Drosophila melanogaster

39 known processes

Irbp (Dmel_CG5247)

Inverted repeat-binding protein

(Aliases: IRBP/Ku70,DmKu70,YPF1,Dmel\CG5247,YPF1beta,Ku70,Ku,p70,ku70,CG5247,Ypf1b,dp70,IRBP)

Irbp biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
double strand break repair GO:0006302 26 0.987
telomere maintenance GO:0000723 21 0.822
dna repair GO:0006281 54 0.816
double strand break repair via nonhomologous end joining GO:0006303 5 0.788
non recombinational repair GO:0000726 7 0.664
dna recombination GO:0006310 32 0.389
Mouse
double strand break repair via homologous recombination GO:0000724 13 0.374
dna damage checkpoint GO:0000077 78 0.372
mitotic dna damage checkpoint GO:0044773 74 0.349
dna metabolic process GO:0006259 227 0.337
response to abiotic stimulus GO:0009628 341 0.291
Mouse
telomere organization GO:0032200 21 0.287
chromosome organization GO:0051276 360 0.278
double strand break repair via synthesis dependent strand annealing GO:0045003 6 0.240
cell cycle checkpoint GO:0000075 95 0.203
nucleotide catabolic process GO:0009166 109 0.200
nucleotide excision repair GO:0006289 8 0.189
cell cycle phase transition GO:0044770 140 0.182
recombinational repair GO:0000725 13 0.174
ribonucleotide metabolic process GO:0009259 145 0.165
mitotic recombination GO:0006312 2 0.159
dna integrity checkpoint GO:0031570 81 0.151
cellular response to dna damage stimulus GO:0006974 223 0.138
organic cyclic compound catabolic process GO:1901361 168 0.128
mitotic cell cycle checkpoint GO:0007093 88 0.125
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.123
regulation of dna recombination GO:0000018 4 0.121
anatomical structure homeostasis GO:0060249 97 0.119
positive regulation of biosynthetic process GO:0009891 316 0.119
negative regulation of cell cycle GO:0045786 116 0.117
mitotic cell cycle phase transition GO:0044772 138 0.109
cell aging GO:0007569 2 0.104
negative regulation of response to stimulus GO:0048585 258 0.102
regulation of cell cycle GO:0051726 291 0.102
ribonucleoside triphosphate catabolic process GO:0009203 108 0.092
purine nucleoside triphosphate metabolic process GO:0009144 119 0.092
cellular catabolic process GO:0044248 372 0.091
endocytosis GO:0006897 310 0.090
catabolic process GO:0009056 409 0.089
mitotic dna integrity checkpoint GO:0044774 75 0.088
postreplication repair GO:0006301 2 0.088
growth GO:0040007 359 0.087
dna double strand break processing GO:0000729 3 0.083
nucleoside catabolic process GO:0009164 112 0.082
glycosyl compound catabolic process GO:1901658 112 0.082
ribonucleoside catabolic process GO:0042454 112 0.078
ribonucleoside metabolic process GO:0009119 127 0.077
regulation of cell cycle process GO:0010564 181 0.076
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.073
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.072
purine ribonucleoside metabolic process GO:0046128 127 0.071
small molecule metabolic process GO:0044281 305 0.071
purine nucleoside triphosphate catabolic process GO:0009146 108 0.069
regulation of mitotic cell cycle phase transition GO:1901990 130 0.067
dna synthesis involved in dna repair GO:0000731 5 0.066
purine containing compound catabolic process GO:0072523 112 0.064
carbohydrate derivative catabolic process GO:1901136 118 0.062
purine containing compound metabolic process GO:0072521 155 0.062
regulation of double strand break repair GO:2000779 3 0.061
regulation of catalytic activity GO:0050790 185 0.059
purine ribonucleotide catabolic process GO:0009154 109 0.059
purine nucleoside monophosphate catabolic process GO:0009128 38 0.057
purine nucleoside metabolic process GO:0042278 127 0.055
regulation of molecular function GO:0065009 217 0.055
negative regulation of cell cycle phase transition GO:1901988 103 0.055
purine nucleoside monophosphate metabolic process GO:0009126 50 0.055
aromatic compound catabolic process GO:0019439 166 0.054
purine nucleoside catabolic process GO:0006152 112 0.054
death GO:0016265 284 0.054
ribonucleoside triphosphate metabolic process GO:0009199 119 0.054
meiotic cell cycle GO:0051321 171 0.053
nucleoside phosphate metabolic process GO:0006753 162 0.052
negative regulation of cellular metabolic process GO:0031324 382 0.052
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.051
organonitrogen compound catabolic process GO:1901565 128 0.050
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.050
nucleoside triphosphate catabolic process GO:0009143 108 0.048
purine nucleotide metabolic process GO:0006163 146 0.048
dna geometric change GO:0032392 16 0.047
spermatogenesis GO:0007283 200 0.047
nucleoside triphosphate metabolic process GO:0009141 120 0.047
developmental growth GO:0048589 280 0.046
organonitrogen compound metabolic process GO:1901564 318 0.045
dna biosynthetic process GO:0071897 24 0.045
purine nucleotide catabolic process GO:0006195 109 0.045
single organism catabolic process GO:0044712 228 0.044
ribose phosphate metabolic process GO:0019693 145 0.044
response to biotic stimulus GO:0009607 294 0.044
glycosyl compound metabolic process GO:1901657 127 0.044
response to external biotic stimulus GO:0043207 293 0.043
cellular protein modification process GO:0006464 438 0.042
protein modification process GO:0036211 438 0.041
purine ribonucleotide metabolic process GO:0009150 145 0.041
cellular nitrogen compound catabolic process GO:0044270 165 0.041
regulation of organelle organization GO:0033043 196 0.040
single organism intracellular transport GO:1902582 207 0.040
intracellular transport GO:0046907 228 0.040
organic substance catabolic process GO:1901575 308 0.040
homeostatic process GO:0042592 199 0.039
cellular response to organic substance GO:0071310 132 0.039
embryo development ending in birth or egg hatching GO:0009792 152 0.038
regulation of cell cycle phase transition GO:1901987 130 0.038
transmembrane transport GO:0055085 139 0.038
nucleoside metabolic process GO:0009116 127 0.037
ribonucleotide catabolic process GO:0009261 109 0.036
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.036
membrane organization GO:0061024 112 0.036
nucleoside phosphate catabolic process GO:1901292 110 0.035
regulation of mitotic cell cycle GO:0007346 190 0.035
regulation of cellular ketone metabolic process GO:0010565 3 0.035
atp metabolic process GO:0046034 49 0.035
nucleobase containing compound catabolic process GO:0034655 165 0.035
mitotic g2 m transition checkpoint GO:0044818 70 0.034
meiotic chromosome segregation GO:0045132 59 0.034
negative regulation of mitotic cell cycle GO:0045930 109 0.033
positive regulation of cellular biosynthetic process GO:0031328 316 0.033
mitotic g2 dna damage checkpoint GO:0007095 69 0.032
male gamete generation GO:0048232 201 0.032
heterocycle catabolic process GO:0046700 166 0.032
nucleotide metabolic process GO:0009117 161 0.031
negative regulation of cell cycle process GO:0010948 109 0.031
organophosphate metabolic process GO:0019637 195 0.031
immune system process GO:0002376 347 0.030
Mouse
carboxylic acid metabolic process GO:0019752 92 0.030
regulation of multicellular organismal development GO:2000026 414 0.030
Mouse
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.029
single organism membrane organization GO:0044802 93 0.029
g2 dna damage checkpoint GO:0031572 69 0.028
positive regulation of rna biosynthetic process GO:1902680 266 0.028
cellular macromolecule localization GO:0070727 220 0.028
rna 3 end processing GO:0031123 45 0.028
nuclear division GO:0000280 332 0.027
response to organic substance GO:0010033 284 0.026
cellular response to ionizing radiation GO:0071479 15 0.026
nucleobase containing small molecule metabolic process GO:0055086 174 0.026
compound eye development GO:0048749 307 0.026
regulation of hydrolase activity GO:0051336 97 0.025
organophosphate catabolic process GO:0046434 112 0.025
immune response GO:0006955 246 0.025
vesicle mediated transport GO:0016192 381 0.025
ribonucleoside monophosphate metabolic process GO:0009161 51 0.025
negative regulation of organelle organization GO:0010639 56 0.025
karyosome formation GO:0030717 22 0.025
ion transport GO:0006811 145 0.024
regulation of localization GO:0032879 275 0.024
translesion synthesis GO:0019985 2 0.024
chromosome segregation GO:0007059 157 0.024
regulation of response to stress GO:0080134 200 0.023
regulation of protein metabolic process GO:0051246 256 0.023
dna duplex unwinding GO:0032508 16 0.023
dorsal ventral pattern formation GO:0009953 133 0.023
regulation of cellular protein metabolic process GO:0032268 243 0.023
nucleoside monophosphate metabolic process GO:0009123 52 0.023
negative regulation of nucleic acid templated transcription GO:1903507 240 0.023
positive regulation of macromolecule metabolic process GO:0010604 405 0.022
ribonucleoside monophosphate catabolic process GO:0009158 39 0.022
ameboidal type cell migration GO:0001667 151 0.022
cellular amine metabolic process GO:0044106 12 0.022
regulation of cell proliferation GO:0042127 163 0.022
response to oxygen containing compound GO:1901700 200 0.022
dna dependent dna replication GO:0006261 17 0.022
signal transduction in response to dna damage GO:0042770 3 0.022
dna replication GO:0006260 48 0.022
response to radiation GO:0009314 155 0.022
Mouse
regulation of transport GO:0051049 181 0.021
purine ribonucleoside catabolic process GO:0046130 112 0.021
cell death GO:0008219 279 0.021
protein phosphorylation GO:0006468 169 0.020
telomere maintenance via recombination GO:0000722 1 0.020
rna localization GO:0006403 115 0.019
response to organonitrogen compound GO:0010243 75 0.019
negative regulation of cellular component organization GO:0051129 108 0.019
cell motility GO:0048870 251 0.019
protein localization GO:0008104 284 0.018
response to wounding GO:0009611 94 0.018
response to bacterium GO:0009617 198 0.018
positive regulation of molecular function GO:0044093 136 0.018
mrna processing GO:0006397 104 0.018
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.018
cellular response to chemical stimulus GO:0070887 199 0.018
response to ionizing radiation GO:0010212 32 0.018
Mouse
cellular macromolecular complex assembly GO:0034622 153 0.018
macromolecule catabolic process GO:0009057 161 0.017
guanosine containing compound catabolic process GO:1901069 74 0.017
response to lipopolysaccharide GO:0032496 4 0.017
single organism biosynthetic process GO:0044711 206 0.017
regulation of anatomical structure morphogenesis GO:0022603 242 0.017
meiotic cell cycle process GO:1903046 132 0.017
positive regulation of phosphorus metabolic process GO:0010562 139 0.017
macromolecular complex assembly GO:0065003 256 0.016
proteolysis GO:0006508 192 0.016
guanosine containing compound metabolic process GO:1901068 74 0.016
cell migration GO:0016477 238 0.016
regulation of cellular amine metabolic process GO:0033238 3 0.016
carbohydrate derivative metabolic process GO:1901135 217 0.016
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.016
response to other organism GO:0051707 293 0.016
cytoplasmic transport GO:0016482 130 0.015
regulation of peptidase activity GO:0052547 39 0.015
negative regulation of developmental growth GO:0048640 64 0.015
amine metabolic process GO:0009308 12 0.015
regulation of protein modification process GO:0031399 112 0.015
dendrite development GO:0016358 204 0.015
protein transport GO:0015031 155 0.015
wound healing GO:0042060 75 0.015
negative regulation of gene expression GO:0010629 387 0.015
protein dna complex assembly GO:0065004 63 0.015
epithelium migration GO:0090132 148 0.014
phosphorylation GO:0016310 294 0.014
taxis GO:0042330 304 0.014
cellular macromolecule catabolic process GO:0044265 136 0.014
regulation of cellular component size GO:0032535 98 0.014
regulation of phosphorylation GO:0042325 147 0.014
meiotic chromosome separation GO:0051307 8 0.014
forebrain development GO:0030900 2 0.014
negative regulation of cell communication GO:0010648 223 0.014
small gtpase mediated signal transduction GO:0007264 88 0.013
imaginal disc derived appendage morphogenesis GO:0035114 395 0.013
anterior posterior pattern specification GO:0009952 136 0.013
imaginal disc derived wing morphogenesis GO:0007476 337 0.013
telencephalon development GO:0021537 2 0.013
positive regulation of cell communication GO:0010647 250 0.013
cellular response to abiotic stimulus GO:0071214 58 0.013
chaeta development GO:0022416 97 0.013
regulation of endopeptidase activity GO:0052548 36 0.012
nucleoside monophosphate catabolic process GO:0009125 39 0.012
cellular amino acid metabolic process GO:0006520 61 0.012
enzyme linked receptor protein signaling pathway GO:0007167 179 0.012
positive regulation of phosphate metabolic process GO:0045937 139 0.012
positive regulation of cell death GO:0010942 69 0.012
dendrite morphogenesis GO:0048813 199 0.012
chromatin organization GO:0006325 207 0.012
regionalization GO:0003002 416 0.012
programmed cell death GO:0012501 257 0.012
wing disc morphogenesis GO:0007472 344 0.012
regulation of phosphorus metabolic process GO:0051174 210 0.012
body morphogenesis GO:0010171 2 0.012
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.012
establishment of localization in cell GO:0051649 402 0.012
locomotory behavior GO:0007626 176 0.012
atp catabolic process GO:0006200 38 0.012
regulation of cell death GO:0010941 173 0.012
appendage development GO:0048736 401 0.011
positive regulation of rna metabolic process GO:0051254 271 0.011
muscle structure development GO:0061061 224 0.011
regulation of neurogenesis GO:0050767 158 0.011
Mouse
negative regulation of signal transduction GO:0009968 206 0.011
skin development GO:0043588 65 0.011
regulation of cytoskeleton organization GO:0051493 89 0.011
regulation of developmental growth GO:0048638 174 0.011
positive regulation of response to stimulus GO:0048584 323 0.011
axis specification GO:0009798 167 0.011
striated muscle cell differentiation GO:0051146 90 0.011
protein maturation GO:0051604 71 0.011
rna splicing GO:0008380 83 0.011
photoreceptor cell development GO:0042461 96 0.011
regulation of dna repair GO:0006282 5 0.011
positive regulation of immune system process GO:0002684 68 0.011
histone modification GO:0016570 106 0.011
antimicrobial humoral response GO:0019730 99 0.010
cellular ketone metabolic process GO:0042180 24 0.010
positive regulation of cellular component organization GO:0051130 156 0.010
hematopoietic or lymphoid organ development GO:0048534 57 0.010
negative regulation of biosynthetic process GO:0009890 277 0.010
regulation of anatomical structure size GO:0090066 163 0.010
response to nutrient levels GO:0031667 114 0.010
regulation of phosphate metabolic process GO:0019220 210 0.010
positive regulation of catalytic activity GO:0043085 118 0.010
response to endogenous stimulus GO:0009719 119 0.010
photoreceptor cell differentiation GO:0046530 170 0.010

Irbp disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
thoracic cancer DOID:5093 0 0.014
cancer DOID:162 0 0.014
disease of cellular proliferation DOID:14566 0 0.014
organ system cancer DOID:0050686 0 0.014
disease of anatomical entity DOID:7 0 0.014
nervous system disease DOID:863 0 0.014