biosynthetic process GO:1901137 85 0.013
Zebrafish
neuromuscular process GO:0050905 21 0.013
digestive system development GO:0055123 149 0.013
Zebrafish
positive regulation of cellular protein catabolic process GO:1903364 24 0.013
camera type eye morphogenesis GO:0048593 2 0.013
limb development GO:0060173 1 0.013
organ formation GO:0048645 39 0.013
Fly
gland morphogenesis GO:0022612 145 0.013
dna metabolic process GO:0006259 227 0.013
dendrite morphogenesis GO:0048813 199 0.013
Fly
regulation of protein transport GO:0051223 57 0.013
regulation of establishment of protein localization GO:0070201 61 0.013
regulation of gene expression epigenetic GO:0040029 128 0.013
positive regulation of phosphorylation GO:0042327 87 0.013
positive regulation of wnt signaling pathway GO:0030177 25 0.013
regulation of axonogenesis GO:0050770 32 0.013
heart induction GO:0003129 3 0.013
regulation of organ formation GO:0003156 3 0.012
regulation of cellular response to oxidative stress GO:1900407 4 0.012
regulation of excitatory postsynaptic membrane potential GO:0060079 3 0.012
regulation of compound eye retinal cell programmed cell death GO:0046669 18 0.012
phagocytosis GO:0006909 215 0.012
imaginal disc growth GO:0007446 37 0.012
cellular response to organic substance GO:0071310 132 0.012
Mouse
regulation of long term neuronal synaptic plasticity GO:0048169 1 0.012
endocytosis GO:0006897 310 0.012
body morphogenesis GO:0010171 2 0.012
regulation of cytoskeleton organization GO:0051493 89 0.012
jnk cascade GO:0007254 50 0.012
immune response regulating signaling pathway GO:0002764 2 0.012
regulation of catalytic activity GO:0050790 185 0.012
positive regulation of apoptotic signaling pathway GO:2001235 4 0.012
peptidyl threonine phosphorylation GO:0018107 2 0.012
neuroblast differentiation GO:0014016 29 0.012
developmental induction GO:0031128 3 0.011
negative regulation of biosynthetic process GO:0009890 277 0.011
positive regulation of endocytosis GO:0045807 22 0.011
regulation of stem cell proliferation GO:0072091 40 0.011
cellular response to oxidative stress GO:0034599 28 0.011
head involution GO:0008258 35 0.011
positive regulation of protein catabolic process GO:0045732 34 0.011
regulation of proteolysis GO:0030162 87 0.011
instar larval development GO:0002168 55 0.011
regulation of cellular localization GO:0060341 136 0.011
organic substance catabolic process GO:1901575 308 0.011
Human
membrane depolarization GO:0051899 4 0.011
cellular response to oxygen containing compound GO:1901701 79 0.011
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.011
morphogenesis of a polarized epithelium GO:0001738 93 0.010
compound eye photoreceptor cell differentiation GO:0001751 140 0.010
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.010
endodermal cell fate commitment GO:0001711 3 0.010
imaginal disc derived wing vein specification GO:0007474 48 0.010
negative regulation of rna metabolic process GO:0051253 251 0.010
protein heterooligomerization GO:0051291 4 0.010
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 41 0.010
compound eye photoreceptor development GO:0042051 78 0.010
regulation of transport GO:0051049 181 0.010
positive regulation of catalytic activity GO:0043085 118 0.010

dlp disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.069
cancer DOID:162 0 0.021
disease of cellular proliferation DOID:14566 0 0.021
organ system cancer DOID:0050686 0 0.021
motor neuron disease DOID:231 0 0.018
central nervous system disease DOID:331 0 0.018
neurodegenerative disease DOID:1289 0 0.018
nervous system disease DOID:863 0 0.018