Drosophila melanogaster

67 known processes

MAPk-Ak2 (Dmel_CG3086)

MAP kinase activated protein-kinase-2

(Aliases: DmMAPKAPK-2,MAPKAP,MAPKAPK-2,CG3086,Dmel\CG3086,MK2)

MAPk-Ak2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
ion transmembrane transport GO:0034220 122 0.414
transmembrane transport GO:0055085 139 0.359
membrane fusion GO:0061025 42 0.256
single organism membrane fusion GO:0044801 42 0.239
neurological system process GO:0050877 358 0.202
axonogenesis GO:0007409 290 0.172
membrane organization GO:0061024 112 0.157
negative regulation of response to stimulus GO:0048585 258 0.129
single organism behavior GO:0044708 391 0.120
regulation of organelle organization GO:0033043 196 0.114
regulation of cellular component size GO:0032535 98 0.114
organelle fusion GO:0048284 46 0.112
cell motility GO:0048870 251 0.111
actin filament based process GO:0030029 220 0.102
single organism membrane organization GO:0044802 93 0.096
endocytosis GO:0006897 310 0.094
Mouse
regulation of intracellular signal transduction GO:1902531 236 0.090
regulation of localization GO:0032879 275 0.088
intracellular signal transduction GO:0035556 300 0.084
ion transport GO:0006811 145 0.084
cell adhesion GO:0007155 136 0.084
multi organism behavior GO:0051705 175 0.080
regulation of cell projection organization GO:0031344 92 0.078
sensory perception of mechanical stimulus GO:0050954 72 0.078
negative regulation of signal transduction GO:0009968 206 0.077
cell migration GO:0016477 238 0.076
regulation of anatomical structure size GO:0090066 163 0.076
negative regulation of cell communication GO:0010648 223 0.075
regulation of nervous system development GO:0051960 248 0.074
immune response regulating signaling pathway GO:0002764 2 0.069
Mouse
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.068
positive regulation of cellular component organization GO:0051130 156 0.068
organelle fission GO:0048285 340 0.068
anion transmembrane transport GO:0098656 26 0.067
cellular macromolecular complex assembly GO:0034622 153 0.066
cation transmembrane transport GO:0098655 88 0.066
synaptic transmission GO:0007268 288 0.063
regulation of phosphate metabolic process GO:0019220 210 0.062
regulation of anatomical structure morphogenesis GO:0022603 242 0.060
response to other organism GO:0051707 293 0.059
Mouse
positive regulation of cellular biosynthetic process GO:0031328 316 0.058
neural precursor cell proliferation GO:0061351 75 0.057
regulation of neurogenesis GO:0050767 158 0.057
regulation of multicellular organismal development GO:2000026 414 0.057
negative regulation of cellular metabolic process GO:0031324 382 0.057
immune system process GO:0002376 347 0.055
Mouse
negative regulation of cellular component organization GO:0051129 108 0.054
regulation of phosphorylation GO:0042325 147 0.052
cellular macromolecule localization GO:0070727 220 0.052
cation transport GO:0006812 110 0.051
regulation of cellular component biogenesis GO:0044087 201 0.051
signal transduction by phosphorylation GO:0023014 107 0.051
actin cytoskeleton organization GO:0030036 206 0.051
regulation of growth GO:0040008 233 0.051
regulation of cell development GO:0060284 215 0.050
pigmentation GO:0043473 75 0.050
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.049
Human
regulation of cell shape GO:0008360 113 0.047
response to radiation GO:0009314 155 0.046
anion transport GO:0006820 41 0.045
developmental growth GO:0048589 280 0.045
adult behavior GO:0030534 137 0.044
cell junction organization GO:0034330 57 0.044
ameboidal type cell migration GO:0001667 151 0.043
response to biotic stimulus GO:0009607 294 0.043
Mouse
imaginal disc derived appendage development GO:0048737 399 0.043
localization of cell GO:0051674 257 0.043
negative regulation of gene expression GO:0010629 387 0.042
cellular catabolic process GO:0044248 372 0.042
response to light stimulus GO:0009416 124 0.041
defense response GO:0006952 300 0.041
Mouse
response to bacterium GO:0009617 198 0.040
Mouse
appendage development GO:0048736 401 0.039
carboxylic acid metabolic process GO:0019752 92 0.039
single organism biosynthetic process GO:0044711 206 0.039
amine metabolic process GO:0009308 12 0.039
regulation of developmental growth GO:0048638 174 0.039
positive regulation of growth GO:0045927 75 0.039
nucleotide metabolic process GO:0009117 161 0.039
regulation of transport GO:0051049 181 0.039
intracellular transport GO:0046907 228 0.038
oxoacid metabolic process GO:0043436 103 0.038
adult locomotory behavior GO:0008344 76 0.037
cellular ketone metabolic process GO:0042180 24 0.037
negative regulation of phosphate metabolic process GO:0045936 45 0.036
response to external biotic stimulus GO:0043207 293 0.035
Mouse
protein localization GO:0008104 284 0.034
response to endogenous stimulus GO:0009719 119 0.034
protein modification process GO:0036211 438 0.033
Human Mouse
nuclear division GO:0000280 332 0.033
cellular response to organic substance GO:0071310 132 0.033
Human
cell cell junction organization GO:0045216 55 0.032
phosphorylation GO:0016310 294 0.032
actin filament organization GO:0007015 126 0.032
taxis GO:0042330 304 0.032
purine ribonucleotide metabolic process GO:0009150 145 0.032
macromolecular complex assembly GO:0065003 256 0.032
negative regulation of organelle organization GO:0010639 56 0.031
positive regulation of biosynthetic process GO:0009891 316 0.031
heterocycle catabolic process GO:0046700 166 0.031
nucleoside phosphate metabolic process GO:0006753 162 0.030
single organism intracellular transport GO:1902582 207 0.030
renal tubule morphogenesis GO:0061333 44 0.030
cellular nitrogen compound catabolic process GO:0044270 165 0.030
enzyme linked receptor protein signaling pathway GO:0007167 179 0.029
Human
negative regulation of phosphorylation GO:0042326 35 0.029
negative regulation of nervous system development GO:0051961 92 0.029
establishment of localization in cell GO:0051649 402 0.029
atp metabolic process GO:0046034 49 0.028
cellular response to endogenous stimulus GO:0071495 80 0.028
response to organic substance GO:0010033 284 0.028
Human Mouse
negative regulation of cellular biosynthetic process GO:0031327 277 0.028
regulation of cell morphogenesis GO:0022604 163 0.028
post embryonic appendage morphogenesis GO:0035120 385 0.027
embryonic development via the syncytial blastoderm GO:0001700 148 0.027
regulation of response to stress GO:0080134 200 0.027
single organism catabolic process GO:0044712 228 0.027
catabolic process GO:0009056 409 0.027
tissue migration GO:0090130 155 0.026
organelle assembly GO:0070925 198 0.026
developmental cell growth GO:0048588 52 0.026
positive regulation of developmental process GO:0051094 143 0.026
lipid localization GO:0010876 54 0.025
regulation of molecular function GO:0065009 217 0.025
regulation of cellular ketone metabolic process GO:0010565 3 0.025
store operated calcium entry GO:0002115 3 0.025
mapk cascade GO:0000165 107 0.025
axon development GO:0061564 297 0.025
positive regulation of lipid biosynthetic process GO:0046889 3 0.024
growth GO:0040007 359 0.024
regulation of cytoskeleton organization GO:0051493 89 0.024
body morphogenesis GO:0010171 2 0.024
negative regulation of cytoskeleton organization GO:0051494 30 0.024
regulation of response to external stimulus GO:0032101 115 0.024
phagocytosis GO:0006909 215 0.024
organic substance transport GO:0071702 257 0.024
positive regulation of developmental growth GO:0048639 62 0.024
glycosyl compound metabolic process GO:1901657 127 0.024
cardiovascular system development GO:0072358 82 0.023
axon guidance GO:0007411 233 0.023
aromatic compound catabolic process GO:0019439 166 0.023
small molecule metabolic process GO:0044281 305 0.023
nucleoside triphosphate metabolic process GO:0009141 120 0.023
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.023
vesicle mediated transport GO:0016192 381 0.022
Mouse
purine ribonucleoside metabolic process GO:0046128 127 0.022
cellular response to radiation GO:0071478 52 0.022
heart development GO:0007507 82 0.022
aging GO:0007568 143 0.022
Worm
transforming growth factor beta receptor signaling pathway GO:0007179 16 0.022
small gtpase mediated signal transduction GO:0007264 88 0.022
cellular protein complex assembly GO:0043623 71 0.022
organic acid metabolic process GO:0006082 103 0.022
establishment of protein localization GO:0045184 163 0.022
metal ion transport GO:0030001 74 0.022
purine nucleoside monophosphate catabolic process GO:0009128 38 0.021
nucleobase containing small molecule metabolic process GO:0055086 174 0.021
very long chain fatty acid catabolic process GO:0042760 2 0.021
purine containing compound metabolic process GO:0072521 155 0.021
regulation of immune response GO:0050776 118 0.021
Mouse
lipid metabolic process GO:0006629 121 0.020
salivary gland development GO:0007431 162 0.020
divalent metal ion transport GO:0070838 26 0.020
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.020
regulation of immune system process GO:0002682 176 0.020
Mouse
cellular response to peptide hormone stimulus GO:0071375 28 0.020
purine nucleoside triphosphate metabolic process GO:0009144 119 0.019
cellular response to nitrogen compound GO:1901699 51 0.019
regionalization GO:0003002 416 0.019
purine nucleoside monophosphate metabolic process GO:0009126 50 0.019
regulation of ras protein signal transduction GO:0046578 93 0.019
androgen metabolic process GO:0008209 1 0.019
compound eye development GO:0048749 307 0.019
positive regulation of macromolecule metabolic process GO:0010604 405 0.019
negative regulation of molecular function GO:0044092 51 0.018
negative regulation of phosphatase activity GO:0010923 3 0.018
regulation of cell differentiation GO:0045595 302 0.018
purine nucleotide metabolic process GO:0006163 146 0.018
regulation of cellular amine metabolic process GO:0033238 3 0.018
asymmetric stem cell division GO:0098722 49 0.017
imaginal disc derived appendage morphogenesis GO:0035114 395 0.017
regulation of phosphorus metabolic process GO:0051174 210 0.017
epithelial cell differentiation GO:0030855 322 0.017
protein complex assembly GO:0006461 200 0.017
monovalent inorganic cation transport GO:0015672 40 0.017
atp catabolic process GO:0006200 38 0.017
locomotory behavior GO:0007626 176 0.017
negative regulation of phosphorus metabolic process GO:0010563 45 0.017
positive regulation of intracellular signal transduction GO:1902533 116 0.017
plasma membrane organization GO:0007009 26 0.017
response to abiotic stimulus GO:0009628 341 0.017
regulation of neuron differentiation GO:0045664 103 0.017
appendage morphogenesis GO:0035107 397 0.017
regulation of multi organism process GO:0043900 131 0.017
heart morphogenesis GO:0003007 32 0.017
positive regulation of lipid metabolic process GO:0045834 4 0.017
cellular amine metabolic process GO:0044106 12 0.017
ras protein signal transduction GO:0007265 88 0.017
positive regulation of cell communication GO:0010647 250 0.017
ovarian follicle cell development GO:0030707 248 0.016
open tracheal system development GO:0007424 204 0.016
regulation of mapk cascade GO:0043408 92 0.016
wing disc morphogenesis GO:0007472 344 0.016
positive regulation of cellular component biogenesis GO:0044089 80 0.016
regulation of cellular localization GO:0060341 136 0.016
homeostatic process GO:0042592 199 0.016
regulation of cell cycle process GO:0010564 181 0.016
purine containing compound catabolic process GO:0072523 112 0.016
chromosome organization GO:0051276 360 0.016
nucleoside catabolic process GO:0009164 112 0.016
rac protein signal transduction GO:0016601 3 0.016
chemotaxis GO:0006935 249 0.016
peptidyl amino acid modification GO:0018193 105 0.016
Human
organophosphate metabolic process GO:0019637 195 0.016
endomembrane system organization GO:0010256 119 0.016
chloride transport GO:0006821 10 0.015
organic substance catabolic process GO:1901575 308 0.015
positive regulation of signal transduction GO:0009967 223 0.015
ribose phosphate metabolic process GO:0019693 145 0.015
nucleotide catabolic process GO:0009166 109 0.015
positive regulation of molecular function GO:0044093 136 0.015
developmental growth involved in morphogenesis GO:0060560 65 0.015
negative regulation of signaling GO:0023057 219 0.015
positive regulation of response to stimulus GO:0048584 323 0.015
Mouse
eye development GO:0001654 323 0.015
cellular protein localization GO:0034613 160 0.015
regulation of phosphatase activity GO:0010921 3 0.015
regulation of actin filament based process GO:0032970 42 0.014
neuronal stem cell division GO:0036445 35 0.014
biological adhesion GO:0022610 138 0.014
regulation of immune effector process GO:0002697 52 0.014
ribonucleotide metabolic process GO:0009259 145 0.014
purine nucleoside metabolic process GO:0042278 127 0.014
imaginal disc derived wing morphogenesis GO:0007476 337 0.014
regulation of cellular catabolic process GO:0031329 157 0.014
response to nitrogen compound GO:1901698 90 0.014
response to oxygen containing compound GO:1901700 200 0.014
Mouse
regulation of hemocyte proliferation GO:0035206 37 0.014
cell division GO:0051301 248 0.014
negative regulation of intracellular signal transduction GO:1902532 57 0.014
inorganic ion transmembrane transport GO:0098660 73 0.014
carbohydrate derivative metabolic process GO:1901135 217 0.014
positive regulation of transport GO:0051050 92 0.013
regulation of protein transport GO:0051223 57 0.013
positive regulation of phosphorus metabolic process GO:0010562 139 0.013
dna metabolic process GO:0006259 227 0.013
spindle organization GO:0007051 253 0.013
positive regulation of phosphate metabolic process GO:0045937 139 0.013
stress activated protein kinase signaling cascade GO:0031098 55 0.013
cellular protein modification process GO:0006464 438 0.013
Human Mouse
regulation of actin cytoskeleton organization GO:0032956 42 0.013
regulation of cellular protein metabolic process GO:0032268 243 0.013
fatty acid catabolic process GO:0009062 9 0.013
positive regulation of catalytic activity GO:0043085 118 0.013
cell aging GO:0007569 2 0.013
negative regulation of protein metabolic process GO:0051248 85 0.013
organic acid catabolic process GO:0016054 16 0.012
neuron projection guidance GO:0097485 241 0.012
cellular response to hormone stimulus GO:0032870 44 0.012
purine ribonucleoside monophosphate catabolic process GO:0009169 38 0.012
muscle cell differentiation GO:0042692 103 0.012
sensory perception GO:0007600 196 0.012
embryonic morphogenesis GO:0048598 206 0.012
Zebrafish
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.012
regulation of cell size GO:0008361 63 0.012
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.012
regulation of catalytic activity GO:0050790 185 0.012
septate junction assembly GO:0019991 26 0.012
regulation of protein modification process GO:0031399 112 0.012
cell growth GO:0016049 108 0.012
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.012
nucleoside triphosphate catabolic process GO:0009143 108 0.012
organonitrogen compound catabolic process GO:1901565 128 0.012
organic cyclic compound catabolic process GO:1901361 168 0.012
small molecule catabolic process GO:0044282 21 0.012
cuticle development GO:0042335 86 0.012
positive regulation of signaling GO:0023056 243 0.012
negative regulation of multicellular organismal process GO:0051241 142 0.012
negative regulation of cell death GO:0060548 81 0.012
stress activated mapk cascade GO:0051403 52 0.012
regulation of synapse assembly GO:0051963 94 0.012
muscle structure development GO:0061061 224 0.012
cellular response to abiotic stimulus GO:0071214 58 0.011
organonitrogen compound metabolic process GO:1901564 318 0.011
gland development GO:0048732 191 0.011
gliogenesis GO:0042063 80 0.011
dendrite development GO:0016358 204 0.011
establishment or maintenance of cell polarity GO:0007163 167 0.011
collateral sprouting GO:0048668 3 0.011
response to growth factor GO:0070848 31 0.011
Human
regulation of adult chitin containing cuticle pigmentation GO:0048082 13 0.011
purine nucleoside catabolic process GO:0006152 112 0.011
transcription from rna polymerase ii promoter GO:0006366 368 0.011
regulation of hydrolase activity GO:0051336 97 0.011
regulation of synapse organization GO:0050807 110 0.011
negative regulation of cell differentiation GO:0045596 143 0.011
internal peptidyl lysine acetylation GO:0018393 38 0.011
regulation of small gtpase mediated signal transduction GO:0051056 93 0.011
regulation of protein polymerization GO:0032271 28 0.011
negative regulation of cellular protein metabolic process GO:0032269 85 0.011
nucleocytoplasmic transport GO:0006913 72 0.011
developmental pigmentation GO:0048066 68 0.011
nucleoside monophosphate metabolic process GO:0009123 52 0.011
nucleoside metabolic process GO:0009116 127 0.011
regulation of synapse structure and activity GO:0050803 128 0.010
death GO:0016265 284 0.010
monocarboxylic acid catabolic process GO:0072329 10 0.010
protein phosphorylation GO:0006468 169 0.010
Human Mouse
egg activation GO:0007343 9 0.010
organophosphate catabolic process GO:0046434 112 0.010
regulation of response to biotic stimulus GO:0002831 63 0.010
defense response to other organism GO:0098542 225 0.010
ribonucleoside catabolic process GO:0042454 112 0.010

MAPk-Ak2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.041
disease of metabolism DOID:0014667 0 0.014
inherited metabolic disorder DOID:655 0 0.013
musculoskeletal system disease DOID:17 0 0.010