Drosophila melanogaster

71 known processes

Pcaf (Dmel_CG4107)

CG4107 gene product from transcript CG4107-RA

(Aliases: dPCAF,dmHAG401,CG4107,Gcn5/Pcaf,gcn5,p/CAF,dGCN5,PCAF,Gcn5/PCAF,Ada4,dGCN5 HAT,dKAT2,dGcn5,P/CAF,Gcn5,dmGCN5,anon-WO0172774.89,Dmel\CG4107,GCN5)

Pcaf biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
histone acetylation GO:0016573 38 0.992
histone h3 acetylation GO:0043966 11 0.990
covalent chromatin modification GO:0016569 106 0.985
internal protein amino acid acetylation GO:0006475 38 0.983
peptidyl lysine modification GO:0018205 57 0.968
positive regulation of cellular biosynthetic process GO:0031328 316 0.931
Human Yeast Mouse
negative regulation of cellular biosynthetic process GO:0031327 277 0.931
peptidyl lysine acetylation GO:0018394 39 0.922
histone h4 acetylation GO:0043967 13 0.914
histone modification GO:0016570 106 0.894
positive regulation of gene expression GO:0010628 290 0.875
Human Yeast Mouse
protein acetylation GO:0006473 39 0.858
positive regulation of transcription dna templated GO:0045893 266 0.854
Human Yeast Mouse
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.832
internal peptidyl lysine acetylation GO:0018393 38 0.776
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.768
Human Yeast Mouse
positive regulation of biosynthetic process GO:0009891 316 0.739
Human Yeast Mouse
negative regulation of cellular metabolic process GO:0031324 382 0.732
Mouse
chromatin modification GO:0016568 147 0.702
regulation of cellular protein metabolic process GO:0032268 243 0.681
Human Mouse
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.679
positive regulation of macromolecule metabolic process GO:0010604 405 0.678
Human Yeast Mouse
transcription from rna polymerase ii promoter GO:0006366 368 0.678
Human Yeast Mouse
cellular protein modification process GO:0006464 438 0.669
cell proliferation GO:0008283 299 0.656
Human Mouse
chromatin mediated maintenance of transcription GO:0048096 7 0.653
chromatin organization GO:0006325 207 0.587
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.580
Human Yeast Mouse
regulation of cell cycle GO:0051726 291 0.564
Mouse
protein modification process GO:0036211 438 0.541
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.540
negative regulation of gene expression GO:0010629 387 0.538
negative regulation of signaling GO:0023057 219 0.530
gene silencing GO:0016458 138 0.514
positive regulation of rna biosynthetic process GO:1902680 266 0.494
Human Yeast Mouse
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.483
Human Yeast Mouse
positive regulation of rna metabolic process GO:0051254 271 0.471
Human Yeast Mouse
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.467
Human Yeast Mouse
negative regulation of transcription dna templated GO:0045892 237 0.376
posttranscriptional regulation of gene expression GO:0010608 145 0.370
Human
negative regulation of biosynthetic process GO:0009890 277 0.363
positive regulation of signal transduction GO:0009967 223 0.359
chromatin remodeling GO:0006338 72 0.341
mitotic dna damage checkpoint GO:0044773 74 0.332
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.329
Human Yeast Mouse
chromosome organization GO:0051276 360 0.319
imaginal disc derived leg morphogenesis GO:0007480 80 0.309
protein acylation GO:0043543 42 0.308
positive regulation of nucleic acid templated transcription GO:1903508 266 0.306
Human Yeast Mouse
negative regulation of cell communication GO:0010648 223 0.295
immune response regulating signaling pathway GO:0002764 2 0.294
negative regulation of rna biosynthetic process GO:1902679 240 0.288
regulation of cell proliferation GO:0042127 163 0.284
Human
negative regulation of response to stimulus GO:0048585 258 0.281
axon target recognition GO:0007412 16 0.269
positive regulation of cellular component organization GO:0051130 156 0.265
regulation of gene expression epigenetic GO:0040029 128 0.243
digestive system development GO:0055123 149 0.242
cell death GO:0008219 279 0.238
programmed cell death GO:0012501 257 0.234
negative regulation of rna metabolic process GO:0051253 251 0.219
positive regulation of histone acetylation GO:0035066 3 0.209
multi organism behavior GO:0051705 175 0.203
embryo development ending in birth or egg hatching GO:0009792 152 0.200
Mouse
ribonucleoside catabolic process GO:0042454 112 0.195
regulation of cell cycle phase transition GO:1901987 130 0.195
carbohydrate derivative metabolic process GO:1901135 217 0.194
Human
response to organonitrogen compound GO:0010243 75 0.190
Human
regulation of cell cycle process GO:0010564 181 0.190
positive regulation of signaling GO:0023056 243 0.186
small molecule metabolic process GO:0044281 305 0.185
Mouse
regulation of protein metabolic process GO:0051246 256 0.183
Human Mouse
imaginal disc derived wing morphogenesis GO:0007476 337 0.173
macromolecular complex assembly GO:0065003 256 0.170
regulation of cellular component biogenesis GO:0044087 201 0.158
positive regulation of response to stimulus GO:0048584 323 0.156
death GO:0016265 284 0.154
peptidyl amino acid modification GO:0018193 105 0.150
leg disc morphogenesis GO:0007478 80 0.148
cation transport GO:0006812 110 0.147
skin development GO:0043588 65 0.146
positive regulation of i kappab kinase nf kappab signaling GO:0043123 1 0.146
regulation of mitotic cell cycle phase transition GO:1901990 130 0.146
carbohydrate derivative catabolic process GO:1901136 118 0.139
nucleobase containing compound catabolic process GO:0034655 165 0.137
intracellular transport GO:0046907 228 0.134
multicellular organismal reproductive behavior GO:0033057 110 0.131
response to lipopolysaccharide GO:0032496 4 0.131
cell cycle phase transition GO:0044770 140 0.128
rhythmic process GO:0048511 106 0.126
histone deubiquitination GO:0016578 8 0.124
Human
posttranscriptional gene silencing by rna GO:0035194 45 0.122
macromolecule catabolic process GO:0009057 161 0.121
regulation of mitotic cell cycle GO:0007346 190 0.117
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.105
negative regulation of signal transduction GO:0009968 206 0.104
rhythmic behavior GO:0007622 76 0.102
morphogenesis of an epithelium GO:0002009 276 0.102
Mouse
imaginal disc derived appendage morphogenesis GO:0035114 395 0.100
regulation of phosphorylation GO:0042325 147 0.098
Mouse
mitotic cell cycle phase transition GO:0044772 138 0.097
positive regulation of intracellular signal transduction GO:1902533 116 0.096
response to molecule of bacterial origin GO:0002237 7 0.095
positive regulation of gene expression epigenetic GO:0045815 16 0.090
regionalization GO:0003002 416 0.088
Mouse
imaginal disc derived wing vein morphogenesis GO:0008586 44 0.087
reproductive behavior GO:0019098 122 0.087
oxoacid metabolic process GO:0043436 103 0.087
organonitrogen compound metabolic process GO:1901564 318 0.087
homeostatic process GO:0042592 199 0.083
carboxylic acid metabolic process GO:0019752 92 0.082
apoptotic signaling pathway GO:0097190 27 0.082
forebrain development GO:0030900 2 0.080
Mouse
mapk cascade GO:0000165 107 0.080
phosphorylation GO:0016310 294 0.079
Mouse
mitotic cell cycle checkpoint GO:0007093 88 0.078
cellular macromolecular complex assembly GO:0034622 153 0.078
cellular nitrogen compound catabolic process GO:0044270 165 0.077
head development GO:0060322 135 0.076
Mouse
positive regulation of cell communication GO:0010647 250 0.075
cellular ion homeostasis GO:0006873 39 0.075
organonitrogen compound catabolic process GO:1901565 128 0.075
ubiquitin dependent protein catabolic process GO:0006511 78 0.073
cellular response to dna damage stimulus GO:0006974 223 0.073
immune response activating signal transduction GO:0002757 2 0.072
cellular amino acid metabolic process GO:0006520 61 0.070
cell cycle checkpoint GO:0000075 95 0.070
leg disc development GO:0035218 92 0.069
regulation of apoptotic process GO:0042981 130 0.069
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 24 0.068
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 20 0.067
cell cell signaling involved in cell fate commitment GO:0045168 210 0.067
protein phosphorylation GO:0006468 169 0.067
Mouse
macroautophagy GO:0016236 42 0.067
single organism intracellular transport GO:1902582 207 0.067
circadian behavior GO:0048512 76 0.066
regulation of phosphorus metabolic process GO:0051174 210 0.066
Mouse
multi multicellular organism process GO:0044706 123 0.066
positive regulation of proteasomal protein catabolic process GO:1901800 20 0.066
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.066
regulation of stress activated protein kinase signaling cascade GO:0070302 42 0.065
response to bacterium GO:0009617 198 0.064
autophagic vacuole assembly GO:0000045 2 0.063
compound eye morphogenesis GO:0001745 249 0.063
cation homeostasis GO:0055080 51 0.063
cellular response to oxygen containing compound GO:1901701 79 0.063
Human
multicellular organismal aging GO:0010259 140 0.063
organic acid metabolic process GO:0006082 103 0.063
nuclear division GO:0000280 332 0.061
calcium ion homeostasis GO:0055074 23 0.059
imaginal disc pattern formation GO:0007447 91 0.059
appendage morphogenesis GO:0035107 397 0.059
wing disc morphogenesis GO:0007472 344 0.059
regulation of apoptotic signaling pathway GO:2001233 10 0.058
learning or memory GO:0007611 141 0.058
negative regulation of nucleic acid templated transcription GO:1903507 240 0.057
imaginal disc derived appendage development GO:0048737 399 0.056
regulation of nervous system development GO:0051960 248 0.056
growth GO:0040007 359 0.055
Mouse
protein complex assembly GO:0006461 200 0.055
apoptotic process GO:0006915 159 0.054
anatomical structure homeostasis GO:0060249 97 0.054
regulation of stress activated mapk cascade GO:0032872 41 0.054
posttranscriptional gene silencing GO:0016441 46 0.053
cell growth GO:0016049 108 0.053
locomotory behavior GO:0007626 176 0.053
mrna metabolic process GO:0016071 124 0.052
regulation of proteolysis GO:0030162 87 0.051
negative regulation of cell cycle process GO:0010948 109 0.051
establishment of localization in cell GO:0051649 402 0.050
response to starvation GO:0042594 97 0.050
cell division GO:0051301 248 0.050
stress activated protein kinase signaling cascade GO:0031098 55 0.050
enzyme linked receptor protein signaling pathway GO:0007167 179 0.050
metal ion homeostasis GO:0055065 44 0.050
defense response to bacterium GO:0042742 178 0.050
positive regulation of wnt signaling pathway GO:0030177 25 0.049
cellular macromolecule catabolic process GO:0044265 136 0.049
dna dependent dna replication GO:0006261 17 0.049
proteolysis GO:0006508 192 0.049
response to endogenous stimulus GO:0009719 119 0.048
Human
peptide metabolic process GO:0006518 80 0.048
lipid metabolic process GO:0006629 121 0.047
response to external biotic stimulus GO:0043207 293 0.046
mitotic g2 m transition checkpoint GO:0044818 70 0.046
defense response GO:0006952 300 0.046
cellular response to nutrient levels GO:0031669 62 0.046
organic substance catabolic process GO:1901575 308 0.046
cellular metal ion homeostasis GO:0006875 31 0.045
response to oxidative stress GO:0006979 86 0.045
lateral inhibition GO:0046331 206 0.045
g2 dna damage checkpoint GO:0031572 69 0.044
nucleocytoplasmic transport GO:0006913 72 0.043
organophosphate biosynthetic process GO:0090407 46 0.042
cellular response to organic substance GO:0071310 132 0.042
Human
organelle fission GO:0048285 340 0.042
negative regulation of chromatin silencing GO:0031936 9 0.042
cellular amide metabolic process GO:0043603 80 0.041
post embryonic appendage morphogenesis GO:0035120 385 0.041
cellular homeostasis GO:0019725 80 0.041
meiotic cell cycle process GO:1903046 132 0.041
regulation of growth GO:0040008 233 0.040
wnt signaling pathway GO:0016055 98 0.040
positive regulation of apoptotic process GO:0043065 47 0.040
regulation of nuclear division GO:0051783 58 0.040
mitotic g2 dna damage checkpoint GO:0007095 69 0.039
protein dna complex subunit organization GO:0071824 86 0.038
positive regulation of cellular amine metabolic process GO:0033240 0 0.038
negative regulation of immune system process GO:0002683 50 0.038
response to nitrogen compound GO:1901698 90 0.037
Human
regulation of intracellular signal transduction GO:1902531 236 0.037
glial cell migration GO:0008347 31 0.036
regulation of mapk cascade GO:0043408 92 0.036
cellular component assembly involved in morphogenesis GO:0010927 151 0.035
compound eye development GO:0048749 307 0.035
regulation of cellular amine metabolic process GO:0033238 3 0.035
protein ubiquitination GO:0016567 70 0.035
protein import into nucleus GO:0006606 51 0.034
dna templated transcription initiation GO:0006352 25 0.034
digestive tract morphogenesis GO:0048546 127 0.034
single organism biosynthetic process GO:0044711 206 0.034
Mouse
dna metabolic process GO:0006259 227 0.034
central nervous system development GO:0007417 201 0.034
Mouse
meiotic nuclear division GO:0007126 151 0.033
cellular response to lipopolysaccharide GO:0071222 3 0.033
regulation of erbb signaling pathway GO:1901184 42 0.033
regulation of protein modification process GO:0031399 112 0.033
Human Mouse
vesicle targeting GO:0006903 1 0.033
salivary gland development GO:0007431 162 0.032
nuclear transport GO:0051169 72 0.032
regulation of cellular component size GO:0032535 98 0.031
positive regulation of cell death GO:0010942 69 0.031
transposition rna mediated GO:0032197 3 0.031
respiratory system development GO:0060541 213 0.031
negative regulation of protein metabolic process GO:0051248 85 0.031
Mouse
single organism behavior GO:0044708 391 0.030
body morphogenesis GO:0010171 2 0.030
organic substance transport GO:0071702 257 0.030
regulation of alternative mrna splicing via spliceosome GO:0000381 60 0.030
autophagic cell death GO:0048102 83 0.030
extrinsic apoptotic signaling pathway GO:0097191 1 0.029
positive regulation of protein metabolic process GO:0051247 128 0.029
regulation of anatomical structure morphogenesis GO:0022603 242 0.029
regulation of mrna processing GO:0050684 71 0.029
regulation of cell migration GO:0030334 22 0.029
signal transduction by phosphorylation GO:0023014 107 0.029
positive regulation of cellular catabolic process GO:0031331 95 0.029
apoptotic cell clearance GO:0043277 14 0.029
circadian rhythm GO:0007623 105 0.029
regulation of cellular amino acid metabolic process GO:0006521 0 0.029
cellular lipid metabolic process GO:0044255 83 0.028
regulation of catabolic process GO:0009894 170 0.028
axon development GO:0061564 297 0.028
actin cytoskeleton organization GO:0030036 206 0.028
negative regulation of mitotic cell cycle GO:0045930 109 0.028
regulation of immune response GO:0050776 118 0.028
dna replication GO:0006260 48 0.028
erbb signaling pathway GO:0038127 58 0.027
regulation of localization GO:0032879 275 0.027
regulation of jnk cascade GO:0046328 40 0.027
protein targeting to nucleus GO:0044744 51 0.027
dna templated transcriptional preinitiation complex assembly GO:0070897 20 0.027
eye morphogenesis GO:0048592 260 0.027
cellular response to biotic stimulus GO:0071216 4 0.027
mrna splicing via spliceosome GO:0000398 73 0.027
positive regulation of catabolic process GO:0009896 105 0.026
exocrine system development GO:0035272 162 0.026
multicellular organism growth GO:0035264 46 0.026
Mouse
necrotic cell death GO:0070265 1 0.026
regulation of cell death GO:0010941 173 0.026
positive regulation of cell proliferation GO:0008284 47 0.025
rna splicing via transesterification reactions GO:0000375 73 0.025
amine metabolic process GO:0009308 12 0.025
regulation of cell division GO:0051302 72 0.025
rna processing GO:0006396 147 0.025
mrna processing GO:0006397 104 0.024
immune response GO:0006955 246 0.024
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 19 0.024
response to peptide GO:1901652 29 0.024
Human
innate immune response GO:0045087 144 0.024
positive regulation of proteolysis GO:0045862 52 0.024
immune system process GO:0002376 347 0.024
ribonucleoside metabolic process GO:0009119 127 0.024
transcription initiation from rna polymerase ii promoter GO:0006367 25 0.024
cellular response to molecule of bacterial origin GO:0071219 3 0.024
regulation of transposition rna mediated GO:0010525 3 0.024
regulation of transport GO:0051049 181 0.024
melanization defense response GO:0035006 45 0.024
regulation of phosphate metabolic process GO:0019220 210 0.023
Mouse
cellular response to chemical stimulus GO:0070887 199 0.023
Human
metal ion transport GO:0030001 74 0.023
negative regulation of programmed cell death GO:0043069 72 0.023
response to organic substance GO:0010033 284 0.023
Human
determination of adult lifespan GO:0008340 137 0.023
divalent inorganic cation homeostasis GO:0072507 29 0.023
mitotic dna integrity checkpoint GO:0044774 75 0.023
regulation of epithelial cell proliferation GO:0050678 4 0.023
wing disc pattern formation GO:0035222 66 0.023
cellular response to starvation GO:0009267 61 0.022
response to nutrient levels GO:0031667 114 0.022
activation of innate immune response GO:0002218 4 0.022
regulation of response to stress GO:0080134 200 0.022
organonitrogen compound biosynthetic process GO:1901566 117 0.022
brain development GO:0007420 120 0.022
Mouse
lipid localization GO:0010876 54 0.022
cellular protein catabolic process GO:0044257 83 0.022
histone h4 k16 acetylation GO:0043984 4 0.022
meiotic spindle organization GO:0000212 36 0.021
negative regulation of cell cycle GO:0045786 116 0.021
Mouse
aging GO:0007568 143 0.021
appendage development GO:0048736 401 0.021
negative regulation of innate immune response GO:0045824 30 0.021
response to other organism GO:0051707 293 0.021
autophagy GO:0006914 108 0.021
telencephalon development GO:0021537 2 0.021
Mouse
gland development GO:0048732 191 0.021
gene silencing by mirna GO:0035195 22 0.021
regulation of innate immune response GO:0045088 71 0.020
aromatic compound catabolic process GO:0019439 166 0.020
positive regulation of protein modification process GO:0031401 58 0.020
adult behavior GO:0030534 137 0.020
cellular response to peptide GO:1901653 28 0.020
Human
regulation of protein catabolic process GO:0042176 55 0.020
positive regulation of phosphorus metabolic process GO:0010562 139 0.020
maintenance of gastrointestinal epithelium GO:0030277 3 0.020
response to wounding GO:0009611 94 0.020
regulation of protein phosphorylation GO:0001932 64 0.020
Mouse
regulation of cellular response to stress GO:0080135 89 0.020
cell projection assembly GO:0030031 94 0.020
positive regulation of apoptotic signaling pathway GO:2001235 4 0.020
cell maturation GO:0048469 144 0.020
phagocytosis GO:0006909 215 0.020
positive regulation of developmental process GO:0051094 143 0.019
receptor recycling GO:0001881 2 0.019
double strand break repair GO:0006302 26 0.019
purine nucleoside metabolic process GO:0042278 127 0.019
vesicle mediated transport GO:0016192 381 0.019
histolysis GO:0007559 102 0.019
response to radiation GO:0009314 155 0.019
positive regulation of molecular function GO:0044093 136 0.019
positive regulation of multicellular organismal process GO:0051240 143 0.019
positive regulation of cell motility GO:2000147 3 0.019
response to abiotic stimulus GO:0009628 341 0.019
protein catabolic process GO:0030163 101 0.019
neurological system process GO:0050877 358 0.019
response to oxygen containing compound GO:1901700 200 0.019
Human
regulation of gene silencing GO:0060968 63 0.019
ion transmembrane transport GO:0034220 122 0.019
locomotor rhythm GO:0045475 56 0.019
lipid biosynthetic process GO:0008610 46 0.019
histone h2a acetylation GO:0043968 1 0.018
response to decreased oxygen levels GO:0036293 58 0.018
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.018
gene silencing by rna GO:0031047 57 0.018
regulation of cellular protein catabolic process GO:1903362 44 0.018
oocyte development GO:0048599 124 0.018
protein modification by small protein conjugation or removal GO:0070647 106 0.018
Human
divalent inorganic cation transport GO:0072511 30 0.018
ribonucleoside triphosphate catabolic process GO:0009203 108 0.018
histone h4 k12 acetylation GO:0043983 2 0.018
Mouse
protein maturation GO:0051604 71 0.018
regulation of organelle organization GO:0033043 196 0.018
organic cyclic compound catabolic process GO:1901361 168 0.018
sensory organ morphogenesis GO:0090596 260 0.018
organ formation GO:0048645 39 0.017
negative regulation of cellular protein metabolic process GO:0032269 85 0.017
Mouse
response to lipid GO:0033993 38 0.017
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.017
cellular response to extracellular stimulus GO:0031668 64 0.017
negative regulation of multicellular organismal process GO:0051241 142 0.017
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.017
ribonucleotide catabolic process GO:0009261 109 0.017
mitotic nuclear division GO:0007067 213 0.017
single organism catabolic process GO:0044712 228 0.017
purine nucleoside catabolic process GO:0006152 112 0.017
positive regulation of organelle organization GO:0010638 65 0.016
negative regulation of immune response GO:0050777 39 0.016
regulation of chromatin silencing GO:0031935 36 0.016
positive regulation of programmed cell death GO:0043068 62 0.016
regulation of photoreceptor cell differentiation GO:0046532 34 0.016
histone h3 k9 acetylation GO:0043970 3 0.016
Mouse
ion transport GO:0006811 145 0.016
nucleoside triphosphate catabolic process GO:0009143 108 0.016
salivary gland histolysis GO:0035070 88 0.016
oocyte dorsal ventral axis specification GO:0007310 34 0.016
nucleoside phosphate catabolic process GO:1901292 110 0.016
cognition GO:0050890 141 0.016
organophosphate metabolic process GO:0019637 195 0.016
response to oxygen levels GO:0070482 59 0.016
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.015
negative regulation of phosphorylation GO:0042326 35 0.015
Mouse
taxis GO:0042330 304 0.015
cellular response to external stimulus GO:0071496 66 0.015
germarium derived egg chamber formation GO:0007293 101 0.015
histone methylation GO:0016571 40 0.015
cellular response to insulin stimulus GO:0032869 28 0.015
Human
tube development GO:0035295 244 0.015
Mouse
dna integrity checkpoint GO:0031570 81 0.015
reproductive structure development GO:0048608 74 0.015
hematopoietic or lymphoid organ development GO:0048534 57 0.015
heterocycle catabolic process GO:0046700 166 0.015
cellular divalent inorganic cation homeostasis GO:0072503 23 0.015
innate immune response activating signal transduction GO:0002758 2 0.015
response to hypoxia GO:0001666 53 0.015
cortical cytoskeleton organization GO:0030865 29 0.015
modification dependent protein catabolic process GO:0019941 78 0.015
positive regulation of protein complex assembly GO:0031334 22 0.015
positive regulation of catalytic activity GO:0043085 118 0.015
defense response to gram negative bacterium GO:0050829 94 0.015
oviposition GO:0018991 19 0.014
regulation of establishment of protein localization GO:0070201 61 0.014
reproductive system development GO:0061458 74 0.014
dna biosynthetic process GO:0071897 24 0.014
mesenchymal cell differentiation GO:0048762 1 0.014
wing disc dorsal ventral pattern formation GO:0048190 47 0.014
recombinational repair GO:0000725 13 0.014
regulation of protein complex assembly GO:0043254 42 0.014
positive regulation of cellular component biogenesis GO:0044089 80 0.014
regulation of defense response GO:0031347 102 0.014
nitrogen compound transport GO:0071705 85 0.014
positive regulation of growth GO:0045927 75 0.014
purine containing compound metabolic process GO:0072521 155 0.014
regulation of epidermal growth factor receptor signaling pathway GO:0042058 42 0.014
cell adhesion GO:0007155 136 0.014
establishment or maintenance of cell polarity GO:0007163 167 0.014
negative regulation of neuron death GO:1901215 18 0.014
positive regulation of protein phosphorylation GO:0001934 34 0.014
positive regulation of phosphorylation GO:0042327 87 0.014
cellular amine metabolic process GO:0044106 12 0.014
protein localization GO:0008104 284 0.014
negative regulation of phosphate metabolic process GO:0045936 45 0.014
Mouse
intracellular signal transduction GO:0035556 300 0.014
purine ribonucleoside catabolic process GO:0046130 112 0.014
segmentation GO:0035282 207 0.014
Mouse
glycerolipid metabolic process GO:0046486 34 0.013
protein deubiquitination GO:0016579 17 0.013
Human
oocyte microtubule cytoskeleton polarization GO:0008103 22 0.013
pigmentation GO:0043473 75 0.013
mrna catabolic process GO:0006402 33 0.013
protein modification by small protein conjugation GO:0032446 79 0.013
sulfur compound metabolic process GO:0006790 59 0.013
positive regulation of ras gtpase activity GO:0032320 36 0.013
tissue morphogenesis GO:0048729 297 0.013
Mouse
regulation of mrna splicing via spliceosome GO:0048024 64 0.013
negative regulation of apoptotic signaling pathway GO:2001234 5 0.013
cellular response to sterol depletion GO:0071501 3 0.013
positive regulation of cellular protein catabolic process GO:1903364 24 0.013
developmental growth GO:0048589 280 0.013
secretion GO:0046903 109 0.013
carbohydrate metabolic process GO:0005975 82 0.013
Human Mouse
guanosine containing compound metabolic process GO:1901068 74 0.013
cellular catabolic process GO:0044248 372 0.012
negative regulation of gene expression epigenetic GO:0045814 77 0.012
multicellular organismal homeostasis GO:0048871 41 0.012
calcium ion transmembrane transport GO:0070588 17 0.012
postreplication repair GO:0006301 2 0.012
regulation of cellular ketone metabolic process GO:0010565 3 0.012
Mouse
regulation of notch signaling pathway GO:0008593 100 0.012
regulation of mrna metabolic process GO:1903311 72 0.012
spermatid differentiation GO:0048515 114 0.012
purine containing compound catabolic process GO:0072523 112 0.012
positive regulation of multi organism process GO:0043902 40 0.012
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.012
regulation of gtp catabolic process GO:0033124 44 0.012
negative regulation of intracellular signal transduction GO:1902532 57 0.012
mitochondrial dna metabolic process GO:0032042 1 0.012
histone lysine methylation GO:0034968 32 0.012
dna damage checkpoint GO:0000077 78 0.012
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.012
protein glycosylation GO:0006486 32 0.012
Human
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.012
protein processing GO:0016485 68 0.012
protein complex biogenesis GO:0070271 201 0.012
nuclear import GO:0051170 51 0.012
embryonic development via the syncytial blastoderm GO:0001700 148 0.012

Pcaf disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 0 0.030
disease of anatomical entity DOID:7 0 0.030
nervous system disease DOID:863 0 0.030
myopathy DOID:423 0 0.023
muscular disease DOID:0080000 0 0.023
heart disease DOID:114 0 0.023
cardiomyopathy DOID:0050700 0 0.023
intrinsic cardiomyopathy DOID:0060036 0 0.023
cardiovascular system disease DOID:1287 0 0.023
musculoskeletal system disease DOID:17 0 0.023
muscle tissue disease DOID:66 0 0.023
dilated cardiomyopathy DOID:12930 0 0.021
thoracic cancer DOID:5093 0 0.017
cancer DOID:162 0 0.017
disease of cellular proliferation DOID:14566 0 0.017
organ system cancer DOID:0050686 0 0.017
non syndromic intellectual disability DOID:0050889 0 0.014
disease of mental health DOID:150 0 0.014
developmental disorder of mental health DOID:0060037 0 0.014
specific developmental disorder DOID:0060038 0 0.014
intellectual disability DOID:1059 0 0.014