Drosophila melanogaster

13 known processes

Tm2 (Dmel_CG4843)

Tropomyosin 2

(Aliases: Ifm-TmI,Tm1,CG4843,Dmel\CG4843,DROTROPI1,Ifm(3)3,Ifm(3)5,Tm127,dro Tm,mTmI,Tm,TmI,l(3)nc99Eb,Tn-H)

Tm2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
striated muscle cell development GO:0055002 50 0.995
Human Zebrafish
sarcomere organization GO:0045214 26 0.989
Human
muscle cell development GO:0055001 50 0.983
Human Zebrafish
skeletal muscle adaptation GO:0043501 1 0.955
actin filament based process GO:0030029 220 0.950
Human Zebrafish Rat Worm
myofibril assembly GO:0030239 36 0.942
Human Zebrafish
muscle tissue morphogenesis GO:0060415 2 0.927
Human Mouse
actomyosin structure organization GO:0031032 56 0.868
Human Zebrafish Rat
striated muscle myosin thick filament assembly GO:0071688 3 0.862
actin filament based movement GO:0030048 26 0.842
Rat
actin cytoskeleton organization GO:0030036 206 0.811
Human Zebrafish Rat Worm
myotube differentiation GO:0014902 46 0.792
mesoderm development GO:0007498 78 0.758
striated muscle cell differentiation GO:0051146 90 0.688
Human Zebrafish
muscle thin filament assembly GO:0071689 5 0.642
muscle cell differentiation GO:0042692 103 0.639
Human Zebrafish
skeletal myofibril assembly GO:0014866 6 0.618
blood circulation GO:0008015 26 0.604
Human Zebrafish Mouse Rat
heart process GO:0003015 37 0.600
Human Zebrafish Mouse Rat
regulation of blood circulation GO:1903522 21 0.592
Mouse
skeletal muscle organ development GO:0060538 48 0.545
muscle tissue development GO:0060537 30 0.537
Human Zebrafish Mouse
skeletal muscle myosin thick filament assembly GO:0030241 3 0.530
muscle structure development GO:0061061 224 0.500
Human Zebrafish Mouse
regulation of heart contraction GO:0008016 21 0.464
Mouse
striated muscle tissue development GO:0014706 27 0.436
Human Zebrafish Mouse
regulation of system process GO:0044057 36 0.401
Mouse
muscle organ development GO:0007517 127 0.331
Human Mouse
striated muscle adaptation GO:0014888 1 0.302
actin mediated cell contraction GO:0070252 21 0.300
Rat
organelle assembly GO:0070925 198 0.279
Human Zebrafish
cellular component assembly involved in morphogenesis GO:0010927 151 0.268
Human Zebrafish
cellular ion homeostasis GO:0006873 39 0.243
heart contraction GO:0060047 26 0.231
Human Zebrafish Mouse Rat
myosin filament assembly GO:0031034 5 0.225
circulatory system process GO:0003013 37 0.210
Human Zebrafish Mouse Rat
cellular macromolecular complex assembly GO:0034622 153 0.199
Rat Worm
body morphogenesis GO:0010171 2 0.184
Worm
atp metabolic process GO:0046034 49 0.182
Human Rat
protein complex assembly GO:0006461 200 0.168
Rat Worm
heart development GO:0007507 82 0.152
positive regulation of atp catabolic process GO:1903291 3 0.148
Rat
metal ion homeostasis GO:0055065 44 0.143
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.134
Human Rat
heart morphogenesis GO:0003007 32 0.130
Human Mouse
skeletal muscle fiber development GO:0048741 3 0.129
cation homeostasis GO:0055080 51 0.124
cellular protein complex assembly GO:0043623 71 0.123
Rat Worm
multi multicellular organism process GO:0044706 123 0.119
Worm
embryo development ending in birth or egg hatching GO:0009792 152 0.116
Mouse Worm
multicellular organismal reproductive behavior GO:0033057 110 0.115
Worm
purine ribonucleotide catabolic process GO:0009154 109 0.103
Human Rat
purine ribonucleoside monophosphate catabolic process GO:0009169 38 0.102
Human Rat
protein complex biogenesis GO:0070271 201 0.099
Rat Worm
adult somatic muscle development GO:0007527 14 0.099
regulation of heart rate GO:0002027 11 0.099
Mouse
myotube cell development GO:0014904 3 0.097
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.096
Rat
atp catabolic process GO:0006200 38 0.093
Human Rat
negative regulation of cellular catabolic process GO:0031330 34 0.092
ion homeostasis GO:0050801 55 0.091
cardiac muscle tissue development GO:0048738 9 0.087
Human Zebrafish Mouse
positive regulation of nucleotide catabolic process GO:0030813 46 0.087
Rat
ribose phosphate metabolic process GO:0019693 145 0.086
Human Rat
purine ribonucleotide metabolic process GO:0009150 145 0.083
Human Rat
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.083
Human Rat
purine ribonucleoside metabolic process GO:0046128 127 0.082
Human Rat
ribonucleoside monophosphate catabolic process GO:0009158 39 0.080
Human Rat
cellular cation homeostasis GO:0030003 38 0.078
nucleobase containing small molecule metabolic process GO:0055086 174 0.076
Human Rat
nucleoside triphosphate metabolic process GO:0009141 120 0.073
Human Rat
glycosyl compound metabolic process GO:1901657 127 0.072
Human Rat
ribonucleoside monophosphate metabolic process GO:0009161 51 0.072
Human Rat
muscle contraction GO:0006936 13 0.072
Human Zebrafish Mouse Rat
cytokinesis GO:0000910 90 0.071
Worm
myosin filament organization GO:0031033 5 0.070
actin filament organization GO:0007015 126 0.069
Rat Worm
heterocycle catabolic process GO:0046700 166 0.064
Human Rat
ribonucleoside catabolic process GO:0042454 112 0.061
Human Rat
vesicle mediated transport GO:0016192 381 0.061
purine ribonucleoside catabolic process GO:0046130 112 0.059
Human Rat
purine nucleoside monophosphate catabolic process GO:0009128 38 0.058
Human Rat
axonal fasciculation GO:0007413 12 0.056
small molecule metabolic process GO:0044281 305 0.055
Human Rat
cytoskeleton dependent cytokinesis GO:0061640 81 0.054
oviposition GO:0018991 19 0.054
Worm
muscle fiber development GO:0048747 12 0.053
epithelial tube morphogenesis GO:0060562 88 0.052
nucleoside triphosphate catabolic process GO:0009143 108 0.052
Human Rat
striated muscle contraction GO:0006941 5 0.052
Human Zebrafish Mouse Rat
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.051
Human Rat
glycolytic process GO:0006096 6 0.050
nucleobase containing compound catabolic process GO:0034655 165 0.050
Human Rat
camera type eye development GO:0043010 4 0.050
carbohydrate derivative catabolic process GO:1901136 118 0.048
Human Rat
mitotic cytokinesis GO:0000281 50 0.048
nucleoside phosphate metabolic process GO:0006753 162 0.048
Human Rat
endocytosis GO:0006897 310 0.047
alditol phosphate metabolic process GO:0052646 2 0.047
purine nucleotide metabolic process GO:0006163 146 0.047
Human Rat
aging GO:0007568 143 0.046
ribonucleoside triphosphate metabolic process GO:0009199 119 0.046
Human Rat
somatic muscle development GO:0007525 66 0.045
purine nucleoside catabolic process GO:0006152 112 0.045
Human Rat
purine nucleotide catabolic process GO:0006195 109 0.045
Human Rat
establishment of nucleus localization GO:0040023 26 0.044
purine nucleoside metabolic process GO:0042278 127 0.043
Human Rat
response to heat GO:0009408 63 0.043
aromatic compound catabolic process GO:0019439 166 0.043
Human Rat
actin cytoskeleton reorganization GO:0031532 22 0.043
muscle organ morphogenesis GO:0048644 7 0.041
Human Mouse
positive regulation of catabolic process GO:0009896 105 0.040
Rat
ribonucleoside metabolic process GO:0009119 127 0.039
Human Rat
skeletal muscle tissue development GO:0007519 13 0.039
multi organism reproductive behavior GO:0044705 121 0.038
Worm
regulation of multicellular organismal development GO:2000026 414 0.038
cellular metal ion homeostasis GO:0006875 31 0.038
muscle system process GO:0003012 21 0.036
Human Zebrafish Mouse Rat
cellular homeostasis GO:0019725 80 0.036
cell recognition GO:0008037 102 0.036
kidney development GO:0001822 3 0.035
growth GO:0040007 359 0.035
nucleoside catabolic process GO:0009164 112 0.034
Human Rat
gonad development GO:0008406 50 0.034
Worm
neuron recognition GO:0008038 101 0.034
positive regulation of protein import into nucleus GO:0042307 21 0.034
regionalization GO:0003002 416 0.034
immune system development GO:0002520 57 0.034
organophosphate metabolic process GO:0019637 195 0.033
Human Rat
cellular chemical homeostasis GO:0055082 40 0.033
nucleotide metabolic process GO:0009117 161 0.033
Human Rat
positive regulation of phosphorus metabolic process GO:0010562 139 0.033
Rat
organic cyclic compound catabolic process GO:1901361 168 0.033
Human Rat
positive regulation of transcription factor import into nucleus GO:0042993 19 0.033
ribonucleotide catabolic process GO:0009261 109 0.033
Human Rat
positive regulation of nucleocytoplasmic transport GO:0046824 24 0.032
ribonucleoside triphosphate catabolic process GO:0009203 108 0.032
Human Rat
adult behavior GO:0030534 137 0.031
appendage morphogenesis GO:0035107 397 0.031
response to anesthetic GO:0072347 9 0.031
positive regulation of actin filament polymerization GO:0030838 11 0.031
regulation of cytoskeleton organization GO:0051493 89 0.031
Rat Worm
muscle adaptation GO:0043500 1 0.031
organonitrogen compound metabolic process GO:1901564 318 0.030
Human Rat
divalent inorganic cation homeostasis GO:0072507 29 0.030
regulation of cellular localization GO:0060341 136 0.029
organonitrogen compound catabolic process GO:1901565 128 0.029
Human Rat
nucleoside monophosphate metabolic process GO:0009123 52 0.029
Human Rat
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.029
Rat
regulation of organelle organization GO:0033043 196 0.028
Rat Worm
positive regulation of cellular catabolic process GO:0031331 95 0.028
Rat
regulation of phosphorus metabolic process GO:0051174 210 0.028
Human Rat
sex differentiation GO:0007548 81 0.028
Worm
larval somatic muscle development GO:0007526 19 0.028
positive regulation of purine nucleotide catabolic process GO:0033123 46 0.028
Rat
regulation of muscle system process GO:0090257 6 0.028
cellular response to chemical stimulus GO:0070887 199 0.027
Human
calcium ion homeostasis GO:0055074 23 0.027
tissue morphogenesis GO:0048729 297 0.027
Human Mouse
multi organism behavior GO:0051705 175 0.027
Worm
maintenance of location GO:0051235 73 0.027
development of primary sexual characteristics GO:0045137 50 0.027
Worm
cellular nitrogen compound catabolic process GO:0044270 165 0.026
Human Rat
protein modification process GO:0036211 438 0.026
glycosyl compound catabolic process GO:1901658 112 0.026
Human Rat
purine nucleoside triphosphate metabolic process GO:0009144 119 0.025
Human Rat
actin filament polymerization GO:0030041 27 0.025
Rat Worm
nucleoside phosphate catabolic process GO:1901292 110 0.025
Human Rat
negative regulation of sequestering of calcium ion GO:0051283 2 0.025
hematopoietic progenitor cell differentiation GO:0002244 1 0.025
embryonic morphogenesis GO:0048598 206 0.025
actin polymerization or depolymerization GO:0008154 31 0.025
Rat Worm
regulation of actin filament length GO:0030832 27 0.024
Rat Worm
nucleoside monophosphate catabolic process GO:0009125 39 0.024
Human Rat
cellular protein complex disassembly GO:0043624 35 0.023
Rat Worm
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.023
Rat
regulation of actin filament polymerization GO:0030833 25 0.023
Rat Worm
macromolecular complex assembly GO:0065003 256 0.023
Rat Worm
anatomical structure homeostasis GO:0060249 97 0.023
organophosphate catabolic process GO:0046434 112 0.023
Human Rat
ribonucleotide metabolic process GO:0009259 145 0.023
Human Rat
negative regulation of cellular metabolic process GO:0031324 382 0.022
regulation of purine nucleotide metabolic process GO:1900542 62 0.022
Human Rat
single organism catabolic process GO:0044712 228 0.022
Human Rat
cell division GO:0051301 248 0.022
Worm
chemical homeostasis GO:0048878 92 0.021
carbohydrate derivative metabolic process GO:1901135 217 0.021
Human Rat
regulation of tube length open tracheal system GO:0035159 24 0.021
sequestering of calcium ion GO:0051208 5 0.020
macromolecule catabolic process GO:0009057 161 0.020
protein depolymerization GO:0051261 31 0.020
Rat Worm
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.020
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.020
negative regulation of catabolic process GO:0009895 36 0.020
microtubule organizing center organization GO:0031023 168 0.020
localization of cell GO:0051674 257 0.019
Rat
mitotic chromosome condensation GO:0007076 22 0.019
stem cell differentiation GO:0048863 117 0.019
regulation of anatomical structure morphogenesis GO:0022603 242 0.019
positive regulation of nfat protein import into nucleus GO:0051533 16 0.019
epithelial cell development GO:0002064 274 0.018
positive regulation of cellular component organization GO:0051130 156 0.018
Rat
regulation of catalytic activity GO:0050790 185 0.018
Human Rat
regulation of sarcomere organization GO:0060297 2 0.018
larval development GO:0002164 104 0.018
Worm
phagocytosis GO:0006909 215 0.018
organelle localization GO:0051640 148 0.018
organic substance catabolic process GO:1901575 308 0.018
Human Rat
cellular calcium ion homeostasis GO:0006874 21 0.018
negative regulation of cellular component organization GO:0051129 108 0.017
Rat Worm
tube development GO:0035295 244 0.017
Worm
regulation of molecular function GO:0065009 217 0.017
Human Rat Worm
embryonic development via the syncytial blastoderm GO:0001700 148 0.017
regulation of cell morphogenesis GO:0022604 163 0.017
multicellular organism growth GO:0035264 46 0.017
synapse organization GO:0050808 196 0.017
oxoacid metabolic process GO:0043436 103 0.017
cytosolic calcium ion transport GO:0060401 2 0.017
positive regulation of protein transport GO:0051222 37 0.017
single organism nuclear import GO:1902593 51 0.017
regulation of cell cycle GO:0051726 291 0.017
ovulation GO:0030728 4 0.017
Worm
purine containing compound catabolic process GO:0072523 112 0.017
Human Rat
morphogenesis of an epithelium GO:0002009 276 0.016
cytoplasmic transport GO:0016482 130 0.016
positive regulation of nucleoside metabolic process GO:0045979 47 0.016
Rat
positive regulation of transport GO:0051050 92 0.016
regulation of sequestering of calcium ion GO:0051282 3 0.016
circulatory system development GO:0072359 82 0.016
regulation of cellular catabolic process GO:0031329 157 0.015
Human Rat
regulation of actin polymerization or depolymerization GO:0008064 27 0.015
Rat Worm
imaginal disc derived appendage development GO:0048737 399 0.015
regulation of establishment of protein localization GO:0070201 61 0.015
cellular divalent inorganic cation homeostasis GO:0072503 23 0.015
positive regulation of intracellular transport GO:0032388 42 0.015
regulation of phosphate metabolic process GO:0019220 210 0.015
Human Rat
protein polymerization GO:0051258 42 0.015
Rat Worm
regulation of intracellular protein transport GO:0033157 46 0.015
tube morphogenesis GO:0035239 191 0.015
centrosome organization GO:0051297 163 0.015
establishment of localization in cell GO:0051649 402 0.015
catabolic process GO:0009056 409 0.014
Human Rat
cellular catabolic process GO:0044248 372 0.014
Human Rat
regulation of cellular component size GO:0032535 98 0.014
Rat Worm
lipid storage GO:0019915 38 0.014
regulation of protein localization GO:0032880 76 0.014
regulation of growth GO:0040008 233 0.014
anterior posterior pattern specification GO:0009952 136 0.014
chromosome condensation GO:0030261 41 0.014
stem cell development GO:0048864 79 0.014
cell aging GO:0007569 2 0.014
nuclear import GO:0051170 51 0.013
outflow tract morphogenesis GO:0003151 4 0.013
negative regulation of cell cycle GO:0045786 116 0.013
protein targeting to nucleus GO:0044744 51 0.013
neuroblast proliferation GO:0007405 74 0.013
nucleotide catabolic process GO:0009166 109 0.013
Human Rat
purine nucleoside monophosphate metabolic process GO:0009126 50 0.013
Human Rat
intracellular transport GO:0046907 228 0.013
intracellular signal transduction GO:0035556 300 0.013
regulation of muscle contraction GO:0006937 5 0.013
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.013
imaginal disc derived appendage morphogenesis GO:0035114 395 0.012
post embryonic appendage morphogenesis GO:0035120 385 0.012
negative regulation of homeostatic process GO:0032845 2 0.012
regulation of transcription factor import into nucleus GO:0042990 22 0.012
protein catabolic process GO:0030163 101 0.012
positive regulation of hydrolase activity GO:0051345 78 0.012
Rat
regulation of nucleotide catabolic process GO:0030811 48 0.012
Human Rat
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.012
regulation of cell shape GO:0008360 113 0.012
homeostatic process GO:0042592 199 0.012
positive regulation of catalytic activity GO:0043085 118 0.012
Rat
response to metal ion GO:0010038 23 0.012
positive regulation of endocytosis GO:0045807 22 0.011
columnar cuboidal epithelial cell development GO:0002066 249 0.011
cell adhesion GO:0007155 136 0.011
Rat
protein localization to nucleus GO:0034504 55 0.011
negative regulation of cytoskeleton organization GO:0051494 30 0.011
Rat Worm
mitotic nuclear division GO:0007067 213 0.011
phosphorylation GO:0016310 294 0.011
purine containing compound metabolic process GO:0072521 155 0.011
Human Rat
response to ionizing radiation GO:0010212 32 0.011
organelle fission GO:0048285 340 0.011
regulation of cell differentiation GO:0045595 302 0.011
positive regulation of gene expression GO:0010628 290 0.011
hematopoietic or lymphoid organ development GO:0048534 57 0.011
negative regulation of phosphorus metabolic process GO:0010563 45 0.011
positive regulation of molecular function GO:0044093 136 0.011
Rat
establishment of organelle localization GO:0051656 122 0.011
calcium ion transport into cytosol GO:0060402 2 0.011
reactive oxygen species metabolic process GO:0072593 22 0.011
renal system development GO:0072001 72 0.010
positive regulation of intracellular protein transport GO:0090316 30 0.010
epithelial cell morphogenesis GO:0003382 25 0.010
regulation of phosphatase activity GO:0010921 3 0.010
formation of anatomical boundary GO:0048859 37 0.010

Tm2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
myopathy DOID:423 0 0.315
Human
muscular disease DOID:0080000 0 0.315
Human
heart disease DOID:114 0 0.315
Human
cardiomyopathy DOID:0050700 0 0.315
Human
disease of anatomical entity DOID:7 0 0.315
Human
cardiovascular system disease DOID:1287 0 0.315
Human
musculoskeletal system disease DOID:17 0 0.315
Human
muscle tissue disease DOID:66 0 0.315
Human
dilated cardiomyopathy DOID:12930 0 0.058
Human
intrinsic cardiomyopathy DOID:0060036 0 0.058
Human
central nervous system disease DOID:331 0 0.017
neurodegenerative disease DOID:1289 0 0.017
nervous system disease DOID:863 0 0.017