Drosophila melanogaster

247 known processes

spas (Dmel_CG5977)

spastin

(Aliases: CG5977,D-spastin,Dspastin,Spas,Dmel\CG5977)

spas biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
establishment of localization in cell GO:0051649 402 0.999
Human
regulation of dendrite morphogenesis GO:0048814 28 0.999
synapse assembly GO:0007416 143 0.998
ovarian follicle cell migration GO:0007297 121 0.997
regulation of anatomical structure morphogenesis GO:0022603 242 0.996
synaptic growth at neuromuscular junction GO:0051124 119 0.994
cell migration GO:0016477 238 0.993
border follicle cell migration GO:0007298 113 0.983
positive regulation of dendrite morphogenesis GO:0050775 9 0.983
epithelial cell migration GO:0010631 148 0.983
locomotory behavior GO:0007626 176 0.976
dendrite morphogenesis GO:0048813 199 0.958
neuromuscular junction development GO:0007528 149 0.941
synapse organization GO:0050808 196 0.940
dendrite development GO:0016358 204 0.938
ovarian follicle cell development GO:0030707 248 0.928
protein complex assembly GO:0006461 200 0.927
Human
cell motility GO:0048870 251 0.919
positive regulation of response to stimulus GO:0048584 323 0.908
cell growth GO:0016049 108 0.902
Zebrafish
macromolecular complex assembly GO:0065003 256 0.867
Human
developmental growth GO:0048589 280 0.865
localization of cell GO:0051674 257 0.826
regulation of synaptic growth at neuromuscular junction GO:0008582 89 0.826
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.823
regulation of cell projection organization GO:0031344 92 0.820
response to abiotic stimulus GO:0009628 341 0.811
morphogenesis of an epithelium GO:0002009 276 0.811
protein localization GO:0008104 284 0.793
tissue morphogenesis GO:0048729 297 0.793
regulation of localization GO:0032879 275 0.790
regulation of protein metabolic process GO:0051246 256 0.786
negative regulation of cellular component organization GO:0051129 108 0.781
positive regulation of macromolecule metabolic process GO:0010604 405 0.780
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.780
central nervous system development GO:0007417 201 0.751
Zebrafish
positive regulation of transcription dna templated GO:0045893 266 0.735
cellular amine metabolic process GO:0044106 12 0.718
positive regulation of protein metabolic process GO:0051247 128 0.703
regulation of cellular component biogenesis GO:0044087 201 0.702
actin filament based process GO:0030029 220 0.691
phosphorylation GO:0016310 294 0.675
epithelial cell differentiation GO:0030855 322 0.667
regulation of protein phosphorylation GO:0001932 64 0.658
death GO:0016265 284 0.658
Zebrafish
immune system process GO:0002376 347 0.636
protein phosphorylation GO:0006468 169 0.635
positive regulation of cell communication GO:0010647 250 0.629
immune response GO:0006955 246 0.612
regulation of developmental growth GO:0048638 174 0.600
positive regulation of synaptic growth at neuromuscular junction GO:0045887 26 0.589
regulation of phosphate metabolic process GO:0019220 210 0.586
regulation of synapse structure and activity GO:0050803 128 0.584
positive regulation of signaling GO:0023056 243 0.584
regulation of cellular protein metabolic process GO:0032268 243 0.583
organic substance transport GO:0071702 257 0.557
axonogenesis GO:0007409 290 0.553
Zebrafish
columnar cuboidal epithelial cell development GO:0002066 249 0.549
amine metabolic process GO:0009308 12 0.527
positive regulation of cellular component organization GO:0051130 156 0.522
catabolic process GO:0009056 409 0.519
organonitrogen compound metabolic process GO:1901564 318 0.514
regulation of cell differentiation GO:0045595 302 0.511
establishment of mitochondrion localization GO:0051654 7 0.502
growth GO:0040007 359 0.502
regulation of neuron projection development GO:0010975 69 0.497
epithelium migration GO:0090132 148 0.497
brain development GO:0007420 120 0.492
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.490
secretion by cell GO:0032940 101 0.480
epithelial cell development GO:0002064 274 0.473
regulation of phosphorus metabolic process GO:0051174 210 0.469
positive regulation of cell morphogenesis involved in differentiation GO:0010770 12 0.469
endomembrane system organization GO:0010256 119 0.461
Zebrafish
forebrain development GO:0030900 2 0.460
regulation of secretion by cell GO:1903530 39 0.458
positive regulation of developmental growth GO:0048639 62 0.455
regulation of cellular amino acid metabolic process GO:0006521 0 0.453
actin filament polymerization GO:0030041 27 0.439
positive regulation of phosphorylation GO:0042327 87 0.433
regulation of response to stress GO:0080134 200 0.426
intracellular signal transduction GO:0035556 300 0.410
positive regulation of axon guidance GO:1902669 1 0.409
positive regulation of phosphorus metabolic process GO:0010562 139 0.407
regulation of cell morphogenesis GO:0022604 163 0.405
regulation of transport GO:0051049 181 0.405
positive regulation of cellular biosynthetic process GO:0031328 316 0.405
regulation of dendrite development GO:0050773 37 0.392
regulation of nervous system development GO:0051960 248 0.391
regulation of actin polymerization or depolymerization GO:0008064 27 0.382
small molecule metabolic process GO:0044281 305 0.381
regulation of growth GO:0040008 233 0.379
regulation of catalytic activity GO:0050790 185 0.364
regulation of cellular amine metabolic process GO:0033238 3 0.360
posttranscriptional regulation of gene expression GO:0010608 145 0.358
positive regulation of protein modification process GO:0031401 58 0.352
positive regulation of protein phosphorylation GO:0001934 34 0.352
positive regulation of developmental process GO:0051094 143 0.345
negative regulation of cell communication GO:0010648 223 0.335
taxis GO:0042330 304 0.332
endocytosis GO:0006897 310 0.322
secretion GO:0046903 109 0.319
cellular protein modification process GO:0006464 438 0.318
tissue migration GO:0090130 155 0.313
regulation of cellular localization GO:0060341 136 0.313
cellular component assembly involved in morphogenesis GO:0010927 151 0.313
regulation of actin filament length GO:0030832 27 0.312
gliogenesis GO:0042063 80 0.311
positive regulation of cell motility GO:2000147 3 0.306
establishment of organelle localization GO:0051656 122 0.305
regulation of hydrolase activity GO:0051336 97 0.303
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.294
ion transmembrane transport GO:0034220 122 0.291
synaptic vesicle endocytosis GO:0048488 28 0.288
autophagy GO:0006914 108 0.285
intrinsic apoptotic signaling pathway GO:0097193 16 0.284
cellular protein complex assembly GO:0043623 71 0.282
positive regulation of multicellular organismal process GO:0051240 143 0.276
axon guidance GO:0007411 233 0.271
positive regulation of nervous system development GO:0051962 69 0.265
regulation of cell development GO:0060284 215 0.264
cell projection assembly GO:0030031 94 0.262
regulation of molecular function GO:0065009 217 0.261
microtubule polymerization or depolymerization GO:0031109 39 0.256
vesicle mediated transport GO:0016192 381 0.256
Human
positive regulation of organelle organization GO:0010638 65 0.255
adult locomotory behavior GO:0008344 76 0.255
adult behavior GO:0030534 137 0.252
actin polymerization or depolymerization GO:0008154 31 0.250
regulation of protein localization GO:0032880 76 0.249
positive regulation of cellular component biogenesis GO:0044089 80 0.248
response to wounding GO:0009611 94 0.245
regulation of protein modification process GO:0031399 112 0.245
regulation of multicellular organismal development GO:2000026 414 0.243
positive regulation of immune system process GO:0002684 68 0.242
organic cyclic compound catabolic process GO:1901361 168 0.242
positive regulation of signal transduction GO:0009967 223 0.240
cellular macromolecule localization GO:0070727 220 0.237
regulation of intracellular signal transduction GO:1902531 236 0.237
developmental growth involved in morphogenesis GO:0060560 65 0.234
Zebrafish
sex differentiation GO:0007548 81 0.232
regulation of cellular ketone metabolic process GO:0010565 3 0.232
positive regulation of intracellular signal transduction GO:1902533 116 0.231
lipid homeostasis GO:0055088 33 0.225
regulation of immune system process GO:0002682 176 0.225
negative regulation of synaptic growth at neuromuscular junction GO:0045886 39 0.224
protein transport GO:0015031 155 0.218
positive regulation of phosphate metabolic process GO:0045937 139 0.216
axon development GO:0061564 297 0.215
Zebrafish
learning or memory GO:0007611 141 0.209
organophosphate metabolic process GO:0019637 195 0.202
homeostatic process GO:0042592 199 0.201
cell death GO:0008219 279 0.201
Zebrafish
ion transport GO:0006811 145 0.194
single organism intracellular transport GO:1902582 207 0.194
Human
regulation of neuron differentiation GO:0045664 103 0.189
response to organic substance GO:0010033 284 0.187
regulation of transferase activity GO:0051338 58 0.185
organelle assembly GO:0070925 198 0.183
positive regulation of cell projection organization GO:0031346 29 0.183
cellular ketone metabolic process GO:0042180 24 0.183
regulation of axonogenesis GO:0050770 32 0.181
Zebrafish
telencephalon development GO:0021537 2 0.181
eye photoreceptor cell differentiation GO:0001754 145 0.181
signal release GO:0023061 49 0.178
neuron neuron synaptic transmission GO:0007270 14 0.175
muscle structure development GO:0061061 224 0.172
cell proliferation GO:0008283 299 0.169
appendage morphogenesis GO:0035107 397 0.162
cellular amino acid metabolic process GO:0006520 61 0.160
defense response to other organism GO:0098542 225 0.159
establishment of protein localization GO:0045184 163 0.158
regulation of organelle organization GO:0033043 196 0.156
protein polymerization GO:0051258 42 0.156
regulation of neurogenesis GO:0050767 158 0.152
sperm mitochondrion organization GO:0030382 7 0.151
regulation of kinase activity GO:0043549 53 0.151
regulation of synapse organization GO:0050807 110 0.147
anatomical structure homeostasis GO:0060249 97 0.147
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.146
positive regulation of molecular function GO:0044093 136 0.146
positive regulation of nucleic acid templated transcription GO:1903508 266 0.145
collateral sprouting GO:0048668 3 0.145
regulation of erbb signaling pathway GO:1901184 42 0.144
negative regulation of response to stimulus GO:0048585 258 0.143
regulation of secretion GO:0051046 44 0.139
regulation of cell adhesion GO:0030155 27 0.139
lipid metabolic process GO:0006629 121 0.139
nucleobase containing compound catabolic process GO:0034655 165 0.138
muscle attachment GO:0016203 36 0.136
organic hydroxy compound metabolic process GO:1901615 83 0.135
positive regulation of biosynthetic process GO:0009891 316 0.134
tissue homeostasis GO:0001894 36 0.132
dorsal closure GO:0007391 79 0.132
response to bacterium GO:0009617 198 0.132
positive regulation of cellular amine metabolic process GO:0033240 0 0.132
response to external biotic stimulus GO:0043207 293 0.131
regulation of proteolysis GO:0030162 87 0.129
negative regulation of developmental process GO:0051093 201 0.126
positive regulation of protein kinase activity GO:0045860 25 0.124
purine nucleoside triphosphate catabolic process GO:0009146 108 0.121
oocyte fate determination GO:0030716 27 0.120
glycosyl compound metabolic process GO:1901657 127 0.120
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.119
positive regulation of growth GO:0045927 75 0.119
actin filament organization GO:0007015 126 0.119
cellular macromolecular complex assembly GO:0034622 153 0.117
regulation of establishment of protein localization GO:0070201 61 0.116
protein modification process GO:0036211 438 0.113
mitotic spindle organization GO:0007052 220 0.113
neurological system process GO:0050877 358 0.112
regulation of protein kinase activity GO:0045859 51 0.110
ribose phosphate metabolic process GO:0019693 145 0.109
cell division GO:0051301 248 0.108
Human
connective tissue development GO:0061448 3 0.108
chemotaxis GO:0006935 249 0.108
cellular lipid metabolic process GO:0044255 83 0.106
ribonucleotide catabolic process GO:0009261 109 0.105
regulation of endocytosis GO:0030100 37 0.103
actomyosin structure organization GO:0031032 56 0.102
pole cell development GO:0007277 26 0.102
epithelial tube morphogenesis GO:0060562 88 0.101
activation of protein kinase activity GO:0032147 12 0.100
aging GO:0007568 143 0.100
ribonucleoside triphosphate catabolic process GO:0009203 108 0.099
enzyme linked receptor protein signaling pathway GO:0007167 179 0.098
positive regulation of cellular protein metabolic process GO:0032270 118 0.096
single organism behavior GO:0044708 391 0.095
regulation of protein transport GO:0051223 57 0.095
aromatic compound catabolic process GO:0019439 166 0.095
regulation of actin filament polymerization GO:0030833 25 0.092
response to virus GO:0009615 28 0.092
establishment of synaptic vesicle localization GO:0097480 50 0.092
wound healing GO:0042060 75 0.091
cation transport GO:0006812 110 0.090
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.090
multicellular organismal aging GO:0010259 140 0.089
metal ion transport GO:0030001 74 0.088
single organism cellular localization GO:1902580 180 0.088
proteolysis GO:0006508 192 0.088
regulation of vesicle mediated transport GO:0060627 59 0.087
cognition GO:0050890 141 0.086
multicellular organismal homeostasis GO:0048871 41 0.086
response to other organism GO:0051707 293 0.086
larval behavior GO:0030537 42 0.085
regulation of apoptotic process GO:0042981 130 0.084
Zebrafish
intracellular protein transport GO:0006886 104 0.084
positive regulation of rna biosynthetic process GO:1902680 266 0.082
positive regulation of neuron projection development GO:0010976 14 0.081
neuroblast proliferation GO:0007405 74 0.081
dna packaging GO:0006323 91 0.081
negative regulation of cellular metabolic process GO:0031324 382 0.080
regulation of intracellular protein transport GO:0033157 46 0.080
camera type eye morphogenesis GO:0048593 2 0.080
synaptic transmission GO:0007268 288 0.080
positive regulation of cell death GO:0010942 69 0.079
defense response to bacterium GO:0042742 178 0.077
negative regulation of synapse assembly GO:0051964 39 0.077
negative regulation of cellular response to oxidative stress GO:1900408 1 0.076
developmental maturation GO:0021700 172 0.076
regulation of synaptic transmission GO:0050804 69 0.075
cellular protein localization GO:0034613 160 0.075
positive regulation of cell migration GO:0030335 2 0.075
protein localization to plasma membrane GO:0072659 13 0.074
regulation of cell migration GO:0030334 22 0.074
negative regulation of signaling GO:0023057 219 0.073
protein localization to organelle GO:0033365 82 0.073
phospholipid metabolic process GO:0006644 23 0.072
positive regulation of transport GO:0051050 92 0.072
regulation of cell death GO:0010941 173 0.071
Zebrafish
regulation of cell proliferation GO:0042127 163 0.070
neuron maturation GO:0042551 31 0.070
head development GO:0060322 135 0.069
regulation of phosphorylation GO:0042325 147 0.068
positive regulation of jun kinase activity GO:0043507 4 0.067
actin filament based movement GO:0030048 26 0.067
axon extension GO:0048675 32 0.066
Zebrafish
ribonucleoside metabolic process GO:0009119 127 0.066
positive regulation of gene expression GO:0010628 290 0.065
regulation of synapse structural plasticity GO:0051823 3 0.064
negative regulation of gene expression GO:0010629 387 0.064
purine nucleoside metabolic process GO:0042278 127 0.064
cell cell junction organization GO:0045216 55 0.064
regulation of programmed cell death GO:0043067 152 0.063
Zebrafish
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 4 0.063
negative regulation of transcription dna templated GO:0045892 237 0.062
membrane organization GO:0061024 112 0.061
regulation of axon extension GO:0030516 8 0.061
Zebrafish
purine containing compound catabolic process GO:0072523 112 0.061
establishment of vesicle localization GO:0051650 51 0.061
ameboidal type cell migration GO:0001667 151 0.061
hemopoiesis GO:0030097 46 0.061
photoreceptor cell differentiation GO:0046530 170 0.060
lipid biosynthetic process GO:0008610 46 0.060
nucleobase containing small molecule metabolic process GO:0055086 174 0.059
mitochondrion distribution GO:0048311 10 0.059
mitochondrion localization GO:0051646 17 0.058
tor signaling GO:0031929 32 0.057
cellular protein complex disassembly GO:0043624 35 0.057
germarium derived oocyte fate determination GO:0007294 26 0.057
cellular response to chemical stimulus GO:0070887 199 0.057
positive regulation of apoptotic signaling pathway GO:2001235 4 0.056
organic acid metabolic process GO:0006082 103 0.056
vesicle organization GO:0016050 44 0.056
stem cell proliferation GO:0072089 88 0.056
melanin metabolic process GO:0006582 47 0.056
response to axon injury GO:0048678 12 0.056
response to oxygen containing compound GO:1901700 200 0.056
posttranscriptional gene silencing GO:0016441 46 0.056
embryonic morphogenesis GO:0048598 206 0.056
heart contraction GO:0060047 26 0.055
regulation of cellular response to oxidative stress GO:1900407 4 0.053
development of primary sexual characteristics GO:0045137 50 0.053
negative regulation of response to oxidative stress GO:1902883 1 0.053
purine nucleoside catabolic process GO:0006152 112 0.053
regulation of bmp signaling pathway GO:0030510 23 0.052
regulation of chromosome organization GO:0033044 64 0.052
organelle localization GO:0051640 148 0.052
embryonic development via the syncytial blastoderm GO:0001700 148 0.051
peptidyl lysine modification GO:0018205 57 0.051
sensory organ morphogenesis GO:0090596 260 0.051
phagocytosis GO:0006909 215 0.051
inorganic ion transmembrane transport GO:0098660 73 0.050
modification dependent macromolecule catabolic process GO:0043632 79 0.050
positive regulation of programmed cell death GO:0043068 62 0.049
negative regulation of nervous system development GO:0051961 92 0.049
negative regulation of programmed cell death GO:0043069 72 0.049
Zebrafish
organic substance catabolic process GO:1901575 308 0.049
regulation of catabolic process GO:0009894 170 0.049
regulation of synaptic plasticity GO:0048167 14 0.049
muscle cell development GO:0055001 50 0.049
regulation of intracellular transport GO:0032386 64 0.048
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.048
regulation of actin cytoskeleton organization GO:0032956 42 0.048
nucleoside phosphate metabolic process GO:0006753 162 0.048
circadian rhythm GO:0007623 105 0.047
axon extension involved in axon guidance GO:0048846 10 0.047
regulation of cellular component movement GO:0051270 42 0.046
regulation of protein complex assembly GO:0043254 42 0.046
ubiquitin dependent protein catabolic process GO:0006511 78 0.045
negative regulation of cellular biosynthetic process GO:0031327 277 0.045
positive regulation of apoptotic process GO:0043065 47 0.045
cellular component disassembly GO:0022411 46 0.045
morphogenesis of a branching structure GO:0001763 45 0.044
circulatory system development GO:0072359 82 0.044
response to radiation GO:0009314 155 0.043
neuron projection guidance GO:0097485 241 0.043
microtubule depolymerization GO:0007019 25 0.042
establishment of protein localization to organelle GO:0072594 62 0.042
nitrogen compound transport GO:0071705 85 0.042
monovalent inorganic cation transport GO:0015672 40 0.041
determination of adult lifespan GO:0008340 137 0.041
nucleoside catabolic process GO:0009164 112 0.041
apoptotic signaling pathway GO:0097190 27 0.041
anion transport GO:0006820 41 0.041
eye development GO:0001654 323 0.041
translation GO:0006412 69 0.041
lipid localization GO:0010876 54 0.041
cell maturation GO:0048469 144 0.040
actin filament bundle organization GO:0061572 28 0.040
protein complex biogenesis GO:0070271 201 0.039
Human
positive regulation of defense response to virus by host GO:0002230 10 0.038
reproductive system development GO:0061458 74 0.038
developmental cell growth GO:0048588 52 0.038
Zebrafish
regulation of innate immune response GO:0045088 71 0.037
phenol containing compound metabolic process GO:0018958 57 0.037
gland development GO:0048732 191 0.037
bmp signaling pathway GO:0030509 27 0.037
regulation of ion transport GO:0043269 39 0.036
carboxylic acid metabolic process GO:0019752 92 0.036
regulation of defense response to virus by host GO:0050691 10 0.036
potassium ion transport GO:0006813 20 0.035
positive regulation of axon extension GO:0045773 2 0.035
Zebrafish
defense response GO:0006952 300 0.035
regulation of neuron death GO:1901214 26 0.034
negative regulation of intracellular signal transduction GO:1902532 57 0.034
negative regulation of neuron death GO:1901215 18 0.034
peptidyl amino acid modification GO:0018193 105 0.034
regulation of response to oxidative stress GO:1902882 4 0.034
cell type specific apoptotic process GO:0097285 38 0.033
response to organophosphorus GO:0046683 2 0.033
eye antennal disc development GO:0035214 60 0.033
protein targeting GO:0006605 64 0.033
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.033
establishment of mitochondrion localization microtubule mediated GO:0034643 6 0.032
intracellular transport GO:0046907 228 0.032
Human
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.032
positive regulation of secretion by cell GO:1903532 20 0.032
purine ribonucleoside metabolic process GO:0046128 127 0.032
negative regulation of catalytic activity GO:0043086 42 0.031
response to temperature stimulus GO:0009266 106 0.031
synaptic transmission dopaminergic GO:0001963 2 0.031
purine nucleotide catabolic process GO:0006195 109 0.031
positive regulation of actin filament polymerization GO:0030838 11 0.031
actin cytoskeleton organization GO:0030036 206 0.031
protein import into nucleus GO:0006606 51 0.031
regulation of response to external stimulus GO:0032101 115 0.031
cell recognition GO:0008037 102 0.030
reproductive structure development GO:0048608 74 0.030
positive regulation of cytoskeleton organization GO:0051495 21 0.030
positive regulation of catalytic activity GO:0043085 118 0.030
regulation of cytoskeleton organization GO:0051493 89 0.030
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.030
stress activated protein kinase signaling cascade GO:0031098 55 0.029
regulation of stem cell proliferation GO:0072091 40 0.029
rhythmic process GO:0048511 106 0.029
positive regulation of exocytosis GO:0045921 4 0.029
regulation of mitotic cell cycle GO:0007346 190 0.029
protein localization to nucleus GO:0034504 55 0.029
regulation of cellular component size GO:0032535 98 0.028
Zebrafish
positive regulation of cell development GO:0010720 61 0.028
posttranscriptional gene silencing by rna GO:0035194 45 0.028
regulation of cell shape GO:0008360 113 0.028
gene silencing GO:0016458 138 0.028
imaginal disc derived wing morphogenesis GO:0007476 337 0.028
embryonic heart tube development GO:0035050 22 0.028
organophosphate catabolic process GO:0046434 112 0.027
regulation of cellular protein catabolic process GO:1903362 44 0.027
neuron death GO:0070997 27 0.027
neural precursor cell proliferation GO:0061351 75 0.027
regulation of peptidase activity GO:0052547 39 0.027
production of small rna involved in gene silencing by rna GO:0070918 15 0.027
regulation of pole plasm oskar mrna localization GO:0007317 27 0.026
activation of jun kinase activity GO:0007257 3 0.026
response to lipopolysaccharide GO:0032496 4 0.026
neuron recognition GO:0008038 101 0.026
cytoplasmic transport GO:0016482 130 0.026
Human
negative regulation of cytoskeleton organization GO:0051494 30 0.026
planar cell polarity pathway involved in axis elongation GO:0003402 3 0.026
regulation of cell growth GO:0001558 43 0.026
Zebrafish
mapk cascade GO:0000165 107 0.025
striated muscle cell development GO:0055002 50 0.025
chemical homeostasis GO:0048878 92 0.025
regulation of actin filament depolymerization GO:0030834 3 0.025
regulation of protein polymerization GO:0032271 28 0.025
glycerolipid metabolic process GO:0046486 34 0.025
immune effector process GO:0002252 98 0.025
regulation of epidermal growth factor receptor signaling pathway GO:0042058 42 0.025
regulation of jnk cascade GO:0046328 40 0.025
gene silencing by mirna GO:0035195 22 0.025
regulation of peptidyl tyrosine phosphorylation GO:0050730 10 0.025
outflow tract morphogenesis GO:0003151 4 0.024
regulation of tor signaling GO:0032006 21 0.024
regulation of cell motility GO:2000145 23 0.024
purine ribonucleoside catabolic process GO:0046130 112 0.024
neuromuscular synaptic transmission GO:0007274 67 0.024
negative regulation of signal transduction GO:0009968 206 0.024
innate immune response GO:0045087 144 0.024
negative regulation of protein metabolic process GO:0051248 85 0.024
protein complex disassembly GO:0043241 36 0.023
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 38 0.023
chromosome segregation GO:0007059 157 0.023
neuron apoptotic process GO:0051402 17 0.023
spermatid differentiation GO:0048515 114 0.023
cytoskeleton dependent cytokinesis GO:0061640 81 0.023
apoptotic process GO:0006915 159 0.023
Zebrafish
cell junction organization GO:0034330 57 0.023
synaptic vesicle recycling GO:0036465 28 0.023
gene silencing by rna GO:0031047 57 0.022
glycerophospholipid metabolic process GO:0006650 23 0.022
regulation of cell matrix adhesion GO:0001952 1 0.022
hindgut development GO:0061525 58 0.022
macromolecule catabolic process GO:0009057 161 0.022
regulation of immune response GO:0050776 118 0.022
neuron remodeling GO:0016322 29 0.022
regulation of stress activated mapk cascade GO:0032872 41 0.022
single organism membrane organization GO:0044802 93 0.022
skeletal muscle organ development GO:0060538 48 0.022
positive regulation of locomotion GO:0040017 8 0.021
chromatin silencing GO:0006342 76 0.021
nuclear division GO:0000280 332 0.021
nucleoside triphosphate catabolic process GO:0009143 108 0.021
response to monosaccharide GO:0034284 4 0.021
positive regulation of stem cell proliferation GO:2000648 8 0.021
cellular homeostasis GO:0019725 80 0.021
regulation of embryonic development GO:0045995 68 0.021
peptidyl tyrosine phosphorylation GO:0018108 24 0.021
regulation of cell substrate adhesion GO:0010810 2 0.021
regulation of chemotaxis GO:0050920 12 0.020
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.020
regulation of cellular response to stress GO:0080135 89 0.020
programmed cell death GO:0012501 257 0.020
Zebrafish
regulation of locomotion GO:0040012 42 0.020
positive regulation of kinase activity GO:0033674 25 0.020
inorganic cation transmembrane transport GO:0098662 61 0.020
actin filament depolymerization GO:0030042 5 0.020
establishment of planar polarity GO:0001736 87 0.020
positive regulation of autophagy GO:0010508 21 0.019
regulation of protein catabolic process GO:0042176 55 0.019
cardiovascular system development GO:0072358 82 0.019
carbohydrate derivative metabolic process GO:1901135 217 0.019

spas disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
motor neuron disease DOID:231 0 0.042
central nervous system disease DOID:331 0 0.042
Human
disease of anatomical entity DOID:7 0 0.042
Human
neurodegenerative disease DOID:1289 0 0.042
nervous system disease DOID:863 0 0.042
Human
disease of metabolism DOID:0014667 0 0.041
cancer DOID:162 0 0.033
disease of cellular proliferation DOID:14566 0 0.033