Drosophila melanogaster

16 known processes

Spn3 (Dmel_CG9334)

Serine protease inhibitor 3

(Aliases: Dmel\CG9334,Sp3,Spn38F,CG9334,sp3)

Spn3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
sterol homeostasis GO:0055092 4 0.187
cholesterol homeostasis GO:0042632 3 0.143
insemination GO:0007320 22 0.121
sperm competition GO:0046692 21 0.059
protein modification process GO:0036211 438 0.052
small molecule metabolic process GO:0044281 305 0.048
organic acid metabolic process GO:0006082 103 0.043
carboxylic acid metabolic process GO:0019752 92 0.043
sperm storage GO:0046693 10 0.042
vesicle mediated transport GO:0016192 381 0.040
homeostatic process GO:0042592 199 0.038
oxoacid metabolic process GO:0043436 103 0.037
imaginal disc derived appendage development GO:0048737 399 0.037
catabolic process GO:0009056 409 0.035
response to abiotic stimulus GO:0009628 341 0.035
cellular protein modification process GO:0006464 438 0.034
imaginal disc derived wing morphogenesis GO:0007476 337 0.033
multicellular organismal reproductive behavior GO:0033057 110 0.033
endocytosis GO:0006897 310 0.033
appendage morphogenesis GO:0035107 397 0.033
cell cell signaling involved in cell fate commitment GO:0045168 210 0.031
multi organism behavior GO:0051705 175 0.031
appendage development GO:0048736 401 0.031
organonitrogen compound metabolic process GO:1901564 318 0.031
Fly
phagocytosis GO:0006909 215 0.030
imaginal disc derived appendage morphogenesis GO:0035114 395 0.030
cellular catabolic process GO:0044248 372 0.029
regulation of multicellular organismal development GO:2000026 414 0.029
wing disc morphogenesis GO:0007472 344 0.029
organic hydroxy compound metabolic process GO:1901615 83 0.029
post embryonic appendage morphogenesis GO:0035120 385 0.029
negative regulation of cellular metabolic process GO:0031324 382 0.028
Rat Fly
body morphogenesis GO:0010171 2 0.028
regionalization GO:0003002 416 0.027
developmental growth GO:0048589 280 0.027
Rat
mating GO:0007618 120 0.026
positive regulation of response to stimulus GO:0048584 323 0.026
response to external biotic stimulus GO:0043207 293 0.026
organic substance catabolic process GO:1901575 308 0.026
ethanolamine containing compound metabolic process GO:0042439 4 0.026
lateral inhibition GO:0046331 206 0.025
positive regulation of cell communication GO:0010647 250 0.025
lipid metabolic process GO:0006629 121 0.025
female mating behavior GO:0060180 30 0.025
cellular amino acid metabolic process GO:0006520 61 0.024
oxidation reduction process GO:0055114 123 0.024
single organism behavior GO:0044708 391 0.024
regulation of localization GO:0032879 275 0.024
triglyceride biosynthetic process GO:0019432 2 0.023
forebrain development GO:0030900 2 0.023
open tracheal system development GO:0007424 204 0.023
response to other organism GO:0051707 293 0.023
compound eye development GO:0048749 307 0.023
establishment of localization in cell GO:0051649 402 0.023
negative regulation of gene expression GO:0010629 387 0.023
Rat Fly
cell proliferation GO:0008283 299 0.023
acylglycerol catabolic process GO:0046464 3 0.023
response to biotic stimulus GO:0009607 294 0.023
regulation of female receptivity GO:0045924 24 0.023
kidney development GO:0001822 3 0.022
compound eye morphogenesis GO:0001745 249 0.022
growth GO:0040007 359 0.022
Rat
single organism catabolic process GO:0044712 228 0.022
organic substance transport GO:0071702 257 0.022
phosphorylation GO:0016310 294 0.022
chromosome organization GO:0051276 360 0.022
regulation of female receptivity post mating GO:0046008 17 0.022
immune system process GO:0002376 347 0.022
Fly
lipid homeostasis GO:0055088 33 0.022
cellular lipid metabolic process GO:0044255 83 0.021
regulation of cellular ketone metabolic process GO:0010565 3 0.021
nuclear division GO:0000280 332 0.021
single organism biosynthetic process GO:0044711 206 0.021
neurological system process GO:0050877 358 0.021
positive regulation of lipid storage GO:0010884 4 0.021
defense response to other organism GO:0098542 225 0.021
intracellular signal transduction GO:0035556 300 0.021
epithelial cell differentiation GO:0030855 322 0.021
amine metabolic process GO:0009308 12 0.020
salivary gland development GO:0007431 162 0.020
protein complex biogenesis GO:0070271 201 0.020
negative regulation of female receptivity GO:0007621 14 0.020
response to nutrient levels GO:0031667 114 0.020
Rat
positive regulation of signal transduction GO:0009967 223 0.020
response to organic substance GO:0010033 284 0.020
organelle fission GO:0048285 340 0.020
positive regulation of signaling GO:0023056 243 0.020
regulation of immune system process GO:0002682 176 0.020
Fly
response to lipopolysaccharide GO:0032496 4 0.020
cellular amine metabolic process GO:0044106 12 0.019
negative regulation of signaling GO:0023057 219 0.019
Fly
protein localization GO:0008104 284 0.019
regulation of response to stress GO:0080134 200 0.019
Rat
cellular response to dna damage stimulus GO:0006974 223 0.019
sensory perception of smell GO:0007608 80 0.019
defense response to bacterium GO:0042742 178 0.019
regulation of cellular amine metabolic process GO:0033238 3 0.019
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.019
regulation of molecular function GO:0065009 217 0.019
Rat Fly
cholesterol transport GO:0030301 2 0.019
negative regulation of signal transduction GO:0009968 206 0.018
Fly
immune response GO:0006955 246 0.018
Fly
macromolecular complex assembly GO:0065003 256 0.018
negative regulation of response to stimulus GO:0048585 258 0.018
Rat Fly
carbohydrate derivative metabolic process GO:1901135 217 0.018
proteolysis GO:0006508 192 0.018
Rat Fly
negative regulation of cell communication GO:0010648 223 0.018
Fly
regulation of cell differentiation GO:0045595 302 0.018
cell division GO:0051301 248 0.018
xenobiotic catabolic process GO:0042178 1 0.018
regulation of cellular protein metabolic process GO:0032268 243 0.018
Rat Fly
steroid catabolic process GO:0006706 1 0.018
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.018
Fly
reproductive behavior GO:0019098 122 0.018
camera type eye development GO:0043010 4 0.018
photoreceptor cell differentiation GO:0046530 170 0.018
gland development GO:0048732 191 0.018
telencephalon development GO:0021537 2 0.017
negative regulation of developmental process GO:0051093 201 0.017
positive regulation of biosynthetic process GO:0009891 316 0.017
cell death GO:0008219 279 0.017
adult behavior GO:0030534 137 0.017
positive regulation of macromolecule metabolic process GO:0010604 405 0.017
triglyceride catabolic process GO:0019433 3 0.017
single organism intracellular transport GO:1902582 207 0.017
sensory organ morphogenesis GO:0090596 260 0.017
regulation of multi organism process GO:0043900 131 0.017
Fly
regulation of transport GO:0051049 181 0.017
regulation of cellular amino acid metabolic process GO:0006521 0 0.017
intracellular transport GO:0046907 228 0.017
eye morphogenesis GO:0048592 260 0.017
developmental maturation GO:0021700 172 0.017
antimicrobial humoral response GO:0019730 99 0.016
Fly
positive regulation of cellular biosynthetic process GO:0031328 316 0.016
small gtpase mediated signal transduction GO:0007264 88 0.016
cellular response to chemical stimulus GO:0070887 199 0.016
mating behavior GO:0007617 106 0.016
organophosphate metabolic process GO:0019637 195 0.016
cellular ketone metabolic process GO:0042180 24 0.016
response to bacterium GO:0009617 198 0.016
defense response GO:0006952 300 0.016
acylglycerol biosynthetic process GO:0046463 2 0.016
tube morphogenesis GO:0035239 191 0.016
positive regulation of sequestering of triglyceride GO:0010890 1 0.016
regulation of protein metabolic process GO:0051246 256 0.016
Rat Fly
regulation of cell cycle GO:0051726 291 0.016
tube development GO:0035295 244 0.016
positive regulation of cell motility GO:2000147 3 0.016
response to extracellular stimulus GO:0009991 116 0.016
Rat
chemical homeostasis GO:0048878 92 0.016
axis specification GO:0009798 167 0.015
eye development GO:0001654 323 0.015
regulation of nervous system development GO:0051960 248 0.015
eye photoreceptor cell differentiation GO:0001754 145 0.015
peptide metabolic process GO:0006518 80 0.015
Fly
death GO:0016265 284 0.015
dna metabolic process GO:0006259 227 0.015
segmentation GO:0035282 207 0.015
protein hydroxylation GO:0018126 1 0.015
organic cyclic compound catabolic process GO:1901361 168 0.015
anion homeostasis GO:0055081 3 0.015
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.015
cellular macromolecule catabolic process GO:0044265 136 0.015
macromolecule catabolic process GO:0009057 161 0.015
negative regulation of multicellular organismal process GO:0051241 142 0.015
response to monosaccharide GO:0034284 4 0.015
positive regulation of nucleic acid templated transcription GO:1903508 266 0.015
multi multicellular organism process GO:0044706 123 0.015
regulation of catalytic activity GO:0050790 185 0.015
Rat Fly
taxis GO:0042330 304 0.015
regulation of cell development GO:0060284 215 0.015
copulation GO:0007620 26 0.015
protein complex assembly GO:0006461 200 0.015
gland morphogenesis GO:0022612 145 0.015
gene silencing GO:0016458 138 0.015
spermatogenesis GO:0007283 200 0.015
response to copper ion GO:0046688 4 0.015
male gamete generation GO:0048232 201 0.015
negative regulation of nucleic acid templated transcription GO:1903507 240 0.015
ras protein signal transduction GO:0007265 88 0.015
respiratory system development GO:0060541 213 0.015
response to radiation GO:0009314 155 0.014
cellular nitrogen compound catabolic process GO:0044270 165 0.014
morphogenesis of an epithelium GO:0002009 276 0.014
response to organophosphorus GO:0046683 2 0.014
epithelial cell development GO:0002064 274 0.014
embryonic pattern specification GO:0009880 174 0.014
negative regulation of biosynthetic process GO:0009890 277 0.014
regulation of gene expression epigenetic GO:0040029 128 0.014
regulation of phosphorus metabolic process GO:0051174 210 0.014
negative regulation of cellular biosynthetic process GO:0031327 277 0.014
negative regulation of rna biosynthetic process GO:1902679 240 0.014
blastoderm segmentation GO:0007350 159 0.014
cellular macromolecule localization GO:0070727 220 0.014
carbohydrate derivative biosynthetic process GO:1901137 85 0.014
regulation of anatomical structure morphogenesis GO:0022603 242 0.014
multicellular organismal aging GO:0010259 140 0.014
meiotic cell cycle GO:0051321 171 0.014
aromatic compound catabolic process GO:0019439 166 0.014
response to oxygen containing compound GO:1901700 200 0.014
protein phosphorylation GO:0006468 169 0.014
organelle assembly GO:0070925 198 0.014
sensory perception of chemical stimulus GO:0007606 116 0.014
mitotic nuclear division GO:0007067 213 0.014
response to hexose GO:0009746 3 0.014
regulation of anatomical structure size GO:0090066 163 0.014
positive regulation of multicellular organismal process GO:0051240 143 0.014
multi organism reproductive behavior GO:0044705 121 0.014
regulation of developmental growth GO:0048638 174 0.014
tissue morphogenesis GO:0048729 297 0.014
salivary gland morphogenesis GO:0007435 145 0.014
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.014
protein maturation GO:0051604 71 0.014
Fly
exocrine system development GO:0035272 162 0.014
regulation of cellular component biogenesis GO:0044087 201 0.014
regulation of intracellular signal transduction GO:1902531 236 0.014
positive regulation of gene expression GO:0010628 290 0.013
axon development GO:0061564 297 0.013
glycerolipid catabolic process GO:0046503 3 0.013
immune effector process GO:0002252 98 0.013
Fly
heterocycle catabolic process GO:0046700 166 0.013
positive regulation of rna metabolic process GO:0051254 271 0.013
compound eye photoreceptor cell differentiation GO:0001751 140 0.013
positive regulation of rna biosynthetic process GO:1902680 266 0.013
regulation of phosphate metabolic process GO:0019220 210 0.013
positive regulation of cell migration GO:0030335 2 0.013
peptidyl amino acid modification GO:0018193 105 0.013
columnar cuboidal epithelial cell development GO:0002066 249 0.013
regulation of defense response GO:0031347 102 0.013
Rat
enzyme linked receptor protein signaling pathway GO:0007167 179 0.013
transcription from rna polymerase ii promoter GO:0006366 368 0.013
peptidyl proline modification GO:0018208 3 0.013
synaptic transmission GO:0007268 288 0.013
connective tissue development GO:0061448 3 0.013
single organism cellular localization GO:1902580 180 0.013
negative regulation of female receptivity post mating GO:0045434 12 0.013
sulfur compound metabolic process GO:0006790 59 0.013
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.013
regulation of immune response GO:0050776 118 0.013
Fly
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.013
transmembrane transport GO:0055085 139 0.013
protein transport GO:0015031 155 0.013
response to wounding GO:0009611 94 0.013
Rat
nucleobase containing compound catabolic process GO:0034655 165 0.013
regulation of mitotic cell cycle GO:0007346 190 0.013
rna localization GO:0006403 115 0.013
negative regulation of rna metabolic process GO:0051253 251 0.013
regulation of growth GO:0040008 233 0.013
cytoplasmic transport GO:0016482 130 0.013
regulation of cellular localization GO:0060341 136 0.012
mapk cascade GO:0000165 107 0.012
maintenance of location GO:0051235 73 0.012
modification dependent macromolecule catabolic process GO:0043632 79 0.012
negative regulation of cell differentiation GO:0045596 143 0.012
programmed cell death GO:0012501 257 0.012
phosphatidic acid metabolic process GO:0046473 1 0.012
dorsal ventral pattern formation GO:0009953 133 0.012
positive regulation of transcription dna templated GO:0045893 266 0.012
regulation of cell death GO:0010941 173 0.012
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.012
aging GO:0007568 143 0.012
cellular macromolecular complex assembly GO:0034622 153 0.012
chaeta development GO:0022416 97 0.012
response to glucose GO:0009749 2 0.012
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.012
very long chain fatty acid metabolic process GO:0000038 4 0.012
neutral lipid biosynthetic process GO:0046460 2 0.012
organophosphate catabolic process GO:0046434 112 0.012
rna processing GO:0006396 147 0.012
immune response activating signal transduction GO:0002757 2 0.012
cell cycle phase transition GO:0044770 140 0.012
alditol phosphate metabolic process GO:0052646 2 0.012
g protein coupled receptor signaling pathway GO:0007186 136 0.012
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.012
embryonic development via the syncytial blastoderm GO:0001700 148 0.012
ovarian follicle cell development GO:0030707 248 0.012
establishment of protein localization GO:0045184 163 0.012
endomembrane system organization GO:0010256 119 0.012
dorsal ventral axis specification GO:0009950 66 0.012
response to organic cyclic compound GO:0014070 89 0.012
positive regulation of cellular amine metabolic process GO:0033240 0 0.012
axonogenesis GO:0007409 290 0.012
monocarboxylic acid metabolic process GO:0032787 29 0.012
phosphatidylcholine metabolic process GO:0046470 3 0.012
positive regulation of phosphorus metabolic process GO:0010562 139 0.012
nucleoside phosphate metabolic process GO:0006753 162 0.012
cell adhesion GO:0007155 136 0.012
Rat
chromatin remodeling GO:0006338 72 0.012
limb development GO:0060173 1 0.012
response to endogenous stimulus GO:0009719 119 0.012
dendrite morphogenesis GO:0048813 199 0.011
chromatin modification GO:0016568 147 0.011
regulation of phosphorylation GO:0042325 147 0.011
innate immune response GO:0045087 144 0.011
chromatin organization GO:0006325 207 0.011
wnt signaling pathway GO:0016055 98 0.011
spindle organization GO:0007051 253 0.011
regulation of sterol transport GO:0032371 1 0.011
regulation of catabolic process GO:0009894 170 0.011
regulation of cellular catabolic process GO:0031329 157 0.011
regulation of synapse structure and activity GO:0050803 128 0.011
regulation of reproductive process GO:2000241 54 0.011
protein catabolic process GO:0030163 101 0.011
cell migration GO:0016477 238 0.011
actin cytoskeleton organization GO:0030036 206 0.011
polyol biosynthetic process GO:0046173 3 0.011
medium chain fatty acid metabolic process GO:0051791 1 0.011
regulation of humoral immune response GO:0002920 51 0.011
Fly
cellular response to organic substance GO:0071310 132 0.011
regulation of sequestering of triglyceride GO:0010889 3 0.011
vitamin biosynthetic process GO:0009110 1 0.011
immune response regulating signaling pathway GO:0002764 2 0.011
regulation of production of molecular mediator of immune response GO:0002700 44 0.011
Fly
mesenchymal cell differentiation GO:0048762 1 0.011
mitotic spindle organization GO:0007052 220 0.011
regulation of epithelial cell differentiation GO:0030856 4 0.011
sensory perception GO:0007600 196 0.011
regulation of organelle organization GO:0033043 196 0.011
modification dependent protein catabolic process GO:0019941 78 0.011
fat soluble vitamin metabolic process GO:0006775 1 0.011
cell maturation GO:0048469 144 0.011
retina development in camera type eye GO:0060041 4 0.011
nucleobase containing small molecule metabolic process GO:0055086 174 0.011
response to temperature stimulus GO:0009266 106 0.011
central nervous system development GO:0007417 201 0.011
notch signaling pathway GO:0007219 120 0.011
axon guidance GO:0007411 233 0.011
cell motility GO:0048870 251 0.011
hindbrain development GO:0030902 2 0.011
regulation of programmed cell death GO:0043067 152 0.011
cellular protein localization GO:0034613 160 0.011
embryonic morphogenesis GO:0048598 206 0.011
positive regulation of intracellular signal transduction GO:1902533 116 0.011
photoreceptor cell development GO:0042461 96 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.011
negative regulation of protein metabolic process GO:0051248 85 0.011
Rat Fly
neutral lipid catabolic process GO:0046461 3 0.011
dendrite development GO:0016358 204 0.011
chromosome segregation GO:0007059 157 0.011
response to starvation GO:0042594 97 0.011
androgen metabolic process GO:0008209 1 0.011
localization of cell GO:0051674 257 0.011
regulation of cellular response to stress GO:0080135 89 0.011
regulation of mitotic cell cycle phase transition GO:1901990 130 0.011
hematopoietic progenitor cell differentiation GO:0002244 1 0.011
somatic muscle development GO:0007525 66 0.011
estrogen metabolic process GO:0008210 1 0.011
kidney epithelium development GO:0072073 3 0.011
cellular response to ethanol GO:0071361 4 0.011
centrosome organization GO:0051297 163 0.011
microtubule organizing center organization GO:0031023 168 0.011
mesenchymal cell development GO:0014031 1 0.010
regulation of proteolysis GO:0030162 87 0.010
Rat Fly
cellular amide metabolic process GO:0043603 80 0.010
Fly
anterior posterior pattern specification GO:0009952 136 0.010
positive regulation of phosphate metabolic process GO:0045937 139 0.010
positive regulation of developmental process GO:0051094 143 0.010
embryonic axis specification GO:0000578 107 0.010
nucleotide metabolic process GO:0009117 161 0.010
cognition GO:0050890 141 0.010
mrna metabolic process GO:0016071 124 0.010
cellular protein catabolic process GO:0044257 83 0.010
regulation of lipid transport GO:0032368 3 0.010
regulation of epithelial cell proliferation GO:0050678 4 0.010
locomotory behavior GO:0007626 176 0.010
defense response to gram negative bacterium GO:0050829 94 0.010
nitrogen compound transport GO:0071705 85 0.010
response to organonitrogen compound GO:0010243 75 0.010
organonitrogen compound biosynthetic process GO:1901566 117 0.010
vitamin metabolic process GO:0006766 2 0.010
monocarboxylic acid transport GO:0015718 3 0.010
cellular component assembly involved in morphogenesis GO:0010927 151 0.010
positive regulation of catabolic process GO:0009896 105 0.010
regulation of cell cycle phase transition GO:1901987 130 0.010
determination of adult lifespan GO:0008340 137 0.010
synapse organization GO:0050808 196 0.010
actin filament based process GO:0030029 220 0.010
regulation of notch signaling pathway GO:0008593 100 0.010
positive regulation of molecular function GO:0044093 136 0.010
tripartite regional subdivision GO:0007351 103 0.010
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.010
ribonucleotide metabolic process GO:0009259 145 0.010
limb morphogenesis GO:0035108 1 0.010
glycoprotein metabolic process GO:0009100 41 0.010
ribonucleoside metabolic process GO:0009119 127 0.010
mitotic sister chromatid segregation GO:0000070 87 0.010

Spn3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.046
diabetes mellitus DOID:9351 0 0.023
disease of metabolism DOID:0014667 0 0.023
carbohydrate metabolism disease DOID:0050013 0 0.023
glucose metabolism disease DOID:4194 0 0.023
acquired metabolic disease DOID:0060158 0 0.023
inherited metabolic disorder DOID:655 0 0.023
nervous system disease DOID:863 0 0.019
type 2 diabetes mellitus DOID:9352 0 0.017
familial hypertriglyceridemia DOID:0050527 0 0.015
lipid metabolism disorder DOID:3146 0 0.015
sensory system disease DOID:0050155 0 0.012
cardiovascular system disease DOID:1287 0 0.012
hypertension DOID:10763 0 0.012
artery disease DOID:0050828 0 0.012
vascular disease DOID:178 0 0.012
cancer DOID:162 0 0.012
disease of cellular proliferation DOID:14566 0 0.012
eye and adnexa disease DOID:1492 0 0.010