Drosophila melanogaster

50 known processes

Ir (Dmel_CG6747)

Inwardly rectifying potassium channel

(Aliases: irk1,CG6747,ir,Dmel\CG6747,Dir,DIR,dKirI)

Ir biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
circadian rhythm GO:0007623 105 0.596
circadian behavior GO:0048512 76 0.363
rhythmic behavior GO:0007622 76 0.284
rhythmic process GO:0048511 106 0.224
locomotor rhythm GO:0045475 56 0.189
intracellular signal transduction GO:0035556 300 0.113
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.102
single organism behavior GO:0044708 391 0.100
ion transmembrane transport GO:0034220 122 0.100
locomotory behavior GO:0007626 176 0.098
appendage morphogenesis GO:0035107 397 0.096
negative regulation of cell communication GO:0010648 223 0.091
Human Fly
positive regulation of response to stimulus GO:0048584 323 0.090
regulation of intracellular signal transduction GO:1902531 236 0.089
response to organonitrogen compound GO:0010243 75 0.078
Human Rat
negative regulation of rna biosynthetic process GO:1902679 240 0.076
regulation of protein metabolic process GO:0051246 256 0.073
negative regulation of gene expression GO:0010629 387 0.073
negative regulation of signaling GO:0023057 219 0.065
Human Fly
neurological system process GO:0050877 358 0.065
Human Rat
positive regulation of signal transduction GO:0009967 223 0.064
organonitrogen compound metabolic process GO:1901564 318 0.062
positive regulation of signaling GO:0023056 243 0.058
negative regulation of nucleic acid templated transcription GO:1903507 240 0.058
negative regulation of cellular metabolic process GO:0031324 382 0.057
defense response to bacterium GO:0042742 178 0.056
regulation of cellular protein metabolic process GO:0032268 243 0.052
negative regulation of rna metabolic process GO:0051253 251 0.051
response to organic cyclic compound GO:0014070 89 0.050
Human Rat
small molecule metabolic process GO:0044281 305 0.049
innate immune response GO:0045087 144 0.048
positive regulation of cell communication GO:0010647 250 0.047
compound eye morphogenesis GO:0001745 249 0.047
response to organophosphorus GO:0046683 2 0.046
Human
immune system process GO:0002376 347 0.046
developmental growth GO:0048589 280 0.046
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.045
negative regulation of transcription dna templated GO:0045892 237 0.045
immune response GO:0006955 246 0.044
response to nitrogen compound GO:1901698 90 0.044
Human Rat
regulation of phosphate metabolic process GO:0019220 210 0.044
response to other organism GO:0051707 293 0.043
response to lipopolysaccharide GO:0032496 4 0.043
regulation of catalytic activity GO:0050790 185 0.042
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.042
regulation of molecular function GO:0065009 217 0.041
Rat
cell death GO:0008219 279 0.040
tissue morphogenesis GO:0048729 297 0.040
negative regulation of cellular biosynthetic process GO:0031327 277 0.040
cellular protein modification process GO:0006464 438 0.039
imaginal disc derived appendage development GO:0048737 399 0.039
regulation of phosphorylation GO:0042325 147 0.039
protein modification process GO:0036211 438 0.039
positive regulation of phosphorus metabolic process GO:0010562 139 0.039
transmembrane transport GO:0055085 139 0.038
regulation of cell differentiation GO:0045595 302 0.038
regionalization GO:0003002 416 0.037
photoreceptor cell differentiation GO:0046530 170 0.037
positive regulation of biosynthetic process GO:0009891 316 0.037
regulation of circadian rhythm GO:0042752 49 0.037
ion transport GO:0006811 145 0.036
gene silencing GO:0016458 138 0.035
nitrogen compound transport GO:0071705 85 0.035
Human Rat
oxoacid metabolic process GO:0043436 103 0.035
columnar cuboidal epithelial cell development GO:0002066 249 0.035
regulation of response to stress GO:0080134 200 0.035
negative regulation of response to stimulus GO:0048585 258 0.034
Fly
compound eye photoreceptor cell differentiation GO:0001751 140 0.033
response to oxygen containing compound GO:1901700 200 0.033
Human Rat
imaginal disc derived wing morphogenesis GO:0007476 337 0.033
wing disc morphogenesis GO:0007472 344 0.033
organic substance transport GO:0071702 257 0.033
Human Rat
establishment of localization in cell GO:0051649 402 0.033
Human
sensory perception GO:0007600 196 0.032
Rat
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.032
positive regulation of catalytic activity GO:0043085 118 0.032
mapk cascade GO:0000165 107 0.032
positive regulation of defense response GO:0031349 59 0.031
cellular amino acid metabolic process GO:0006520 61 0.031
positive regulation of intracellular signal transduction GO:1902533 116 0.031
regulation of cell death GO:0010941 173 0.031
immune response activating signal transduction GO:0002757 2 0.031
regulation of phosphorus metabolic process GO:0051174 210 0.030
cellular response to dna damage stimulus GO:0006974 223 0.030
regulation of immune response GO:0050776 118 0.030
carboxylic acid metabolic process GO:0019752 92 0.030
appendage development GO:0048736 401 0.030
regulation of transport GO:0051049 181 0.030
organic substance catabolic process GO:1901575 308 0.030
single organism cellular localization GO:1902580 180 0.030
catabolic process GO:0009056 409 0.030
humoral immune response GO:0006959 117 0.029
regulation of multi organism process GO:0043900 131 0.029
organic acid metabolic process GO:0006082 103 0.029
defense response to other organism GO:0098542 225 0.029
regulation of catabolic process GO:0009894 170 0.029
regulation of anatomical structure morphogenesis GO:0022603 242 0.029
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.029
positive regulation of phosphate metabolic process GO:0045937 139 0.029
homeostatic process GO:0042592 199 0.029
Rat
negative regulation of signal transduction GO:0009968 206 0.029
Fly
regulation of organelle organization GO:0033043 196 0.028
compound eye development GO:0048749 307 0.028
protein phosphorylation GO:0006468 169 0.028
carbohydrate derivative metabolic process GO:1901135 217 0.028
purine containing compound metabolic process GO:0072521 155 0.027
response to biotic stimulus GO:0009607 294 0.027
negative regulation of biosynthetic process GO:0009890 277 0.027
jnk cascade GO:0007254 50 0.027
response to external biotic stimulus GO:0043207 293 0.027
organelle fission GO:0048285 340 0.027
regulation of cellular localization GO:0060341 136 0.027
Human
positive regulation of protein metabolic process GO:0051247 128 0.026
signal transduction by phosphorylation GO:0023014 107 0.026
cuticle development GO:0042335 86 0.026
imaginal disc derived appendage morphogenesis GO:0035114 395 0.026
sensory perception of chemical stimulus GO:0007606 116 0.026
innate immune response activating signal transduction GO:0002758 2 0.026
response to abiotic stimulus GO:0009628 341 0.025
Rat
regulation of cellular ketone metabolic process GO:0010565 3 0.025
response to endogenous stimulus GO:0009719 119 0.025
Human Rat
single organism biosynthetic process GO:0044711 206 0.025
l amino acid import GO:0043092 2 0.025
Rat
nucleoside phosphate metabolic process GO:0006753 162 0.025
regulation of localization GO:0032879 275 0.024
sensory organ morphogenesis GO:0090596 260 0.024
negative regulation of multicellular organismal process GO:0051241 142 0.024
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.024
eye development GO:0001654 323 0.023
transcription from rna polymerase ii promoter GO:0006366 368 0.023
epithelial cell development GO:0002064 274 0.023
stress activated protein kinase signaling cascade GO:0031098 55 0.023
nucleobase containing small molecule metabolic process GO:0055086 174 0.023
secondary metabolic process GO:0019748 75 0.023
cellular catabolic process GO:0044248 372 0.022
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.022
phosphorylation GO:0016310 294 0.022
response to organic substance GO:0010033 284 0.022
Human Rat
post embryonic appendage morphogenesis GO:0035120 385 0.022
positive regulation of gene expression GO:0010628 290 0.022
regulation of immune system process GO:0002682 176 0.022
regulation of protein modification process GO:0031399 112 0.022
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.022
response to monosaccharide GO:0034284 4 0.022
Rat
cellular amine metabolic process GO:0044106 12 0.022
amine metabolic process GO:0009308 12 0.022
cellular macromolecule localization GO:0070727 220 0.022
defense response GO:0006952 300 0.022
Rat
ras protein signal transduction GO:0007265 88 0.022
secretion by cell GO:0032940 101 0.021
Human
cellular response to organic substance GO:0071310 132 0.021
Rat
peptide metabolic process GO:0006518 80 0.021
negative regulation of cellular protein metabolic process GO:0032269 85 0.021
gliogenesis GO:0042063 80 0.021
positive regulation of mapk cascade GO:0043410 63 0.021
response to light stimulus GO:0009416 124 0.021
Rat
response to purine containing compound GO:0014074 12 0.021
Human
response to alkaloid GO:0043279 26 0.021
Rat
positive regulation of phosphorylation GO:0042327 87 0.021
proteolysis GO:0006508 192 0.021
negative regulation of phosphate metabolic process GO:0045936 45 0.021
immune response regulating signaling pathway GO:0002764 2 0.021
response to hexose GO:0009746 3 0.021
Rat
body morphogenesis GO:0010171 2 0.021
negative regulation of protein metabolic process GO:0051248 85 0.021
organic hydroxy compound metabolic process GO:1901615 83 0.021
cellular response to lipopolysaccharide GO:0071222 3 0.021
small gtpase mediated signal transduction GO:0007264 88 0.020
regulation of cell cycle GO:0051726 291 0.020
ribonucleotide metabolic process GO:0009259 145 0.020
regulation of smoothened signaling pathway GO:0008589 28 0.020
macromolecule catabolic process GO:0009057 161 0.020
regulation of defense response GO:0031347 102 0.020
protein complex assembly GO:0006461 200 0.020
Human Rat
taxis GO:0042330 304 0.020
chaeta development GO:0022416 97 0.020
response to radiation GO:0009314 155 0.020
Rat
monocarboxylic acid transport GO:0015718 3 0.020
positive regulation of cellular biosynthetic process GO:0031328 316 0.020
stress activated mapk cascade GO:0051403 52 0.020
growth GO:0040007 359 0.019
nuclear division GO:0000280 332 0.019
positive regulation of macromolecule metabolic process GO:0010604 405 0.019
intracellular transport GO:0046907 228 0.019
regulation of neurogenesis GO:0050767 158 0.019
cellular response to biotic stimulus GO:0071216 4 0.019
regulation of protein phosphorylation GO:0001932 64 0.019
chromosome segregation GO:0007059 157 0.018
secretion GO:0046903 109 0.018
Human
chromosome organization GO:0051276 360 0.018
epithelial cell differentiation GO:0030855 322 0.018
cell proliferation GO:0008283 299 0.018
inorganic ion transmembrane transport GO:0098660 73 0.018
metal ion transport GO:0030001 74 0.018
cellular response to chemical stimulus GO:0070887 199 0.018
Rat
kidney development GO:0001822 3 0.018
Rat
regulation of protein kinase activity GO:0045859 51 0.018
positive regulation of catabolic process GO:0009896 105 0.018
pigmentation GO:0043473 75 0.018
positive regulation of molecular function GO:0044093 136 0.018
Rat
regulation of gene expression epigenetic GO:0040029 128 0.018
organophosphate metabolic process GO:0019637 195 0.018
positive regulation of rna biosynthetic process GO:1902680 266 0.018
defense response to gram negative bacterium GO:0050829 94 0.017
regulation of small gtpase mediated signal transduction GO:0051056 93 0.017
cell motility GO:0048870 251 0.017
negative regulation of phosphorus metabolic process GO:0010563 45 0.017
positive regulation of transcription dna templated GO:0045893 266 0.017
cellular response to carbohydrate stimulus GO:0071322 4 0.017
Rat
positive regulation of programmed cell death GO:0043068 62 0.017
response to glucose GO:0009749 2 0.017
Rat
single organism intracellular transport GO:1902582 207 0.017
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.017
defense response to fungus GO:0050832 48 0.017
antimicrobial humoral response GO:0019730 99 0.017
morphogenesis of an epithelium GO:0002009 276 0.016
regulation of multicellular organismal development GO:2000026 414 0.016
actin filament based process GO:0030029 220 0.016
Rat
chemosensory behavior GO:0007635 106 0.016
cognition GO:0050890 141 0.016
multi organism behavior GO:0051705 175 0.016
regulation of secretion by cell GO:1903530 39 0.016
Human
eye photoreceptor cell fate commitment GO:0042706 37 0.016
imaginal disc pattern formation GO:0007447 91 0.016
negative regulation of insulin secretion GO:0046676 1 0.016
Human
positive regulation of ion transmembrane transporter activity GO:0032414 4 0.016
Rat
cellular response to endogenous stimulus GO:0071495 80 0.016
Rat
cellular homeostasis GO:0019725 80 0.016
Rat
regulation of cellular response to stress GO:0080135 89 0.016
eye morphogenesis GO:0048592 260 0.016
positive regulation of cellular catabolic process GO:0031331 95 0.016
detection of stimulus involved in sensory perception GO:0050906 92 0.016
positive regulation of rna metabolic process GO:0051254 271 0.016
immune effector process GO:0002252 98 0.016
ribose phosphate metabolic process GO:0019693 145 0.016
nucleotide metabolic process GO:0009117 161 0.016
pattern recognition receptor signaling pathway GO:0002221 2 0.016
negative regulation of catalytic activity GO:0043086 42 0.016
regulation of cell development GO:0060284 215 0.015
regulation of response to external stimulus GO:0032101 115 0.015
response to starvation GO:0042594 97 0.015
negative regulation of intracellular signal transduction GO:1902532 57 0.015
eye photoreceptor cell differentiation GO:0001754 145 0.015
positive regulation of apoptotic signaling pathway GO:2001235 4 0.015
regulation of innate immune response GO:0045088 71 0.015
long term memory GO:0007616 62 0.015
protein localization GO:0008104 284 0.015
l glutamate import GO:0051938 1 0.015
Rat
learning or memory GO:0007611 141 0.015
photoreceptor cell fate commitment GO:0046552 41 0.015
phagocytosis GO:0006909 215 0.015
single organism catabolic process GO:0044712 228 0.015
enzyme linked receptor protein signaling pathway GO:0007167 179 0.015
Fly
positive regulation of cellular protein metabolic process GO:0032270 118 0.015
regulation of kinase activity GO:0043549 53 0.015
cellular ketone metabolic process GO:0042180 24 0.015
morphogenesis of a polarized epithelium GO:0001738 93 0.015
cellular nitrogen compound catabolic process GO:0044270 165 0.015
cellular response to hexose stimulus GO:0071331 1 0.014
Rat
regulation of cellular amino acid metabolic process GO:0006521 0 0.014
regulation of nervous system development GO:0051960 248 0.014
regulation of transmembrane transport GO:0034762 27 0.014
lipopolysaccharide mediated signaling pathway GO:0031663 1 0.014
protein processing GO:0016485 68 0.014
positive regulation of immune response GO:0050778 63 0.014
apoptotic process GO:0006915 159 0.014
epithelial cell migration GO:0010631 148 0.014
regulation of transferase activity GO:0051338 58 0.014
organonitrogen compound catabolic process GO:1901565 128 0.014
regulation of mapk cascade GO:0043408 92 0.014
vesicle mediated transport GO:0016192 381 0.014
cell cell signaling involved in cell fate commitment GO:0045168 210 0.014
purine nucleotide metabolic process GO:0006163 146 0.014
regulation of growth GO:0040008 233 0.014
regulation of proteolysis GO:0030162 87 0.014
establishment of tissue polarity GO:0007164 87 0.014
macromolecular complex assembly GO:0065003 256 0.014
Human Rat
cellular response to monosaccharide stimulus GO:0071326 2 0.014
Rat
death GO:0016265 284 0.013
muscle organ development GO:0007517 127 0.013
intracellular protein transport GO:0006886 104 0.013
positive regulation of apoptotic process GO:0043065 47 0.013
ameboidal type cell migration GO:0001667 151 0.013
gene silencing by rna GO:0031047 57 0.013
cytoplasmic transport GO:0016482 130 0.013
hippo signaling GO:0035329 20 0.013
mitotic nuclear division GO:0007067 213 0.013
spermatogenesis GO:0007283 200 0.013
response to bacterium GO:0009617 198 0.013
erbb signaling pathway GO:0038127 58 0.013
regulation of humoral immune response GO:0002920 51 0.013
protein complex biogenesis GO:0070271 201 0.013
Human Rat
negative regulation of kinase activity GO:0033673 16 0.013
organonitrogen compound biosynthetic process GO:1901566 117 0.013
ovarian follicle cell development GO:0030707 248 0.013
posttranscriptional regulation of gene expression GO:0010608 145 0.013
reproductive behavior GO:0019098 122 0.013
epithelium migration GO:0090132 148 0.013
male gamete generation GO:0048232 201 0.013
dna integrity checkpoint GO:0031570 81 0.013
cation transport GO:0006812 110 0.013
response to extracellular stimulus GO:0009991 116 0.013
cell division GO:0051301 248 0.013
extrinsic apoptotic signaling pathway GO:0097191 1 0.013
chemical homeostasis GO:0048878 92 0.012
Rat
cell adhesion GO:0007155 136 0.012
wnt signaling pathway GO:0016055 98 0.012
anion transport GO:0006820 41 0.012
Rat
regulation of cellular amine metabolic process GO:0033238 3 0.012
neuron projection guidance GO:0097485 241 0.012
melanization defense response GO:0035006 45 0.012
negative regulation of phosphorylation GO:0042326 35 0.012
cell cell junction organization GO:0045216 55 0.012
segmentation GO:0035282 207 0.012
carbohydrate derivative biosynthetic process GO:1901137 85 0.012
eggshell chorion assembly GO:0007306 66 0.012
establishment of protein localization GO:0045184 163 0.012
cellular response to organic cyclic compound GO:0071407 32 0.012
Rat
photoreceptor cell development GO:0042461 96 0.012
olfactory behavior GO:0042048 97 0.012
regulation of response to biotic stimulus GO:0002831 63 0.012
axon development GO:0061564 297 0.012
ribonucleotide biosynthetic process GO:0009260 28 0.012
central nervous system development GO:0007417 201 0.012
response to temperature stimulus GO:0009266 106 0.012
notch signaling pathway GO:0007219 120 0.012
protein transport GO:0015031 155 0.012
antibacterial humoral response GO:0019731 44 0.012
meiotic nuclear division GO:0007126 151 0.012
salivary gland development GO:0007431 162 0.012
epithelial tube morphogenesis GO:0060562 88 0.012
cellular protein localization GO:0034613 160 0.012
carboxylic acid transport GO:0046942 18 0.012
Rat
regulation of jnk cascade GO:0046328 40 0.011
positive regulation of hydrolase activity GO:0051345 78 0.011
protein heterooligomerization GO:0051291 4 0.011
smoothened signaling pathway GO:0007224 49 0.011
response to wounding GO:0009611 94 0.011
posttranscriptional gene silencing by rna GO:0035194 45 0.011
determination of adult lifespan GO:0008340 137 0.011
regulation of cell morphogenesis GO:0022604 163 0.011
negative regulation of developmental growth GO:0048640 64 0.011
heterocycle catabolic process GO:0046700 166 0.011
regulation of mitotic cell cycle GO:0007346 190 0.011
open tracheal system development GO:0007424 204 0.011
detection of stimulus GO:0051606 156 0.011
muscle structure development GO:0061061 224 0.011
programmed cell death GO:0012501 257 0.011
chromatin organization GO:0006325 207 0.011
wound healing GO:0042060 75 0.011
regulation of production of molecular mediator of immune response GO:0002700 44 0.011
negative regulation of growth GO:0045926 84 0.011
cell cycle checkpoint GO:0000075 95 0.011
negative regulation of developmental process GO:0051093 201 0.011
cell fate determination GO:0001709 91 0.011
regulation of system process GO:0044057 36 0.011
Human Rat
nucleoside catabolic process GO:0009164 112 0.011
melanin metabolic process GO:0006582 47 0.011
regulation of ras protein signal transduction GO:0046578 93 0.011
cellular response to nitrogen compound GO:1901699 51 0.011
Rat
positive regulation of cellular component organization GO:0051130 156 0.011
phenol containing compound metabolic process GO:0018958 57 0.011
cellular amide metabolic process GO:0043603 80 0.011
organic anion transport GO:0015711 28 0.011
Rat
sensory perception of smell GO:0007608 80 0.011
positive regulation of transport GO:0051050 92 0.011
Rat
gene silencing by mirna GO:0035195 22 0.011
nucleocytoplasmic transport GO:0006913 72 0.010
regulation of programmed cell death GO:0043067 152 0.010
posttranscriptional gene silencing GO:0016441 46 0.010
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.010
Fly
establishment of planar polarity GO:0001736 87 0.010
endocytosis GO:0006897 310 0.010
dendrite development GO:0016358 204 0.010
ribonucleotide catabolic process GO:0009261 109 0.010
cellular macromolecular complex assembly GO:0034622 153 0.010
regulation of antimicrobial humoral response GO:0002759 50 0.010
response to ketone GO:1901654 34 0.010
Rat
protein import into nucleus GO:0006606 51 0.010
response to gravity GO:0009629 26 0.010
salivary gland histolysis GO:0035070 88 0.010
organelle assembly GO:0070925 198 0.010
eye photoreceptor cell development GO:0042462 81 0.010
respiratory system development GO:0060541 213 0.010
regulation of ion transmembrane transport GO:0034765 27 0.010
centrosome organization GO:0051297 163 0.010
regulation of immune effector process GO:0002697 52 0.010

Ir disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.079
Human
inherited metabolic disorder DOID:655 0 0.042
Human
disease of anatomical entity DOID:7 0 0.039
Human
nervous system disease DOID:863 0 0.025
Human
acquired metabolic disease DOID:0060158 0 0.023
Human
diabetes mellitus DOID:9351 0 0.015
Human
type 2 diabetes mellitus DOID:9352 0 0.015
Human
carbohydrate metabolism disease DOID:0050013 0 0.015
Human
glucose metabolism disease DOID:4194 0 0.015
Human
urinary system disease DOID:18 0 0.013
Human
sensory system disease DOID:0050155 0 0.013
Human
eye and adnexa disease DOID:1492 0 0.013
Human
eye disease DOID:5614 0 0.012
Human