Drosophila melanogaster

128 known processes

pcm (Dmel_CG3291)

pacman

(Aliases: CG3291,Xrn1p,XRN1/pcm,Xrn1,Dmel\CG3291,Pcm,XRN1)

pcm biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of gene expression GO:0010629 387 0.376
regulation of multi organism process GO:0043900 131 0.179
tissue morphogenesis GO:0048729 297 0.143
nuclear division GO:0000280 332 0.116
vesicle mediated transport GO:0016192 381 0.099
ncrna 3 end processing GO:0043628 17 0.098
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.097
regulation of response to stress GO:0080134 200 0.087
positive regulation of response to stimulus GO:0048584 323 0.086
chromosome organization GO:0051276 360 0.083
single organism intracellular transport GO:1902582 207 0.081
homeostatic process GO:0042592 199 0.078
cell proliferation GO:0008283 299 0.078
developmental growth GO:0048589 280 0.077
gland development GO:0048732 191 0.075
protein complex assembly GO:0006461 200 0.072
regulation of cell cycle process GO:0010564 181 0.070
snrna metabolic process GO:0016073 14 0.070
regulation of immune system process GO:0002682 176 0.069
negative regulation of biosynthetic process GO:0009890 277 0.068
dna metabolic process GO:0006259 227 0.068
positive regulation of signaling GO:0023056 243 0.064
establishment of localization in cell GO:0051649 402 0.062
embryonic morphogenesis GO:0048598 206 0.059
negative regulation of cellular biosynthetic process GO:0031327 277 0.059
negative regulation of apoptotic process GO:0043066 63 0.057
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.056
transcription from rna polymerase ii promoter GO:0006366 368 0.056
sperm individualization GO:0007291 48 0.055
regulation of localization GO:0032879 275 0.054
mitotic nuclear division GO:0007067 213 0.054
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.052
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.052
positive regulation of rna biosynthetic process GO:1902680 266 0.049
male gamete generation GO:0048232 201 0.049
spermatid development GO:0007286 98 0.048
response to abiotic stimulus GO:0009628 341 0.047
ncrna metabolic process GO:0034660 43 0.046
Human
endocytosis GO:0006897 310 0.045
regulation of cell morphogenesis GO:0022604 163 0.044
organelle fission GO:0048285 340 0.042
determination of adult lifespan GO:0008340 137 0.042
embryonic pattern specification GO:0009880 174 0.041
defense response GO:0006952 300 0.039
regulation of mitotic cell cycle GO:0007346 190 0.039
positive regulation of protein metabolic process GO:0051247 128 0.038
positive regulation of gene expression GO:0010628 290 0.038
posttranscriptional gene silencing by rna GO:0035194 45 0.038
regulation of molecular function GO:0065009 217 0.038
chromatin modification GO:0016568 147 0.038
centrosome organization GO:0051297 163 0.037
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.035
regulation of cell differentiation GO:0045595 302 0.035
regulation of response to external stimulus GO:0032101 115 0.033
gene silencing by rna GO:0031047 57 0.032
positive regulation of nucleic acid templated transcription GO:1903508 266 0.032
connective tissue development GO:0061448 3 0.032
stem cell proliferation GO:0072089 88 0.032
cellular catabolic process GO:0044248 372 0.031
intracellular transport GO:0046907 228 0.031
regulation of cellular component biogenesis GO:0044087 201 0.031
post embryonic appendage morphogenesis GO:0035120 385 0.030
regulation of cellular amine metabolic process GO:0033238 3 0.030
positive regulation of cellular biosynthetic process GO:0031328 316 0.030
anterior posterior pattern specification GO:0009952 136 0.030
positive regulation of macromolecule metabolic process GO:0010604 405 0.030
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.030
gonad development GO:0008406 50 0.029
snrna 3 end processing GO:0034472 14 0.029
spermatid differentiation GO:0048515 114 0.029
neurological system process GO:0050877 358 0.028
growth GO:0040007 359 0.028
protein transport GO:0015031 155 0.028
anatomical structure homeostasis GO:0060249 97 0.028
histone modification GO:0016570 106 0.028
organic substance transport GO:0071702 257 0.028
protein modification process GO:0036211 438 0.027
multi organism behavior GO:0051705 175 0.027
carbohydrate derivative metabolic process GO:1901135 217 0.026
rna localization GO:0006403 115 0.026
chromatin organization GO:0006325 207 0.026
positive regulation of cell communication GO:0010647 250 0.025
dendrite development GO:0016358 204 0.024
protein localization GO:0008104 284 0.024
positive regulation of developmental process GO:0051094 143 0.023
protein localization to organelle GO:0033365 82 0.023
cellular protein localization GO:0034613 160 0.023
regulation of bmp signaling pathway GO:0030510 23 0.023
negative regulation of programmed cell death GO:0043069 72 0.023
positive regulation of transcription dna templated GO:0045893 266 0.023
sex differentiation GO:0007548 81 0.023
oocyte microtubule cytoskeleton organization GO:0016325 35 0.023
mrna metabolic process GO:0016071 124 0.022
positive regulation of catalytic activity GO:0043085 118 0.022
regulation of embryonic development GO:0045995 68 0.022
nucleobase containing small molecule metabolic process GO:0055086 174 0.022
intracellular signal transduction GO:0035556 300 0.021
positive regulation of rna metabolic process GO:0051254 271 0.021
chromosome segregation GO:0007059 157 0.021
negative regulation of cellular metabolic process GO:0031324 382 0.021
regulation of protein metabolic process GO:0051246 256 0.021
negative regulation of rna biosynthetic process GO:1902679 240 0.020
macromolecule methylation GO:0043414 45 0.020
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.020
embryo development ending in birth or egg hatching GO:0009792 152 0.019
small molecule metabolic process GO:0044281 305 0.019
death GO:0016265 284 0.019
cellular protein modification process GO:0006464 438 0.019
regulation of cell proliferation GO:0042127 163 0.019
embryonic axis specification GO:0000578 107 0.019
regulation of developmental growth GO:0048638 174 0.018
cellularization GO:0007349 90 0.018
peptidyl amino acid modification GO:0018193 105 0.018
negative regulation of nucleic acid templated transcription GO:1903507 240 0.018
response to wounding GO:0009611 94 0.018
regulation of organelle organization GO:0033043 196 0.018
negative regulation of rna metabolic process GO:0051253 251 0.018
regulation of apoptotic process GO:0042981 130 0.018
rna interference GO:0016246 27 0.017
regulation of cell cycle GO:0051726 291 0.017
innate immune response GO:0045087 144 0.017
tripartite regional subdivision GO:0007351 103 0.017
morphogenesis of a branching structure GO:0001763 45 0.017
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.017
catabolic process GO:0009056 409 0.017
ribonucleotide metabolic process GO:0009259 145 0.017
segmentation GO:0035282 207 0.017
wound healing GO:0042060 75 0.017
regulation of locomotion GO:0040012 42 0.017
ncrna processing GO:0034470 30 0.017
eye development GO:0001654 323 0.016
camera type eye development GO:0043010 4 0.016
mrna splicing via spliceosome GO:0000398 73 0.016
regionalization GO:0003002 416 0.016
single organism catabolic process GO:0044712 228 0.016
regulation of multicellular organismal development GO:2000026 414 0.016
regulation of microtubule depolymerization GO:0031114 24 0.016
regulation of protein localization GO:0032880 76 0.015
development of primary sexual characteristics GO:0045137 50 0.015
ribonucleoside metabolic process GO:0009119 127 0.015
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.015
nucleocytoplasmic transport GO:0006913 72 0.015
regulation of cellular ketone metabolic process GO:0010565 3 0.015
protein complex biogenesis GO:0070271 201 0.015
mrna processing GO:0006397 104 0.015
mitotic sister chromatid segregation GO:0000070 87 0.015
aromatic compound catabolic process GO:0019439 166 0.015
regulation of transport GO:0051049 181 0.015
exocrine system development GO:0035272 162 0.015
kidney epithelium development GO:0072073 3 0.014
taxis GO:0042330 304 0.014
pole plasm assembly GO:0007315 61 0.014
nuclear pore organization GO:0006999 1 0.014
positive regulation of immune system process GO:0002684 68 0.014
regulation of reproductive process GO:2000241 54 0.014
cellular component assembly involved in morphogenesis GO:0010927 151 0.014
cellular macromolecule localization GO:0070727 220 0.014
negative regulation of cell death GO:0060548 81 0.014
salivary gland development GO:0007431 162 0.014
kidney development GO:0001822 3 0.014
reproductive structure development GO:0048608 74 0.014
body morphogenesis GO:0010171 2 0.014
regulation of response to wounding GO:1903034 19 0.014
aging GO:0007568 143 0.014
germarium derived female germ line cyst formation GO:0030727 42 0.014
positive regulation of phosphate metabolic process GO:0045937 139 0.013
cellular macromolecular complex assembly GO:0034622 153 0.013
organic cyclic compound catabolic process GO:1901361 168 0.013
positive regulation of multicellular organismal process GO:0051240 143 0.013
organic substance catabolic process GO:1901575 308 0.013
cell cell signaling involved in cell fate commitment GO:0045168 210 0.013
rna splicing GO:0008380 83 0.012
macromolecule catabolic process GO:0009057 161 0.012
rna processing GO:0006396 147 0.012
eye morphogenesis GO:0048592 260 0.012
regulation of protein modification by small protein conjugation or removal GO:1903320 25 0.012
muscle structure development GO:0061061 224 0.012
negative regulation of signaling GO:0023057 219 0.012
axis specification GO:0009798 167 0.012
camera type eye morphogenesis GO:0048593 2 0.012
ribose phosphate metabolic process GO:0019693 145 0.011
immune system process GO:0002376 347 0.011
posttranscriptional gene silencing GO:0016441 46 0.011
positive regulation of molecular function GO:0044093 136 0.011
regulation of mitotic spindle organization GO:0060236 9 0.011
receptor mediated endocytosis GO:0006898 21 0.011
nucleoside phosphate metabolic process GO:0006753 162 0.011
nucleus organization GO:0006997 45 0.011
enzyme linked receptor protein signaling pathway GO:0007167 179 0.011
positive regulation of signal transduction GO:0009967 223 0.011
regulation of purine nucleotide metabolic process GO:1900542 62 0.011
regulation of neuron projection development GO:0010975 69 0.011
response to external biotic stimulus GO:0043207 293 0.011
protein targeting to nucleus GO:0044744 51 0.011
hematopoietic or lymphoid organ development GO:0048534 57 0.011
cellular nitrogen compound catabolic process GO:0044270 165 0.011
apoptotic process GO:0006915 159 0.011
nucleobase containing compound catabolic process GO:0034655 165 0.011
programmed cell death GO:0012501 257 0.011
regulation of neurogenesis GO:0050767 158 0.011
regulation of catalytic activity GO:0050790 185 0.011
photoreceptor cell differentiation GO:0046530 170 0.011
positive regulation of binding GO:0051099 4 0.010
chromatin silencing GO:0006342 76 0.010
positive regulation of cellular amine metabolic process GO:0033240 0 0.010
cellular response to dna damage stimulus GO:0006974 223 0.010

pcm disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.016
nervous system disease DOID:863 0 0.016
cancer DOID:162 0 0.016
disease of cellular proliferation DOID:14566 0 0.016
sensory system disease DOID:0050155 0 0.010