Drosophila melanogaster

83 known processes

ial (Dmel_CG6620)

IplI-aurora-like kinase

(Aliases: aurB,IAL,DmAurB,Aurora B,Ial,CG6620,DmAuroraB,Aurora-B,IAL1,AurB,DmAIRK2,aurora B,Dmel\CG6620)

ial biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
spindle organization GO:0007051 253 0.453
chromosome segregation GO:0007059 157 0.428
mitotic spindle organization GO:0007052 220 0.401
chromosome organization GO:0051276 360 0.372
nuclear division GO:0000280 332 0.200
organelle fission GO:0048285 340 0.187
positive regulation of biosynthetic process GO:0009891 316 0.183
mitotic nuclear division GO:0007067 213 0.177
post embryonic appendage morphogenesis GO:0035120 385 0.137
sister chromatid segregation GO:0000819 92 0.132
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.124
imaginal disc derived appendage morphogenesis GO:0035114 395 0.121
negative regulation of nucleic acid templated transcription GO:1903507 240 0.120
Human
organic substance catabolic process GO:1901575 308 0.113
mitotic spindle elongation GO:0000022 81 0.110
Human
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.108
Human
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.096
dna conformation change GO:0071103 105 0.090
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.090
Human
appendage development GO:0048736 401 0.090
imaginal disc derived appendage development GO:0048737 399 0.089
positive regulation of macromolecule metabolic process GO:0010604 405 0.088
catabolic process GO:0009056 409 0.085
chromosome separation GO:0051304 42 0.081
protein modification process GO:0036211 438 0.079
imaginal disc derived wing morphogenesis GO:0007476 337 0.078
establishment of localization in cell GO:0051649 402 0.077
Fly
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.076
appendage morphogenesis GO:0035107 397 0.074
cellular protein modification process GO:0006464 438 0.072
establishment of organelle localization GO:0051656 122 0.068
Fly
regulation of cell death GO:0010941 173 0.068
Human
tube morphogenesis GO:0035239 191 0.067
proteolysis GO:0006508 192 0.067
positive regulation of cellular biosynthetic process GO:0031328 316 0.065
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.065
Human
positive regulation of gene expression GO:0010628 290 0.062
mrna metabolic process GO:0016071 124 0.058
intracellular transport GO:0046907 228 0.058
columnar cuboidal epithelial cell development GO:0002066 249 0.057
gene silencing GO:0016458 138 0.056
negative regulation of rna metabolic process GO:0051253 251 0.055
Human
regulation of proteasomal protein catabolic process GO:0061136 39 0.054
wing disc morphogenesis GO:0007472 344 0.054
mitotic sister chromatid segregation GO:0000070 87 0.053
dna metabolic process GO:0006259 227 0.052
regulation of mitotic cell cycle GO:0007346 190 0.051
ubiquitin dependent protein catabolic process GO:0006511 78 0.050
negative regulation of transcription dna templated GO:0045892 237 0.049
Human
programmed cell death GO:0012501 257 0.049
Human
positive regulation of rna biosynthetic process GO:1902680 266 0.049
regulation of programmed cell death GO:0043067 152 0.049
Human
death GO:0016265 284 0.048
Human
histone modification GO:0016570 106 0.047
spindle assembly involved in mitosis GO:0090307 50 0.047
cellular catabolic process GO:0044248 372 0.046
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.046
Human
endocytosis GO:0006897 310 0.046
negative regulation of gene expression GO:0010629 387 0.046
Human
tube development GO:0035295 244 0.046
modification dependent macromolecule catabolic process GO:0043632 79 0.045
heterocycle catabolic process GO:0046700 166 0.045
cellular response to dna damage stimulus GO:0006974 223 0.044
negative regulation of biosynthetic process GO:0009890 277 0.043
Human
regulation of mitosis GO:0007088 56 0.042
regulation of organelle organization GO:0033043 196 0.041
Human
positive regulation of nucleic acid templated transcription GO:1903508 266 0.041
positive regulation of transcription dna templated GO:0045893 266 0.041
macromolecule catabolic process GO:0009057 161 0.041
mitotic cell cycle phase transition GO:0044772 138 0.040
growth GO:0040007 359 0.039
tissue morphogenesis GO:0048729 297 0.038
cellular macromolecule catabolic process GO:0044265 136 0.038
regulation of cellular catabolic process GO:0031329 157 0.038
mitotic cytokinesis GO:0000281 50 0.038
organic cyclic compound catabolic process GO:1901361 168 0.038
embryo development ending in birth or egg hatching GO:0009792 152 0.038
regulation of mitotic cell cycle phase transition GO:1901990 130 0.038
eye morphogenesis GO:0048592 260 0.037
organelle localization GO:0051640 148 0.037
Fly
small molecule metabolic process GO:0044281 305 0.037
body morphogenesis GO:0010171 2 0.037
cellular nitrogen compound catabolic process GO:0044270 165 0.036
microtubule cytoskeleton organization involved in mitosis GO:1902850 52 0.036
cellular component assembly involved in morphogenesis GO:0010927 151 0.036
single organism catabolic process GO:0044712 228 0.035
morphogenesis of an epithelium GO:0002009 276 0.035
aromatic compound catabolic process GO:0019439 166 0.035
negative regulation of cell cycle process GO:0010948 109 0.035
cell division GO:0051301 248 0.035
regulation of catalytic activity GO:0050790 185 0.034
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.034
Human
eye development GO:0001654 323 0.034
response to biotic stimulus GO:0009607 294 0.034
regulation of chromosome organization GO:0033044 64 0.034
intracellular signal transduction GO:0035556 300 0.034
chromatin organization GO:0006325 207 0.034
developmental growth GO:0048589 280 0.033
regulation of catabolic process GO:0009894 170 0.033
regulation of gene expression epigenetic GO:0040029 128 0.033
protein complex assembly GO:0006461 200 0.033
negative regulation of cellular metabolic process GO:0031324 382 0.032
Human
digestive tract development GO:0048565 149 0.032
regulation of protein metabolic process GO:0051246 256 0.032
organic substance transport GO:0071702 257 0.032
chromatin silencing GO:0006342 76 0.032
digestive tract morphogenesis GO:0048546 127 0.032
regulation of proteolysis GO:0030162 87 0.031
organonitrogen compound metabolic process GO:1901564 318 0.031
regulation of cell division GO:0051302 72 0.031
Human
centrosome organization GO:0051297 163 0.031
Fly
nucleobase containing compound catabolic process GO:0034655 165 0.031
camera type eye development GO:0043010 4 0.031
cell death GO:0008219 279 0.030
Human
ameboidal type cell migration GO:0001667 151 0.029
positive regulation of response to stimulus GO:0048584 323 0.029
immune system process GO:0002376 347 0.029
cellular protein catabolic process GO:0044257 83 0.029
negative regulation of cellular biosynthetic process GO:0031327 277 0.029
Human
spindle elongation GO:0051231 83 0.029
Human
negative regulation of organelle organization GO:0010639 56 0.028
Human
positive regulation of cellular component organization GO:0051130 156 0.028
organonitrogen compound catabolic process GO:1901565 128 0.028
proteasomal protein catabolic process GO:0010498 59 0.028
cell cycle phase transition GO:0044770 140 0.028
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.028
positive regulation of cellular protein metabolic process GO:0032270 118 0.027
covalent chromatin modification GO:0016569 106 0.027
modification dependent protein catabolic process GO:0019941 78 0.027
regulation of cell cycle GO:0051726 291 0.027
Human
digestive system development GO:0055123 149 0.027
metaphase plate congression GO:0051310 19 0.026
regulation of cell cycle phase transition GO:1901987 130 0.026
regionalization GO:0003002 416 0.025
vesicle mediated transport GO:0016192 381 0.024
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.024
regulation of localization GO:0032879 275 0.024
negative regulation of mitotic cell cycle GO:0045930 109 0.024
regulation of cell cycle process GO:0010564 181 0.024
Human
regulation of cellular amine metabolic process GO:0033238 3 0.023
single organism intracellular transport GO:1902582 207 0.023
cellularization GO:0007349 90 0.022
Fly
positive regulation of cell communication GO:0010647 250 0.022
transcription from rna polymerase ii promoter GO:0006366 368 0.022
Human
negative regulation of cell cycle phase transition GO:1901988 103 0.022
mitotic sister chromatid separation GO:0051306 30 0.022
embryonic morphogenesis GO:0048598 206 0.022
carbohydrate derivative metabolic process GO:1901135 217 0.021
negative regulation of rna biosynthetic process GO:1902679 240 0.021
Human
positive regulation of catalytic activity GO:0043085 118 0.021
regulation of growth GO:0040008 233 0.021
nuclear transport GO:0051169 72 0.021
negative regulation of response to stimulus GO:0048585 258 0.021
nucleoside metabolic process GO:0009116 127 0.020
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.020
apoptotic process GO:0006915 159 0.020
Human
positive regulation of signaling GO:0023056 243 0.020
positive regulation of rna metabolic process GO:0051254 271 0.020
cytoplasmic transport GO:0016482 130 0.020
response to organic substance GO:0010033 284 0.020
nucleoside phosphate metabolic process GO:0006753 162 0.020
spermatogenesis GO:0007283 200 0.020
protein localization GO:0008104 284 0.019
Human Fly
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.019
ovarian follicle cell development GO:0030707 248 0.019
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.019
phagocytosis GO:0006909 215 0.019
negative regulation of gene expression epigenetic GO:0045814 77 0.019
regulation of microtubule cytoskeleton organization GO:0070507 41 0.019
Human
dna integrity checkpoint GO:0031570 81 0.019
localization of cell GO:0051674 257 0.019
muscle structure development GO:0061061 224 0.018
nucleocytoplasmic transport GO:0006913 72 0.018
imaginal disc pattern formation GO:0007447 91 0.018
peptidyl lysine modification GO:0018205 57 0.018
regulation of intracellular signal transduction GO:1902531 236 0.018
regulation of nuclear division GO:0051783 58 0.017
protein complex biogenesis GO:0070271 201 0.017
establishment of spindle orientation GO:0051294 18 0.017
Fly
regulation of cellular amino acid metabolic process GO:0006521 0 0.017
regulation of cellular component biogenesis GO:0044087 201 0.017
male gamete generation GO:0048232 201 0.017
epithelial cell differentiation GO:0030855 322 0.017
regulation of cell shape GO:0008360 113 0.017
response to other organism GO:0051707 293 0.017
regulation of cellular protein catabolic process GO:1903362 44 0.017
regulation of response to stress GO:0080134 200 0.017
chromosome localization GO:0050000 20 0.016
actin cytoskeleton organization GO:0030036 206 0.016
response to external biotic stimulus GO:0043207 293 0.016
regulation of cell proliferation GO:0042127 163 0.016
nucleobase containing small molecule metabolic process GO:0055086 174 0.016
g1 s transition of mitotic cell cycle GO:0000082 31 0.016
gland development GO:0048732 191 0.016
protein catabolic process GO:0030163 101 0.016
development of primary sexual characteristics GO:0045137 50 0.016
purine nucleoside triphosphate metabolic process GO:0009144 119 0.016
protein dna complex subunit organization GO:0071824 86 0.016
protein processing GO:0016485 68 0.016
cell migration GO:0016477 238 0.016
purine containing compound metabolic process GO:0072521 155 0.016
positive regulation of cellular catabolic process GO:0031331 95 0.016
negative regulation of apoptotic process GO:0043066 63 0.016
Human
macromolecular complex assembly GO:0065003 256 0.016
nucleotide metabolic process GO:0009117 161 0.015
aging GO:0007568 143 0.015
Rat
regulation of notch signaling pathway GO:0008593 100 0.015
nucleoside triphosphate metabolic process GO:0009141 120 0.015
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.015
peptidyl amino acid modification GO:0018193 105 0.015
Mouse
spindle assembly GO:0051225 80 0.015
mitotic cell cycle embryonic GO:0045448 38 0.015
cell motility GO:0048870 251 0.015
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.015
negative regulation of cell communication GO:0010648 223 0.015
neurological system process GO:0050877 358 0.015
gland morphogenesis GO:0022612 145 0.015
regulation of protein localization GO:0032880 76 0.015
positive regulation of catabolic process GO:0009896 105 0.015
purine ribonucleotide metabolic process GO:0009150 145 0.015
ribonucleotide metabolic process GO:0009259 145 0.015
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.015
dna packaging GO:0006323 91 0.015
actomyosin structure organization GO:0031032 56 0.015
cell cell signaling involved in cell fate commitment GO:0045168 210 0.015
metaphase anaphase transition of cell cycle GO:0044784 28 0.014
meiotic chromosome segregation GO:0045132 59 0.014
single organism cellular localization GO:1902580 180 0.014
Fly
regulation of mitotic sister chromatid separation GO:0010965 28 0.014
single organism behavior GO:0044708 391 0.014
purine nucleotide metabolic process GO:0006163 146 0.014
protein localization to nucleus GO:0034504 55 0.014
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.014
regulation of multicellular organismal development GO:2000026 414 0.014
Fly
regulation of immune system process GO:0002682 176 0.014
cell cycle checkpoint GO:0000075 95 0.014
purine ribonucleoside metabolic process GO:0046128 127 0.014
positive regulation of signal transduction GO:0009967 223 0.014
gene silencing by rna GO:0031047 57 0.014
amine metabolic process GO:0009308 12 0.013
regulation of mitotic sister chromatid segregation GO:0033047 28 0.013
negative regulation of signaling GO:0023057 219 0.013
synapse organization GO:0050808 196 0.013
negative regulation of cellular catabolic process GO:0031330 34 0.013
ribonucleotide catabolic process GO:0009261 109 0.013
organophosphate metabolic process GO:0019637 195 0.013
regulation of sister chromatid segregation GO:0033045 28 0.013
response to temperature stimulus GO:0009266 106 0.013
g2 dna damage checkpoint GO:0031572 69 0.013
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.013
organic acid metabolic process GO:0006082 103 0.013
epithelial tube morphogenesis GO:0060562 88 0.013
posttranscriptional gene silencing by rna GO:0035194 45 0.013
purine ribonucleotide catabolic process GO:0009154 109 0.013
positive regulation of lipid metabolic process GO:0045834 4 0.013
regulation of cellular protein metabolic process GO:0032268 243 0.013
negative regulation of signal transduction GO:0009968 206 0.013
positive regulation of intracellular signal transduction GO:1902533 116 0.013
positive regulation of phosphorus metabolic process GO:0010562 139 0.013
glycosyl compound metabolic process GO:1901657 127 0.013
negative regulation of programmed cell death GO:0043069 72 0.013
Human
chorion containing eggshell formation GO:0007304 105 0.013
cellular protein localization GO:0034613 160 0.013
Human
cellular ketone metabolic process GO:0042180 24 0.012
cytoskeleton dependent cytokinesis GO:0061640 81 0.012
protein acylation GO:0043543 42 0.012
negative regulation of cellular component organization GO:0051129 108 0.012
Human
regulation of protein import into nucleus GO:0042306 28 0.012
carboxylic acid metabolic process GO:0019752 92 0.012
double strand break repair GO:0006302 26 0.012
positive regulation of cellular amine metabolic process GO:0033240 0 0.012
dorsal ventral pattern formation GO:0009953 133 0.012
protein modification by small protein conjugation or removal GO:0070647 106 0.012
mrna processing GO:0006397 104 0.012
segmentation GO:0035282 207 0.012
positive regulation of protein metabolic process GO:0051247 128 0.012
gtp catabolic process GO:0006184 72 0.012
synaptic transmission GO:0007268 288 0.012
lateral inhibition GO:0046331 206 0.012
cell cycle g1 s phase transition GO:0044843 31 0.012
mitotic dna integrity checkpoint GO:0044774 75 0.012
protein modification by small protein conjugation GO:0032446 79 0.012
regulation of cellular localization GO:0060341 136 0.012
negative regulation of cell cycle GO:0045786 116 0.012
regulation of apoptotic process GO:0042981 130 0.012
Human
posttranscriptional regulation of gene expression GO:0010608 145 0.011
ribonucleoside triphosphate metabolic process GO:0009199 119 0.011
gtp metabolic process GO:0046039 72 0.011
internal peptidyl lysine acetylation GO:0018393 38 0.011
sensory organ morphogenesis GO:0090596 260 0.011
epithelial cell development GO:0002064 274 0.011
regulation of anatomical structure size GO:0090066 163 0.011
imaginal disc derived leg morphogenesis GO:0007480 80 0.011
regulation of hydrolase activity GO:0051336 97 0.011
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.011
regulation of cellular ketone metabolic process GO:0010565 3 0.011
neuromuscular junction development GO:0007528 149 0.011
purine nucleoside metabolic process GO:0042278 127 0.011
purine nucleoside triphosphate catabolic process GO:0009146 108 0.011
rna catabolic process GO:0006401 37 0.011
positive regulation of organelle organization GO:0010638 65 0.011
gonad development GO:0008406 50 0.011
positive regulation of mitotic cell cycle GO:0045931 34 0.011
gastrulation GO:0007369 70 0.011
mitotic g2 m transition checkpoint GO:0044818 70 0.011
dendrite development GO:0016358 204 0.011
cell proliferation GO:0008283 299 0.011
Rat
organelle assembly GO:0070925 198 0.011
internal protein amino acid acetylation GO:0006475 38 0.011
posttranscriptional gene silencing GO:0016441 46 0.011
organophosphate catabolic process GO:0046434 112 0.011
cellular amine metabolic process GO:0044106 12 0.010
positive regulation of transport GO:0051050 92 0.010
purine ribonucleoside catabolic process GO:0046130 112 0.010
determination of adult lifespan GO:0008340 137 0.010
negative regulation of cell death GO:0060548 81 0.010
Human
larval development GO:0002164 104 0.010
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 30 0.010
small gtpase mediated signal transduction GO:0007264 88 0.010
spinal cord development GO:0021510 1 0.010
regulation of anatomical structure morphogenesis GO:0022603 242 0.010
regulation of protein catabolic process GO:0042176 55 0.010
histone acetylation GO:0016573 38 0.010
anatomical structure homeostasis GO:0060249 97 0.010
nuclear import GO:0051170 51 0.010

ial disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.068
nervous system disease DOID:863 0 0.023