Drosophila melanogaster

73 known processes

Spn1 (Dmel_CG9456)

Serine protease inhibitor 1

(Aliases: Dmel\CG9456,Spn42Dd,CG9456,sp1)

Spn1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
defense response GO:0006952 300 0.859
response to fungus GO:0009620 50 0.854
defense response to other organism GO:0098542 225 0.808
immune response GO:0006955 246 0.801
antifungal humoral response GO:0019732 12 0.796
Fly
response to external biotic stimulus GO:0043207 293 0.746
regulation of response to biotic stimulus GO:0002831 63 0.741
humoral immune response GO:0006959 117 0.740
immune system process GO:0002376 347 0.710
defense response to fungus GO:0050832 48 0.694
regulation of biosynthetic process of antibacterial peptides active against gram positive bacteria GO:0002816 3 0.683
antimicrobial humoral response GO:0019730 99 0.679
innate immune response GO:0045087 144 0.671
defense response to gram positive bacterium GO:0050830 41 0.660
response to other organism GO:0051707 293 0.630
defense response to bacterium GO:0042742 178 0.614
Fly
regulation of response to external stimulus GO:0032101 115 0.594
regulation of defense response to bacterium GO:1900424 30 0.586
regulation of multi organism process GO:0043900 131 0.558
positive regulation of response to external stimulus GO:0032103 44 0.552
immune effector process GO:0002252 98 0.465
production of molecular mediator of immune response GO:0002440 46 0.455
secondary metabolic process GO:0019748 75 0.397
negative regulation of peptidoglycan recognition protein signaling pathway GO:0061060 3 0.392
regulation of cellular amide metabolic process GO:0034248 39 0.384
Fly
regulation of immune system process GO:0002682 176 0.379
antimicrobial peptide production GO:0002775 46 0.379
positive regulation of response to biotic stimulus GO:0002833 31 0.372
positive regulation of defense response GO:0031349 59 0.366
peptidoglycan recognition protein signaling pathway GO:0061057 16 0.363
organic hydroxy compound metabolic process GO:1901615 83 0.363
response to biotic stimulus GO:0009607 294 0.352
regulation of peptidoglycan recognition protein signaling pathway GO:0061058 4 0.328
positive regulation of antimicrobial peptide production GO:0002225 28 0.321
pigment metabolic process GO:0042440 84 0.310
pattern recognition receptor signaling pathway GO:0002221 2 0.302
positive regulation of antimicrobial peptide biosynthetic process GO:0002807 26 0.301
regulation of defense response GO:0031347 102 0.283
Rat
positive regulation of antimicrobial humoral response GO:0002760 28 0.282
regulation of antimicrobial peptide production GO:0002784 44 0.278
regulation of immune effector process GO:0002697 52 0.266
antibacterial humoral response GO:0019731 44 0.264
peptide metabolic process GO:0006518 80 0.260
Fly
phenol containing compound metabolic process GO:0018958 57 0.259
melanization defense response GO:0035006 45 0.239
positive regulation of multi organism process GO:0043902 40 0.239
biosynthetic process of antibacterial peptides active against gram positive bacteria GO:0002815 3 0.237
regulation of antimicrobial humoral response GO:0002759 50 0.235
immune response activating signal transduction GO:0002757 2 0.229
regulation of antimicrobial peptide biosynthetic process GO:0002805 38 0.223
cellular amide metabolic process GO:0043603 80 0.219
Fly
innate immune response activating signal transduction GO:0002758 2 0.208
activation of innate immune response GO:0002218 4 0.203
response to bacterium GO:0009617 198 0.201
Fly
regulation of innate immune response GO:0045088 71 0.189
peptidoglycan catabolic process GO:0009253 3 0.187
regulation of humoral immune response GO:0002920 51 0.185
regionalization GO:0003002 416 0.179
amide biosynthetic process GO:0043604 42 0.178
antimicrobial peptide biosynthetic process GO:0002777 38 0.175
regulation of immune response GO:0050776 118 0.170
melanin metabolic process GO:0006582 47 0.169
positive regulation of response to stimulus GO:0048584 323 0.164
positive regulation of biosynthetic process of antibacterial peptides active against gram positive bacteria GO:0006965 3 0.154
organonitrogen compound metabolic process GO:1901564 318 0.152
Fly
organonitrogen compound biosynthetic process GO:1901566 117 0.150
positive regulation of melanization defense response GO:0035008 1 0.150
endocytosis GO:0006897 310 0.146
hemolymph coagulation GO:0042381 10 0.145
defense response to gram negative bacterium GO:0050829 94 0.138
Fly
biosynthetic process of antibacterial peptides active against gram negative bacteria GO:0002812 14 0.137
regulation of response to stress GO:0080134 200 0.136
Rat
positive regulation of cellular amide metabolic process GO:0034250 26 0.128
dorsal ventral pattern formation GO:0009953 133 0.127
positive regulation of humoral immune response GO:0002922 28 0.127
positive regulation of defense response to bacterium GO:1900426 23 0.121
response to virus GO:0009615 28 0.119
regulation of biosynthetic process of antibacterial peptides active against gram negative bacteria GO:0002813 14 0.116
dorsal ventral axis specification GO:0009950 66 0.109
positive regulation of immune response GO:0050778 63 0.109
antibacterial peptide biosynthetic process GO:0002780 22 0.103
positive regulation of antibacterial peptide production GO:0002803 20 0.102
regulation of secondary metabolic process GO:0043455 7 0.102
axis specification GO:0009798 167 0.100
antibacterial peptide production GO:0002778 22 0.096
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.094
immune response regulating signaling pathway GO:0002764 2 0.094
vesicle mediated transport GO:0016192 381 0.093
positive regulation of immune effector process GO:0002699 28 0.092
wound healing GO:0042060 75 0.091
Rat
positive regulation of production of molecular mediator of immune response GO:0002702 28 0.090
organic substance catabolic process GO:1901575 308 0.089
positive regulation of biosynthetic process of antibacterial peptides active against gram negative bacteria GO:0006964 12 0.087
regulation of melanization defense response GO:0035007 6 0.086
negative regulation of defense response to bacterium GO:1900425 7 0.084
positive regulation of antibacterial peptide biosynthetic process GO:0006963 20 0.084
regulation of production of molecular mediator of immune response GO:0002700 44 0.084
positive regulation of cellular biosynthetic process GO:0031328 316 0.083
regulation of antibacterial peptide production GO:0002786 22 0.080
positive regulation of biosynthetic process GO:0009891 316 0.080
aging GO:0007568 143 0.078
catabolic process GO:0009056 409 0.077
negative regulation of signal transduction GO:0009968 206 0.073
Fly
response to organic substance GO:0010033 284 0.069
response to radiation GO:0009314 155 0.068
protein maturation GO:0051604 71 0.067
Fly
positive regulation of immune system process GO:0002684 68 0.066
positive regulation of cell communication GO:0010647 250 0.065
response to light stimulus GO:0009416 124 0.064
zymogen activation GO:0031638 20 0.064
response to peptidoglycan GO:0032494 2 0.064
small molecule metabolic process GO:0044281 305 0.063
pigment metabolic process involved in pigmentation GO:0043474 33 0.063
response to wounding GO:0009611 94 0.062
Rat
pigment biosynthetic process GO:0046148 36 0.061
positive regulation of signaling GO:0023056 243 0.060
peptidoglycan metabolic process GO:0000270 3 0.060
peptide biosynthetic process GO:0043043 42 0.060
lipopolysaccharide mediated signaling pathway GO:0031663 1 0.060
phagocytosis GO:0006909 215 0.058
regulation of antibacterial peptide biosynthetic process GO:0002808 22 0.057
organonitrogen compound catabolic process GO:1901565 128 0.056
cellular catabolic process GO:0044248 372 0.056
glycosaminoglycan catabolic process GO:0006027 3 0.055
response to oxygen containing compound GO:1901700 200 0.054
carbohydrate derivative metabolic process GO:1901135 217 0.054
cellular amino acid metabolic process GO:0006520 61 0.053
appendage morphogenesis GO:0035107 397 0.052
multicellular organismal aging GO:0010259 140 0.052
biological adhesion GO:0022610 138 0.050
Rat
defense response to virus GO:0051607 23 0.048
lateral inhibition GO:0046331 206 0.048
single organism biosynthetic process GO:0044711 206 0.047
regulation of toll signaling pathway GO:0008592 17 0.044
Fly
cellular response to organic substance GO:0071310 132 0.044
cellular response to lipopolysaccharide GO:0071222 3 0.042
chemical homeostasis GO:0048878 92 0.042
response to abiotic stimulus GO:0009628 341 0.041
gland development GO:0048732 191 0.041
carboxylic acid metabolic process GO:0019752 92 0.038
negative regulation of signaling GO:0023057 219 0.037
Fly
aminoglycan catabolic process GO:0006026 6 0.036
positive regulation of signal transduction GO:0009967 223 0.035
imaginal disc derived appendage morphogenesis GO:0035114 395 0.034
response to nitrogen compound GO:1901698 90 0.034
response to lipopolysaccharide GO:0032496 4 0.034
regulation of phosphorus metabolic process GO:0051174 210 0.034
oxoacid metabolic process GO:0043436 103 0.033
cell adhesion GO:0007155 136 0.033
Rat
cellular response to molecule of bacterial origin GO:0071219 3 0.032
developmental pigmentation GO:0048066 68 0.032
detection of stimulus GO:0051606 156 0.032
cellular response to biotic stimulus GO:0071216 4 0.032
intracellular signal transduction GO:0035556 300 0.031
protein processing GO:0016485 68 0.031
Fly
regulation of phosphate metabolic process GO:0019220 210 0.031
regulation of intracellular signal transduction GO:1902531 236 0.030
hormone catabolic process GO:0042447 3 0.030
negative regulation of cell communication GO:0010648 223 0.030
Fly
regulation of body fluid levels GO:0050878 14 0.029
cell cell signaling involved in cell fate commitment GO:0045168 210 0.029
single organism cell adhesion GO:0098602 47 0.028
salivary gland development GO:0007431 162 0.028
cell death GO:0008219 279 0.028
response to endogenous stimulus GO:0009719 119 0.027
pigmentation GO:0043473 75 0.027
cation homeostasis GO:0055080 51 0.027
cell recognition GO:0008037 102 0.026
detection of abiotic stimulus GO:0009582 66 0.026
negative regulation of cellular metabolic process GO:0031324 382 0.026
killing of cells of other organism GO:0031640 1 0.026
positive regulation of innate immune response GO:0045089 38 0.026
regulation of cell cycle GO:0051726 291 0.026
negative regulation of response to stimulus GO:0048585 258 0.026
Rat Fly
response to organophosphorus GO:0046683 2 0.025
toll signaling pathway GO:0008063 25 0.025
Fly
lipid metabolic process GO:0006629 121 0.025
proteolysis GO:0006508 192 0.025
homeostatic process GO:0042592 199 0.025
post embryonic appendage morphogenesis GO:0035120 385 0.025
phosphorylation GO:0016310 294 0.025
imaginal disc derived wing morphogenesis GO:0007476 337 0.024
signal transduction by phosphorylation GO:0023014 107 0.024
cellular ketone metabolic process GO:0042180 24 0.024
single organism behavior GO:0044708 391 0.024
regulation of cellular response to stress GO:0080135 89 0.024
organic substance transport GO:0071702 257 0.024
multi organism behavior GO:0051705 175 0.023
single organism catabolic process GO:0044712 228 0.023
organelle fission GO:0048285 340 0.023
appendage development GO:0048736 401 0.023
coagulation GO:0050817 10 0.023
organophosphate metabolic process GO:0019637 195 0.023
death GO:0016265 284 0.023
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.023
body morphogenesis GO:0010171 2 0.022
epithelial cell differentiation GO:0030855 322 0.022
cellular amine metabolic process GO:0044106 12 0.022
neurotransmitter metabolic process GO:0042133 2 0.022
eye pigment biosynthetic process GO:0006726 32 0.022
pigment metabolic process involved in developmental pigmentation GO:0043324 33 0.022
regulation of molecular function GO:0065009 217 0.021
cellular response to chemical stimulus GO:0070887 199 0.021
response to organonitrogen compound GO:0010243 75 0.021
glycosaminoglycan metabolic process GO:0030203 11 0.021
response to nutrient levels GO:0031667 114 0.021
Rat
growth GO:0040007 359 0.021
Rat
stress activated mapk cascade GO:0051403 52 0.020
developmental programmed cell death GO:0010623 138 0.020
cellular homeostasis GO:0019725 80 0.020
mapk cascade GO:0000165 107 0.020
negative regulation of growth GO:0045926 84 0.020
exocrine system development GO:0035272 162 0.020
synaptic transmission GO:0007268 288 0.020
detection of chemical stimulus GO:0009593 93 0.020
gland morphogenesis GO:0022612 145 0.020
cellular protein modification process GO:0006464 438 0.020
negative regulation of defense response GO:0031348 35 0.019
Rat
stress activated protein kinase signaling cascade GO:0031098 55 0.019
regulation of localization GO:0032879 275 0.019
protein modification process GO:0036211 438 0.019
regulation of transport GO:0051049 181 0.019
nuclear division GO:0000280 332 0.019
regulation of mapk cascade GO:0043408 92 0.019
cellular response to lipid GO:0071396 20 0.019
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.019
Fly
regulation of jnk cascade GO:0046328 40 0.019
macromolecule catabolic process GO:0009057 161 0.019
negative regulation of response to external stimulus GO:0032102 22 0.019
Rat
amine metabolic process GO:0009308 12 0.019
positive regulation of cellular component organization GO:0051130 156 0.019
eye pigmentation GO:0048069 43 0.018
negative regulation of innate immune response GO:0045824 30 0.018
neurological system process GO:0050877 358 0.018
negative regulation of stress activated protein kinase signaling cascade GO:0070303 20 0.018
imaginal disc derived appendage development GO:0048737 399 0.018
cellular cation homeostasis GO:0030003 38 0.018
actin filament based process GO:0030029 220 0.018
salivary gland morphogenesis GO:0007435 145 0.018
negative regulation of immune response GO:0050777 39 0.017
wing disc morphogenesis GO:0007472 344 0.017
protein localization GO:0008104 284 0.017
detection of external stimulus GO:0009581 66 0.017
columnar cuboidal epithelial cell development GO:0002066 249 0.017
chemotaxis GO:0006935 249 0.017
male gamete generation GO:0048232 201 0.017
ethanolamine containing compound metabolic process GO:0042439 4 0.017
cytolysis GO:0019835 1 0.017
regulation of behavior GO:0050795 75 0.017
organic acid metabolic process GO:0006082 103 0.017
regulation of cell death GO:0010941 173 0.017
multi multicellular organism process GO:0044706 123 0.017
regulation of cell adhesion GO:0030155 27 0.017
Rat
regulation of multicellular organismal development GO:2000026 414 0.017
mating GO:0007618 120 0.017
regulation of catalytic activity GO:0050790 185 0.017
determination of adult lifespan GO:0008340 137 0.016
spermatogenesis GO:0007283 200 0.016
aromatic compound catabolic process GO:0019439 166 0.016
response to extracellular stimulus GO:0009991 116 0.016
Rat
salivary gland histolysis GO:0035070 88 0.016
open tracheal system development GO:0007424 204 0.016
septate junction assembly GO:0019991 26 0.016
negative regulation of developmental process GO:0051093 201 0.015
organic cyclic compound catabolic process GO:1901361 168 0.015
positive regulation of catalytic activity GO:0043085 118 0.015
benzene containing compound metabolic process GO:0042537 3 0.015
cell motility GO:0048870 251 0.015
spermatid differentiation GO:0048515 114 0.015
negative regulation of intracellular signal transduction GO:1902532 57 0.015
localization of cell GO:0051674 257 0.015
cell cell junction organization GO:0045216 55 0.015
positive regulation of cell migration GO:0030335 2 0.015
kidney development GO:0001822 3 0.015
negative regulation of gene expression GO:0010629 387 0.014
macromolecular complex assembly GO:0065003 256 0.014
tissue death GO:0016271 102 0.014
cellular ion homeostasis GO:0006873 39 0.014
glycerolipid catabolic process GO:0046503 3 0.014
negative regulation of phosphorylation GO:0042326 35 0.014
ameboidal type cell migration GO:0001667 151 0.014
multi organism reproductive behavior GO:0044705 121 0.014
establishment of localization in cell GO:0051649 402 0.014
cellularization GO:0007349 90 0.014
androgen metabolic process GO:0008209 1 0.014
regulation of cellular catabolic process GO:0031329 157 0.014
cellular response to dna damage stimulus GO:0006974 223 0.014
protein complex assembly GO:0006461 200 0.014
epithelial cell development GO:0002064 274 0.014
autophagic cell death GO:0048102 83 0.014
aminoglycan metabolic process GO:0006022 18 0.014
programmed cell death GO:0012501 257 0.014
positive regulation of macromolecule metabolic process GO:0010604 405 0.014
cell proliferation GO:0008283 299 0.014
gene silencing GO:0016458 138 0.014
positive regulation of cell motility GO:2000147 3 0.014
rhodopsin biosynthetic process GO:0016063 9 0.014
jnk cascade GO:0007254 50 0.013
retina development in camera type eye GO:0060041 4 0.013
spindle organization GO:0007051 253 0.013
connective tissue development GO:0061448 3 0.013
posttranscriptional regulation of gene expression GO:0010608 145 0.013
embryonic pattern specification GO:0009880 174 0.013
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.013
axon development GO:0061564 297 0.013
maintenance of location GO:0051235 73 0.013
regulation of phosphorylation GO:0042325 147 0.013
regulation of ph GO:0006885 7 0.013
taxis GO:0042330 304 0.013
endomembrane system organization GO:0010256 119 0.013
cellular response to oxygen containing compound GO:1901701 79 0.013
regulation of cellular ketone metabolic process GO:0010565 3 0.013
rna localization GO:0006403 115 0.013
negative regulation of cell death GO:0060548 81 0.013
cellular response to radiation GO:0071478 52 0.013
regulation of stress activated mapk cascade GO:0032872 41 0.012
ras protein signal transduction GO:0007265 88 0.012
regulation of cellular component biogenesis GO:0044087 201 0.012
epithelial cell migration GO:0010631 148 0.012
sterol homeostasis GO:0055092 4 0.012
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.012
positive regulation of catabolic process GO:0009896 105 0.012
cellular macromolecule localization GO:0070727 220 0.012
small gtpase mediated signal transduction GO:0007264 88 0.012
positive regulation of behavior GO:0048520 19 0.012
rhythmic behavior GO:0007622 76 0.012
cellular chemical homeostasis GO:0055082 40 0.012
blastoderm segmentation GO:0007350 159 0.012
negative regulation of cell differentiation GO:0045596 143 0.012
multicellular organismal reproductive behavior GO:0033057 110 0.012
cytolysis in other organism GO:0051715 1 0.012
single organismal cell cell adhesion GO:0016337 45 0.012
monocarboxylic acid transport GO:0015718 3 0.012
developmental maturation GO:0021700 172 0.012
carbohydrate derivative catabolic process GO:1901136 118 0.012
response to protozoan GO:0001562 3 0.012
negative regulation of immune system process GO:0002683 50 0.012
regulation of cellular amine metabolic process GO:0033238 3 0.012
positive regulation of phosphorus metabolic process GO:0010562 139 0.011
heterocycle catabolic process GO:0046700 166 0.011
rhythmic process GO:0048511 106 0.011
drinking behavior GO:0042756 2 0.011
respiratory system development GO:0060541 213 0.011
cellular protein localization GO:0034613 160 0.011
protein complex biogenesis GO:0070271 201 0.011
establishment of protein localization GO:0045184 163 0.011
chromosome segregation GO:0007059 157 0.011
nucleoside metabolic process GO:0009116 127 0.011
negative regulation of peptide hormone processing GO:0060570 1 0.011
Fly
negative regulation of biosynthetic process GO:0009890 277 0.011
positive regulation of intracellular signal transduction GO:1902533 116 0.011
cellular response to nutrient levels GO:0031669 62 0.011
male mating behavior GO:0060179 70 0.011
nucleobase containing small molecule metabolic process GO:0055086 174 0.011
cellular lipid metabolic process GO:0044255 83 0.011
protein transport GO:0015031 155 0.011
axonogenesis GO:0007409 290 0.011
telencephalon development GO:0021537 2 0.011
neuron recognition GO:0008038 101 0.011
non sensory hair organization GO:0035316 47 0.011
forebrain development GO:0030900 2 0.011
actin cytoskeleton organization GO:0030036 206 0.011
purine nucleoside metabolic process GO:0042278 127 0.011
regulation of vesicle mediated transport GO:0060627 59 0.011
limb development GO:0060173 1 0.011
histolysis GO:0007559 102 0.011
regulation of proteolysis GO:0030162 87 0.011
mrna metabolic process GO:0016071 124 0.011
g protein coupled receptor signaling pathway GO:0007186 136 0.010
regulation of cellular protein metabolic process GO:0032268 243 0.010
cell migration GO:0016477 238 0.010
disruption of cells of other organism GO:0044364 1 0.010
circulatory system development GO:0072359 82 0.010
regulation of endocytosis GO:0030100 37 0.010
epithelium migration GO:0090132 148 0.010
negative regulation of multicellular organismal process GO:0051241 142 0.010
salivary gland cell autophagic cell death GO:0035071 83 0.010
positive regulation of molecular function GO:0044093 136 0.010
heart development GO:0007507 82 0.010
alpha amino acid metabolic process GO:1901605 20 0.010
negative regulation of catalytic activity GO:0043086 42 0.010
nucleoside phosphate metabolic process GO:0006753 162 0.010
segmentation GO:0035282 207 0.010
choline catabolic process GO:0042426 1 0.010
regulation of catabolic process GO:0009894 170 0.010
imaginal disc derived wing margin morphogenesis GO:0008587 41 0.010
camera type eye development GO:0043010 4 0.010
regulation of growth GO:0040008 233 0.010
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.010
compound eye morphogenesis GO:0001745 249 0.010

Spn1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.043
disease of metabolism DOID:0014667 0 0.015
nervous system disease DOID:863 0 0.014
inherited metabolic disorder DOID:655 0 0.013
disease of cellular proliferation DOID:14566 0 0.010