Drosophila melanogaster

128 known processes

Crk (Dmel_CG1587)

CG1587 gene product from transcript CG1587-RC

(Aliases: dCrk,dCRK,CG1587,D-Crk,DCrk,Dmel\CG1587,crk,D-CRK,CRK,Dcrk)

Crk biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular catabolic process GO:0044248 372 0.271
Human
protein localization GO:0008104 284 0.176
cellular response to dna damage stimulus GO:0006974 223 0.168
regulation of cell morphogenesis GO:0022604 163 0.126
heterocycle catabolic process GO:0046700 166 0.118
Human
cgmp metabolic process GO:0046068 11 0.117
organic substance catabolic process GO:1901575 308 0.109
Human
regulation of cellular protein metabolic process GO:0032268 243 0.105
catabolic process GO:0009056 409 0.097
Human
endocytosis GO:0006897 310 0.096
chromosome organization GO:0051276 360 0.096
regulation of cellular response to stress GO:0080135 89 0.093
negative regulation of cellular biosynthetic process GO:0031327 277 0.090
posttranscriptional regulation of gene expression GO:0010608 145 0.089
regulation of protein metabolic process GO:0051246 256 0.089
single organism intracellular transport GO:1902582 207 0.085
single organism cellular localization GO:1902580 180 0.078
cellular macromolecule catabolic process GO:0044265 136 0.077
protein modification process GO:0036211 438 0.076
regulation of cell shape GO:0008360 113 0.074
organic cyclic compound catabolic process GO:1901361 168 0.071
Human
single organism catabolic process GO:0044712 228 0.071
Human
regulation of localization GO:0032879 275 0.066
compound eye development GO:0048749 307 0.063
regulation of response to stress GO:0080134 200 0.062
eye development GO:0001654 323 0.058
vesicle mediated transport GO:0016192 381 0.054
negative regulation of nucleic acid templated transcription GO:1903507 240 0.052
regulation of anatomical structure morphogenesis GO:0022603 242 0.046
compound eye morphogenesis GO:0001745 249 0.045
regulation of neuron differentiation GO:0045664 103 0.045
photoreceptor cell differentiation GO:0046530 170 0.043
establishment of protein localization GO:0045184 163 0.043
carbohydrate derivative metabolic process GO:1901135 217 0.043
Human
lateral inhibition GO:0046331 206 0.039
stem cell differentiation GO:0048863 117 0.039
nucleoside metabolic process GO:0009116 127 0.039
Human
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.038
developmental growth GO:0048589 280 0.037
body morphogenesis GO:0010171 2 0.037
cellular nitrogen compound catabolic process GO:0044270 165 0.036
Human
negative regulation of cellular metabolic process GO:0031324 382 0.035
regulation of cellular component biogenesis GO:0044087 201 0.033
cell cycle phase transition GO:0044770 140 0.033
nucleobase containing compound catabolic process GO:0034655 165 0.033
Human
nucleotide catabolic process GO:0009166 109 0.033
Human
regulation of translation GO:0006417 56 0.033
regulation of organelle organization GO:0033043 196 0.033
Human Mouse
compound eye photoreceptor cell differentiation GO:0001751 140 0.032
nucleobase containing small molecule metabolic process GO:0055086 174 0.032
Human
negative regulation of cell communication GO:0010648 223 0.031
positive regulation of multicellular organismal process GO:0051240 143 0.031
positive regulation of developmental process GO:0051094 143 0.031
membrane organization GO:0061024 112 0.030
covalent chromatin modification GO:0016569 106 0.030
modification dependent protein catabolic process GO:0019941 78 0.029
cellular response to starvation GO:0009267 61 0.029
mitotic cell cycle phase transition GO:0044772 138 0.028
negative regulation of signaling GO:0023057 219 0.028
macromolecular complex assembly GO:0065003 256 0.028
photoreceptor cell development GO:0042461 96 0.028
regionalization GO:0003002 416 0.027
Mouse
spermatogenesis GO:0007283 200 0.027
aromatic compound catabolic process GO:0019439 166 0.027
Human
negative regulation of rna biosynthetic process GO:1902679 240 0.026
glycoprotein metabolic process GO:0009100 41 0.026
response to organic substance GO:0010033 284 0.026
vesicle organization GO:0016050 44 0.026
protein complex assembly GO:0006461 200 0.025
intracellular transport GO:0046907 228 0.024
hematopoietic or lymphoid organ development GO:0048534 57 0.024
Mouse
ribonucleotide catabolic process GO:0009261 109 0.023
Human
negative regulation of gene expression GO:0010629 387 0.023
cell cycle checkpoint GO:0000075 95 0.023
dendrite development GO:0016358 204 0.022
macromolecule catabolic process GO:0009057 161 0.022
organonitrogen compound metabolic process GO:1901564 318 0.022
Human
ribonucleotide metabolic process GO:0009259 145 0.021
Human
regulation of multicellular organismal development GO:2000026 414 0.021
histone modification GO:0016570 106 0.021
actin cytoskeleton organization GO:0030036 206 0.020
Human Mouse
small gtpase mediated signal transduction GO:0007264 88 0.020
Rat
purine containing compound metabolic process GO:0072521 155 0.020
Human
cellular response to organic substance GO:0071310 132 0.020
cell death GO:0008219 279 0.020
chromatin modification GO:0016568 147 0.019
negative regulation of rna metabolic process GO:0051253 251 0.019
programmed cell death GO:0012501 257 0.019
negative regulation of biosynthetic process GO:0009890 277 0.019
cell motility GO:0048870 251 0.019
intracellular signal transduction GO:0035556 300 0.019
protein localization to organelle GO:0033365 82 0.019
regulation of cell cycle phase transition GO:1901987 130 0.019
localization of cell GO:0051674 257 0.019
cellular macromolecular complex assembly GO:0034622 153 0.018
establishment of protein localization to organelle GO:0072594 62 0.018
actin filament organization GO:0007015 126 0.018
negative regulation of response to stimulus GO:0048585 258 0.018
cgmp biosynthetic process GO:0006182 8 0.018
stem cell development GO:0048864 79 0.018
regulation of transport GO:0051049 181 0.017
positive regulation of molecular function GO:0044093 136 0.017
eye morphogenesis GO:0048592 260 0.017
single organism behavior GO:0044708 391 0.017
death GO:0016265 284 0.017
camera type eye development GO:0043010 4 0.017
sensory organ morphogenesis GO:0090596 260 0.017
retrograde transport endosome to golgi GO:0042147 3 0.017
cellular response to chemical stimulus GO:0070887 199 0.017
anterior posterior pattern specification GO:0009952 136 0.017
Mouse
carbohydrate derivative biosynthetic process GO:1901137 85 0.017
regulation of purine nucleotide biosynthetic process GO:1900371 14 0.017
protein transport GO:0015031 155 0.017
organelle assembly GO:0070925 198 0.017
muscle structure development GO:0061061 224 0.016
Zebrafish
positive regulation of cell communication GO:0010647 250 0.016
embryo development ending in birth or egg hatching GO:0009792 152 0.016
regulation of hemocyte proliferation GO:0035206 37 0.016
phagocytosis GO:0006909 215 0.016
proteasomal protein catabolic process GO:0010498 59 0.016
rrna processing GO:0006364 3 0.016
atp metabolic process GO:0046034 49 0.016
actin filament based process GO:0030029 220 0.016
Human Mouse
male gamete generation GO:0048232 201 0.016
cellular macromolecule localization GO:0070727 220 0.016
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.016
regulation of mrna metabolic process GO:1903311 72 0.016
response to extracellular stimulus GO:0009991 116 0.015
negative regulation of signal transduction GO:0009968 206 0.015
eye photoreceptor cell differentiation GO:0001754 145 0.015
protein modification by small protein conjugation or removal GO:0070647 106 0.015
cellular protein localization GO:0034613 160 0.015
response to lipopolysaccharide GO:0032496 4 0.015
ribose phosphate metabolic process GO:0019693 145 0.015
Human
regulation of cellular localization GO:0060341 136 0.015
positive regulation of catalytic activity GO:0043085 118 0.014
regulation of cell development GO:0060284 215 0.014
regulation of protein stability GO:0031647 43 0.014
single organism membrane organization GO:0044802 93 0.014
regulation of response to external stimulus GO:0032101 115 0.014
meiotic cell cycle GO:0051321 171 0.014
establishment of localization in cell GO:0051649 402 0.014
immune system development GO:0002520 57 0.014
Mouse
positive regulation of cellular component organization GO:0051130 156 0.014
positive regulation of protein metabolic process GO:0051247 128 0.014
endomembrane system organization GO:0010256 119 0.013
purine nucleoside triphosphate catabolic process GO:0009146 108 0.013
Human
ribonucleoside catabolic process GO:0042454 112 0.013
Human
organic substance transport GO:0071702 257 0.013
ovulation cycle GO:0042698 1 0.013
cellular response to nitrogen compound GO:1901699 51 0.013
organelle fission GO:0048285 340 0.012
regulation of photoreceptor cell differentiation GO:0046532 34 0.012
cellular protein complex assembly GO:0043623 71 0.012
larval development GO:0002164 104 0.012
scf dependent proteasomal ubiquitin dependent protein catabolic process GO:0031146 1 0.012
response to axon injury GO:0048678 12 0.012
single organism biosynthetic process GO:0044711 206 0.011
ribonucleoside triphosphate catabolic process GO:0009203 108 0.011
Human
hemopoiesis GO:0030097 46 0.011
regulation of phosphorus metabolic process GO:0051174 210 0.011
regulation of protein modification process GO:0031399 112 0.011
nucleoside triphosphate metabolic process GO:0009141 120 0.011
Human
maintenance of location GO:0051235 73 0.011
positive regulation of cell projection organization GO:0031346 29 0.011
mitotic cell cycle checkpoint GO:0007093 88 0.011
translation GO:0006412 69 0.011
cytoplasmic transport GO:0016482 130 0.011
compound eye photoreceptor development GO:0042051 78 0.011
tor signaling GO:0031929 32 0.011
cytoskeleton dependent intracellular transport GO:0030705 44 0.011
response to radiation GO:0009314 155 0.011
cellular protein modification process GO:0006464 438 0.011
cellular response to nutrient levels GO:0031669 62 0.011
positive regulation of cgmp biosynthetic process GO:0030828 1 0.011
homeostatic process GO:0042592 199 0.010
ncrna processing GO:0034470 30 0.010
cellular protein catabolic process GO:0044257 83 0.010
intermediate filament based process GO:0045103 1 0.010
ncrna metabolic process GO:0034660 43 0.010
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.010
nucleoside triphosphate catabolic process GO:0009143 108 0.010
Human
dendrite morphogenesis GO:0048813 199 0.010
protein complex biogenesis GO:0070271 201 0.010
positive regulation of biosynthetic process GO:0009891 316 0.010
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.010
positive regulation of cell cycle GO:0045787 43 0.010

Crk disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
osteochondrodysplasia DOID:2256 0 0.014
osteogenesis imperfecta DOID:12347 0 0.014
bone development disease DOID:0080006 0 0.014
bone disease DOID:0080001 0 0.014
disease of anatomical entity DOID:7 0 0.014
musculoskeletal system disease DOID:17 0 0.014
connective tissue disease DOID:65 0 0.014