Drosophila melanogaster

43 known processes

poe (Dmel_CG14472)

purity of essence

(Aliases: ms(2)01659,CG14472,ms(2)5970,3420,ms(2)3420,Dmel\CG14472,Calo,calo,push,ms(2)27C,POE)

poe biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
sperm individualization GO:0007291 48 0.946
spermatid differentiation GO:0048515 114 0.915
regulation of cellular component biogenesis GO:0044087 201 0.753
growth GO:0040007 359 0.701
spermatogenesis GO:0007283 200 0.659
developmental growth GO:0048589 280 0.653
cellularization GO:0007349 90 0.595
cellular macromolecule catabolic process GO:0044265 136 0.393
Human
male gamete generation GO:0048232 201 0.347
heterocycle catabolic process GO:0046700 166 0.319
gliogenesis GO:0042063 80 0.297
nuclear transcribed mrna catabolic process nonsense mediated decay GO:0000184 8 0.292
posttranscriptional regulation of gene expression GO:0010608 145 0.266
catabolic process GO:0009056 409 0.246
Human
single organism membrane organization GO:0044802 93 0.239
oocyte differentiation GO:0009994 145 0.196
regulation of response to stress GO:0080134 200 0.193
regulation of growth GO:0040008 233 0.181
macromolecule catabolic process GO:0009057 161 0.161
Human
developmental cell growth GO:0048588 52 0.159
vesicle mediated transport GO:0016192 381 0.157
organic cyclic compound catabolic process GO:1901361 168 0.152
protein modification process GO:0036211 438 0.139
Human
regulation of synaptic growth at neuromuscular junction GO:0008582 89 0.139
cell growth GO:0016049 108 0.128
single organism cellular localization GO:1902580 180 0.115
cellular protein modification process GO:0006464 438 0.115
Human
establishment of localization in cell GO:0051649 402 0.113
cell motility GO:0048870 251 0.111
regulation of cell death GO:0010941 173 0.111
cell cell signaling involved in cell fate commitment GO:0045168 210 0.110
regulation of nervous system development GO:0051960 248 0.110
cell maturation GO:0048469 144 0.109
cellular protein localization GO:0034613 160 0.106
positive regulation of cellular component organization GO:0051130 156 0.106
rna catabolic process GO:0006401 37 0.106
regulation of multicellular organismal development GO:2000026 414 0.102
membrane organization GO:0061024 112 0.101
endocytosis GO:0006897 310 0.099
mrna metabolic process GO:0016071 124 0.099
molting cycle chitin based cuticle GO:0007591 56 0.093
cellular catabolic process GO:0044248 372 0.089
Human
oocyte axis specification GO:0007309 108 0.086
plasma membrane organization GO:0007009 26 0.084
locomotory behavior GO:0007626 176 0.084
nucleobase containing compound catabolic process GO:0034655 165 0.083
actin cytoskeleton organization GO:0030036 206 0.083
mrna catabolic process GO:0006402 33 0.082
nuclear transcribed mrna catabolic process GO:0000956 24 0.081
negative regulation of cellular metabolic process GO:0031324 382 0.081
synaptic growth at neuromuscular junction GO:0051124 119 0.081
lateral inhibition GO:0046331 206 0.081
ion transmembrane transport GO:0034220 122 0.079
developmental maturation GO:0021700 172 0.074
cell death GO:0008219 279 0.070
neuromuscular synaptic transmission GO:0007274 67 0.070
regulation of synapse assembly GO:0051963 94 0.069
positive regulation of apoptotic signaling pathway GO:2001235 4 0.069
establishment of protein localization to plasma membrane GO:0090002 9 0.065
response to external biotic stimulus GO:0043207 293 0.064
immune system process GO:0002376 347 0.064
endomembrane system organization GO:0010256 119 0.063
regulation of cell differentiation GO:0045595 302 0.062
spermatid development GO:0007286 98 0.062
dna metabolic process GO:0006259 227 0.061
maternal determination of anterior posterior axis embryo GO:0008358 74 0.060
organelle assembly GO:0070925 198 0.059
organelle fission GO:0048285 340 0.058
organic substance catabolic process GO:1901575 308 0.058
Human
organophosphate metabolic process GO:0019637 195 0.056
organic substance transport GO:0071702 257 0.056
oocyte development GO:0048599 124 0.056
oocyte construction GO:0007308 112 0.056
mitotic nuclear division GO:0007067 213 0.053
regulation of protein metabolic process GO:0051246 256 0.052
protein complex assembly GO:0006461 200 0.051
cellular macromolecular complex assembly GO:0034622 153 0.051
neurological system process GO:0050877 358 0.050
synaptic transmission GO:0007268 288 0.050
cellular protein complex assembly GO:0043623 71 0.048
actin filament based process GO:0030029 220 0.047
positive regulation of cellular biosynthetic process GO:0031328 316 0.045
aromatic compound catabolic process GO:0019439 166 0.045
death GO:0016265 284 0.045
phosphorylation GO:0016310 294 0.045
positive regulation of protein complex assembly GO:0031334 22 0.045
protein transport GO:0015031 155 0.043
translation GO:0006412 69 0.043
male meiosis cytokinesis GO:0007112 26 0.043
Fly
regulation of cellular response to stress GO:0080135 89 0.042
response to biotic stimulus GO:0009607 294 0.042
microtubule based transport GO:0010970 42 0.041
positive regulation of multicellular organismal process GO:0051240 143 0.040
modification dependent protein catabolic process GO:0019941 78 0.040
Human
regulation of programmed cell death GO:0043067 152 0.040
transmembrane transport GO:0055085 139 0.039
embryo development ending in birth or egg hatching GO:0009792 152 0.039
response to other organism GO:0051707 293 0.038
single organism intracellular transport GO:1902582 207 0.037
protein localization GO:0008104 284 0.037
regulation of protein complex assembly GO:0043254 42 0.036
programmed cell death GO:0012501 257 0.036
positive regulation of nervous system development GO:0051962 69 0.034
regulation of developmental growth GO:0048638 174 0.034
cation transport GO:0006812 110 0.033
molting cycle GO:0042303 56 0.032
cellular protein complex disassembly GO:0043624 35 0.032
response to heat GO:0009408 63 0.032
regulation of localization GO:0032879 275 0.032
cell cycle phase transition GO:0044770 140 0.031
regulation of secretion GO:0051046 44 0.030
cellular nitrogen compound catabolic process GO:0044270 165 0.030
regulation of embryonic pattern specification GO:1902875 27 0.030
anterior posterior axis specification embryo GO:0008595 103 0.030
negative regulation of cell differentiation GO:0045596 143 0.030
regulation of system process GO:0044057 36 0.030
endosomal transport GO:0016197 44 0.029
organophosphate catabolic process GO:0046434 112 0.029
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.029
central nervous system development GO:0007417 201 0.028
regulation of organelle organization GO:0033043 196 0.028
regulation of neurogenesis GO:0050767 158 0.027
oocyte anterior posterior axis specification GO:0007314 72 0.027
dna repair GO:0006281 54 0.027
establishment of protein localization GO:0045184 163 0.027
positive regulation of cellular amine metabolic process GO:0033240 0 0.027
carbohydrate metabolic process GO:0005975 82 0.027
positive regulation of organelle organization GO:0010638 65 0.026
notch signaling pathway GO:0007219 120 0.026
neurotransmitter transport GO:0006836 37 0.026
establishment of protein localization to membrane GO:0090150 11 0.026
regulation of microtubule polymerization or depolymerization GO:0031110 27 0.026
protein catabolic process GO:0030163 101 0.026
Human
neuronal action potential GO:0019228 10 0.025
regulation of secretion by cell GO:1903530 39 0.025
cellular component disassembly GO:0022411 46 0.025
modification dependent macromolecule catabolic process GO:0043632 79 0.025
Human
circadian rhythm GO:0007623 105 0.024
microtubule polymerization or depolymerization GO:0031109 39 0.024
regulation of cell development GO:0060284 215 0.024
nuclear division GO:0000280 332 0.023
dephosphorylation GO:0016311 51 0.023
cell proliferation GO:0008283 299 0.022
regulation of transport GO:0051049 181 0.022
oxoacid metabolic process GO:0043436 103 0.022
embryonic axis specification GO:0000578 107 0.022
anterior posterior axis specification GO:0009948 109 0.022
negative regulation of signal transduction GO:0009968 206 0.021
single organism catabolic process GO:0044712 228 0.021
secretion by cell GO:0032940 101 0.021
regulation of microtubule cytoskeleton organization GO:0070507 41 0.021
eye morphogenesis GO:0048592 260 0.021
regulation of mitotic cell cycle GO:0007346 190 0.021
regulation of apoptotic process GO:0042981 130 0.021
negative regulation of response to stimulus GO:0048585 258 0.021
protein complex biogenesis GO:0070271 201 0.021
positive regulation of cell differentiation GO:0045597 64 0.021
positive regulation of axonogenesis GO:0050772 2 0.020
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.020
Human
skeletal muscle adaptation GO:0043501 1 0.020
rna localization GO:0006403 115 0.020
enzyme linked receptor protein signaling pathway GO:0007167 179 0.020
myofibril assembly GO:0030239 36 0.020
cytoplasmic transport GO:0016482 130 0.019
synaptic vesicle exocytosis GO:0016079 16 0.019
regulation of cellular amino acid metabolic process GO:0006521 0 0.019
regulation of endocytosis GO:0030100 37 0.019
exocytosis GO:0006887 28 0.019
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.019
neuroblast proliferation GO:0007405 74 0.019
synaptic vesicle recycling GO:0036465 28 0.019
regulation of translation GO:0006417 56 0.018
forebrain development GO:0030900 2 0.018
regulation of microtubule based process GO:0032886 49 0.018
protein polymerization GO:0051258 42 0.018
female germ line cyst formation GO:0048135 42 0.018
negative regulation of multicellular organismal process GO:0051241 142 0.018
regulation of cytoskeleton organization GO:0051493 89 0.018
positive regulation of developmental process GO:0051094 143 0.018
cellular macromolecule localization GO:0070727 220 0.018
negative regulation of developmental process GO:0051093 201 0.017
regulation of response to external stimulus GO:0032101 115 0.017
regulation of neuroblast proliferation GO:1902692 34 0.017
establishment of organelle localization GO:0051656 122 0.017
positive regulation of response to wounding GO:1903036 15 0.017
small molecule metabolic process GO:0044281 305 0.017
macromolecular complex assembly GO:0065003 256 0.017
tripartite regional subdivision GO:0007351 103 0.017
sensory perception of mechanical stimulus GO:0050954 72 0.017
organelle fusion GO:0048284 46 0.016
striated muscle myosin thick filament assembly GO:0071688 3 0.016
epithelial cell differentiation GO:0030855 322 0.016
extrinsic apoptotic signaling pathway GO:0097191 1 0.016
sensory perception GO:0007600 196 0.016
establishment of cell polarity GO:0030010 40 0.016
response to wounding GO:0009611 94 0.016
localization of cell GO:0051674 257 0.016
negative regulation of apoptotic process GO:0043066 63 0.016
erbb signaling pathway GO:0038127 58 0.015
rhythmic process GO:0048511 106 0.015
microtubule based movement GO:0007018 51 0.015
ncrna metabolic process GO:0034660 43 0.015
negative regulation of protein metabolic process GO:0051248 85 0.015
proteolysis GO:0006508 192 0.015
Human
synaptic vesicle endocytosis GO:0048488 28 0.015
regulation of autophagy GO:0010506 62 0.015
regulation of immune system process GO:0002682 176 0.015
negative regulation of programmed cell death GO:0043069 72 0.015
synaptic vesicle localization GO:0097479 53 0.015
synapse assembly GO:0007416 143 0.015
negative regulation of cell death GO:0060548 81 0.015
exocrine system development GO:0035272 162 0.015
regulation of cellular localization GO:0060341 136 0.015
negative regulation of autophagy GO:0010507 16 0.015
secretion GO:0046903 109 0.014
establishment or maintenance of cell polarity GO:0007163 167 0.014
somatic muscle development GO:0007525 66 0.014
positive regulation of macromolecule metabolic process GO:0010604 405 0.014
immune system development GO:0002520 57 0.014
negative regulation of intracellular signal transduction GO:1902532 57 0.014
biological adhesion GO:0022610 138 0.014
telencephalon development GO:0021537 2 0.014
protein complex disassembly GO:0043241 36 0.014
chemical homeostasis GO:0048878 92 0.014
multicellular organism growth GO:0035264 46 0.014
chromosome organization GO:0051276 360 0.014
regulation of cell cycle GO:0051726 291 0.014
rna splicing GO:0008380 83 0.014
circulatory system development GO:0072359 82 0.013
positive regulation of response to stimulus GO:0048584 323 0.013
positive regulation of developmental growth GO:0048639 62 0.013
salivary gland development GO:0007431 162 0.013
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.013
spindle organization GO:0007051 253 0.013
macromolecular complex disassembly GO:0032984 37 0.013
brain development GO:0007420 120 0.013
centriole replication GO:0007099 24 0.013
establishment of synaptic vesicle localization GO:0097480 50 0.013
inositol lipid mediated signaling GO:0048017 4 0.013
purine containing compound catabolic process GO:0072523 112 0.013
taxis GO:0042330 304 0.013
protein depolymerization GO:0051261 31 0.013
axonogenesis GO:0007409 290 0.012
negative regulation of neuron death GO:1901215 18 0.012
protein modification by small protein conjugation GO:0032446 79 0.012
Human
regulation of multi organism process GO:0043900 131 0.012
negative regulation of gene expression GO:0010629 387 0.012
defense response to bacterium GO:0042742 178 0.012
positive regulation of endocytosis GO:0045807 22 0.012
imaginal disc derived appendage morphogenesis GO:0035114 395 0.012
retrograde axon cargo transport GO:0008090 9 0.012
negative regulation of mitotic cell cycle GO:0045930 109 0.012
protein localization to plasma membrane GO:0072659 13 0.012
intracellular transport GO:0046907 228 0.012
regulation of synaptic transmission GO:0050804 69 0.012
negative regulation of cellular protein metabolic process GO:0032269 85 0.012
positive regulation of protein metabolic process GO:0051247 128 0.012
apoptotic process GO:0006915 159 0.012
instar larval development GO:0002168 55 0.012
spinal cord development GO:0021510 1 0.012
regulation of catabolic process GO:0009894 170 0.011
negative regulation of cell communication GO:0010648 223 0.011
regulation of intracellular signal transduction GO:1902531 236 0.011
golgi organization GO:0007030 66 0.011
carbohydrate derivative catabolic process GO:1901136 118 0.011
organonitrogen compound catabolic process GO:1901565 128 0.011
positive regulation of neuron projection development GO:0010976 14 0.011
positive regulation of cellular component biogenesis GO:0044089 80 0.011
muscle structure development GO:0061061 224 0.011
response to temperature stimulus GO:0009266 106 0.011
cell migration GO:0016477 238 0.011
hematopoietic or lymphoid organ development GO:0048534 57 0.011
glycosyl compound metabolic process GO:1901657 127 0.011
neurotransmitter secretion GO:0007269 35 0.011
positive regulation of biosynthetic process GO:0009891 316 0.011
regulation of cellular protein metabolic process GO:0032268 243 0.011
regulation of protein stability GO:0031647 43 0.011
mitochondrion organization GO:0007005 65 0.011
nucleoside catabolic process GO:0009164 112 0.011
neuromuscular process GO:0050905 21 0.011
intracellular protein transport GO:0006886 104 0.011
microtubule polymerization GO:0046785 15 0.011
actin polymerization or depolymerization GO:0008154 31 0.011
regulation of cell proliferation GO:0042127 163 0.011
regulation of cell size GO:0008361 63 0.010
negative regulation of erk1 and erk2 cascade GO:0070373 3 0.010
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.010
regulation of cell cycle phase transition GO:1901987 130 0.010
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.010
appendage development GO:0048736 401 0.010
regulation of anatomical structure size GO:0090066 163 0.010
response to calcium ion GO:0051592 1 0.010
transcription from rna polymerase ii promoter GO:0006366 368 0.010
negative regulation of cellular biosynthetic process GO:0031327 277 0.010
cytoplasm organization GO:0007028 64 0.010
cellular response to dna damage stimulus GO:0006974 223 0.010
dna templated transcriptional preinitiation complex assembly GO:0070897 20 0.010
wnt signaling pathway GO:0016055 98 0.010
segmentation GO:0035282 207 0.010
anterior posterior pattern specification GO:0009952 136 0.010

poe disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.055
cancer DOID:162 0 0.049
disease of cellular proliferation DOID:14566 0 0.049
organ system cancer DOID:0050686 0 0.049
central nervous system disease DOID:331 0 0.019
neurodegenerative disease DOID:1289 0 0.019
nervous system disease DOID:863 0 0.019
vascular disease DOID:178 0 0.015
cardiovascular system disease DOID:1287 0 0.015
muscular disease DOID:0080000 0 0.012
musculoskeletal system disease DOID:17 0 0.012
muscle tissue disease DOID:66 0 0.012