Drosophila melanogaster

45 known processes

Orc1 (Dmel_CG10667)

Origin recognition complex subunit 1

(Aliases: DmOrc1p,dORC1,CG10667,ORC1,DmORC1,Dmel\CG10667,orc1,ORC,rDmORC)

Orc1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna metabolic process GO:0006259 227 0.956
organelle fission GO:0048285 340 0.927
positive regulation of macromolecule metabolic process GO:0010604 405 0.613
microtubule organizing center organization GO:0031023 168 0.568
dna biosynthetic process GO:0071897 24 0.553
nuclear division GO:0000280 332 0.532
dna amplification GO:0006277 11 0.515
chromosome organization GO:0051276 360 0.470
regulation of neurogenesis GO:0050767 158 0.420
eye development GO:0001654 323 0.388
negative regulation of transcription dna templated GO:0045892 237 0.339
negative regulation of rna biosynthetic process GO:1902679 240 0.286
eggshell chorion gene amplification GO:0007307 9 0.278
macromolecular complex assembly GO:0065003 256 0.262
sister chromatid segregation GO:0000819 92 0.252
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.248
cell cycle phase transition GO:0044770 140 0.244
regulation of mitotic cell cycle GO:0007346 190 0.243
regulation of cell cycle process GO:0010564 181 0.242
regulation of cell death GO:0010941 173 0.234
cellular component assembly involved in morphogenesis GO:0010927 151 0.223
epithelial cell differentiation GO:0030855 322 0.220
cell proliferation GO:0008283 299 0.217
cell cycle dna replication GO:0044786 23 0.215
negative regulation of gene expression GO:0010629 387 0.211
regulation of cell cycle GO:0051726 291 0.202
mitotic nuclear division GO:0007067 213 0.192
programmed cell death GO:0012501 257 0.176
dna conformation change GO:0071103 105 0.170
dna packaging GO:0006323 91 0.166
cellular response to dna damage stimulus GO:0006974 223 0.160
negative regulation of biosynthetic process GO:0009890 277 0.159
photoreceptor cell differentiation GO:0046530 170 0.157
epithelial cell development GO:0002064 274 0.157
spindle organization GO:0007051 253 0.151
gene silencing GO:0016458 138 0.148
regulation of apoptotic process GO:0042981 130 0.144
brain development GO:0007420 120 0.143
centrosome organization GO:0051297 163 0.142
growth GO:0040007 359 0.141
Zebrafish
regulation of multicellular organismal development GO:2000026 414 0.141
intracellular signal transduction GO:0035556 300 0.140
protein dna complex subunit organization GO:0071824 86 0.137
regulation of nervous system development GO:0051960 248 0.136
positive regulation of rna metabolic process GO:0051254 271 0.133
cell death GO:0008219 279 0.132
compound eye morphogenesis GO:0001745 249 0.127
chorion containing eggshell formation GO:0007304 105 0.127
nuclear dna replication GO:0033260 1 0.123
head development GO:0060322 135 0.118
nucleosome organization GO:0034728 59 0.117
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.115
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.113
negative regulation of rna metabolic process GO:0051253 251 0.111
protein complex assembly GO:0006461 200 0.110
embryonic pattern specification GO:0009880 174 0.110
positive regulation of cellular biosynthetic process GO:0031328 316 0.110
positive regulation of biosynthetic process GO:0009891 316 0.106
negative regulation of nucleic acid templated transcription GO:1903507 240 0.105
regulation of programmed cell death GO:0043067 152 0.105
developmental growth GO:0048589 280 0.105
Zebrafish
compound eye photoreceptor cell differentiation GO:0001751 140 0.102
regulation of cell development GO:0060284 215 0.102
segmentation GO:0035282 207 0.099
compound eye development GO:0048749 307 0.099
eye photoreceptor cell differentiation GO:0001754 145 0.098
gliogenesis GO:0042063 80 0.095
enzyme linked receptor protein signaling pathway GO:0007167 179 0.095
positive regulation of gene expression GO:0010628 290 0.093
proteolysis GO:0006508 192 0.093
cell adhesion GO:0007155 136 0.090
cellular catabolic process GO:0044248 372 0.088
sensory organ morphogenesis GO:0090596 260 0.087
negative regulation of cellular biosynthetic process GO:0031327 277 0.086
spermatogenesis GO:0007283 200 0.083
regulation of cell proliferation GO:0042127 163 0.082
apoptotic signaling pathway GO:0097190 27 0.081
regulation of dna metabolic process GO:0051052 34 0.081
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.080
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.079
mitotic dna damage checkpoint GO:0044773 74 0.077
protein complex biogenesis GO:0070271 201 0.076
eggshell chorion assembly GO:0007306 66 0.076
regionalization GO:0003002 416 0.075
cellular protein modification process GO:0006464 438 0.075
single organism biosynthetic process GO:0044711 206 0.075
eye morphogenesis GO:0048592 260 0.073
regulation of anatomical structure morphogenesis GO:0022603 242 0.071
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.071
tube morphogenesis GO:0035239 191 0.068
negative regulation of developmental process GO:0051093 201 0.068
protein targeting to nucleus GO:0044744 51 0.067
morphogenesis of an epithelium GO:0002009 276 0.066
positive regulation of protein metabolic process GO:0051247 128 0.066
protein dna complex assembly GO:0065004 63 0.065
mitotic chromosome condensation GO:0007076 22 0.065
mitotic sister chromatid segregation GO:0000070 87 0.065
protein modification process GO:0036211 438 0.064
eggshell formation GO:0030703 105 0.064
protein modification by small protein conjugation or removal GO:0070647 106 0.063
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.063
positive regulation of cellular protein metabolic process GO:0032270 118 0.063
mitotic g2 dna damage checkpoint GO:0007095 69 0.062
negative regulation of programmed cell death GO:0043069 72 0.061
dna dependent dna replication GO:0006261 17 0.060
phosphorylation GO:0016310 294 0.057
centrosome cycle GO:0007098 137 0.057
organic substance catabolic process GO:1901575 308 0.057
regulation of cell division GO:0051302 72 0.057
regulation of growth GO:0040008 233 0.057
Zebrafish
protein localization to nucleus GO:0034504 55 0.055
death GO:0016265 284 0.055
regulation of gene expression epigenetic GO:0040029 128 0.055
dendrite development GO:0016358 204 0.055
regulation of localization GO:0032879 275 0.054
regulation of neuron differentiation GO:0045664 103 0.053
male gamete generation GO:0048232 201 0.053
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.053
regulation of intracellular signal transduction GO:1902531 236 0.052
positive regulation of neurogenesis GO:0050769 41 0.052
cellular macromolecule localization GO:0070727 220 0.052
protein import into nucleus GO:0006606 51 0.052
negative regulation of cell cycle process GO:0010948 109 0.051
organophosphate metabolic process GO:0019637 195 0.050
meiotic nuclear division GO:0007126 151 0.049
carbohydrate derivative metabolic process GO:1901135 217 0.049
regulation of mitosis GO:0007088 56 0.048
axon development GO:0061564 297 0.048
dna replication GO:0006260 48 0.048
negative regulation of cell death GO:0060548 81 0.048
nuclear import GO:0051170 51 0.047
mitotic cell cycle checkpoint GO:0007093 88 0.047
small molecule metabolic process GO:0044281 305 0.046
positive regulation of multicellular organismal process GO:0051240 143 0.046
regulation of transport GO:0051049 181 0.045
ubiquitin dependent protein catabolic process GO:0006511 78 0.044
cell fate determination GO:0001709 91 0.043
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.043
ribonucleotide metabolic process GO:0009259 145 0.043
small gtpase mediated signal transduction GO:0007264 88 0.042
cell motility GO:0048870 251 0.042
positive regulation of developmental process GO:0051094 143 0.042
positive regulation of phosphate metabolic process GO:0045937 139 0.041
carboxylic acid metabolic process GO:0019752 92 0.041
regulation of nuclear division GO:0051783 58 0.041
positive regulation of rna biosynthetic process GO:1902680 266 0.041
cell cycle checkpoint GO:0000075 95 0.041
gene silencing by rna GO:0031047 57 0.039
positive regulation of nucleic acid templated transcription GO:1903508 266 0.039
positive regulation of cellular amine metabolic process GO:0033240 0 0.038
negative regulation of cellular metabolic process GO:0031324 382 0.038
catabolic process GO:0009056 409 0.038
meiotic cell cycle GO:0051321 171 0.037
positive regulation of signal transduction GO:0009967 223 0.037
axonogenesis GO:0007409 290 0.037
regulation of cellular protein metabolic process GO:0032268 243 0.037
regulation of catalytic activity GO:0050790 185 0.036
ribose phosphate metabolic process GO:0019693 145 0.036
rna localization GO:0006403 115 0.036
regulation of phosphorus metabolic process GO:0051174 210 0.036
response to organic substance GO:0010033 284 0.035
regulation of neuron projection development GO:0010975 69 0.035
dna damage checkpoint GO:0000077 78 0.035
regulation of mitotic cell cycle phase transition GO:1901990 130 0.035
apoptotic process GO:0006915 159 0.035
positive regulation of proteolysis GO:0045862 52 0.034
regulation of protein metabolic process GO:0051246 256 0.034
nucleobase containing compound catabolic process GO:0034655 165 0.034
negative regulation of cell cycle GO:0045786 116 0.034
regulation of organelle organization GO:0033043 196 0.034
positive regulation of phosphorylation GO:0042327 87 0.033
negative regulation of response to stimulus GO:0048585 258 0.033
positive regulation of transcription dna templated GO:0045893 266 0.033
sex differentiation GO:0007548 81 0.032
Worm
regulation of cellular ketone metabolic process GO:0010565 3 0.032
meiosis i GO:0007127 59 0.032
transcription from rna polymerase ii promoter GO:0006366 368 0.032
eye photoreceptor cell development GO:0042462 81 0.032
mitotic cell cycle phase transition GO:0044772 138 0.032
protein import GO:0017038 55 0.032
cellular ketone metabolic process GO:0042180 24 0.032
anatomical structure homeostasis GO:0060249 97 0.031
organonitrogen compound metabolic process GO:1901564 318 0.031
endocytosis GO:0006897 310 0.031
purine ribonucleotide metabolic process GO:0009150 145 0.031
dendrite morphogenesis GO:0048813 199 0.030
meiotic chromosome segregation GO:0045132 59 0.030
anterior posterior axis specification GO:0009948 109 0.030
single organism cellular localization GO:1902580 180 0.030
positive regulation of phosphorus metabolic process GO:0010562 139 0.029
cellular nitrogen compound catabolic process GO:0044270 165 0.029
positive regulation of signaling GO:0023056 243 0.029
negative regulation of apoptotic process GO:0043066 63 0.029
regulation of cellular amine metabolic process GO:0033238 3 0.029
mitotic spindle organization GO:0007052 220 0.028
regulation of multicellular organism growth GO:0040014 40 0.027
Zebrafish
positive regulation of mapk cascade GO:0043410 63 0.027
oocyte differentiation GO:0009994 145 0.027
response to abiotic stimulus GO:0009628 341 0.027
neuron death GO:0070997 27 0.027
germarium derived egg chamber formation GO:0007293 101 0.026
cellular macromolecule catabolic process GO:0044265 136 0.026
positive regulation of transport GO:0051050 92 0.026
negative regulation of signal transduction GO:0009968 206 0.026
regulation of protein catabolic process GO:0042176 55 0.026
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.025
erk1 and erk2 cascade GO:0070371 39 0.025
single organism nuclear import GO:1902593 51 0.025
cell division GO:0051301 248 0.025
dna repair GO:0006281 54 0.025
positive regulation of cell development GO:0010720 61 0.025
peptidyl amino acid modification GO:0018193 105 0.025
regulation of ras protein signal transduction GO:0046578 93 0.024
regulation of cellular localization GO:0060341 136 0.024
aromatic compound catabolic process GO:0019439 166 0.024
neuroblast proliferation GO:0007405 74 0.024
nucleotide metabolic process GO:0009117 161 0.024
cellular amine metabolic process GO:0044106 12 0.024
regulation of phosphorylation GO:0042325 147 0.024
chromatin assembly or disassembly GO:0006333 52 0.024
regulation of catabolic process GO:0009894 170 0.024
mitotic g2 m transition checkpoint GO:0044818 70 0.024
double strand break repair GO:0006302 26 0.023
recombinational repair GO:0000725 13 0.023
negative regulation of mitotic cell cycle GO:0045930 109 0.023
posttranscriptional gene silencing GO:0016441 46 0.022
regulation of molecular function GO:0065009 217 0.022
oxoacid metabolic process GO:0043436 103 0.022
organic acid metabolic process GO:0006082 103 0.022
positive regulation of response to stimulus GO:0048584 323 0.022
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.022
regulation of cell morphogenesis GO:0022604 163 0.021
oocyte anterior posterior axis specification GO:0007314 72 0.021
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.021
nucleoside phosphate metabolic process GO:0006753 162 0.021
transposition GO:0032196 13 0.021
negative regulation of oskar mrna translation GO:0007319 5 0.021
rna processing GO:0006396 147 0.021
chromosome segregation GO:0007059 157 0.021
protein localization GO:0008104 284 0.021
protein catabolic process GO:0030163 101 0.020
negative regulation of meiotic cell cycle GO:0051447 2 0.020
tissue morphogenesis GO:0048729 297 0.020
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.020
macromolecule catabolic process GO:0009057 161 0.020
meiotic cell cycle process GO:1903046 132 0.020
ribonucleoside triphosphate catabolic process GO:0009203 108 0.020
protein ubiquitination GO:0016567 70 0.020
cellular amino acid metabolic process GO:0006520 61 0.020
regulation of small gtpase mediated signal transduction GO:0051056 93 0.019
regulation of cellular response to stress GO:0080135 89 0.019
regulation of cellular amino acid metabolic process GO:0006521 0 0.019
purine nucleoside triphosphate metabolic process GO:0009144 119 0.019
protein phosphorylation GO:0006468 169 0.019
localization of cell GO:0051674 257 0.019
establishment or maintenance of cell polarity GO:0007163 167 0.019
chromatin organization GO:0006325 207 0.019
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.019
dna recombination GO:0006310 32 0.018
response to biotic stimulus GO:0009607 294 0.018
Zebrafish
protein modification by small protein conjugation GO:0032446 79 0.018
negative regulation of signaling GO:0023057 219 0.018
nucleoside metabolic process GO:0009116 127 0.018
posttranscriptional gene silencing by rna GO:0035194 45 0.018
modification dependent macromolecule catabolic process GO:0043632 79 0.018
respiratory system development GO:0060541 213 0.018
embryonic axis specification GO:0000578 107 0.018
biological adhesion GO:0022610 138 0.018
purine containing compound metabolic process GO:0072521 155 0.018
posttranscriptional regulation of gene expression GO:0010608 145 0.018
regulation of phosphate metabolic process GO:0019220 210 0.018
organic cyclic compound catabolic process GO:1901361 168 0.018
regulation of apoptotic signaling pathway GO:2001233 10 0.017
amine metabolic process GO:0009308 12 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.017
dna endoreduplication GO:0042023 22 0.017
regulation of embryonic development GO:0045995 68 0.017
regulation of response to stress GO:0080134 200 0.017
positive regulation of protein catabolic process GO:0045732 34 0.017
purine ribonucleoside metabolic process GO:0046128 127 0.017
positive regulation of cell cycle GO:0045787 43 0.017
locomotory behavior GO:0007626 176 0.017
response to bacterium GO:0009617 198 0.017
nucleotide catabolic process GO:0009166 109 0.017
germarium derived oocyte fate determination GO:0007294 26 0.017
telomere maintenance GO:0000723 21 0.017
regulation of cell size GO:0008361 63 0.017
karyosome formation GO:0030717 22 0.016
purine nucleoside catabolic process GO:0006152 112 0.016
neurological system process GO:0050877 358 0.016
cellular protein localization GO:0034613 160 0.016
phagocytosis GO:0006909 215 0.016
regulation of cellular catabolic process GO:0031329 157 0.016
positive regulation of catalytic activity GO:0043085 118 0.016
purine nucleotide metabolic process GO:0006163 146 0.015
cell maturation GO:0048469 144 0.015
oocyte dorsal ventral axis specification GO:0007310 34 0.015
g2 dna damage checkpoint GO:0031572 69 0.015
secretion by cell GO:0032940 101 0.015
ribonucleotide catabolic process GO:0009261 109 0.015
mitotic sister chromatid separation GO:0051306 30 0.014
regulation of mitotic sister chromatid segregation GO:0033047 28 0.014
appendage development GO:0048736 401 0.014
oocyte maturation GO:0001556 3 0.014
pole plasm assembly GO:0007315 61 0.014
dna integrity checkpoint GO:0031570 81 0.014
negative regulation of cell communication GO:0010648 223 0.014
compound eye photoreceptor development GO:0042051 78 0.014
columnar cuboidal epithelial cell development GO:0002066 249 0.014
positive regulation of cell communication GO:0010647 250 0.014
neuron recognition GO:0008038 101 0.014
lateral inhibition GO:0046331 206 0.014
positive regulation of intracellular signal transduction GO:1902533 116 0.014
regulation of cell shape GO:0008360 113 0.014
single organism catabolic process GO:0044712 228 0.014
nucleobase containing small molecule metabolic process GO:0055086 174 0.014
positive regulation of catabolic process GO:0009896 105 0.013
positive regulation of nervous system development GO:0051962 69 0.013
carbohydrate derivative catabolic process GO:1901136 118 0.013
positive regulation of neuron differentiation GO:0045666 26 0.013
ras protein signal transduction GO:0007265 88 0.013
chromatin silencing GO:0006342 76 0.013
regulation of hydrolase activity GO:0051336 97 0.013
regulation of meiosis GO:0040020 3 0.013
positive regulation of cellular protein catabolic process GO:1903364 24 0.013
positive regulation of cellular catabolic process GO:0031331 95 0.013
modification dependent protein catabolic process GO:0019941 78 0.013
single organism cell adhesion GO:0098602 47 0.013
double strand break repair via homologous recombination GO:0000724 13 0.013
regulation of reproductive process GO:2000241 54 0.013
tube development GO:0035295 244 0.012
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.012
positive regulation of cell proliferation GO:0008284 47 0.012
wound healing GO:0042060 75 0.012
regulation of cell differentiation GO:0045595 302 0.012
nuclear transport GO:0051169 72 0.012
mrna processing GO:0006397 104 0.012
tripartite regional subdivision GO:0007351 103 0.012
regulation of proteolysis GO:0030162 87 0.012
regulation of g1 s transition of mitotic cell cycle GO:2000045 23 0.012
positive regulation of protein phosphorylation GO:0001934 34 0.012
mitotic dna integrity checkpoint GO:0044774 75 0.012
regulation of purine nucleotide metabolic process GO:1900542 62 0.012
blastoderm segmentation GO:0007350 159 0.011
positive regulation of protein transport GO:0051222 37 0.011
exocrine system development GO:0035272 162 0.011
regulation of transcription by chromatin organization GO:0034401 3 0.011
chromatin assembly GO:0031497 48 0.011
intracellular mrna localization GO:0008298 66 0.011
telomere organization GO:0032200 21 0.011
oocyte construction GO:0007308 112 0.011
immune system process GO:0002376 347 0.011
negative regulation of cellular component organization GO:0051129 108 0.011
wnt signaling pathway GO:0016055 98 0.011
heterocycle catabolic process GO:0046700 166 0.011
regulation of cellular component size GO:0032535 98 0.011
cell fate specification GO:0001708 71 0.011
maintenance of location GO:0051235 73 0.011
single organism behavior GO:0044708 391 0.011
regulation of cellular protein catabolic process GO:1903362 44 0.011
positive regulation of transcription factor import into nucleus GO:0042993 19 0.011
developmental maturation GO:0021700 172 0.011
dorsal appendage formation GO:0046843 47 0.011
purine containing compound catabolic process GO:0072523 112 0.011
protein transport GO:0015031 155 0.011
positive regulation of hydrolase activity GO:0051345 78 0.010
photoreceptor cell development GO:0042461 96 0.010
single organismal cell cell adhesion GO:0016337 45 0.010
anterior posterior pattern specification GO:0009952 136 0.010
positive regulation of molecular function GO:0044093 136 0.010
atp metabolic process GO:0046034 49 0.010
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.010
response to oxygen containing compound GO:1901700 200 0.010
positive regulation of nucleocytoplasmic transport GO:0046824 24 0.010
vesicle mediated transport GO:0016192 381 0.010
chromatin remodeling GO:0006338 72 0.010

Orc1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.044
vascular disease DOID:178 0 0.023
cardiovascular system disease DOID:1287 0 0.023
disease of cellular proliferation DOID:14566 0 0.012
cancer DOID:162 0 0.010
organ system cancer DOID:0050686 0 0.010