Drosophila melanogaster

45 known processes

hkl (Dmel_CG10473)

hook-like

(Aliases: CG10473,CG10437,Dmel\CG10473,Ba,l(2)37Ba)

hkl biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of transcription dna templated GO:0045893 266 0.446
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.436
rna splicing GO:0008380 83 0.423
Human
chromosome organization GO:0051276 360 0.392
Human
positive regulation of nucleic acid templated transcription GO:1903508 266 0.340
mitotic cell cycle phase transition GO:0044772 138 0.318
ribonucleoside catabolic process GO:0042454 112 0.315
regulation of cell cycle phase transition GO:1901987 130 0.301
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.300
cell proliferation GO:0008283 299 0.293
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.290
regulation of cell cycle process GO:0010564 181 0.288
regulation of mitotic cell cycle GO:0007346 190 0.266
regulation of cell proliferation GO:0042127 163 0.244
positive regulation of biosynthetic process GO:0009891 316 0.233
nucleosome mobilization GO:0042766 9 0.221
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.220
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.207
chromatin organization GO:0006325 207 0.205
negative regulation of gene expression GO:0010629 387 0.198
Human
regulation of organ growth GO:0046620 42 0.197
intracellular receptor signaling pathway GO:0030522 19 0.185
regulation of cysteine type endopeptidase activity GO:2000116 27 0.167
negative regulation of biosynthetic process GO:0009890 277 0.166
mitotic dna integrity checkpoint GO:0044774 75 0.161
cellular protein modification process GO:0006464 438 0.147
nucleobase containing small molecule metabolic process GO:0055086 174 0.145
spindle organization GO:0007051 253 0.143
chromatin modification GO:0016568 147 0.127
small molecule metabolic process GO:0044281 305 0.126
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.125
regulation of mrna processing GO:0050684 71 0.119
Human
regulation of localization GO:0032879 275 0.115
positive regulation of gene expression GO:0010628 290 0.115
glycosyl compound catabolic process GO:1901658 112 0.113
mitotic spindle organization GO:0007052 220 0.112
dna metabolic process GO:0006259 227 0.109
Human
transcription from rna polymerase ii promoter GO:0006366 368 0.108
purine nucleoside catabolic process GO:0006152 112 0.103
response to monosaccharide GO:0034284 4 0.102
mrna metabolic process GO:0016071 124 0.100
Human
positive regulation of rna biosynthetic process GO:1902680 266 0.098
gene silencing by rna GO:0031047 57 0.097
intracellular signal transduction GO:0035556 300 0.095
cell cycle checkpoint GO:0000075 95 0.094
mitotic cell cycle checkpoint GO:0007093 88 0.091
positive regulation of organelle organization GO:0010638 65 0.085
posttranscriptional gene silencing by rna GO:0035194 45 0.083
organonitrogen compound catabolic process GO:1901565 128 0.083
small gtpase mediated signal transduction GO:0007264 88 0.082
sensory organ morphogenesis GO:0090596 260 0.078
regulation of cell cycle GO:0051726 291 0.078
positive regulation of rna metabolic process GO:0051254 271 0.077
negative regulation of transcription dna templated GO:0045892 237 0.077
heterochromatin organization GO:0070828 25 0.075
protein modification process GO:0036211 438 0.073
regulation of mitotic cell cycle phase transition GO:1901990 130 0.073
positive regulation of phosphate metabolic process GO:0045937 139 0.072
positive regulation of endopeptidase activity GO:0010950 26 0.070
vesicle mediated transport GO:0016192 381 0.069
peptidyl lysine methylation GO:0018022 16 0.068
positive regulation of macromolecule metabolic process GO:0010604 405 0.066
regulation of alternative mrna splicing via spliceosome GO:0000381 60 0.062
response to glucose GO:0009749 2 0.062
ribose phosphate metabolic process GO:0019693 145 0.062
regulation of cell differentiation GO:0045595 302 0.062
Human
nucleoside catabolic process GO:0009164 112 0.061
lateral inhibition GO:0046331 206 0.061
negative regulation of cell proliferation GO:0008285 69 0.059
oocyte construction GO:0007308 112 0.058
regulation of intracellular signal transduction GO:1902531 236 0.057
establishment of localization in cell GO:0051649 402 0.057
dna packaging GO:0006323 91 0.057
Human
organelle fission GO:0048285 340 0.055
nucleoside triphosphate catabolic process GO:0009143 108 0.055
posttranscriptional regulation of gene expression GO:0010608 145 0.055
dna damage checkpoint GO:0000077 78 0.054
purine nucleoside triphosphate catabolic process GO:0009146 108 0.054
nucleoside phosphate catabolic process GO:1901292 110 0.053
rna splicing via transesterification reactions GO:0000375 73 0.052
Human
response to abiotic stimulus GO:0009628 341 0.052
negative regulation of mitotic cell cycle GO:0045930 109 0.051
chromosome segregation GO:0007059 157 0.050
negative regulation of cell cycle process GO:0010948 109 0.050
nucleotide catabolic process GO:0009166 109 0.049
histone methylation GO:0016571 40 0.048
carbohydrate derivative metabolic process GO:1901135 217 0.048
positive regulation of cellular component organization GO:0051130 156 0.047
organophosphate metabolic process GO:0019637 195 0.047
chromatin assembly GO:0031497 48 0.046
heterocycle catabolic process GO:0046700 166 0.045
purine containing compound catabolic process GO:0072523 112 0.043
mrna processing GO:0006397 104 0.043
Human
response to temperature stimulus GO:0009266 106 0.043
nucleoside triphosphate metabolic process GO:0009141 120 0.041
histone modification GO:0016570 106 0.041
single organism catabolic process GO:0044712 228 0.041
purine nucleoside metabolic process GO:0042278 127 0.041
intracellular steroid hormone receptor signaling pathway GO:0030518 12 0.040
posttranscriptional gene silencing GO:0016441 46 0.039
nucleosome organization GO:0034728 59 0.039
purine containing compound metabolic process GO:0072521 155 0.039
nucleotide metabolic process GO:0009117 161 0.039
regulation of transport GO:0051049 181 0.037
regulation of cellular localization GO:0060341 136 0.037
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.036
covalent chromatin modification GO:0016569 106 0.036
regulation of transcription by chromatin organization GO:0034401 3 0.036
nucleoside phosphate metabolic process GO:0006753 162 0.035
response to heat GO:0009408 63 0.035
negative regulation of signaling GO:0023057 219 0.034
organonitrogen compound metabolic process GO:1901564 318 0.033
nuclear division GO:0000280 332 0.033
eye development GO:0001654 323 0.033
regulation of cellular amine metabolic process GO:0033238 3 0.032
response to organic substance GO:0010033 284 0.032
positive regulation of phosphorus metabolic process GO:0010562 139 0.032
endosomal transport GO:0016197 44 0.032
purine ribonucleoside catabolic process GO:0046130 112 0.032
regulation of hydrolase activity GO:0051336 97 0.031
stem cell maintenance GO:0019827 67 0.031
ribonucleotide catabolic process GO:0009261 109 0.030
positive regulation of cellular biosynthetic process GO:0031328 316 0.030
response to hexose GO:0009746 3 0.029
dna conformation change GO:0071103 105 0.029
Human
negative regulation of cell cycle phase transition GO:1901988 103 0.029
proteolysis GO:0006508 192 0.028
detection of external stimulus GO:0009581 66 0.028
negative regulation of cellular biosynthetic process GO:0031327 277 0.028
cytoplasmic transport GO:0016482 130 0.028
eye morphogenesis GO:0048592 260 0.028
spermatid differentiation GO:0048515 114 0.027
ribonucleoside triphosphate catabolic process GO:0009203 108 0.027
ribonucleotide metabolic process GO:0009259 145 0.027
peptidyl lysine trimethylation GO:0018023 6 0.027
mitotic sister chromatid segregation GO:0000070 87 0.027
purine nucleotide metabolic process GO:0006163 146 0.027
catabolic process GO:0009056 409 0.026
mitotic spindle elongation GO:0000022 81 0.026
histone h4 acetylation GO:0043967 13 0.025
macromolecular complex assembly GO:0065003 256 0.025
regulation of phosphate metabolic process GO:0019220 210 0.025
positive regulation of histone h3 k9 methylation GO:0051574 3 0.025
learning or memory GO:0007611 141 0.024
body morphogenesis GO:0010171 2 0.024
compound eye morphogenesis GO:0001745 249 0.024
negative regulation of rna metabolic process GO:0051253 251 0.023
Human
regulation of phosphorus metabolic process GO:0051174 210 0.023
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.023
purine ribonucleotide metabolic process GO:0009150 145 0.023
positive regulation of intracellular signal transduction GO:1902533 116 0.023
regulation of cellular component movement GO:0051270 42 0.023
spermatogenesis GO:0007283 200 0.023
establishment or maintenance of cell polarity GO:0007163 167 0.023
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.023
lipid metabolic process GO:0006629 121 0.022
ribonucleoside monophosphate catabolic process GO:0009158 39 0.022
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.022
cell death GO:0008219 279 0.022
Human
response to light stimulus GO:0009416 124 0.022
forebrain development GO:0030900 2 0.022
wing disc morphogenesis GO:0007472 344 0.022
nucleoside metabolic process GO:0009116 127 0.022
negative regulation of signal transduction by p53 class mediator GO:1901797 1 0.022
single organism biosynthetic process GO:0044711 206 0.022
organelle localization GO:0051640 148 0.021
endocytosis GO:0006897 310 0.021
meiotic cell cycle GO:0051321 171 0.021
single organism behavior GO:0044708 391 0.021
purine nucleotide catabolic process GO:0006195 109 0.021
nucleobase containing compound catabolic process GO:0034655 165 0.021
regulation of cellular component biogenesis GO:0044087 201 0.021
response to oxygen containing compound GO:1901700 200 0.021
chemical homeostasis GO:0048878 92 0.020
photoreceptor cell development GO:0042461 96 0.020
multi organism behavior GO:0051705 175 0.020
cell cycle phase transition GO:0044770 140 0.020
positive regulation of cellular component biogenesis GO:0044089 80 0.020
response to organic cyclic compound GO:0014070 89 0.020
production of small rna involved in gene silencing by rna GO:0070918 15 0.020
carbohydrate derivative catabolic process GO:1901136 118 0.019
dna integrity checkpoint GO:0031570 81 0.019
locomotory behavior GO:0007626 176 0.019
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.019
single organism intracellular transport GO:1902582 207 0.019
negative regulation of organ growth GO:0046621 15 0.018
compound eye photoreceptor development GO:0042051 78 0.018
regulation of cell motility GO:2000145 23 0.018
actin cytoskeleton organization GO:0030036 206 0.018
regulation of catalytic activity GO:0050790 185 0.018
nuclear pore organization GO:0006999 1 0.018
regulation of gene silencing GO:0060968 63 0.017
negative regulation of rna biosynthetic process GO:1902679 240 0.017
programmed cell death GO:0012501 257 0.017
Human
rna export from nucleus GO:0006405 12 0.017
ribonucleoside triphosphate metabolic process GO:0009199 119 0.017
neural precursor cell proliferation GO:0061351 75 0.017
chromatin remodeling GO:0006338 72 0.017
positive regulation of hydrolase activity GO:0051345 78 0.017
organophosphate catabolic process GO:0046434 112 0.016
response to dsrna GO:0043331 15 0.016
regulation of multi organism process GO:0043900 131 0.016
purine ribonucleotide catabolic process GO:0009154 109 0.016
cell division GO:0051301 248 0.016
apoptotic process GO:0006915 159 0.016
Human
purine nucleoside triphosphate metabolic process GO:0009144 119 0.016
male gamete generation GO:0048232 201 0.016
negative regulation of gene expression epigenetic GO:0045814 77 0.016
regulation of catabolic process GO:0009894 170 0.015
instar larval development GO:0002168 55 0.015
signal transduction by phosphorylation GO:0023014 107 0.015
regulation of ras protein signal transduction GO:0046578 93 0.015
aromatic compound catabolic process GO:0019439 166 0.015
neuron projection guidance GO:0097485 241 0.014
spindle elongation GO:0051231 83 0.014
axis specification GO:0009798 167 0.014
regulation of g1 s transition of mitotic cell cycle GO:2000045 23 0.014
positive regulation of signaling GO:0023056 243 0.014
organic hydroxy compound metabolic process GO:1901615 83 0.014
blastoderm segmentation GO:0007350 159 0.014
g2 dna damage checkpoint GO:0031572 69 0.014
positive regulation of molecular function GO:0044093 136 0.014
regulation of protein localization GO:0032880 76 0.014
regulation of small gtpase mediated signal transduction GO:0051056 93 0.014
positive regulation of programmed cell death GO:0043068 62 0.014
Human
positive regulation of cellular protein metabolic process GO:0032270 118 0.014
negative regulation of multicellular organismal process GO:0051241 142 0.014
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.013
Human
dna templated transcription elongation GO:0006354 18 0.013
positive regulation of cell communication GO:0010647 250 0.013
negative regulation of nucleic acid templated transcription GO:1903507 240 0.013
olfactory learning GO:0008355 56 0.013
organic substance catabolic process GO:1901575 308 0.013
atp catabolic process GO:0006200 38 0.013
negative regulation of imaginal disc growth GO:0045571 8 0.013
positive regulation of response to stimulus GO:0048584 323 0.013
ribonucleoside metabolic process GO:0009119 127 0.013
chromatin assembly or disassembly GO:0006333 52 0.013
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.013
Human
purine nucleoside monophosphate catabolic process GO:0009128 38 0.013
positive regulation of nucleotide metabolic process GO:0045981 55 0.013
cellular response to hexose stimulus GO:0071331 1 0.013
regulation of lipid transport GO:0032368 3 0.012
lipid localization GO:0010876 54 0.012
nuclear body organization GO:0030575 6 0.012
phagocytosis GO:0006909 215 0.012
positive regulation of cysteine type endopeptidase activity GO:2001056 24 0.012
regulation of organelle organization GO:0033043 196 0.012
regulation of cell junction assembly GO:1901888 2 0.012
cellular nitrogen compound catabolic process GO:0044270 165 0.012
mitotic dna damage checkpoint GO:0044773 74 0.012
phosphorylation GO:0016310 294 0.012
interspecies interaction between organisms GO:0044419 16 0.012
organonitrogen compound biosynthetic process GO:1901566 117 0.012
purine ribonucleoside monophosphate catabolic process GO:0009169 38 0.012
positive regulation of heterochromatin assembly GO:0031453 5 0.012
oocyte axis specification GO:0007309 108 0.012
death GO:0016265 284 0.012
Human
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.012
Human
alternative mrna splicing via spliceosome GO:0000380 60 0.011
regulation of mrna metabolic process GO:1903311 72 0.011
Human
positive regulation of catabolic process GO:0009896 105 0.011
positive regulation of cell proliferation GO:0008284 47 0.011
cellular macromolecular complex assembly GO:0034622 153 0.011
regulation of cellular protein metabolic process GO:0032268 243 0.011
positive regulation of protein metabolic process GO:0051247 128 0.011
cellular response to organic substance GO:0071310 132 0.011
regulation of molecular function GO:0065009 217 0.011
positive regulation of stem cell differentiation GO:2000738 3 0.011
secretion GO:0046903 109 0.011
sister chromatid segregation GO:0000819 92 0.010
glycosyl compound metabolic process GO:1901657 127 0.010
cellular response to nitrogen compound GO:1901699 51 0.010
regulation of embryonic development GO:0045995 68 0.010
stem cell division GO:0017145 69 0.010
histone h3 k4 methylation GO:0051568 16 0.010
negative regulation of cell cycle GO:0045786 116 0.010

hkl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.023