Drosophila melanogaster

107 known processes

l(1)sc (Dmel_CG3839)

lethal of scute

(Aliases: bHLHc28,CG3839,L(1)sc,L'Sc,l'sc,l(1)1Ba,lsc,ASC-T3,T3,L'sc,ascT3,sc/T3,AS-C T3,Dmel\CG3839,EG:198A6.2,l-sc,AS-T3)

l(1)sc biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
tube morphogenesis GO:0035239 191 0.174
negative regulation of gene expression GO:0010629 387 0.170
Human Zebrafish
negative regulation of rna biosynthetic process GO:1902679 240 0.160
Human
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.151
Human
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.147
Human
tube development GO:0035295 244 0.127
single organism behavior GO:0044708 391 0.123
epithelial cell differentiation GO:0030855 322 0.102
Zebrafish Mouse
tissue morphogenesis GO:0048729 297 0.100
negative regulation of biosynthetic process GO:0009890 277 0.098
Human
negative regulation of cellular metabolic process GO:0031324 382 0.097
Human
response to abiotic stimulus GO:0009628 341 0.090
Human
regulation of growth GO:0040008 233 0.088
Worm
negative regulation of nucleic acid templated transcription GO:1903507 240 0.088
Human
epithelial cell development GO:0002064 274 0.088
Zebrafish
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.088
Human
negative regulation of cellular biosynthetic process GO:0031327 277 0.080
Human
body morphogenesis GO:0010171 2 0.079
Worm
notch signaling pathway GO:0007219 120 0.078
Human Mouse
digestive system development GO:0055123 149 0.077
telencephalon development GO:0021537 2 0.076
Mouse
negative regulation of transcription dna templated GO:0045892 237 0.075
Human
transcription from rna polymerase ii promoter GO:0006366 368 0.074
regulation of behavior GO:0050795 75 0.074
Worm
regionalization GO:0003002 416 0.073
Mouse
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.070
negative regulation of rna metabolic process GO:0051253 251 0.069
Human
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.066
brain development GO:0007420 120 0.066
Human Zebrafish Mouse
regulation of multicellular organismal development GO:2000026 414 0.065
Human Mouse Rat Worm
forebrain development GO:0030900 2 0.064
Human Zebrafish Mouse
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.064
Human
multi organism behavior GO:0051705 175 0.063
Worm
central nervous system development GO:0007417 201 0.062
Human Zebrafish Mouse
gland development GO:0048732 191 0.061
Zebrafish Mouse
cell fate specification GO:0001708 71 0.060
Mouse Worm
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.060
Mouse
multi organism reproductive behavior GO:0044705 121 0.059
Worm
developmental growth GO:0048589 280 0.056
Zebrafish Worm
regulation of cell size GO:0008361 63 0.055
Worm
localization of cell GO:0051674 257 0.055
Mouse Worm
epithelial tube morphogenesis GO:0060562 88 0.052
growth GO:0040007 359 0.052
Zebrafish Worm
segmentation GO:0035282 207 0.051
multicellular organismal reproductive behavior GO:0033057 110 0.050
Worm
positive regulation of signal transduction GO:0009967 223 0.049
Mouse
neural precursor cell proliferation GO:0061351 75 0.049
Mouse
response to organic substance GO:0010033 284 0.048
Human
positive regulation of rna biosynthetic process GO:1902680 266 0.048
organelle fission GO:0048285 340 0.047
Fly
regulation of gene expression epigenetic GO:0040029 128 0.047
nuclear division GO:0000280 332 0.046
Fly
embryonic morphogenesis GO:0048598 206 0.046
positive regulation of response to stimulus GO:0048584 323 0.045
Mouse
hindbrain development GO:0030902 2 0.045
Zebrafish Mouse
regulation of organelle organization GO:0033043 196 0.045
Fly
respiratory system development GO:0060541 213 0.045
Mouse
digestive tract development GO:0048565 149 0.044
mitotic nuclear division GO:0007067 213 0.043
Fly
salivary gland development GO:0007431 162 0.043
taxis GO:0042330 304 0.043
Worm
sensory organ morphogenesis GO:0090596 260 0.043
Zebrafish
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.042
positive regulation of biosynthetic process GO:0009891 316 0.042
regulation of mitotic cell cycle GO:0007346 190 0.042
Mouse Fly
head development GO:0060322 135 0.041
Human Zebrafish Mouse
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.040
dna metabolic process GO:0006259 227 0.040
chaeta development GO:0022416 97 0.040
Fly
regulation of axon extension involved in axon guidance GO:0048841 4 0.039
Worm
regulation of response to external stimulus GO:0032101 115 0.039
Worm Fly
regulation of cell morphogenesis GO:0022604 163 0.039
Worm
regulation of developmental growth GO:0048638 174 0.038
Worm
regulation of cell development GO:0060284 215 0.038
Human Mouse Rat Worm
compound eye development GO:0048749 307 0.038
regulation of nervous system development GO:0051960 248 0.037
Human Mouse Rat Worm
regulation of cellular component size GO:0032535 98 0.036
Worm
positive regulation of gene expression GO:0010628 290 0.036
renal tubule development GO:0061326 64 0.035
axon development GO:0061564 297 0.035
Worm
positive regulation of cellular biosynthetic process GO:0031328 316 0.034
neuron projection guidance GO:0097485 241 0.034
Worm
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.034
Human
compound eye morphogenesis GO:0001745 249 0.034
positive regulation of signaling GO:0023056 243 0.034
Mouse
negative regulation of cell cycle GO:0045786 116 0.034
Fly
response to oxygen containing compound GO:1901700 200 0.033
Human
negative regulation of developmental process GO:0051093 201 0.033
Human Mouse Rat
dorsal ventral pattern formation GO:0009953 133 0.032
Mouse
positive regulation of rna metabolic process GO:0051254 271 0.032
exocrine system development GO:0035272 162 0.031
regulation of notch signaling pathway GO:0008593 100 0.031
Mouse
morphogenesis of an epithelium GO:0002009 276 0.031
eye development GO:0001654 323 0.031
mesoderm development GO:0007498 78 0.031
chromosome organization GO:0051276 360 0.031
salivary gland morphogenesis GO:0007435 145 0.031
organonitrogen compound metabolic process GO:1901564 318 0.030
Fly
locomotory behavior GO:0007626 176 0.030
eye morphogenesis GO:0048592 260 0.030
regulation of reproductive process GO:2000241 54 0.030
Worm
response to external biotic stimulus GO:0043207 293 0.030
Fly
regulation of localization GO:0032879 275 0.029
Worm
homeostatic process GO:0042592 199 0.029
axonogenesis GO:0007409 290 0.028
Worm
small molecule metabolic process GO:0044281 305 0.028
cell division GO:0051301 248 0.028
Worm Fly
wound healing GO:0042060 75 0.028
Zebrafish
regulation of axonogenesis GO:0050770 32 0.028
Worm
negative regulation of mitotic cell cycle GO:0045930 109 0.028
Fly
malpighian tubule morphogenesis GO:0007443 44 0.028
regulation of cell cycle process GO:0010564 181 0.027
Fly
imaginal disc derived wing morphogenesis GO:0007476 337 0.027
camera type eye development GO:0043010 4 0.027
death GO:0016265 284 0.027
Human Mouse Worm Fly
cell motility GO:0048870 251 0.027
Mouse Worm
regulation of neural precursor cell proliferation GO:2000177 35 0.026
Mouse
negative regulation of response to stimulus GO:0048585 258 0.026
segment specification GO:0007379 33 0.026
cell proliferation GO:0008283 299 0.026
phosphorylation GO:0016310 294 0.026
developmental maturation GO:0021700 172 0.025
Zebrafish Mouse
regulation of cell differentiation GO:0045595 302 0.025
Human Mouse Rat Worm
photoreceptor cell differentiation GO:0046530 170 0.025
multi multicellular organism process GO:0044706 123 0.025
Worm
negative regulation of multicellular organismal process GO:0051241 142 0.025
Human Rat
stem cell proliferation GO:0072089 88 0.025
Mouse
spinal cord development GO:0021510 1 0.025
Mouse
embryonic pattern specification GO:0009880 174 0.024
blastoderm segmentation GO:0007350 159 0.024
cellular macromolecular complex assembly GO:0034622 153 0.024
regulation of neurogenesis GO:0050767 158 0.024
Human Mouse Rat Worm
single organism cellular localization GO:1902580 180 0.024
positive regulation of nucleic acid templated transcription GO:1903508 266 0.024
regulation of cell cycle GO:0051726 291 0.024
Mouse Fly
regulation of anatomical structure morphogenesis GO:0022603 242 0.024
Worm
regulation of anatomical structure size GO:0090066 163 0.024
Worm
intracellular signal transduction GO:0035556 300 0.023
positive regulation of transcription dna templated GO:0045893 266 0.023
cell growth GO:0016049 108 0.023
Worm
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.023
gastrulation GO:0007369 70 0.023
gene silencing GO:0016458 138 0.023
gland morphogenesis GO:0022612 145 0.023
imaginal disc pattern formation GO:0007447 91 0.023
stem cell development GO:0048864 79 0.022
Mouse
macromolecular complex assembly GO:0065003 256 0.022
imaginal disc derived appendage morphogenesis GO:0035114 395 0.022
cell death GO:0008219 279 0.022
Human Mouse Worm Fly
appendage development GO:0048736 401 0.022
response to wounding GO:0009611 94 0.022
Zebrafish
nephron development GO:0072006 3 0.022
chaeta morphogenesis GO:0008407 42 0.022
Fly
compound eye photoreceptor cell differentiation GO:0001751 140 0.021
connective tissue development GO:0061448 3 0.021
positive regulation of developmental process GO:0051094 143 0.021
Mouse
cell fate determination GO:0001709 91 0.021
Mouse
positive regulation of macromolecule metabolic process GO:0010604 405 0.021
negative regulation of programmed cell death GO:0043069 72 0.021
Human Fly
regulation of intracellular signal transduction GO:1902531 236 0.021
regulation of mitosis GO:0007088 56 0.021
Fly
enzyme linked receptor protein signaling pathway GO:0007167 179 0.021
imaginal disc derived appendage development GO:0048737 399 0.020
positive regulation of cell communication GO:0010647 250 0.020
Mouse
nephron epithelium development GO:0072009 3 0.020
neuron fate commitment GO:0048663 50 0.020
Human Mouse
regulation of oviposition GO:0046662 14 0.020
Worm
response to biotic stimulus GO:0009607 294 0.020
Fly
regulation of neuron differentiation GO:0045664 103 0.020
Human Mouse Worm
negative regulation of signal transduction GO:0009968 206 0.020
protein modification process GO:0036211 438 0.019
cellular protein modification process GO:0006464 438 0.019
intracellular transport GO:0046907 228 0.019
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.019
Worm
positive regulation of multicellular organismal process GO:0051240 143 0.019
Mouse
post embryonic appendage morphogenesis GO:0035120 385 0.019
chromatin modification GO:0016568 147 0.019
mesenchymal cell development GO:0014031 1 0.019
reproductive behavior GO:0019098 122 0.019
Worm
regulation of programmed cell death GO:0043067 152 0.019
Human Mouse Worm Fly
regulation of response to stress GO:0080134 200 0.019
positive regulation of growth GO:0045927 75 0.019
Worm
immune effector process GO:0002252 98 0.019
Fly
negative regulation of cellular component organization GO:0051129 108 0.018
Fly
adult behavior GO:0030534 137 0.018
sex determination GO:0007530 18 0.018
Fly
anterior posterior pattern specification GO:0009952 136 0.018
negative regulation of cell cycle process GO:0010948 109 0.018
Fly
eye photoreceptor cell differentiation GO:0001754 145 0.018
regulation of immune response GO:0050776 118 0.018
Fly
regulation of epithelial cell differentiation GO:0030856 4 0.018
Mouse
ameboidal type cell migration GO:0001667 151 0.018
response to decreased oxygen levels GO:0036293 58 0.018
Human
immune response GO:0006955 246 0.018
Fly
organic acid metabolic process GO:0006082 103 0.018
malpighian tubule development GO:0072002 64 0.018
larval development GO:0002164 104 0.018
Worm
vesicle mediated transport GO:0016192 381 0.018
neuron projection extension GO:1990138 32 0.017
Worm
ovarian follicle cell development GO:0030707 248 0.017
carboxylic acid metabolic process GO:0019752 92 0.017
neuroepithelial cell differentiation GO:0060563 6 0.017
Mouse
multicellular organismal aging GO:0010259 140 0.017
regulation of immune effector process GO:0002697 52 0.017
Fly
chemotaxis GO:0006935 249 0.017
Worm
regulation of locomotion GO:0040012 42 0.017
Worm
stem cell fate commitment GO:0048865 25 0.017
Mouse Worm
catabolic process GO:0009056 409 0.017
regulation of cell proliferation GO:0042127 163 0.017
Mouse Rat
hindgut development GO:0061525 58 0.017
mesenchymal cell differentiation GO:0048762 1 0.017
renal system development GO:0072001 72 0.017
apoptotic process GO:0006915 159 0.017
Human Mouse Fly
cell adhesion GO:0007155 136 0.017
dendrite morphogenesis GO:0048813 199 0.017
positive regulation of intracellular signal transduction GO:1902533 116 0.017
wing disc pattern formation GO:0035222 66 0.016
retina development in camera type eye GO:0060041 4 0.016
hindgut morphogenesis GO:0007442 58 0.016
peptide metabolic process GO:0006518 80 0.016
Fly
regulation of phosphorus metabolic process GO:0051174 210 0.016
negative regulation of cell differentiation GO:0045596 143 0.016
Human Mouse Rat
single organism biosynthetic process GO:0044711 206 0.016
positive regulation of cell cycle GO:0045787 43 0.016
Mouse
regulation of apoptotic process GO:0042981 130 0.016
Human Mouse Fly
establishment of localization in cell GO:0051649 402 0.016
organic substance transport GO:0071702 257 0.015
cellular response to dna damage stimulus GO:0006974 223 0.015
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.015
negative regulation of cell communication GO:0010648 223 0.015
oxoacid metabolic process GO:0043436 103 0.015
organic substance catabolic process GO:1901575 308 0.015
response to temperature stimulus GO:0009266 106 0.015
phagocytosis GO:0006909 215 0.015
gliogenesis GO:0042063 80 0.015
Mouse Rat
regulation of antimicrobial humoral response GO:0002759 50 0.015
Fly
humoral immune response GO:0006959 117 0.015
Fly
cellular amide metabolic process GO:0043603 80 0.015
Fly
positive regulation of notch signaling pathway GO:0045747 34 0.015
Mouse
peptide biosynthetic process GO:0043043 42 0.015
Fly
negative regulation of signaling GO:0023057 219 0.015
columnar cuboidal epithelial cell development GO:0002066 249 0.015
cellular response to chemical stimulus GO:0070887 199 0.015
peripheral nervous system development GO:0007422 52 0.015
Fly
antimicrobial humoral response GO:0019730 99 0.015
Fly
appendage morphogenesis GO:0035107 397 0.015
programmed cell death GO:0012501 257 0.015
Human Mouse Worm Fly
developmental cell growth GO:0048588 52 0.015
Worm
embryonic development via the syncytial blastoderm GO:0001700 148 0.014
negative regulation of cell development GO:0010721 62 0.014
Human Rat
negative regulation of organelle organization GO:0010639 56 0.014
Fly
anatomical structure homeostasis GO:0060249 97 0.014
regulation of cellular ketone metabolic process GO:0010565 3 0.014
renal tubule morphogenesis GO:0061333 44 0.014
axon guidance GO:0007411 233 0.014
Worm
sensory perception of mechanical stimulus GO:0050954 72 0.014
camera type eye morphogenesis GO:0048593 2 0.014
positive regulation of neuron apoptotic process GO:0043525 1 0.014
Mouse
single organism intracellular transport GO:1902582 207 0.014
response to lipopolysaccharide GO:0032496 4 0.014
cellular catabolic process GO:0044248 372 0.013
neuroblast proliferation GO:0007405 74 0.013
Mouse
response to other organism GO:0051707 293 0.013
Fly
regulation of nuclear division GO:0051783 58 0.013
Fly
cell type specific apoptotic process GO:0097285 38 0.013
Mouse
dorsal ventral pattern formation imaginal disc GO:0007450 51 0.013
sensory organ boundary specification GO:0008052 22 0.013
locomotor rhythm GO:0045475 56 0.013
positive regulation of cell differentiation GO:0045597 64 0.013
Mouse
gastrulation involving germ band extension GO:0010004 36 0.013
hematopoietic progenitor cell differentiation GO:0002244 1 0.013
wing disc morphogenesis GO:0007472 344 0.013
cellular amine metabolic process GO:0044106 12 0.013
carbohydrate derivative metabolic process GO:1901135 217 0.013
gastrulation with mouth forming first GO:0001703 36 0.013
response to heat GO:0009408 63 0.013
cellular ketone metabolic process GO:0042180 24 0.013
cell migration GO:0016477 238 0.013
Mouse Worm
cellular amino acid metabolic process GO:0006520 61 0.013
dendrite development GO:0016358 204 0.013
formation of organ boundary GO:0010160 30 0.013
regulation of production of molecular mediator of immune response GO:0002700 44 0.013
Fly
digestive tract morphogenesis GO:0048546 127 0.012
detection of external stimulus GO:0009581 66 0.012
eggshell formation GO:0030703 105 0.012
neurological system process GO:0050877 358 0.012
kidney development GO:0001822 3 0.012
glycosyl compound metabolic process GO:1901657 127 0.012
sensory organ precursor cell fate determination GO:0016360 19 0.012
sensory perception of pain GO:0019233 4 0.012
muscle structure development GO:0061061 224 0.012
regulation of cellular amine metabolic process GO:0033238 3 0.012
embryonic axis specification GO:0000578 107 0.012
establishment or maintenance of cell polarity GO:0007163 167 0.012
regulation of cell death GO:0010941 173 0.012
Human Mouse Worm Fly
glial cell differentiation GO:0010001 35 0.012
Mouse
negative regulation of gene expression epigenetic GO:0045814 77 0.012
lipid metabolic process GO:0006629 121 0.012
larval behavior GO:0030537 42 0.012
spindle organization GO:0007051 253 0.012
organophosphate metabolic process GO:0019637 195 0.012
embryonic hindgut morphogenesis GO:0048619 48 0.011
regulation of immune system process GO:0002682 176 0.011
Fly
rna processing GO:0006396 147 0.011
determination of adult lifespan GO:0008340 137 0.011
negative regulation of growth GO:0045926 84 0.011
chromatin silencing GO:0006342 76 0.011
cell maturation GO:0048469 144 0.011
Zebrafish Mouse
regulation of stem cell proliferation GO:0072091 40 0.011
amine metabolic process GO:0009308 12 0.011
organelle localization GO:0051640 148 0.011
regulation of cellular amino acid metabolic process GO:0006521 0 0.011
organonitrogen compound biosynthetic process GO:1901566 117 0.011
Fly
cranial nerve development GO:0021545 1 0.011
cellular response to molecule of bacterial origin GO:0071219 3 0.011
embryo development ending in birth or egg hatching GO:0009792 152 0.011
Human Mouse
axis specification GO:0009798 167 0.011
antimicrobial peptide biosynthetic process GO:0002777 38 0.011
Fly
histolysis GO:0007559 102 0.011
covalent chromatin modification GO:0016569 106 0.011
protein complex assembly GO:0006461 200 0.011
cytoplasmic transport GO:0016482 130 0.011
endocytosis GO:0006897 310 0.011
mrna processing GO:0006397 104 0.011
regulation of epidermal cell differentiation GO:0045604 3 0.011
protein localization GO:0008104 284 0.011
nephron tubule development GO:0072080 3 0.011
positive regulation of catalytic activity GO:0043085 118 0.011
regulation of cellular component movement GO:0051270 42 0.011
Worm
salivary gland histolysis GO:0035070 88 0.011
chitin based cuticle development GO:0040003 49 0.010
regulation of neuron projection development GO:0010975 69 0.010
Worm
cardiovascular system development GO:0072358 82 0.010
urogenital system development GO:0001655 72 0.010
negative regulation of notch signaling pathway GO:0045746 41 0.010
developmental programmed cell death GO:0010623 138 0.010
regulation of cellular protein metabolic process GO:0032268 243 0.010
actin filament based process GO:0030029 220 0.010
vitamin metabolic process GO:0006766 2 0.010
positive regulation of cellular component organization GO:0051130 156 0.010
dna conformation change GO:0071103 105 0.010

l(1)sc disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.028
musculoskeletal system disease DOID:17 0 0.026
disease of metabolism DOID:0014667 0 0.015
connective tissue disease DOID:65 0 0.015
nervous system disease DOID:863 0 0.011
renal tubular transport disease DOID:447 0 0.011
kidney disease DOID:557 0 0.011
urinary system disease DOID:18 0 0.011