Drosophila melanogaster

9 known processes

dtr (Dmel_CG31623)

defective transmitter release

(Aliases: CG31623,Dmel\CG31623)

dtr biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of multicellular organismal development GO:2000026 414 0.057
regionalization GO:0003002 416 0.040
cellular protein modification process GO:0006464 438 0.040
organonitrogen compound metabolic process GO:1901564 318 0.038
regulation of localization GO:0032879 275 0.035
protein modification process GO:0036211 438 0.034
epithelial cell development GO:0002064 274 0.034
negative regulation of response to stimulus GO:0048585 258 0.033
eye development GO:0001654 323 0.033
establishment of localization in cell GO:0051649 402 0.033
compound eye development GO:0048749 307 0.032
blastoderm segmentation GO:0007350 159 0.032
intracellular signal transduction GO:0035556 300 0.031
negative regulation of cellular metabolic process GO:0031324 382 0.031
small molecule metabolic process GO:0044281 305 0.030
columnar cuboidal epithelial cell development GO:0002066 249 0.029
segmentation GO:0035282 207 0.029
catabolic process GO:0009056 409 0.029
positive regulation of response to stimulus GO:0048584 323 0.029
negative regulation of biosynthetic process GO:0009890 277 0.029
negative regulation of rna biosynthetic process GO:1902679 240 0.029
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.028
cell maturation GO:0048469 144 0.028
single organism behavior GO:0044708 391 0.028
camera type eye development GO:0043010 4 0.028
developmental maturation GO:0021700 172 0.028
protein localization GO:0008104 284 0.027
endocytosis GO:0006897 310 0.027
organic substance transport GO:0071702 257 0.027
epithelial cell differentiation GO:0030855 322 0.027
body morphogenesis GO:0010171 2 0.027
appendage development GO:0048736 401 0.027
spermatogenesis GO:0007283 200 0.027
negative regulation of cell communication GO:0010648 223 0.027
regulation of cell cycle GO:0051726 291 0.027
phosphorylation GO:0016310 294 0.027
regulation of cell differentiation GO:0045595 302 0.026
cellular amino acid metabolic process GO:0006520 61 0.026
negative regulation of cellular biosynthetic process GO:0031327 277 0.026
negative regulation of gene expression GO:0010629 387 0.026
oxoacid metabolic process GO:0043436 103 0.025
localization of cell GO:0051674 257 0.025
phagocytosis GO:0006909 215 0.025
negative regulation of developmental process GO:0051093 201 0.025
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.025
transcription from rna polymerase ii promoter GO:0006366 368 0.025
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.025
regulation of nervous system development GO:0051960 248 0.025
male gamete generation GO:0048232 201 0.025
positive regulation of macromolecule metabolic process GO:0010604 405 0.024
negative regulation of signal transduction GO:0009968 206 0.024
appendage morphogenesis GO:0035107 397 0.024
cellular macromolecule localization GO:0070727 220 0.024
positive regulation of signaling GO:0023056 243 0.024
regulation of cellular amine metabolic process GO:0033238 3 0.024
imaginal disc derived appendage development GO:0048737 399 0.024
negative regulation of signaling GO:0023057 219 0.024
forebrain development GO:0030900 2 0.024
organic acid metabolic process GO:0006082 103 0.023
embryonic pattern specification GO:0009880 174 0.023
cell motility GO:0048870 251 0.023
post embryonic appendage morphogenesis GO:0035120 385 0.023
wing disc morphogenesis GO:0007472 344 0.023
chromosome organization GO:0051276 360 0.023
response to lipopolysaccharide GO:0032496 4 0.023
defense response GO:0006952 300 0.023
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.023
carboxylic acid metabolic process GO:0019752 92 0.022
imaginal disc derived appendage morphogenesis GO:0035114 395 0.022
regulation of cellular component biogenesis GO:0044087 201 0.022
organic substance catabolic process GO:1901575 308 0.022
positive regulation of cell communication GO:0010647 250 0.022
ovarian follicle cell development GO:0030707 248 0.022
response to abiotic stimulus GO:0009628 341 0.022
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.022
regulation of cellular ketone metabolic process GO:0010565 3 0.022
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.022
oocyte construction GO:0007308 112 0.022
vesicle mediated transport GO:0016192 381 0.021
negative regulation of transcription dna templated GO:0045892 237 0.021
regulation of response to stress GO:0080134 200 0.021
response to radiation GO:0009314 155 0.021
cellular amine metabolic process GO:0044106 12 0.021
cellular catabolic process GO:0044248 372 0.021
amine metabolic process GO:0009308 12 0.021
positive regulation of signal transduction GO:0009967 223 0.021
imaginal disc derived wing morphogenesis GO:0007476 337 0.021
axis specification GO:0009798 167 0.020
eye morphogenesis GO:0048592 260 0.020
central nervous system development GO:0007417 201 0.020
regulation of epithelial cell differentiation GO:0030856 4 0.020
embryonic axis specification GO:0000578 107 0.020
negative regulation of nucleic acid templated transcription GO:1903507 240 0.020
positive regulation of nucleic acid templated transcription GO:1903508 266 0.020
regulation of cell development GO:0060284 215 0.020
positive regulation of biosynthetic process GO:0009891 316 0.020
mating GO:0007618 120 0.019
developmental programmed cell death GO:0010623 138 0.019
negative regulation of rna metabolic process GO:0051253 251 0.019
intracellular transport GO:0046907 228 0.019
oocyte differentiation GO:0009994 145 0.019
morphogenesis of an epithelium GO:0002009 276 0.019
organelle fission GO:0048285 340 0.019
cell projection assembly GO:0030031 94 0.018
response to other organism GO:0051707 293 0.018
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.018
chromatin modification GO:0016568 147 0.018
cell death GO:0008219 279 0.018
single organism cellular localization GO:1902580 180 0.018
retina development in camera type eye GO:0060041 4 0.018
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.018
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.018
regulation of mitotic cell cycle GO:0007346 190 0.018
compound eye morphogenesis GO:0001745 249 0.018
tripartite regional subdivision GO:0007351 103 0.017
regulation of cellular amino acid metabolic process GO:0006521 0 0.017
neurological system process GO:0050877 358 0.017
response to external biotic stimulus GO:0043207 293 0.017
regulation of anatomical structure morphogenesis GO:0022603 242 0.017
immune system process GO:0002376 347 0.017
ameboidal type cell migration GO:0001667 151 0.017
nuclear division GO:0000280 332 0.017
detection of stimulus GO:0051606 156 0.017
homeostatic process GO:0042592 199 0.017
sensory organ morphogenesis GO:0090596 260 0.017
cellular macromolecule catabolic process GO:0044265 136 0.017
positive regulation of cellular biosynthetic process GO:0031328 316 0.017
regulation of immune system process GO:0002682 176 0.017
anterior posterior pattern specification GO:0009952 136 0.017
carbohydrate derivative metabolic process GO:1901135 217 0.017
locomotory behavior GO:0007626 176 0.017
macromolecule catabolic process GO:0009057 161 0.017
growth GO:0040007 359 0.016
regulation of intracellular signal transduction GO:1902531 236 0.016
cell migration GO:0016477 238 0.016
peptidyl amino acid modification GO:0018193 105 0.016
cellular response to dna damage stimulus GO:0006974 223 0.016
regulation of growth GO:0040008 233 0.016
response to organic substance GO:0010033 284 0.016
regulation of transport GO:0051049 181 0.016
positive regulation of rna biosynthetic process GO:1902680 266 0.016
positive regulation of rna metabolic process GO:0051254 271 0.016
kidney development GO:0001822 3 0.016
regulation of protein metabolic process GO:0051246 256 0.016
cellular component assembly involved in morphogenesis GO:0010927 151 0.016
response to bacterium GO:0009617 198 0.016
single organism biosynthetic process GO:0044711 206 0.016
immune response GO:0006955 246 0.016
photoreceptor cell differentiation GO:0046530 170 0.016
mitotic nuclear division GO:0007067 213 0.016
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.016
positive regulation of cell motility GO:2000147 3 0.016
posttranscriptional regulation of gene expression GO:0010608 145 0.015
tissue morphogenesis GO:0048729 297 0.015
anterior posterior axis specification GO:0009948 109 0.015
spindle organization GO:0007051 253 0.015
dendrite morphogenesis GO:0048813 199 0.015
cellular ketone metabolic process GO:0042180 24 0.015
regulation of cellular protein metabolic process GO:0032268 243 0.015
chromatin organization GO:0006325 207 0.015
response to biotic stimulus GO:0009607 294 0.015
cell cell signaling involved in cell fate commitment GO:0045168 210 0.015
salivary gland development GO:0007431 162 0.015
small gtpase mediated signal transduction GO:0007264 88 0.015
regulation of cellular localization GO:0060341 136 0.015
single organism intracellular transport GO:1902582 207 0.015
regulation of phosphate metabolic process GO:0019220 210 0.015
Mouse
proteolysis GO:0006508 192 0.015
negative regulation of cell differentiation GO:0045596 143 0.015
negative regulation of nervous system development GO:0051961 92 0.015
positive regulation of cell migration GO:0030335 2 0.015
single organism catabolic process GO:0044712 228 0.015
lateral inhibition GO:0046331 206 0.014
rna localization GO:0006403 115 0.014
negative regulation of multicellular organismal process GO:0051241 142 0.014
oocyte axis specification GO:0007309 108 0.014
optomotor response GO:0071632 3 0.014
macromolecular complex assembly GO:0065003 256 0.014
positive regulation of defense response GO:0031349 59 0.014
dendrite development GO:0016358 204 0.014
rna processing GO:0006396 147 0.014
mapk cascade GO:0000165 107 0.014
cellular nitrogen compound catabolic process GO:0044270 165 0.014
response to temperature stimulus GO:0009266 106 0.014
tube development GO:0035295 244 0.014
ion transport GO:0006811 145 0.014
positive regulation of gene expression GO:0010628 290 0.014
heterocycle catabolic process GO:0046700 166 0.014
organophosphate metabolic process GO:0019637 195 0.014
regulation of phosphorus metabolic process GO:0051174 210 0.014
Mouse
nucleoside phosphate metabolic process GO:0006753 162 0.014
modification dependent protein catabolic process GO:0019941 78 0.014
oocyte development GO:0048599 124 0.014
adult behavior GO:0030534 137 0.014
regulation of response to external stimulus GO:0032101 115 0.014
sterol homeostasis GO:0055092 4 0.014
nucleobase containing compound catabolic process GO:0034655 165 0.014
hindbrain development GO:0030902 2 0.014
exocrine system development GO:0035272 162 0.014
limb development GO:0060173 1 0.013
anterior posterior axis specification embryo GO:0008595 103 0.013
eggshell formation GO:0030703 105 0.013
taxis GO:0042330 304 0.013
cellular response to chemical stimulus GO:0070887 199 0.013
ras protein signal transduction GO:0007265 88 0.013
cell division GO:0051301 248 0.013
photoreceptor cell development GO:0042461 96 0.013
nucleotide metabolic process GO:0009117 161 0.013
cellular response to abiotic stimulus GO:0071214 58 0.013
axonogenesis GO:0007409 290 0.013
protein phosphorylation GO:0006468 169 0.013
connective tissue development GO:0061448 3 0.013
regulation of multi organism process GO:0043900 131 0.013
protein complex assembly GO:0006461 200 0.013
regulation of cell cycle process GO:0010564 181 0.013
mrna metabolic process GO:0016071 124 0.013
g protein coupled receptor signaling pathway GO:0007186 136 0.013
regulation of mapk cascade GO:0043408 92 0.013
developmental growth GO:0048589 280 0.013
salivary gland morphogenesis GO:0007435 145 0.013
endomembrane system organization GO:0010256 119 0.013
regulation of defense response GO:0031347 102 0.013
ubiquitin dependent protein catabolic process GO:0006511 78 0.013
maternal determination of anterior posterior axis embryo GO:0008358 74 0.013
response to light stimulus GO:0009416 124 0.013
monocarboxylic acid transport GO:0015718 3 0.013
regulation of developmental growth GO:0048638 174 0.013
eye photoreceptor cell differentiation GO:0001754 145 0.013
pole plasm mrna localization GO:0019094 49 0.013
secretion GO:0046903 109 0.013
camera type eye morphogenesis GO:0048593 2 0.013
adult locomotory behavior GO:0008344 76 0.013
protein transport GO:0015031 155 0.013
nitrogen compound transport GO:0071705 85 0.013
reproductive behavior GO:0019098 122 0.013
axon development GO:0061564 297 0.013
intracellular mrna localization involved in anterior posterior axis specification GO:0060811 53 0.013
modification dependent macromolecule catabolic process GO:0043632 79 0.013
aromatic compound catabolic process GO:0019439 166 0.013
cytoplasmic transport GO:0016482 130 0.012
programmed cell death GO:0012501 257 0.012
maintenance of location GO:0051235 73 0.012
death GO:0016265 284 0.012
immune response regulating signaling pathway GO:0002764 2 0.012
purine ribonucleotide metabolic process GO:0009150 145 0.012
cellular cation homeostasis GO:0030003 38 0.012
positive regulation of cellular component organization GO:0051130 156 0.012
positive regulation of multicellular organismal process GO:0051240 143 0.012
purine ribonucleotide catabolic process GO:0009154 109 0.012
cell proliferation GO:0008283 299 0.012
regulation of neuron differentiation GO:0045664 103 0.012
immune response activating signal transduction GO:0002757 2 0.012
regulation of epithelial cell proliferation GO:0050678 4 0.012
cellular response to lipopolysaccharide GO:0071222 3 0.012
gland development GO:0048732 191 0.012
signal transduction by phosphorylation GO:0023014 107 0.012
chemical homeostasis GO:0048878 92 0.012
mrna processing GO:0006397 104 0.012
regulation of mitotic cell cycle phase transition GO:1901990 130 0.012
male mating behavior GO:0060179 70 0.012
negative regulation of homeostatic process GO:0032845 2 0.012
tissue migration GO:0090130 155 0.012
respiratory system development GO:0060541 213 0.012
regulation of immune response GO:0050776 118 0.012
myotube cell development GO:0014904 3 0.012
regulation of catabolic process GO:0009894 170 0.012
digestive system development GO:0055123 149 0.012
defense response to other organism GO:0098542 225 0.012
regulation of molecular function GO:0065009 217 0.012
Mouse
salivary gland cell autophagic cell death GO:0035071 83 0.012
enzyme linked receptor protein signaling pathway GO:0007167 179 0.012
response to wounding GO:0009611 94 0.011
protein catabolic process GO:0030163 101 0.011
organelle assembly GO:0070925 198 0.011
chemotaxis GO:0006935 249 0.011
autophagic cell death GO:0048102 83 0.011
covalent chromatin modification GO:0016569 106 0.011
cholesterol homeostasis GO:0042632 3 0.011
positive regulation of intracellular signal transduction GO:1902533 116 0.011
response to organophosphorus GO:0046683 2 0.011
chromosome segregation GO:0007059 157 0.011
ribonucleotide catabolic process GO:0009261 109 0.011
embryonic morphogenesis GO:0048598 206 0.011
peptidyl threonine phosphorylation GO:0018107 2 0.011
tube morphogenesis GO:0035239 191 0.011
cytoplasm organization GO:0007028 64 0.011
cell cycle phase transition GO:0044770 140 0.011
open tracheal system development GO:0007424 204 0.011
nucleoside metabolic process GO:0009116 127 0.011
gland morphogenesis GO:0022612 145 0.011
negative regulation of neurogenesis GO:0050768 53 0.011
pole plasm assembly GO:0007315 61 0.011
salivary gland histolysis GO:0035070 88 0.011
regulation of phosphorylation GO:0042325 147 0.011
cellular homeostasis GO:0019725 80 0.011
regulation of cellular response to stress GO:0080135 89 0.011
spinal cord development GO:0021510 1 0.011
spermatid differentiation GO:0048515 114 0.011
organic cyclic compound catabolic process GO:1901361 168 0.011
phototransduction GO:0007602 52 0.011
regulation of programmed cell death GO:0043067 152 0.011
positive regulation of transcription dna templated GO:0045893 266 0.011
telencephalon development GO:0021537 2 0.011
limb morphogenesis GO:0035108 1 0.011
spermatid development GO:0007286 98 0.011
ribose phosphate metabolic process GO:0019693 145 0.011
oocyte anterior posterior axis specification GO:0007314 72 0.011
microtubule based movement GO:0007018 51 0.011
response to hexose GO:0009746 3 0.011
compound eye photoreceptor cell differentiation GO:0001751 140 0.011
cellular protein catabolic process GO:0044257 83 0.011
leg disc development GO:0035218 92 0.011
nucleobase containing small molecule metabolic process GO:0055086 174 0.011
cellular protein localization GO:0034613 160 0.011
neural retina development GO:0003407 4 0.011
axon guidance GO:0007411 233 0.011
negative regulation of protein metabolic process GO:0051248 85 0.011
regulation of neurogenesis GO:0050767 158 0.011
intracellular mrna localization GO:0008298 66 0.011
secretion by cell GO:0032940 101 0.011
cellular response to molecule of bacterial origin GO:0071219 3 0.011
detection of stimulus involved in sensory perception GO:0050906 92 0.011
histone modification GO:0016570 106 0.011
response to monosaccharide GO:0034284 4 0.011
positive regulation of developmental process GO:0051094 143 0.011
peptidyl threonine modification GO:0018210 3 0.011
multi organism reproductive behavior GO:0044705 121 0.011
cellular response to biotic stimulus GO:0071216 4 0.010
cellularization GO:0007349 90 0.010
positive regulation of cellular catabolic process GO:0031331 95 0.010
transmembrane transport GO:0055085 139 0.010
tissue death GO:0016271 102 0.010
mitotic spindle organization GO:0007052 220 0.010
wnt signaling pathway GO:0016055 98 0.010
regulation of gene expression epigenetic GO:0040029 128 0.010
embryo development ending in birth or egg hatching GO:0009792 152 0.010
notch signaling pathway GO:0007219 120 0.010
embryonic development via the syncytial blastoderm GO:0001700 148 0.010
negative regulation of cellular component organization GO:0051129 108 0.010
positive regulation of molecular function GO:0044093 136 0.010
histolysis GO:0007559 102 0.010
organonitrogen compound biosynthetic process GO:1901566 117 0.010
defense response to bacterium GO:0042742 178 0.010
regulation of cell cycle phase transition GO:1901987 130 0.010
establishment of protein localization GO:0045184 163 0.010
intracellular mrna localization involved in pattern specification process GO:0060810 56 0.010
cellular macromolecular complex assembly GO:0034622 153 0.010
regulation of cell death GO:0010941 173 0.010
cell cycle checkpoint GO:0000075 95 0.010
epithelial cell migration GO:0010631 148 0.010
regulation of proteolysis GO:0030162 87 0.010
nucleotide catabolic process GO:0009166 109 0.010
organic hydroxy compound metabolic process GO:1901615 83 0.010
detection of external stimulus GO:0009581 66 0.010
establishment or maintenance of cell polarity GO:0007163 167 0.010

dtr disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.028
nervous system disease DOID:863 0 0.021
disease of metabolism DOID:0014667 0 0.017
inherited metabolic disorder DOID:655 0 0.012
acquired metabolic disease DOID:0060158 0 0.012
cancer DOID:162 0 0.011
disease of cellular proliferation DOID:14566 0 0.011
sensory system disease DOID:0050155 0 0.010