Drosophila melanogaster

124 known processes

Rga (Dmel_CG2161)

Regena

(Aliases: CG2161,not2,NOT2,Dmel\CG2161,CG2138,l(3)03834)

Rga biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
chromosome organization GO:0051276 360 0.901
negative regulation of cellular biosynthetic process GO:0031327 277 0.857
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.826
Human
negative regulation of nucleic acid templated transcription GO:1903507 240 0.816
Human
regulation of gene expression epigenetic GO:0040029 128 0.784
chromatin organization GO:0006325 207 0.766
covalent chromatin modification GO:0016569 106 0.671
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.665
Human
negative regulation of transcription dna templated GO:0045892 237 0.630
Human
chromatin silencing GO:0006342 76 0.581
chromatin modification GO:0016568 147 0.570
histone modification GO:0016570 106 0.536
negative regulation of gene expression GO:0010629 387 0.530
regulation of cell cycle GO:0051726 291 0.498
negative regulation of biosynthetic process GO:0009890 277 0.482
meiotic cell cycle GO:0051321 171 0.447
histone acetylation GO:0016573 38 0.415
negative regulation of cellular metabolic process GO:0031324 382 0.401
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.398
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.350
Human
negative regulation of rna metabolic process GO:0051253 251 0.348
Human
protein acetylation GO:0006473 39 0.333
negative regulation of rna biosynthetic process GO:1902679 240 0.282
Human
cellular protein modification process GO:0006464 438 0.280
regulation of mitotic cell cycle GO:0007346 190 0.279
regulation of cell cycle process GO:0010564 181 0.274
positive regulation of transcription dna templated GO:0045893 266 0.266
gene silencing GO:0016458 138 0.261
negative regulation of gene expression epigenetic GO:0045814 77 0.239
protein acylation GO:0043543 42 0.238
death GO:0016265 284 0.236
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.235
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.229
spindle organization GO:0007051 253 0.225
cell death GO:0008219 279 0.225
positive regulation of rna biosynthetic process GO:1902680 266 0.215
mrna processing GO:0006397 104 0.215
spermatid differentiation GO:0048515 114 0.205
spermatogenesis GO:0007283 200 0.197
positive regulation of cellular biosynthetic process GO:0031328 316 0.183
internal protein amino acid acetylation GO:0006475 38 0.183
transcription from rna polymerase ii promoter GO:0006366 368 0.182
Human
male gamete generation GO:0048232 201 0.181
regulation of mitotic cell cycle phase transition GO:1901990 130 0.181
regulation of protein metabolic process GO:0051246 256 0.174
rna processing GO:0006396 147 0.169
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.167
embryo development ending in birth or egg hatching GO:0009792 152 0.163
Worm
protein modification process GO:0036211 438 0.151
negative regulation of mitotic cell cycle GO:0045930 109 0.148
organelle fission GO:0048285 340 0.141
regulation of organelle organization GO:0033043 196 0.139
Human
peptidyl lysine modification GO:0018205 57 0.137
regulation of gene silencing GO:0060968 63 0.130
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.129
positive regulation of nucleic acid templated transcription GO:1903508 266 0.125
regulation of alternative mrna splicing via spliceosome GO:0000381 60 0.122
positive regulation of rna metabolic process GO:0051254 271 0.121
organic substance catabolic process GO:1901575 308 0.120
regulation of rna splicing GO:0043484 69 0.116
meiotic nuclear division GO:0007126 151 0.113
gland morphogenesis GO:0022612 145 0.097
compound eye development GO:0048749 307 0.097
regulation of chromatin silencing GO:0031935 36 0.093
regulation of cellular protein metabolic process GO:0032268 243 0.091
positive regulation of gene expression GO:0010628 290 0.084
internal peptidyl lysine acetylation GO:0018393 38 0.080
cellular catabolic process GO:0044248 372 0.079
sex differentiation GO:0007548 81 0.077
Worm
purine nucleotide metabolic process GO:0006163 146 0.075
macromolecule catabolic process GO:0009057 161 0.074
regulation of mrna processing GO:0050684 71 0.074
catabolic process GO:0009056 409 0.073
imaginal disc derived wing morphogenesis GO:0007476 337 0.070
tissue death GO:0016271 102 0.070
negative regulation of signaling GO:0023057 219 0.067
Human
nuclear division GO:0000280 332 0.066
larval development GO:0002164 104 0.066
Worm
chromatin mediated maintenance of transcription GO:0048096 7 0.064
programmed cell death GO:0012501 257 0.064
purine containing compound metabolic process GO:0072521 155 0.064
organonitrogen compound metabolic process GO:1901564 318 0.063
organonitrogen compound catabolic process GO:1901565 128 0.060
body morphogenesis GO:0010171 2 0.060
gene silencing by rna GO:0031047 57 0.058
ribonucleotide metabolic process GO:0009259 145 0.057
regulation of cell cycle phase transition GO:1901987 130 0.057
immune system process GO:0002376 347 0.057
eye development GO:0001654 323 0.057
reproductive structure development GO:0048608 74 0.055
Worm
regulation of meiosis GO:0040020 3 0.055
eye morphogenesis GO:0048592 260 0.055
histone h3 k9 acetylation GO:0043970 3 0.054
salivary gland histolysis GO:0035070 88 0.054
genitalia development GO:0048806 26 0.053
Worm
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.053
chromatin assembly or disassembly GO:0006333 52 0.052
exocrine system development GO:0035272 162 0.052
protein modification by small protein conjugation GO:0032446 79 0.051
regulation of chromosome organization GO:0033044 64 0.050
apoptotic process GO:0006915 159 0.049
rna splicing GO:0008380 83 0.049
chromatin remodeling GO:0006338 72 0.048
peptidyl lysine acetylation GO:0018394 39 0.048
reproductive system development GO:0061458 74 0.046
Worm
regulation of chromatin organization GO:1902275 32 0.046
regulation of sister chromatid cohesion GO:0007063 2 0.045
spermatid development GO:0007286 98 0.045
purine nucleoside metabolic process GO:0042278 127 0.045
organic cyclic compound catabolic process GO:1901361 168 0.045
nucleoside metabolic process GO:0009116 127 0.044
glycosyl compound catabolic process GO:1901658 112 0.043
dna metabolic process GO:0006259 227 0.043
positive regulation of gene expression epigenetic GO:0045815 16 0.042
positive regulation of biosynthetic process GO:0009891 316 0.042
regulation of chromatin modification GO:1903308 28 0.042
mrna splicing via spliceosome GO:0000398 73 0.042
photoreceptor cell differentiation GO:0046530 170 0.042
defense response GO:0006952 300 0.041
chromosome segregation GO:0007059 157 0.041
purine ribonucleoside metabolic process GO:0046128 127 0.041
vesicle mediated transport GO:0016192 381 0.040
Worm
negative regulation of response to stimulus GO:0048585 258 0.040
Human
protein modification by small protein conjugation or removal GO:0070647 106 0.040
dna repair GO:0006281 54 0.039
negative regulation of chromatin silencing GO:0031936 9 0.038
nuclear migration GO:0007097 20 0.038
dna conformation change GO:0071103 105 0.037
salivary gland development GO:0007431 162 0.036
retina development in camera type eye GO:0060041 4 0.036
growth GO:0040007 359 0.035
Worm
purine nucleoside triphosphate catabolic process GO:0009146 108 0.035
regulation of cell death GO:0010941 173 0.034
nucleotide metabolic process GO:0009117 161 0.034
protein ubiquitination GO:0016567 70 0.034
purine nucleoside catabolic process GO:0006152 112 0.034
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.034
positive regulation of catabolic process GO:0009896 105 0.034
regulation of mrna metabolic process GO:1903311 72 0.034
positive regulation of macromolecule metabolic process GO:0010604 405 0.034
peptidyl amino acid modification GO:0018193 105 0.034
negative regulation of cell cycle process GO:0010948 109 0.033
cytokinesis GO:0000910 90 0.033
negative regulation of cell cycle GO:0045786 116 0.033
histone lysine demethylation GO:0070076 6 0.032
cytoskeleton dependent cytokinesis GO:0061640 81 0.031
negative regulation of chromosome organization GO:2001251 19 0.031
negative regulation of cell communication GO:0010648 223 0.030
Human
metaphase anaphase transition of cell cycle GO:0044784 28 0.028
proteolysis GO:0006508 192 0.028
nucleoside catabolic process GO:0009164 112 0.028
regulation of protein deacetylation GO:0090311 2 0.028
ribose phosphate metabolic process GO:0019693 145 0.027
autophagic cell death GO:0048102 83 0.027
mitotic dna integrity checkpoint GO:0044774 75 0.026
salivary gland morphogenesis GO:0007435 145 0.026
nucleotide catabolic process GO:0009166 109 0.026
negative regulation of chromosome segregation GO:0051985 14 0.026
sister chromatid segregation GO:0000819 92 0.025
response to other organism GO:0051707 293 0.025
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.025
Human
regulation of mrna splicing via spliceosome GO:0048024 64 0.024
meiotic cell cycle process GO:1903046 132 0.024
regulation of catalytic activity GO:0050790 185 0.024
regulation of programmed cell death GO:0043067 152 0.024
chromosome condensation GO:0030261 41 0.024
nucleoside triphosphate catabolic process GO:0009143 108 0.024
positive regulation of protein metabolic process GO:0051247 128 0.024
histone h4 k16 acetylation GO:0043984 4 0.023
cellular component assembly involved in morphogenesis GO:0010927 151 0.023
mitotic cell cycle phase transition GO:0044772 138 0.023
ribonucleoside metabolic process GO:0009119 127 0.023
regulation of cell proliferation GO:0042127 163 0.023
cellular response to organic substance GO:0071310 132 0.022
regulation of apoptotic process GO:0042981 130 0.022
nuclear transport GO:0051169 72 0.022
protein localization to organelle GO:0033365 82 0.022
organelle assembly GO:0070925 198 0.021
Human
gonad development GO:0008406 50 0.021
Worm
regulation of catabolic process GO:0009894 170 0.021
histolysis GO:0007559 102 0.021
positive regulation of hydrolase activity GO:0051345 78 0.021
salivary gland cell autophagic cell death GO:0035071 83 0.021
purine nucleoside triphosphate metabolic process GO:0009144 119 0.021
negative regulation of organelle organization GO:0010639 56 0.021
negative regulation of signal transduction GO:0009968 206 0.021
Human
regulation of response to stress GO:0080134 200 0.020
positive regulation of chromatin silencing GO:0031937 16 0.020
development of primary sexual characteristics GO:0045137 50 0.020
Worm
negative regulation of intracellular signal transduction GO:1902532 57 0.020
negative regulation of nucleoside metabolic process GO:0045978 1 0.020
positive regulation of catalytic activity GO:0043085 118 0.020
phagocytosis GO:0006909 215 0.020
mitotic nuclear division GO:0007067 213 0.020
macromolecular complex assembly GO:0065003 256 0.020
Human
ribonucleotide catabolic process GO:0009261 109 0.019
negative regulation of cell cycle phase transition GO:1901988 103 0.019
ribonucleoside catabolic process GO:0042454 112 0.019
ras protein signal transduction GO:0007265 88 0.019
formation of a compartment boundary GO:0060288 4 0.019
compound eye morphogenesis GO:0001745 249 0.019
response to organic substance GO:0010033 284 0.019
dna templated transcription elongation GO:0006354 18 0.018
protein complex assembly GO:0006461 200 0.018
cell migration GO:0016477 238 0.018
regulation of immune system process GO:0002682 176 0.018
protein catabolic process GO:0030163 101 0.018
posttranscriptional gene silencing GO:0016441 46 0.017
macromolecule methylation GO:0043414 45 0.017
regulation of cellular catabolic process GO:0031329 157 0.017
methylation GO:0032259 47 0.017
nucleoside triphosphate metabolic process GO:0009141 120 0.017
response to external biotic stimulus GO:0043207 293 0.017
head development GO:0060322 135 0.016
ribonucleoside triphosphate metabolic process GO:0009199 119 0.016
purine ribonucleotide metabolic process GO:0009150 145 0.016
tracheal outgrowth open tracheal system GO:0007426 18 0.016
mitotic sister chromatid segregation GO:0000070 87 0.016
photoreceptor cell development GO:0042461 96 0.016
nucleobase containing compound catabolic process GO:0034655 165 0.016
negative regulation of cellular component organization GO:0051129 108 0.016
small molecule metabolic process GO:0044281 305 0.016
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.016
purine containing compound catabolic process GO:0072523 112 0.016
mitotic g2 dna damage checkpoint GO:0007095 69 0.015
regionalization GO:0003002 416 0.015
mitotic spindle organization GO:0007052 220 0.015
protein import GO:0017038 55 0.015
organophosphate metabolic process GO:0019637 195 0.015
response to abiotic stimulus GO:0009628 341 0.015
negative regulation of nucleotide metabolic process GO:0045980 4 0.014
rna splicing via transesterification reactions GO:0000375 73 0.014
single organism catabolic process GO:0044712 228 0.014
carbohydrate derivative catabolic process GO:1901136 118 0.014
protein modification by small protein removal GO:0070646 28 0.014
diterpenoid biosynthetic process GO:0016102 1 0.014
intracellular signal transduction GO:0035556 300 0.014
purine ribonucleotide catabolic process GO:0009154 109 0.014
atp metabolic process GO:0046034 49 0.014
maintenance of location GO:0051235 73 0.014
Worm
purine nucleotide catabolic process GO:0006195 109 0.013
protein targeting GO:0006605 64 0.013
response to sterol GO:0036314 34 0.013
purine ribonucleoside catabolic process GO:0046130 112 0.013
dendrite development GO:0016358 204 0.013
ubiquitin dependent protein catabolic process GO:0006511 78 0.013
nucleoside phosphate catabolic process GO:1901292 110 0.013
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.013
endocytosis GO:0006897 310 0.013
Worm
open tracheal system development GO:0007424 204 0.013
cellular nitrogen compound catabolic process GO:0044270 165 0.013
multi multicellular organism process GO:0044706 123 0.013
modification dependent macromolecule catabolic process GO:0043632 79 0.013
innate immune response GO:0045087 144 0.013
ribonucleoside monophosphate metabolic process GO:0009161 51 0.013
histone h4 k20 methylation GO:0034770 4 0.013
regulation of response to gamma radiation GO:2001228 4 0.013
synaptonemal complex organization GO:0070193 5 0.012
cellular amino acid metabolic process GO:0006520 61 0.012
carbohydrate derivative metabolic process GO:1901135 217 0.012
cell division GO:0051301 248 0.012
compound eye photoreceptor development GO:0042051 78 0.012
aromatic compound catabolic process GO:0019439 166 0.012
cellular response to dna damage stimulus GO:0006974 223 0.012
hindbrain development GO:0030902 2 0.012
nucleosome positioning GO:0016584 3 0.012
regulation of intracellular signal transduction GO:1902531 236 0.012
secondary metabolic process GO:0019748 75 0.012
cellular response to chemical stimulus GO:0070887 199 0.012
glycosyl compound metabolic process GO:1901657 127 0.012
regulation of nuclear division GO:0051783 58 0.012
nucleobase containing small molecule metabolic process GO:0055086 174 0.012
establishment of nucleus localization GO:0040023 26 0.011
small gtpase mediated signal transduction GO:0007264 88 0.011
nucleobase containing compound transport GO:0015931 56 0.011
amine metabolic process GO:0009308 12 0.011
cellular protein localization GO:0034613 160 0.011
regulation of nucleocytoplasmic transport GO:0046822 35 0.011
translation GO:0006412 69 0.011
heterocycle catabolic process GO:0046700 166 0.011
regulation of protein localization GO:0032880 76 0.011
positive regulation of organelle organization GO:0010638 65 0.011
Human
cellular protein catabolic process GO:0044257 83 0.011
regulation of defense response to virus by host GO:0050691 10 0.011
establishment of protein localization to organelle GO:0072594 62 0.011
modification dependent protein catabolic process GO:0019941 78 0.011
establishment of rna localization GO:0051236 47 0.011
nucleoside phosphate metabolic process GO:0006753 162 0.011
single organism biosynthetic process GO:0044711 206 0.010
mitochondrial membrane organization GO:0007006 3 0.010
immune response GO:0006955 246 0.010
regulation of cell division GO:0051302 72 0.010
protein complex biogenesis GO:0070271 201 0.010
chromosome organization involved in meiosis GO:0070192 10 0.010

Rga disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.022
disease of cellular proliferation DOID:14566 0 0.014