Drosophila melanogaster

21 known processes

PGRP-SC2 (Dmel_CG14745)

CG14745 gene product from transcript CG14745-RA

(Aliases: Dmel\CG14745,PGRP-SC,CG14745 PGRP,CG14745)

PGRP-SC2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
response to bacterium GO:0009617 198 0.369
Human Fly
immune response GO:0006955 246 0.350
aging GO:0007568 143 0.254
Fly
regulation of defense response GO:0031347 102 0.225
defense response GO:0006952 300 0.218
determination of adult lifespan GO:0008340 137 0.200
Fly
response to external biotic stimulus GO:0043207 293 0.186
Human Fly
immune system process GO:0002376 347 0.157
defense response to bacterium GO:0042742 178 0.148
Human Fly
regulation of immune response GO:0050776 118 0.146
defense response to gram negative bacterium GO:0050829 94 0.128
Fly
positive regulation of response to stimulus GO:0048584 323 0.124
Human Fly
multicellular organismal aging GO:0010259 140 0.105
Fly
defense response to other organism GO:0098542 225 0.104
Human Fly
regulation of immune system process GO:0002682 176 0.103
exocrine system development GO:0035272 162 0.099
tissue death GO:0016271 102 0.096
positive regulation of cell communication GO:0010647 250 0.084
regulation of multi organism process GO:0043900 131 0.081
Fly
salivary gland development GO:0007431 162 0.081
response to other organism GO:0051707 293 0.077
Human Fly
regulation of cell cycle GO:0051726 291 0.073
response to biotic stimulus GO:0009607 294 0.072
Human Fly
imaginal disc derived appendage development GO:0048737 399 0.072
gland development GO:0048732 191 0.071
regulation of intracellular signal transduction GO:1902531 236 0.071
Fly
mitotic cell cycle phase transition GO:0044772 138 0.070
regulation of response to stress GO:0080134 200 0.069
response to oxygen containing compound GO:1901700 200 0.067
Fly
cellular amino acid metabolic process GO:0006520 61 0.066
negative regulation of immune system process GO:0002683 50 0.065
humoral immune response GO:0006959 117 0.065
Fly
negative regulation of cell cycle process GO:0010948 109 0.064
imaginal disc derived appendage morphogenesis GO:0035114 395 0.063
appendage morphogenesis GO:0035107 397 0.062
cell cycle phase transition GO:0044770 140 0.062
positive regulation of signaling GO:0023056 243 0.061
activation of innate immune response GO:0002218 4 0.060
Human Fly
intracellular signal transduction GO:0035556 300 0.060
Fly
cellular response to chemical stimulus GO:0070887 199 0.060
Fly
single organism behavior GO:0044708 391 0.059
Rat
response to oxidative stress GO:0006979 86 0.059
regulation of mitotic cell cycle phase transition GO:1901990 130 0.059
organonitrogen compound metabolic process GO:1901564 318 0.058
Fly
cellular protein modification process GO:0006464 438 0.058
negative regulation of cell cycle phase transition GO:1901988 103 0.058
signal transduction by phosphorylation GO:0023014 107 0.057
Fly
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.057
g2 dna damage checkpoint GO:0031572 69 0.057
mitotic cell cycle checkpoint GO:0007093 88 0.056
protein modification process GO:0036211 438 0.056
appendage development GO:0048736 401 0.055
cell proliferation GO:0008283 299 0.054
mitotic dna integrity checkpoint GO:0044774 75 0.053
imaginal disc derived wing morphogenesis GO:0007476 337 0.052
carbohydrate derivative metabolic process GO:1901135 217 0.052
Fly
cellular catabolic process GO:0044248 372 0.052
regulation of protein metabolic process GO:0051246 256 0.052
regulation of cell cycle phase transition GO:1901987 130 0.052
homeostatic process GO:0042592 199 0.051
wing disc morphogenesis GO:0007472 344 0.051
defense response to gram positive bacterium GO:0050830 41 0.050
Human Fly
programmed cell death GO:0012501 257 0.050
regulation of cell cycle process GO:0010564 181 0.049
gland morphogenesis GO:0022612 145 0.049
mitotic g2 m transition checkpoint GO:0044818 70 0.049
developmental programmed cell death GO:0010623 138 0.049
salivary gland morphogenesis GO:0007435 145 0.048
regulation of mitotic cell cycle GO:0007346 190 0.048
salivary gland cell autophagic cell death GO:0035071 83 0.048
oxoacid metabolic process GO:0043436 103 0.048
innate immune response GO:0045087 144 0.047
small molecule metabolic process GO:0044281 305 0.046
organic hydroxy compound metabolic process GO:1901615 83 0.046
Fly
negative regulation of cellular metabolic process GO:0031324 382 0.046
Fly
death GO:0016265 284 0.045
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.044
sterol homeostasis GO:0055092 4 0.044
positive regulation of biosynthetic process GO:0009891 316 0.043
Fly
microtubule organizing center organization GO:0031023 168 0.043
dna damage checkpoint GO:0000077 78 0.043
compound eye morphogenesis GO:0001745 249 0.042
mitotic g2 dna damage checkpoint GO:0007095 69 0.042
cell cycle checkpoint GO:0000075 95 0.041
response to abiotic stimulus GO:0009628 341 0.041
mapk cascade GO:0000165 107 0.041
Fly
cell death GO:0008219 279 0.041
regulation of cellular protein metabolic process GO:0032268 243 0.039
response to organonitrogen compound GO:0010243 75 0.039
Fly
regulation of phosphorus metabolic process GO:0051174 210 0.039
Fly
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.039
Fly
single organism catabolic process GO:0044712 228 0.039
centrosome organization GO:0051297 163 0.038
regulation of cellular amino acid metabolic process GO:0006521 0 0.038
dna integrity checkpoint GO:0031570 81 0.038
cellular amine metabolic process GO:0044106 12 0.038
regulation of transport GO:0051049 181 0.038
amine metabolic process GO:0009308 12 0.037
catabolic process GO:0009056 409 0.036
Fly
histolysis GO:0007559 102 0.036
regulation of innate immune response GO:0045088 71 0.035
carbohydrate derivative biosynthetic process GO:1901137 85 0.035
negative regulation of response to stimulus GO:0048585 258 0.034
cellular response to oxidative stress GO:0034599 28 0.034
protein phosphorylation GO:0006468 169 0.034
autophagic cell death GO:0048102 83 0.034
response to endogenous stimulus GO:0009719 119 0.033
Fly
regulation of phosphorylation GO:0042325 147 0.033
Fly
post embryonic appendage morphogenesis GO:0035120 385 0.033
growth GO:0040007 359 0.033
Mouse
regulation of cellular amine metabolic process GO:0033238 3 0.033
cellular response to organic substance GO:0071310 132 0.033
Fly
response to nitrogen compound GO:1901698 90 0.033
Fly
cellular response to lipopolysaccharide GO:0071222 3 0.032
Fly
phosphorylation GO:0016310 294 0.032
Fly
neurological system process GO:0050877 358 0.032
carboxylic acid metabolic process GO:0019752 92 0.031
anatomical structure homeostasis GO:0060249 97 0.031
localization of cell GO:0051674 257 0.031
cation transport GO:0006812 110 0.031
negative regulation of mitotic cell cycle GO:0045930 109 0.031
locomotory behavior GO:0007626 176 0.030
negative regulation of cell communication GO:0010648 223 0.030
Fly
positive regulation of cellular amine metabolic process GO:0033240 0 0.030
salivary gland histolysis GO:0035070 88 0.030
organic substance catabolic process GO:1901575 308 0.030
Fly
positive regulation of immune system process GO:0002684 68 0.030
Human Fly
autophagy GO:0006914 108 0.030
positive regulation of lipid metabolic process GO:0045834 4 0.030
cellular response to dna damage stimulus GO:0006974 223 0.029
vesicle mediated transport GO:0016192 381 0.029
positive regulation of signal transduction GO:0009967 223 0.029
centrosome cycle GO:0007098 137 0.029
transcription from rna polymerase ii promoter GO:0006366 368 0.029
stress activated protein kinase signaling cascade GO:0031098 55 0.029
Fly
rhythmic process GO:0048511 106 0.028
Rat
regulation of localization GO:0032879 275 0.028
regulation of cellular ketone metabolic process GO:0010565 3 0.028
regulation of programmed cell death GO:0043067 152 0.028
response to lipopolysaccharide GO:0032496 4 0.028
Fly
negative regulation of defense response GO:0031348 35 0.027
regulation of phosphate metabolic process GO:0019220 210 0.027
Fly
eye morphogenesis GO:0048592 260 0.027
single organism biosynthetic process GO:0044711 206 0.026
positive regulation of cell migration GO:0030335 2 0.026
protein localization GO:0008104 284 0.026
regulation of cell proliferation GO:0042127 163 0.026
developmental growth GO:0048589 280 0.026
kidney development GO:0001822 3 0.025
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.025
regulation of cell death GO:0010941 173 0.025
negative regulation of phosphorylation GO:0042326 35 0.025
Fly
endocytosis GO:0006897 310 0.025
positive regulation of macromolecule metabolic process GO:0010604 405 0.025
compound eye development GO:0048749 307 0.025
single organism intracellular transport GO:1902582 207 0.025
ethanolamine containing compound metabolic process GO:0042439 4 0.025
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.024
regulation of cell differentiation GO:0045595 302 0.024
Mouse
phosphatidic acid metabolic process GO:0046473 1 0.024
epithelial cell differentiation GO:0030855 322 0.024
protein complex biogenesis GO:0070271 201 0.024
organic acid metabolic process GO:0006082 103 0.024
proteolysis GO:0006508 192 0.024
regulation of autophagy GO:0010506 62 0.024
regulation of behavior GO:0050795 75 0.024
Rat
cellular response to oxygen containing compound GO:1901701 79 0.023
Fly
segmentation GO:0035282 207 0.023
body morphogenesis GO:0010171 2 0.023
organonitrogen compound catabolic process GO:1901565 128 0.023
Fly
organonitrogen compound biosynthetic process GO:1901566 117 0.023
Fly
macromolecular complex assembly GO:0065003 256 0.023
regulation of catalytic activity GO:0050790 185 0.023
regulation of multicellular organismal development GO:2000026 414 0.023
Mouse
negative regulation of cell cycle GO:0045786 116 0.023
antimicrobial humoral response GO:0019730 99 0.023
Fly
respiratory system development GO:0060541 213 0.022
negative regulation of gene expression GO:0010629 387 0.022
negative regulation of protein metabolic process GO:0051248 85 0.022
chromosome organization GO:0051276 360 0.022
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.022
regulation of cellular catabolic process GO:0031329 157 0.022
eye development GO:0001654 323 0.022
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.022
positive regulation of phosphate metabolic process GO:0045937 139 0.022
regulation of molecular function GO:0065009 217 0.022
acylglycerol catabolic process GO:0046464 3 0.022
protein complex assembly GO:0006461 200 0.022
wnt signaling pathway GO:0016055 98 0.021
central nervous system development GO:0007417 201 0.021
camera type eye development GO:0043010 4 0.021
negative regulation of immune response GO:0050777 39 0.021
cellular macromolecule localization GO:0070727 220 0.021
regulation of protein kinase activity GO:0045859 51 0.021
negative regulation of phosphate metabolic process GO:0045936 45 0.021
Fly
phagocytosis GO:0006909 215 0.021
nucleobase containing small molecule metabolic process GO:0055086 174 0.021
positive regulation of cellular protein metabolic process GO:0032270 118 0.021
negative regulation of cell differentiation GO:0045596 143 0.020
Mouse
positive regulation of defense response GO:0031349 59 0.020
Human Fly
response to fungus GO:0009620 50 0.020
response to radiation GO:0009314 155 0.020
jnk cascade GO:0007254 50 0.020
Fly
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.020
immune effector process GO:0002252 98 0.020
Mouse Fly
cell migration GO:0016477 238 0.020
columnar cuboidal epithelial cell development GO:0002066 249 0.020
regulation of reproductive process GO:2000241 54 0.020
ovarian follicle cell development GO:0030707 248 0.020
forebrain development GO:0030900 2 0.020
protein transport GO:0015031 155 0.020
long term memory GO:0007616 62 0.019
multi organism behavior GO:0051705 175 0.019
purine containing compound metabolic process GO:0072521 155 0.019
enzyme linked receptor protein signaling pathway GO:0007167 179 0.019
cellular response to molecule of bacterial origin GO:0071219 3 0.019
Fly
stress activated mapk cascade GO:0051403 52 0.019
Fly
positive regulation of cell motility GO:2000147 3 0.019
phosphatidylethanolamine metabolic process GO:0046337 1 0.019
response to copper ion GO:0046688 4 0.019
morphogenesis of an epithelium GO:0002009 276 0.019
translation GO:0006412 69 0.019
multicellular organismal reproductive behavior GO:0033057 110 0.019
circadian rhythm GO:0007623 105 0.019
Rat
epithelial cell development GO:0002064 274 0.019
positive regulation of immune response GO:0050778 63 0.019
Human Fly
nucleoside phosphate metabolic process GO:0006753 162 0.019
macromolecule catabolic process GO:0009057 161 0.019
Fly
neuron death GO:0070997 27 0.019
glycerolipid catabolic process GO:0046503 3 0.019
triglyceride catabolic process GO:0019433 3 0.019
regulation of cellular component biogenesis GO:0044087 201 0.019
establishment of protein localization GO:0045184 163 0.018
positive regulation of transport GO:0051050 92 0.018
myotube differentiation GO:0014902 46 0.018
negative regulation of cellular protein metabolic process GO:0032269 85 0.018
apoptotic process GO:0006915 159 0.018
glycosyl compound metabolic process GO:1901657 127 0.018
regulation of apoptotic process GO:0042981 130 0.018
regulation of response to external stimulus GO:0032101 115 0.018
Fly
positive regulation of cellular biosynthetic process GO:0031328 316 0.018
Fly
regulation of response to biotic stimulus GO:0002831 63 0.018
Fly
kidney epithelium development GO:0072073 3 0.018
negative regulation of nucleic acid templated transcription GO:1903507 240 0.018
organic substance transport GO:0071702 257 0.018
Fly
positive regulation of reactive oxygen species metabolic process GO:2000379 0 0.018
positive regulation of rna metabolic process GO:0051254 271 0.018
positive regulation of phosphorus metabolic process GO:0010562 139 0.018
epithelium migration GO:0090132 148 0.017
positive regulation of molecular function GO:0044093 136 0.017
cellular ketone metabolic process GO:0042180 24 0.017
vitamin biosynthetic process GO:0009110 1 0.017
leg disc development GO:0035218 92 0.017
regulation of transferase activity GO:0051338 58 0.017
single organism cellular localization GO:1902580 180 0.017
negative regulation of signaling GO:0023057 219 0.017
Fly
catechol containing compound biosynthetic process GO:0009713 3 0.017
cellular amide metabolic process GO:0043603 80 0.017
Fly
purine nucleotide metabolic process GO:0006163 146 0.017
digestive system development GO:0055123 149 0.017
positive regulation of phosphorylation GO:0042327 87 0.017
cognition GO:0050890 141 0.017
catecholamine biosynthetic process GO:0042423 3 0.017
positive regulation of protein metabolic process GO:0051247 128 0.017
myotube cell development GO:0014904 3 0.017
ribonucleoside metabolic process GO:0009119 127 0.017
organophosphate catabolic process GO:0046434 112 0.017
regulation of mapk cascade GO:0043408 92 0.016
Fly
open tracheal system development GO:0007424 204 0.016
cytoplasmic transport GO:0016482 130 0.016
tissue homeostasis GO:0001894 36 0.016
purine nucleoside metabolic process GO:0042278 127 0.016
embryonic development via the syncytial blastoderm GO:0001700 148 0.016
regulation of proteolysis GO:0030162 87 0.016
developmental pigmentation GO:0048066 68 0.016
small gtpase mediated signal transduction GO:0007264 88 0.016
cholesterol homeostasis GO:0042632 3 0.016
establishment of tissue polarity GO:0007164 87 0.016
positive regulation of multi organism process GO:0043902 40 0.016
Fly
nucleoside metabolic process GO:0009116 127 0.016
response to organic substance GO:0010033 284 0.016
Fly
extrinsic apoptotic signaling pathway GO:0097191 1 0.016
anion homeostasis GO:0055081 3 0.016
regulation of growth GO:0040008 233 0.016
connective tissue development GO:0061448 3 0.016
regulation of immune effector process GO:0002697 52 0.016
Mouse Fly
hematopoietic progenitor cell differentiation GO:0002244 1 0.016
production of molecular mediator of immune response GO:0002440 46 0.016
Fly
negative regulation of programmed cell death GO:0043069 72 0.016
peptidyl amino acid modification GO:0018193 105 0.016
negative regulation of cell death GO:0060548 81 0.016
cholesterol transport GO:0030301 2 0.016
phenol containing compound metabolic process GO:0018958 57 0.015
Fly
positive regulation of catalytic activity GO:0043085 118 0.015
carbohydrate metabolic process GO:0005975 82 0.015
regionalization GO:0003002 416 0.015
establishment of planar polarity GO:0001736 87 0.015
neutral lipid metabolic process GO:0006638 12 0.015
mitotic dna damage checkpoint GO:0044773 74 0.015
cellular response to endogenous stimulus GO:0071495 80 0.015
regulation of antimicrobial peptide biosynthetic process GO:0002805 38 0.015
Fly
positive regulation of cellular catabolic process GO:0031331 95 0.015
organ growth GO:0035265 56 0.015
purine ribonucleotide metabolic process GO:0009150 145 0.015
positive regulation of developmental process GO:0051094 143 0.015
regulation of neuron death GO:1901214 26 0.015
negative regulation of biosynthetic process GO:0009890 277 0.015
pigment metabolic process GO:0042440 84 0.015
Fly
positive regulation of mapk cascade GO:0043410 63 0.015
response to insulin GO:0032868 29 0.015
nucleotide metabolic process GO:0009117 161 0.014
ras protein signal transduction GO:0007265 88 0.014
glycosaminoglycan catabolic process GO:0006027 3 0.014
Fly
reproductive behavior GO:0019098 122 0.014
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.014
negative regulation of phosphorus metabolic process GO:0010563 45 0.014
Fly
positive regulation of immune effector process GO:0002699 28 0.014
Fly
immune response regulating signaling pathway GO:0002764 2 0.014
Human Fly
cellular response to starvation GO:0009267 61 0.014
memory GO:0007613 94 0.014
phosphatidylinositol mediated signaling GO:0048015 4 0.014
learning or memory GO:0007611 141 0.014
ribose phosphate metabolic process GO:0019693 145 0.014
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.014
regulation of establishment of protein localization GO:0070201 61 0.014
purine nucleoside triphosphate metabolic process GO:0009144 119 0.014
lipid metabolic process GO:0006629 121 0.014
regulation of anatomical structure size GO:0090066 163 0.014
response to organophosphorus GO:0046683 2 0.014
response to organic cyclic compound GO:0014070 89 0.014
lipopolysaccharide mediated signaling pathway GO:0031663 1 0.014
Fly
single organism carbohydrate metabolic process GO:0044723 72 0.014
chemical homeostasis GO:0048878 92 0.014
insulin receptor signaling pathway GO:0008286 25 0.014
ribonucleoside biosynthetic process GO:0042455 3 0.014
negative regulation of molecular function GO:0044092 51 0.014
stem cell proliferation GO:0072089 88 0.014
intracellular transport GO:0046907 228 0.014
somatic muscle development GO:0007525 66 0.014
neutral lipid catabolic process GO:0046461 3 0.014
peptidyl threonine phosphorylation GO:0018107 2 0.014
amide biosynthetic process GO:0043604 42 0.014
Fly
positive regulation of intracellular signal transduction GO:1902533 116 0.014
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.013
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 25 0.013
chromatin modification GO:0016568 147 0.013
response to extracellular stimulus GO:0009991 116 0.013
tissue migration GO:0090130 155 0.013
tissue morphogenesis GO:0048729 297 0.013
regulation of translation GO:0006417 56 0.013
muscle organ development GO:0007517 127 0.013
response to nutrient levels GO:0031667 114 0.013
response to hypoxia GO:0001666 53 0.013
positive regulation of response to biotic stimulus GO:0002833 31 0.013
Fly
response to inorganic substance GO:0010035 44 0.013
mitotic nuclear division GO:0007067 213 0.013
alditol phosphate metabolic process GO:0052646 2 0.013
positive regulation of transcription dna templated GO:0045893 266 0.013
regulation of notch signaling pathway GO:0008593 100 0.013
positive regulation of programmed cell death GO:0043068 62 0.013
regulation of developmental growth GO:0048638 174 0.013
metal ion transport GO:0030001 74 0.013
regulation of organelle organization GO:0033043 196 0.013
regulation of cellular amide metabolic process GO:0034248 39 0.013
Fly
stem cell differentiation GO:0048863 117 0.013
retina development in camera type eye GO:0060041 4 0.013
protein maturation GO:0051604 71 0.013
protein catabolic process GO:0030163 101 0.013
positive regulation of cellular component organization GO:0051130 156 0.013
nucleoside triphosphate metabolic process GO:0009141 120 0.013
regulation of protein modification process GO:0031399 112 0.013
positive regulation of catabolic process GO:0009896 105 0.013
negative regulation of autophagy GO:0010507 16 0.013
cellular response to biotic stimulus GO:0071216 4 0.013
Fly
immune system development GO:0002520 57 0.013
Mouse
muscle structure development GO:0061061 224 0.013
regulation of protein phosphorylation GO:0001932 64 0.013
actin cytoskeleton organization GO:0030036 206 0.013
negative regulation of epithelial cell proliferation GO:0050680 4 0.012
camera type eye morphogenesis GO:0048593 2 0.012
developmental maturation GO:0021700 172 0.012
ameboidal type cell migration GO:0001667 151 0.012
molting cycle chitin based cuticle GO:0007591 56 0.012
regulation of lipid transport GO:0032368 3 0.012
intracellular protein transport GO:0006886 104 0.012
signal transduction in response to dna damage GO:0042770 3 0.012
epithelial cell migration GO:0010631 148 0.012
telencephalon development GO:0021537 2 0.012
secretion GO:0046903 109 0.012
cellular ion homeostasis GO:0006873 39 0.012
negative regulation of apoptotic process GO:0043066 63 0.012
notch signaling pathway GO:0007219 120 0.012
ribonucleotide metabolic process GO:0009259 145 0.012
mesenchymal cell differentiation GO:0048762 1 0.012
sensory organ morphogenesis GO:0090596 260 0.012
actin filament based process GO:0030029 220 0.012
cellular response to abiotic stimulus GO:0071214 58 0.012
regulation of cell development GO:0060284 215 0.012
purine ribonucleoside metabolic process GO:0046128 127 0.012
neuron fate commitment GO:0048663 50 0.012
cellular macromolecular complex assembly GO:0034622 153 0.012
peptide biosynthetic process GO:0043043 42 0.012
Fly
regulation of antimicrobial peptide production GO:0002784 44 0.012
Fly
negative regulation of multicellular organismal process GO:0051241 142 0.012
Mouse
ribose phosphate biosynthetic process GO:0046390 28 0.012
regulation of cell substrate adhesion GO:0010810 2 0.012
convergent extension GO:0060026 2 0.012
cell cycle arrest GO:0007050 4 0.012
adult behavior GO:0030534 137 0.012
biological adhesion GO:0022610 138 0.012
response to light stimulus GO:0009416 124 0.012
carbohydrate derivative catabolic process GO:1901136 118 0.012
Fly
regulation of steroid metabolic process GO:0019218 2 0.012
regulation of system process GO:0044057 36 0.012
tube development GO:0035295 244 0.012
cell motility GO:0048870 251 0.012
positive regulation of gene expression GO:0010628 290 0.012
taxis GO:0042330 304 0.012
endomembrane system organization GO:0010256 119 0.012
inositol lipid mediated signaling GO:0048017 4 0.012
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 3 0.012
response to oxygen levels GO:0070482 59 0.012
negative regulation of catalytic activity GO:0043086 42 0.012
response to wounding GO:0009611 94 0.011
hindbrain development GO:0030902 2 0.011
immune response activating signal transduction GO:0002757 2 0.011
Human Fly
positive regulation of response to external stimulus GO:0032103 44 0.011
Fly
cell adhesion GO:0007155 136 0.011
negative regulation of innate immune response GO:0045824 30 0.011
antimicrobial peptide production GO:0002775 46 0.011
Fly
purine nucleotide catabolic process GO:0006195 109 0.011
cellular response to hormone stimulus GO:0032870 44 0.011
positive regulation of nucleic acid templated transcription GO:1903508 266 0.011
acylglycerol biosynthetic process GO:0046463 2 0.011
embryonic pattern specification GO:0009880 174 0.011
positive regulation of neuron apoptotic process GO:0043525 1 0.011
regulation of protein deacetylation GO:0090311 2 0.011
negative regulation of signal transduction GO:0009968 206 0.011
Fly
negative regulation of transcription dna templated GO:0045892 237 0.011
circadian sleep wake cycle GO:0042745 28 0.011
Rat
establishment of localization in cell GO:0051649 402 0.011
cellular protein complex assembly GO:0043623 71 0.011
chromatin remodeling GO:0006338 72 0.011
positive regulation of defense response to bacterium GO:1900426 23 0.011
Fly
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 4 0.011
gene silencing GO:0016458 138 0.011
dendrite morphogenesis GO:0048813 199 0.011
regulation of production of molecular mediator of immune response GO:0002700 44 0.011
Fly
phosphatidylinositol 3 kinase signaling GO:0014065 4 0.011
response to glucose GO:0009749 2 0.011
regulation of cytoplasmic transport GO:1903649 47 0.011
cellular response to nutrient levels GO:0031669 62 0.011
pyridine containing compound metabolic process GO:0072524 3 0.011
regulation of histone deacetylation GO:0031063 2 0.011
regulation of insulin receptor signaling pathway GO:0046626 17 0.011
melanization defense response GO:0035006 45 0.011
Fly
cellular homeostasis GO:0019725 80 0.011
nucleotide catabolic process GO:0009166 109 0.011
nitrogen compound transport GO:0071705 85 0.011
Fly
positive regulation of protein modification process GO:0031401 58 0.011
imaginal disc pattern formation GO:0007447 91 0.011
cell type specific apoptotic process GO:0097285 38 0.011
positive regulation of cell death GO:0010942 69 0.011
cellular response to carbohydrate stimulus GO:0071322 4 0.011
peptide metabolic process GO:0006518 80 0.011
Fly
aminoglycan metabolic process GO:0006022 18 0.011
Fly
positive regulation of protein deacetylation GO:0090312 2 0.011
heterocycle catabolic process GO:0046700 166 0.011
stem cell development GO:0048864 79 0.011
molting cycle GO:0042303 56 0.011
transmembrane transport GO:0055085 139 0.011
aromatic compound catabolic process GO:0019439 166 0.011
positive regulation of i kappab kinase nf kappab signaling GO:0043123 1 0.011
posttranscriptional regulation of gene expression GO:0010608 145 0.011
protein processing GO:0016485 68 0.011
cation homeostasis GO:0055080 51 0.011
cellular response to monosaccharide stimulus GO:0071326 2 0.011

PGRP-SC2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.044
acquired metabolic disease DOID:0060158 0 0.044
disease of anatomical entity DOID:7 0 0.033
cardiovascular system disease DOID:1287 0 0.017
musculoskeletal system disease DOID:17 0 0.016
cancer DOID:162 0 0.016
disease of cellular proliferation DOID:14566 0 0.016
organ system cancer DOID:0050686 0 0.016
familial hyperlipidemia DOID:1168 0 0.014
lipid metabolism disorder DOID:3146 0 0.014
inherited metabolic disorder DOID:655 0 0.014
nervous system disease DOID:863 0 0.014
familial combined hyperlipidemia DOID:13809 0 0.014
carbohydrate metabolism disease DOID:0050013 0 0.012
integumentary system disease DOID:16 0 0.011
glucose metabolism disease DOID:4194 0 0.011
amyloidosis DOID:9120 0 0.011
familial visceral amyloidosis DOID:0050636 0 0.011