Drosophila melanogaster

65 known processes

CycT (Dmel_CG6292)

Cyclin T

(Aliases: P-TEFb,p124,Dmcyclin T,Dmel\CG6292,CG6292,dT,anon-74EFc)

CycT biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
chromatin modification GO:0016568 147 0.361
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.352
chromosome organization GO:0051276 360 0.340
positive regulation of gene expression GO:0010628 290 0.295
positive regulation of cellular biosynthetic process GO:0031328 316 0.285
histone modification GO:0016570 106 0.268
negative regulation of biosynthetic process GO:0009890 277 0.225
positive regulation of rna metabolic process GO:0051254 271 0.206
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.205
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.182
negative regulation of cellular metabolic process GO:0031324 382 0.180
positive regulation of nucleic acid templated transcription GO:1903508 266 0.169
negative regulation of gene expression GO:0010629 387 0.155
nuclear division GO:0000280 332 0.147
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.147
cellular catabolic process GO:0044248 372 0.135
response to abiotic stimulus GO:0009628 341 0.132
negative regulation of cellular biosynthetic process GO:0031327 277 0.128
covalent chromatin modification GO:0016569 106 0.128
negative regulation of rna biosynthetic process GO:1902679 240 0.125
cell cycle checkpoint GO:0000075 95 0.119
regulation of mitotic cell cycle phase transition GO:1901990 130 0.116
chromatin remodeling GO:0006338 72 0.115
macromolecule catabolic process GO:0009057 161 0.099
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.097
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.089
regulation of cellular response to stress GO:0080135 89 0.087
cellular response to dna damage stimulus GO:0006974 223 0.086
negative regulation of transcription dna templated GO:0045892 237 0.084
negative regulation of cell cycle phase transition GO:1901988 103 0.084
transcription from rna polymerase ii promoter GO:0006366 368 0.083
negative regulation of nucleic acid templated transcription GO:1903507 240 0.083
regulation of cell cycle process GO:0010564 181 0.082
cellular macromolecule catabolic process GO:0044265 136 0.081
negative regulation of rna metabolic process GO:0051253 251 0.079
dna metabolic process GO:0006259 227 0.078
sensory perception GO:0007600 196 0.078
gene silencing GO:0016458 138 0.078
positive regulation of biosynthetic process GO:0009891 316 0.078
regulation of cellular protein metabolic process GO:0032268 243 0.075
chromatin organization GO:0006325 207 0.075
positive regulation of cellular protein metabolic process GO:0032270 118 0.075
positive regulation of transcription dna templated GO:0045893 266 0.070
positive regulation of response to stimulus GO:0048584 323 0.070
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.069
positive regulation of rna biosynthetic process GO:1902680 266 0.068
appendage development GO:0048736 401 0.068
positive regulation of macromolecule metabolic process GO:0010604 405 0.066
regulation of protein metabolic process GO:0051246 256 0.065
protein modification process GO:0036211 438 0.064
Human
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.064
taxis GO:0042330 304 0.063
protein alkylation GO:0008213 43 0.063
post embryonic appendage morphogenesis GO:0035120 385 0.062
negative regulation of cell cycle process GO:0010948 109 0.062
negative regulation of cell cycle GO:0045786 116 0.060
appendage morphogenesis GO:0035107 397 0.059
sensory perception of sound GO:0007605 56 0.058
methylation GO:0032259 47 0.057
regulation of mitotic cell cycle GO:0007346 190 0.056
protein acetylation GO:0006473 39 0.054
protein modification by small protein conjugation or removal GO:0070647 106 0.053
positive regulation of protein metabolic process GO:0051247 128 0.053
protein complex assembly GO:0006461 200 0.053
establishment of localization in cell GO:0051649 402 0.052
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.052
regulation of cell differentiation GO:0045595 302 0.051
macromolecular complex assembly GO:0065003 256 0.051
imaginal disc derived appendage development GO:0048737 399 0.051
imaginal disc derived wing morphogenesis GO:0007476 337 0.050
neurological system process GO:0050877 358 0.050
positive regulation of signaling GO:0023056 243 0.050
nucleoside triphosphate metabolic process GO:0009141 120 0.050
response to nutrient levels GO:0031667 114 0.048
wing disc morphogenesis GO:0007472 344 0.047
regulation of catabolic process GO:0009894 170 0.047
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.047
centrosome organization GO:0051297 163 0.046
positive regulation of signal transduction GO:0009967 223 0.046
modification dependent macromolecule catabolic process GO:0043632 79 0.045
mitotic cell cycle phase transition GO:0044772 138 0.044
negative regulation of developmental process GO:0051093 201 0.044
phosphorylation GO:0016310 294 0.044
Human
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.043
heterocycle catabolic process GO:0046700 166 0.041
positive regulation of cell communication GO:0010647 250 0.041
organic cyclic compound catabolic process GO:1901361 168 0.040
translation GO:0006412 69 0.039
internal protein amino acid acetylation GO:0006475 38 0.039
negative regulation of mitotic cell cycle GO:0045930 109 0.039
connective tissue development GO:0061448 3 0.039
cellular protein modification process GO:0006464 438 0.038
Human
cell cycle phase transition GO:0044770 140 0.038
peptidyl amino acid modification GO:0018193 105 0.037
regionalization GO:0003002 416 0.037
intracellular transport GO:0046907 228 0.036
regulation of phosphate metabolic process GO:0019220 210 0.036
histone methylation GO:0016571 40 0.036
actin filament based process GO:0030029 220 0.036
regulation of cellular component biogenesis GO:0044087 201 0.036
protein catabolic process GO:0030163 101 0.036
regulation of localization GO:0032879 275 0.035
regulation of cell cycle GO:0051726 291 0.035
protein maturation GO:0051604 71 0.034
organonitrogen compound metabolic process GO:1901564 318 0.034
death GO:0016265 284 0.034
regulation of apoptotic process GO:0042981 130 0.034
protein localization GO:0008104 284 0.034
regulation of response to external stimulus GO:0032101 115 0.033
dna repair GO:0006281 54 0.033
catabolic process GO:0009056 409 0.033
protein acylation GO:0043543 42 0.033
oocyte microtubule cytoskeleton organization GO:0016325 35 0.033
negative regulation of cell death GO:0060548 81 0.033
regulation of cell shape GO:0008360 113 0.033
defense response GO:0006952 300 0.033
modification dependent protein catabolic process GO:0019941 78 0.033
neuron projection guidance GO:0097485 241 0.033
embryonic morphogenesis GO:0048598 206 0.032
morphogenesis of an epithelium GO:0002009 276 0.032
cellular nitrogen compound catabolic process GO:0044270 165 0.031
histone lysine methylation GO:0034968 32 0.031
regulation of intracellular signal transduction GO:1902531 236 0.031
regulation of programmed cell death GO:0043067 152 0.031
enzyme linked receptor protein signaling pathway GO:0007167 179 0.031
positive regulation of catalytic activity GO:0043085 118 0.030
proteasomal protein catabolic process GO:0010498 59 0.030
mitotic nuclear division GO:0007067 213 0.030
regulation of oocyte development GO:0060281 27 0.030
protein methylation GO:0006479 43 0.029
sister chromatid segregation GO:0000819 92 0.029
programmed cell death GO:0012501 257 0.029
negative regulation of multicellular organismal process GO:0051241 142 0.028
endocytosis GO:0006897 310 0.028
dna packaging GO:0006323 91 0.028
response to external biotic stimulus GO:0043207 293 0.028
rna localization GO:0006403 115 0.028
nucleocytoplasmic transport GO:0006913 72 0.028
mitotic cell cycle checkpoint GO:0007093 88 0.027
single organism behavior GO:0044708 391 0.027
negative regulation of cell differentiation GO:0045596 143 0.027
dna conformation change GO:0071103 105 0.027
organic substance catabolic process GO:1901575 308 0.027
dorsal ventral pattern formation GO:0009953 133 0.027
adult behavior GO:0030534 137 0.026
regulation of gene expression epigenetic GO:0040029 128 0.026
response to other organism GO:0051707 293 0.026
chemotaxis GO:0006935 249 0.026
regulation of response to stress GO:0080134 200 0.026
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.026
anterior posterior pattern specification GO:0009952 136 0.026
positive regulation of cellular catabolic process GO:0031331 95 0.026
aging GO:0007568 143 0.026
chaeta development GO:0022416 97 0.025
peptidyl lysine modification GO:0018205 57 0.025
imaginal disc derived appendage morphogenesis GO:0035114 395 0.025
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.025
single organism catabolic process GO:0044712 228 0.025
cellular protein catabolic process GO:0044257 83 0.024
negative regulation of signal transduction GO:0009968 206 0.024
locomotory behavior GO:0007626 176 0.024
cellular macromolecular complex assembly GO:0034622 153 0.024
ubiquitin dependent protein catabolic process GO:0006511 78 0.024
nuclear import GO:0051170 51 0.024
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.024
response to biotic stimulus GO:0009607 294 0.024
gene silencing by rna GO:0031047 57 0.024
small molecule metabolic process GO:0044281 305 0.023
regulation of cellular protein catabolic process GO:1903362 44 0.023
salivary gland development GO:0007431 162 0.023
ribonucleoside triphosphate catabolic process GO:0009203 108 0.023
regulation of cell death GO:0010941 173 0.023
protein modification by small protein conjugation GO:0032446 79 0.023
proteolysis GO:0006508 192 0.023
imaginal disc derived wing vein morphogenesis GO:0008586 44 0.023
negative regulation of cellular protein metabolic process GO:0032269 85 0.023
chromosome separation GO:0051304 42 0.023
nucleobase containing compound transport GO:0015931 56 0.023
negative regulation of cell communication GO:0010648 223 0.023
response to extracellular stimulus GO:0009991 116 0.022
positive regulation of molecular function GO:0044093 136 0.022
negative regulation of organelle organization GO:0010639 56 0.022
tissue morphogenesis GO:0048729 297 0.022
organelle fission GO:0048285 340 0.022
chromatin silencing GO:0006342 76 0.022
mrna metabolic process GO:0016071 124 0.022
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.022
regulation of proteasomal protein catabolic process GO:0061136 39 0.022
negative regulation of apoptotic process GO:0043066 63 0.021
eye morphogenesis GO:0048592 260 0.021
phagocytosis GO:0006909 215 0.021
developmental programmed cell death GO:0010623 138 0.021
cellular response to nutrient levels GO:0031669 62 0.021
rna transport GO:0050658 46 0.021
myotube cell development GO:0014904 3 0.021
nucleobase containing compound catabolic process GO:0034655 165 0.021
protein processing GO:0016485 68 0.021
negative regulation of protein metabolic process GO:0051248 85 0.021
dna integrity checkpoint GO:0031570 81 0.020
regulation of notch signaling pathway GO:0008593 100 0.020
mitotic sister chromatid segregation GO:0000070 87 0.020
aromatic compound catabolic process GO:0019439 166 0.020
regulation of cellular localization GO:0060341 136 0.020
regulation of catalytic activity GO:0050790 185 0.020
apoptotic process GO:0006915 159 0.020
determination of adult lifespan GO:0008340 137 0.020
vesicle mediated transport GO:0016192 381 0.020
skeletal muscle fiber development GO:0048741 3 0.019
regulation of translation GO:0006417 56 0.019
positive regulation of intracellular signal transduction GO:1902533 116 0.019
learning or memory GO:0007611 141 0.019
centrosome duplication GO:0051298 121 0.019
regulation of cellular catabolic process GO:0031329 157 0.019
female gonad development GO:0008585 12 0.019
regulation of response to biotic stimulus GO:0002831 63 0.019
positive regulation of cell differentiation GO:0045597 64 0.019
macromolecule methylation GO:0043414 45 0.019
gland morphogenesis GO:0022612 145 0.019
nucleoside triphosphate catabolic process GO:0009143 108 0.019
signal transduction by phosphorylation GO:0023014 107 0.018
response to radiation GO:0009314 155 0.018
negative regulation of response to stimulus GO:0048585 258 0.018
chromatin assembly or disassembly GO:0006333 52 0.018
regulation of protein processing GO:0070613 32 0.018
regulation of cell cycle phase transition GO:1901987 130 0.018
imaginal disc pattern formation GO:0007447 91 0.018
nucleosome organization GO:0034728 59 0.018
exocrine system development GO:0035272 162 0.018
intracellular signal transduction GO:0035556 300 0.018
regulation of protein catabolic process GO:0042176 55 0.018
regulation of cell cycle g1 s phase transition GO:1902806 23 0.018
axon development GO:0061564 297 0.018
embryonic pattern specification GO:0009880 174 0.018
cell proliferation GO:0008283 299 0.018
regulation of cell morphogenesis GO:0022604 163 0.018
immune system process GO:0002376 347 0.018
epithelial cell development GO:0002064 274 0.018
mrna splicing via spliceosome GO:0000398 73 0.017
establishment of rna localization GO:0051236 47 0.017
single organism intracellular transport GO:1902582 207 0.017
purine containing compound metabolic process GO:0072521 155 0.017
positive regulation of protein modification process GO:0031401 58 0.017
ribonucleoprotein complex subunit organization GO:0071826 28 0.017
regulation of molecular function GO:0065009 217 0.017
homeostatic process GO:0042592 199 0.017
posttranscriptional gene silencing by rna GO:0035194 45 0.017
negative regulation of protein catabolic process GO:0042177 17 0.017
response to organic substance GO:0010033 284 0.017
positive regulation of phosphorus metabolic process GO:0010562 139 0.017
regulation of embryonic pattern specification GO:1902875 27 0.017
camera type eye development GO:0043010 4 0.017
embryo development ending in birth or egg hatching GO:0009792 152 0.017
histone acetylation GO:0016573 38 0.017
regulation of anatomical structure morphogenesis GO:0022603 242 0.016
axis specification GO:0009798 167 0.016
central nervous system development GO:0007417 201 0.016
meiosis i GO:0007127 59 0.016
regulation of chromosome organization GO:0033044 64 0.016
negative regulation of signaling GO:0023057 219 0.016
biological adhesion GO:0022610 138 0.016
nucleus organization GO:0006997 45 0.016
negative regulation of proteasomal protein catabolic process GO:1901799 16 0.016
localization of cell GO:0051674 257 0.016
cellular protein complex assembly GO:0043623 71 0.016
gland development GO:0048732 191 0.016
negative regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032435 16 0.016
response to lipopolysaccharide GO:0032496 4 0.016
positive regulation of cell development GO:0010720 61 0.016
negative regulation of protein processing GO:0010955 31 0.016
negative regulation of catabolic process GO:0009895 36 0.016
response to wounding GO:0009611 94 0.016
atp dependent chromatin remodeling GO:0043044 22 0.016
nucleoside catabolic process GO:0009164 112 0.016
regulation of hydrolase activity GO:0051336 97 0.016
rna catabolic process GO:0006401 37 0.015
response to starvation GO:0042594 97 0.015
cell death GO:0008219 279 0.015
immune response GO:0006955 246 0.015
regulation of organelle organization GO:0033043 196 0.015
axonogenesis GO:0007409 290 0.015
negative regulation of cellular catabolic process GO:0031330 34 0.015
erbb signaling pathway GO:0038127 58 0.015
regulation of multi organism process GO:0043900 131 0.015
organophosphate catabolic process GO:0046434 112 0.015
compound eye development GO:0048749 307 0.015
hematopoietic progenitor cell differentiation GO:0002244 1 0.015
single organism biosynthetic process GO:0044711 206 0.015
regulation of immune system process GO:0002682 176 0.015
organic acid metabolic process GO:0006082 103 0.015
eye development GO:0001654 323 0.015
regulation of protein modification process GO:0031399 112 0.015
response to hypoxia GO:0001666 53 0.015
maternal determination of anterior posterior axis embryo GO:0008358 74 0.015
adult locomotory behavior GO:0008344 76 0.014
positive regulation of multicellular organismal process GO:0051240 143 0.014
purine ribonucleotide metabolic process GO:0009150 145 0.014
cell fate determination GO:0001709 91 0.014
salivary gland morphogenesis GO:0007435 145 0.014
positive regulation of phosphorylation GO:0042327 87 0.014
development of primary female sexual characteristics GO:0046545 12 0.014
regulation of cellular amino acid metabolic process GO:0006521 0 0.014
skeletal muscle organ development GO:0060538 48 0.014
nucleoside phosphate catabolic process GO:1901292 110 0.014
establishment or maintenance of cell polarity GO:0007163 167 0.014
wing disc pattern formation GO:0035222 66 0.014
regulation of cell development GO:0060284 215 0.014
protein complex biogenesis GO:0070271 201 0.014
autophagic cell death GO:0048102 83 0.013
nucleosome assembly GO:0006334 35 0.013
body morphogenesis GO:0010171 2 0.013
regulation of protein localization GO:0032880 76 0.013
regulation of nucleotide metabolic process GO:0006140 62 0.013
amine metabolic process GO:0009308 12 0.013
purine containing compound catabolic process GO:0072523 112 0.013
segmentation GO:0035282 207 0.013
columnar cuboidal epithelial cell development GO:0002066 249 0.013
cellular response to organic substance GO:0071310 132 0.013
regulation of antimicrobial peptide biosynthetic process GO:0002805 38 0.013
regulation of dna metabolic process GO:0051052 34 0.013
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 30 0.013
regulation of developmental growth GO:0048638 174 0.013
purine ribonucleotide catabolic process GO:0009154 109 0.013
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.013
spermatid differentiation GO:0048515 114 0.013
positive regulation of developmental process GO:0051094 143 0.013
nuclear transport GO:0051169 72 0.013
cellular amine metabolic process GO:0044106 12 0.013
dorsal closure GO:0007391 79 0.013
negative regulation of gene expression epigenetic GO:0045814 77 0.013
purine nucleotide catabolic process GO:0006195 109 0.013
response to decreased oxygen levels GO:0036293 58 0.013
formation of organ boundary GO:0010160 30 0.013
positive regulation of catabolic process GO:0009896 105 0.013
epidermal growth factor receptor signaling pathway GO:0007173 58 0.013
cellular homeostasis GO:0019725 80 0.013
regulation of cell substrate adhesion GO:0010810 2 0.013
peptidyl lysine acetylation GO:0018394 39 0.013
regulation of antimicrobial peptide production GO:0002784 44 0.013
protein ubiquitination GO:0016567 70 0.013
cellular response to external stimulus GO:0071496 66 0.013
response to oxygen containing compound GO:1901700 200 0.013
compound eye morphogenesis GO:0001745 249 0.012
organic substance transport GO:0071702 257 0.012
microtubule organizing center organization GO:0031023 168 0.012
purine ribonucleoside metabolic process GO:0046128 127 0.012
purine ribonucleoside catabolic process GO:0046130 112 0.012
regulation of phosphorus metabolic process GO:0051174 210 0.012
regulation of proteolysis GO:0030162 87 0.012
endomembrane system organization GO:0010256 119 0.012
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 41 0.012
regulation of small gtpase mediated signal transduction GO:0051056 93 0.012
telencephalon development GO:0021537 2 0.012
digestive system development GO:0055123 149 0.012
positive regulation of cell death GO:0010942 69 0.012
negative regulation of programmed cell death GO:0043069 72 0.012
cell cycle g1 s phase transition GO:0044843 31 0.012
mrna catabolic process GO:0006402 33 0.012
developmental maturation GO:0021700 172 0.012
cytoplasmic transport GO:0016482 130 0.012
positive regulation of nervous system development GO:0051962 69 0.012
dna damage checkpoint GO:0000077 78 0.012
regulation of cytoskeleton organization GO:0051493 89 0.012
axon guidance GO:0007411 233 0.012
nucleobase containing small molecule metabolic process GO:0055086 174 0.012
spermatid development GO:0007286 98 0.012
regulation of immune effector process GO:0002697 52 0.012
cell division GO:0051301 248 0.012
regulation of transport GO:0051049 181 0.011
cell aging GO:0007569 2 0.011
regulation of cellular amine metabolic process GO:0033238 3 0.011
carbohydrate derivative catabolic process GO:1901136 118 0.011
organophosphate metabolic process GO:0019637 195 0.011
pole plasm assembly GO:0007315 61 0.011
stress activated protein kinase signaling cascade GO:0031098 55 0.011
rna interference GO:0016246 27 0.011
ribonucleotide catabolic process GO:0009261 109 0.011
glycosyl compound catabolic process GO:1901658 112 0.011
ribonucleoside triphosphate metabolic process GO:0009199 119 0.011
extrinsic apoptotic signaling pathway GO:0097191 1 0.011
cellular response to decreased oxygen levels GO:0036294 30 0.011
antimicrobial peptide biosynthetic process GO:0002777 38 0.011
response to nitrogen compound GO:1901698 90 0.011
regulation of alternative mrna splicing via spliceosome GO:0000381 60 0.011
antimicrobial humoral response GO:0019730 99 0.011
carbohydrate derivative metabolic process GO:1901135 217 0.011
mitotic sister chromatid separation GO:0051306 30 0.011
response to endoplasmic reticulum stress GO:0034976 28 0.011
cellular ketone metabolic process GO:0042180 24 0.011
stem cell development GO:0048864 79 0.011
g1 s transition of mitotic cell cycle GO:0000082 31 0.011
purine nucleoside metabolic process GO:0042278 127 0.011
cellular response to abiotic stimulus GO:0071214 58 0.011
immune system development GO:0002520 57 0.011
response to temperature stimulus GO:0009266 106 0.011
cellular response to chemical stimulus GO:0070887 199 0.011
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.010
imaginal disc derived leg morphogenesis GO:0007480 80 0.010
heart contraction GO:0060047 26 0.010
mapk cascade GO:0000165 107 0.010
chromatin assembly GO:0031497 48 0.010
ribonucleotide metabolic process GO:0009259 145 0.010
regulation of defense response GO:0031347 102 0.010
embryonic development via the syncytial blastoderm GO:0001700 148 0.010
positive regulation of neurogenesis GO:0050769 41 0.010
positive regulation of response to external stimulus GO:0032103 44 0.010
lymph gland development GO:0048542 28 0.010
negative regulation of notch signaling pathway GO:0045746 41 0.010
positive regulation of cellular component organization GO:0051130 156 0.010
regulation of intracellular transport GO:0032386 64 0.010
mitotic g2 dna damage checkpoint GO:0007095 69 0.010
positive regulation of protein transport GO:0051222 37 0.010
stem cell maintenance GO:0019827 67 0.010
purine nucleotide metabolic process GO:0006163 146 0.010
regulation of anatomical structure size GO:0090066 163 0.010
ameboidal type cell migration GO:0001667 151 0.010
positive regulation of hydrolase activity GO:0051345 78 0.010
regulation of vesicle mediated transport GO:0060627 59 0.010
formation of anatomical boundary GO:0048859 37 0.010

CycT disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.033
nervous system disease DOID:863 0 0.022
central nervous system disease DOID:331 0 0.012
neurodegenerative disease DOID:1289 0 0.012
cancer DOID:162 0 0.011
disease of cellular proliferation DOID:14566 0 0.011