Drosophila melanogaster

16 known processes

His2Av (Dmel_CG5499)

Histone H2A variant

(Aliases: H2avD,h2AvD,gamma-HIS2AV,5499,HIS2AVD,l(3)05146,H2A.X,H2A.Z,H2A.F/Z,H2av,His2AV,His2AvD,HIS2AV,H2AV_DROM,his,H2a.V,gamma-His2Av,H2Av,Hist2av,l(3)97Dd,l(3)810,l(3)L1602,H2AvD,H2AX,H2AZ,gamma-H2Av,HisH2Av,Dmel\CG5499,H2AV,CG5499)

His2Av biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
chromatin silencing GO:0006342 76 0.999
Yeast
negative regulation of gene expression epigenetic GO:0045814 77 0.996
Yeast
negative regulation of transcription dna templated GO:0045892 237 0.986
Yeast
negative regulation of rna metabolic process GO:0051253 251 0.982
Yeast
negative regulation of gene expression GO:0010629 387 0.975
Yeast Worm
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.972
Yeast
negative regulation of rna biosynthetic process GO:1902679 240 0.967
Yeast
protein dna complex subunit organization GO:0071824 86 0.967
negative regulation of cellular biosynthetic process GO:0031327 277 0.949
Yeast
mitotic g2 m transition checkpoint GO:0044818 70 0.948
meiotic cell cycle process GO:1903046 132 0.944
Worm
regulation of gene expression epigenetic GO:0040029 128 0.935
Yeast Worm
chromatin remodeling GO:0006338 72 0.934
Yeast
dna integrity checkpoint GO:0031570 81 0.922
chromatin organization GO:0006325 207 0.911
Yeast
internal protein amino acid acetylation GO:0006475 38 0.902
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.870
Yeast
negative regulation of cellular metabolic process GO:0031324 382 0.866
Yeast
dna damage checkpoint GO:0000077 78 0.861
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.857
Yeast
histone acetylation GO:0016573 38 0.841
atp dependent chromatin remodeling GO:0043044 22 0.827
nucleosome organization GO:0034728 59 0.824
mitotic g2 dna damage checkpoint GO:0007095 69 0.801
mitotic dna integrity checkpoint GO:0044774 75 0.758
g2 dna damage checkpoint GO:0031572 69 0.754
regulation of cell cycle phase transition GO:1901987 130 0.742
histone exchange GO:0043486 21 0.720
cellular protein modification process GO:0006464 438 0.716
cellular response to dna damage stimulus GO:0006974 223 0.672
negative regulation of biosynthetic process GO:0009890 277 0.672
Yeast
chromatin assembly GO:0031497 48 0.664
mitotic dna damage checkpoint GO:0044773 74 0.631
gene silencing GO:0016458 138 0.609
Yeast Worm
protein dna complex assembly GO:0065004 63 0.601
dna conformation change GO:0071103 105 0.600
negative regulation of nucleic acid templated transcription GO:1903507 240 0.591
Yeast
negative regulation of cell cycle phase transition GO:1901988 103 0.580
protein acetylation GO:0006473 39 0.577
histone modification GO:0016570 106 0.543
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.539
Yeast
mrna processing GO:0006397 104 0.528
meiotic cell cycle GO:0051321 171 0.462
Worm
chromatin modification GO:0016568 147 0.458
Yeast
internal peptidyl lysine acetylation GO:0018393 38 0.453
dna packaging GO:0006323 91 0.441
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.441
Human
macromolecular complex assembly GO:0065003 256 0.421
covalent chromatin modification GO:0016569 106 0.416
negative regulation of signaling GO:0023057 219 0.410
regulation of chromatin silencing GO:0031935 36 0.408
meiotic nuclear division GO:0007126 151 0.398
Worm
regulation of gene silencing GO:0060968 63 0.388
nucleotide excision repair GO:0006289 8 0.372
negative regulation of cell communication GO:0010648 223 0.366
meiosis i GO:0007127 59 0.356
sex differentiation GO:0007548 81 0.351
Worm
multi organism behavior GO:0051705 175 0.347
nuclear division GO:0000280 332 0.336
Worm
regulation of mitotic cell cycle GO:0007346 190 0.328
negative regulation of cell cycle process GO:0010948 109 0.327
transcription from rna polymerase ii promoter GO:0006366 368 0.326
Human Yeast
reproductive system development GO:0061458 74 0.324
Worm
mrna metabolic process GO:0016071 124 0.322
Yeast
endocytosis GO:0006897 310 0.317
catabolic process GO:0009056 409 0.300
Yeast
body morphogenesis GO:0010171 2 0.291
Worm
cellular macromolecule catabolic process GO:0044265 136 0.282
Yeast
negative regulation of mitotic cell cycle GO:0045930 109 0.277
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.276
protein modification process GO:0036211 438 0.270
phosphorylation GO:0016310 294 0.270
regulation of mitotic cell cycle phase transition GO:1901990 130 0.264
chromatin assembly or disassembly GO:0006333 52 0.264
histone h2a acetylation GO:0043968 1 0.247
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.243
mitotic cell cycle checkpoint GO:0007093 88 0.239
cellular macromolecular complex assembly GO:0034622 153 0.228
heterocycle catabolic process GO:0046700 166 0.227
Yeast
gonad development GO:0008406 50 0.225
Worm
organelle fission GO:0048285 340 0.225
Worm
embryo development ending in birth or egg hatching GO:0009792 152 0.211
Worm
spindle organization GO:0007051 253 0.208
cellular nitrogen compound catabolic process GO:0044270 165 0.200
Yeast
regulation of mrna splicing via spliceosome GO:0048024 64 0.196
peptidyl lysine acetylation GO:0018394 39 0.195
protein localization GO:0008104 284 0.192
nucleosome mobilization GO:0042766 9 0.190
death GO:0016265 284 0.181
chromosome organization GO:0051276 360 0.159
Yeast
organic substance catabolic process GO:1901575 308 0.156
Yeast
dna repair GO:0006281 54 0.156
reproductive behavior GO:0019098 122 0.144
negative regulation of response to stimulus GO:0048585 258 0.139
cell death GO:0008219 279 0.134
dna replication GO:0006260 48 0.131
macromolecule catabolic process GO:0009057 161 0.130
Yeast
dna metabolic process GO:0006259 227 0.130
negative regulation of signal transduction GO:0009968 206 0.129
development of primary sexual characteristics GO:0045137 50 0.127
Worm
negative regulation of meiotic cell cycle GO:0051447 2 0.126
nucleotide metabolic process GO:0009117 161 0.124
immune system process GO:0002376 347 0.122
nucleobase containing compound catabolic process GO:0034655 165 0.117
Yeast
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.117
Human Yeast
regulation of cell death GO:0010941 173 0.113
protein acylation GO:0043543 42 0.112
histone h4 acetylation GO:0043967 13 0.111
nucleosome assembly GO:0006334 35 0.109
regulation of mrna processing GO:0050684 71 0.108
multicellular organismal reproductive behavior GO:0033057 110 0.106
chromosome segregation GO:0007059 157 0.106
Worm
peptidyl amino acid modification GO:0018193 105 0.106
regulation of cellular response to stress GO:0080135 89 0.105
regulation of cell cycle GO:0051726 291 0.104
aromatic compound catabolic process GO:0019439 166 0.103
Yeast
dendrite guidance GO:0070983 21 0.103
organonitrogen compound metabolic process GO:1901564 318 0.103
regulation of heterochromatin assembly GO:0031445 8 0.102
regulation of dna metabolic process GO:0051052 34 0.102
spindle assembly involved in mitosis GO:0090307 50 0.101
positive regulation of rna biosynthetic process GO:1902680 266 0.100
Human
mitotic spindle organization GO:0007052 220 0.099
mitotic cell cycle phase transition GO:0044772 138 0.097
positive regulation of signal transduction GO:0009967 223 0.097
mrna splicing via spliceosome GO:0000398 73 0.097
dna recombination GO:0006310 32 0.096
protein complex biogenesis GO:0070271 201 0.094
rna processing GO:0006396 147 0.093
dna double strand break processing GO:0000729 3 0.092
regulation of small gtpase mediated signal transduction GO:0051056 93 0.092
negative regulation of cell differentiation GO:0045596 143 0.089
peptidyl lysine modification GO:0018205 57 0.088
positive regulation of signaling GO:0023056 243 0.088
regulation of rna splicing GO:0043484 69 0.088
microtubule cytoskeleton organization involved in mitosis GO:1902850 52 0.087
regulation of meiosis GO:0040020 3 0.087
histone h4 k20 methylation GO:0034770 4 0.086
regulation of cell differentiation GO:0045595 302 0.083
rna splicing GO:0008380 83 0.083
vesicle mediated transport GO:0016192 381 0.081
telomere capping GO:0016233 11 0.080
programmed cell death GO:0012501 257 0.079
response to abiotic stimulus GO:0009628 341 0.077
nucleoside phosphate metabolic process GO:0006753 162 0.076
positive regulation of response to stimulus GO:0048584 323 0.076
aging GO:0007568 143 0.068
regulation of protein metabolic process GO:0051246 256 0.067
dendrite development GO:0016358 204 0.066
negative regulation of cell cycle GO:0045786 116 0.064
positive regulation of nucleic acid templated transcription GO:1903508 266 0.064
Human
positive regulation of dna metabolic process GO:0051054 12 0.063
cell cycle checkpoint GO:0000075 95 0.063
appendage morphogenesis GO:0035107 397 0.063
single organism biosynthetic process GO:0044711 206 0.062
protein alkylation GO:0008213 43 0.061
positive regulation of cell communication GO:0010647 250 0.061
regulation of cell cycle g1 s phase transition GO:1902806 23 0.061
male gamete generation GO:0048232 201 0.060
regulation of mrna metabolic process GO:1903311 72 0.058
regulation of phosphate metabolic process GO:0019220 210 0.058
genitalia development GO:0048806 26 0.057
Worm
recombinational repair GO:0000725 13 0.057
establishment of localization in cell GO:0051649 402 0.055
regulation of cellular protein metabolic process GO:0032268 243 0.055
alternative mrna splicing via spliceosome GO:0000380 60 0.054
positive regulation of biosynthetic process GO:0009891 316 0.054
Human
positive regulation of cellular component organization GO:0051130 156 0.053
cell aging GO:0007569 2 0.053
regulation of catalytic activity GO:0050790 185 0.051
heart development GO:0007507 82 0.049
positive regulation of phosphorus metabolic process GO:0010562 139 0.047
response to organic cyclic compound GO:0014070 89 0.046
Human
double strand break repair GO:0006302 26 0.046
positive regulation of chromatin silencing GO:0031937 16 0.045
regulation of intracellular signal transduction GO:1902531 236 0.045
regulation of phosphorus metabolic process GO:0051174 210 0.044
histone methylation GO:0016571 40 0.044
nuclear body organization GO:0030575 6 0.043
appendage development GO:0048736 401 0.042
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.042
purine nucleotide metabolic process GO:0006163 146 0.042
regulation of phosphorylation GO:0042325 147 0.041
positive regulation of macromolecule metabolic process GO:0010604 405 0.040
Human
ribonucleoprotein complex subunit organization GO:0071826 28 0.040
organelle assembly GO:0070925 198 0.039
protein complex assembly GO:0006461 200 0.039
cellular catabolic process GO:0044248 372 0.039
Yeast
positive regulation of gene expression GO:0010628 290 0.039
Human
meiotic chromosome segregation GO:0045132 59 0.039
Worm
determination of dorsal ventral asymmetry GO:0048262 3 0.038
taxis GO:0042330 304 0.038
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.038
Human
positive regulation of protein metabolic process GO:0051247 128 0.037
small molecule metabolic process GO:0044281 305 0.037
oviposition GO:0018991 19 0.036
rna splicing via transesterification reactions GO:0000375 73 0.036
regulation of dna recombination GO:0000018 4 0.036
organic cyclic compound catabolic process GO:1901361 168 0.036
Yeast
dna alkylation GO:0006305 4 0.035
dendrite morphogenesis GO:0048813 199 0.035
purine ribonucleoside metabolic process GO:0046128 127 0.035
response to light stimulus GO:0009416 124 0.034
regulation of developmental growth GO:0048638 174 0.034
regulation of localization GO:0032879 275 0.033
nucleobase containing small molecule metabolic process GO:0055086 174 0.033
reproductive structure development GO:0048608 74 0.032
Worm
regulation of response to dna damage stimulus GO:2001020 23 0.032
positive regulation of growth GO:0045927 75 0.031
regulation of alternative mrna splicing via spliceosome GO:0000381 60 0.031
protein phosphorylation GO:0006468 169 0.030
regulation of cell cycle process GO:0010564 181 0.030
positive regulation of heterochromatin assembly GO:0031453 5 0.029
cell cycle phase transition GO:0044770 140 0.029
central nervous system development GO:0007417 201 0.029
positive regulation of phosphate metabolic process GO:0045937 139 0.029
mitotic chromosome condensation GO:0007076 22 0.029
cell proliferation GO:0008283 299 0.028
regulation of growth GO:0040008 233 0.028
imaginal disc derived wing morphogenesis GO:0007476 337 0.027
response to alcohol GO:0097305 95 0.027
Human
cytoplasmic transport GO:0016482 130 0.027
response to oxidative stress GO:0006979 86 0.027
striated muscle myosin thick filament assembly GO:0071688 3 0.026
negative regulation of cellular protein metabolic process GO:0032269 85 0.026
regulation of protein deacetylation GO:0090311 2 0.026
intraspecies interaction between organisms GO:0051703 4 0.026
regulation of molecular function GO:0065009 217 0.026
purine ribonucleotide metabolic process GO:0009150 145 0.025
positive regulation of molecular function GO:0044093 136 0.025
regionalization GO:0003002 416 0.024
dna dependent dna replication GO:0006261 17 0.024
intracellular transport GO:0046907 228 0.024
dna methylation or demethylation GO:0044728 4 0.024
positive regulation of cellular protein metabolic process GO:0032270 118 0.023
establishment of spindle orientation GO:0051294 18 0.023
amine metabolic process GO:0009308 12 0.023
histone h3 acetylation GO:0043966 11 0.023
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.023
single organism intracellular transport GO:1902582 207 0.023
spermatogenesis GO:0007283 200 0.022
regulation of cellular localization GO:0060341 136 0.022
regulation of cellular amine metabolic process GO:0033238 3 0.022
ribonucleoprotein complex assembly GO:0022618 23 0.022
regulation of peptidase activity GO:0052547 39 0.022
single organism catabolic process GO:0044712 228 0.022
cellular component assembly involved in morphogenesis GO:0010927 151 0.022
enzyme linked receptor protein signaling pathway GO:0007167 179 0.022
positive regulation of rna metabolic process GO:0051254 271 0.022
Human
ribonucleotide metabolic process GO:0009259 145 0.022
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.022
Human
ras protein signal transduction GO:0007265 88 0.021
nucleus organization GO:0006997 45 0.021
protein processing GO:0016485 68 0.021
regulation of transcription by chromatin organization GO:0034401 3 0.021
response to radiation GO:0009314 155 0.020
telencephalon development GO:0021537 2 0.020
mitotic cell cycle embryonic GO:0045448 38 0.020
regulation of apoptotic process GO:0042981 130 0.020
transcription initiation from rna polymerase ii promoter GO:0006367 25 0.020
mitotic sister chromatid segregation GO:0000070 87 0.020
negative regulation of cell death GO:0060548 81 0.019
negative regulation of organelle organization GO:0010639 56 0.019
positive regulation of cellular amine metabolic process GO:0033240 0 0.019
regulation of cellular ketone metabolic process GO:0010565 3 0.019
intracellular signal transduction GO:0035556 300 0.019
positive regulation of developmental growth GO:0048639 62 0.019
male meiosis GO:0007140 52 0.019
dna templated transcription initiation GO:0006352 25 0.019
multi organism reproductive behavior GO:0044705 121 0.019
regulation of phosphatase activity GO:0010921 3 0.019
positive regulation of nucleotide metabolic process GO:0045981 55 0.018
apoptotic process GO:0006915 159 0.018
larval development GO:0002164 104 0.018
Worm
oocyte differentiation GO:0009994 145 0.018
wnt signaling pathway GO:0016055 98 0.018
homeostatic process GO:0042592 199 0.017
negative regulation of apoptotic process GO:0043066 63 0.017
negative regulation of protein metabolic process GO:0051248 85 0.017
mrna catabolic process GO:0006402 33 0.017
Yeast
modification dependent macromolecule catabolic process GO:0043632 79 0.017
multi multicellular organism process GO:0044706 123 0.017
rna localization GO:0006403 115 0.017
regulation of chromatin organization GO:1902275 32 0.017
regulation of cellular amino acid metabolic process GO:0006521 0 0.017
regulation of cell division GO:0051302 72 0.017
heterochromatin organization GO:0070828 25 0.017
modification dependent protein catabolic process GO:0019941 78 0.017
double strand break repair via nonhomologous end joining GO:0006303 5 0.017
positive regulation of transcription dna templated GO:0045893 266 0.016
Human
mitotic nuclear division GO:0007067 213 0.016
adult behavior GO:0030534 137 0.016
ribonucleoprotein complex biogenesis GO:0022613 31 0.016
axonogenesis GO:0007409 290 0.015
purine nucleoside metabolic process GO:0042278 127 0.015
gene silencing by rna GO:0031047 57 0.015
Worm
oxidation reduction process GO:0055114 123 0.015
protein transport GO:0015031 155 0.015
dna hypermethylation GO:0044026 3 0.015
muscle organ development GO:0007517 127 0.015
negative regulation of molecular function GO:0044092 51 0.015
organophosphate metabolic process GO:0019637 195 0.015
cellular amine metabolic process GO:0044106 12 0.015
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.014
regulation of multicellular organismal development GO:2000026 414 0.014
Worm
muscle structure development GO:0061061 224 0.014
regulation of sister chromatid cohesion GO:0007063 2 0.014
response to temperature stimulus GO:0009266 106 0.014
regulation of chromatin modification GO:1903308 28 0.014
dna methylation GO:0006306 4 0.014
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.014
dna templated transcription elongation GO:0006354 18 0.014
imaginal disc derived appendage morphogenesis GO:0035114 395 0.013
regulation of cellular catabolic process GO:0031329 157 0.013
positive regulation of mitotic cell cycle GO:0045931 34 0.013
multicellular organism growth GO:0035264 46 0.013
determination of adult lifespan GO:0008340 137 0.013
negative regulation of programmed cell death GO:0043069 72 0.013
positive regulation of intracellular signal transduction GO:1902533 116 0.013
nucleoside triphosphate metabolic process GO:0009141 120 0.013
regulation of protein phosphorylation GO:0001932 64 0.013
regulation of wnt signaling pathway GO:0030111 68 0.013
cellular amino acid metabolic process GO:0006520 61 0.013
immune response GO:0006955 246 0.013
regulation of histone h3 k9 methylation GO:0051570 3 0.013
positive regulation of protein modification process GO:0031401 58 0.013
regulation of histone modification GO:0031056 20 0.013
syncytial blastoderm mitotic cell cycle GO:0035186 21 0.013
forebrain development GO:0030900 2 0.012
macromolecule methylation GO:0043414 45 0.012
signal transduction in response to dna damage GO:0042770 3 0.012
translation GO:0006412 69 0.012
protein catabolic process GO:0030163 101 0.012
multicellular organismal aging GO:0010259 140 0.012
camera type eye development GO:0043010 4 0.012
macromolecule deacylation GO:0098732 11 0.012
negative regulation of proteolysis GO:0045861 31 0.011
peptidyl lysine trimethylation GO:0018023 6 0.011
regulation of reactive oxygen species biosynthetic process GO:1903426 0 0.011
regulation of meiotic cell cycle GO:0051445 9 0.011
organic acid metabolic process GO:0006082 103 0.011
positive regulation of catalytic activity GO:0043085 118 0.011
exocrine system development GO:0035272 162 0.011
gene silencing by mirna GO:0035195 22 0.011
glycosyl compound metabolic process GO:1901657 127 0.011
transcription elongation from rna polymerase ii promoter GO:0006368 18 0.011
heterochromatin assembly GO:0031507 13 0.011
ribonucleoside metabolic process GO:0009119 127 0.011
regulation of programmed cell death GO:0043067 152 0.011
purine ribonucleotide catabolic process GO:0009154 109 0.011
ribonucleoside triphosphate metabolic process GO:0009199 119 0.011
organic substance transport GO:0071702 257 0.011
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.010
Human
notch signaling pathway GO:0007219 120 0.010
digestive tract morphogenesis GO:0048546 127 0.010
telomere maintenance GO:0000723 21 0.010
tube morphogenesis GO:0035239 191 0.010
purine containing compound metabolic process GO:0072521 155 0.010
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.010
regulation of catabolic process GO:0009894 170 0.010
proteasomal protein catabolic process GO:0010498 59 0.010
histone lysine methylation GO:0034968 32 0.010
peptidyl lysine dimethylation GO:0018027 3 0.010
immune system development GO:0002520 57 0.010
positive regulation of phosphorylation GO:0042327 87 0.010
positive regulation of lipid catabolic process GO:0050996 1 0.010

His2Av disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.018
disease of cellular proliferation DOID:14566 0 0.018
organ system cancer DOID:0050686 0 0.018
chromosomal disease DOID:0080014 0 0.012