Drosophila melanogaster

312 known processes

Lis-1 (Dmel_CG8440)

Lissencephaly-1

(Aliases: CG8440,Lis 1,Dlis-1,l(2R)W8,lis-1,dLis1,LIS-1,DLIS-1,DLIS1,D-Lis1,l(2)k13209,DLis1,Dmel\CG8440,DLis-1,Dlis1,lis1,Lis1,DmLIS1,n(2)k11702)

Lis-1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
border follicle cell migration GO:0007298 113 1.000
epithelial cell migration GO:0010631 148 1.000
ovarian follicle cell migration GO:0007297 121 1.000
epithelium migration GO:0090132 148 1.000
ovarian follicle cell development GO:0030707 248 1.000
oocyte microtubule cytoskeleton organization GO:0016325 35 0.998
cell migration GO:0016477 238 0.997
pronuclear migration GO:0035046 4 0.997
Worm
ovarian fusome organization GO:0030723 11 0.996
cell motility GO:0048870 251 0.995
ameboidal type cell migration GO:0001667 151 0.993
localization of cell GO:0051674 257 0.992
axonogenesis GO:0007409 290 0.991
germarium derived oocyte fate determination GO:0007294 26 0.991
organelle localization GO:0051640 148 0.990
germarium derived oocyte differentiation GO:0030706 29 0.989
eye development GO:0001654 323 0.987
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.986
cell division GO:0051301 248 0.986
immune system process GO:0002376 347 0.985
Mouse
nucleus localization GO:0051647 34 0.983
single organism cellular localization GO:1902580 180 0.982
oocyte construction GO:0007308 112 0.981
epithelial cell differentiation GO:0030855 322 0.980
developmental maturation GO:0021700 172 0.976
oocyte axis specification GO:0007309 108 0.974
meiotic nuclear division GO:0007126 151 0.972
Worm
developmental growth GO:0048589 280 0.971
Rat
anterior posterior pattern specification GO:0009952 136 0.969
germarium derived egg chamber formation GO:0007293 101 0.967
segmentation GO:0035282 207 0.963
oocyte nucleus localization involved in oocyte dorsal ventral axis specification GO:0051663 12 0.961
actin cytoskeleton organization GO:0030036 206 0.954
Mouse
cytokinesis GO:0000910 90 0.949
regulation of neuron differentiation GO:0045664 103 0.948
establishment or maintenance of cytoskeleton polarity GO:0030952 44 0.948
pole plasm mrna localization GO:0019094 49 0.946
columnar cuboidal epithelial cell development GO:0002066 249 0.937
oocyte anterior posterior axis specification GO:0007314 72 0.924
regulation of cell differentiation GO:0045595 302 0.924
cytoskeleton dependent cytokinesis GO:0061640 81 0.923
regulation of cell projection organization GO:0031344 92 0.920
regulation of cell development GO:0060284 215 0.920
regulation of dendrite morphogenesis GO:0048814 28 0.919
spermatogenesis GO:0007283 200 0.918
taxis GO:0042330 304 0.912
chemotaxis GO:0006935 249 0.911
photoreceptor cell differentiation GO:0046530 170 0.910
mitotic nuclear division GO:0007067 213 0.906
Worm
intracellular signal transduction GO:0035556 300 0.897
Mouse
epithelial cell development GO:0002064 274 0.889
axon guidance GO:0007411 233 0.887
oocyte development GO:0048599 124 0.885
fertilization GO:0009566 26 0.885
Worm
cellular protein modification process GO:0006464 438 0.884
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 41 0.879
regulation of dendrite development GO:0050773 37 0.868
establishment of organelle localization GO:0051656 122 0.867
regulation of anatomical structure morphogenesis GO:0022603 242 0.864
synapse organization GO:0050808 196 0.864
regulation of immune system process GO:0002682 176 0.860
growth GO:0040007 359 0.855
Rat
mitotic spindle organization GO:0007052 220 0.855
Worm
regulation of phosphate metabolic process GO:0019220 210 0.850
Mouse
fusome organization GO:0045478 13 0.837
single fertilization GO:0007338 24 0.836
Worm
defense response GO:0006952 300 0.834
embryonic pattern specification GO:0009880 174 0.833
oocyte fate determination GO:0030716 27 0.820
blastoderm segmentation GO:0007350 159 0.820
cell maturation GO:0048469 144 0.813
immune effector process GO:0002252 98 0.799
oocyte differentiation GO:0009994 145 0.797
embryo development ending in birth or egg hatching GO:0009792 152 0.797
Worm
male gamete generation GO:0048232 201 0.795
response to organic substance GO:0010033 284 0.794
Mouse
establishment of localization in cell GO:0051649 402 0.790
positive regulation of response to stimulus GO:0048584 323 0.789
Mouse
actin filament organization GO:0007015 126 0.785
pole plasm rna localization GO:0007316 52 0.774
compound eye photoreceptor cell differentiation GO:0001751 140 0.759
positive regulation of cell communication GO:0010647 250 0.753
Mouse
maternal determination of anterior posterior axis embryo GO:0008358 74 0.751
regulation of cell morphogenesis GO:0022604 163 0.741
positive regulation of cellular component organization GO:0051130 156 0.741
Rat
determination of adult lifespan GO:0008340 137 0.738
regulation of neurogenesis GO:0050767 158 0.726
regulation of neuron projection development GO:0010975 69 0.723
microtubule polymerization or depolymerization GO:0031109 39 0.720
protein complex assembly GO:0006461 200 0.719
response to biotic stimulus GO:0009607 294 0.713
regulation of protein metabolic process GO:0051246 256 0.698
brain development GO:0007420 120 0.692
cellular response to chemical stimulus GO:0070887 199 0.691
Mouse
establishment of nucleus localization GO:0040023 26 0.677
anterior posterior axis specification embryo GO:0008595 103 0.675
cellular response to organic substance GO:0071310 132 0.670
Mouse
organelle fission GO:0048285 340 0.662
Worm
chorion containing eggshell pattern formation GO:0030381 11 0.646
positive regulation of protein metabolic process GO:0051247 128 0.629
sensory organ morphogenesis GO:0090596 260 0.617
regionalization GO:0003002 416 0.608
cellular macromolecule localization GO:0070727 220 0.607
organonitrogen compound metabolic process GO:1901564 318 0.603
Mouse
protein localization GO:0008104 284 0.597
cell death GO:0008219 279 0.594
vesicle mediated transport GO:0016192 381 0.593
Worm
regulation of pole plasm oskar mrna localization GO:0007317 27 0.593
regulation of intracellular signal transduction GO:1902531 236 0.592
Mouse
neuron projection guidance GO:0097485 241 0.588
cellular component disassembly GO:0022411 46 0.579
Mouse
regulation of nervous system development GO:0051960 248 0.574
ras protein signal transduction GO:0007265 88 0.572
cytoskeleton dependent intracellular transport GO:0030705 44 0.570
ribonucleoside triphosphate metabolic process GO:0009199 119 0.568
Mouse
pole plasm assembly GO:0007315 61 0.566
positive regulation of signaling GO:0023056 243 0.564
Mouse
immune response GO:0006955 246 0.551
cognition GO:0050890 141 0.548
Mouse
innate immune response GO:0045087 144 0.545
establishment of vesicle localization GO:0051650 51 0.539
Mouse Worm
cytoplasm organization GO:0007028 64 0.531
response to external biotic stimulus GO:0043207 293 0.527
organelle assembly GO:0070925 198 0.526
neuron remodeling GO:0016322 29 0.523
tripartite regional subdivision GO:0007351 103 0.511
pole plasm oskar mrna localization GO:0045451 46 0.508
cellular protein complex assembly GO:0043623 71 0.503
axon development GO:0061564 297 0.500
single organism intracellular transport GO:1902582 207 0.496
intracellular mrna localization involved in pattern specification process GO:0060810 56 0.493
rna localization GO:0006403 115 0.486
regulation of multicellular organismal development GO:2000026 414 0.482
positive regulation of phosphate metabolic process GO:0045937 139 0.482
eye morphogenesis GO:0048592 260 0.479
oocyte microtubule cytoskeleton polarization GO:0008103 22 0.478
actin filament based process GO:0030029 220 0.476
Mouse
nuclear migration GO:0007097 20 0.461
organic substance catabolic process GO:1901575 308 0.460
Mouse
nucleobase containing small molecule metabolic process GO:0055086 174 0.457
Mouse
compound eye morphogenesis GO:0001745 249 0.452
establishment of oocyte nucleus localization involved in oocyte dorsal ventral axis specification GO:0030722 6 0.449
endocytosis GO:0006897 310 0.447
Worm
regulation of response to stress GO:0080134 200 0.444
Mouse
regulation of cellular localization GO:0060341 136 0.442
spindle organization GO:0007051 253 0.435
cellular protein localization GO:0034613 160 0.432
cystoblast division GO:0007282 10 0.419
developmental growth involved in morphogenesis GO:0060560 65 0.419
Rat
larval development GO:0002164 104 0.419
Worm
programmed cell death GO:0012501 257 0.412
regulation of microtubule cytoskeleton organization GO:0070507 41 0.409
multicellular organismal aging GO:0010259 140 0.408
regulation of cell cycle process GO:0010564 181 0.408
response to abiotic stimulus GO:0009628 341 0.408
eggshell formation GO:0030703 105 0.404
positive regulation of macromolecule metabolic process GO:0010604 405 0.400
intracellular mrna localization involved in anterior posterior axis specification GO:0060811 53 0.400
synapse assembly GO:0007416 143 0.398
positive regulation of developmental growth GO:0048639 62 0.393
Rat
apoptotic process GO:0006915 159 0.385
tissue morphogenesis GO:0048729 297 0.385
embryonic development via the syncytial blastoderm GO:0001700 148 0.383
regulation of cellular component size GO:0032535 98 0.382
Rat
neuron projection extension GO:1990138 32 0.372
Rat
positive regulation of intracellular signal transduction GO:1902533 116 0.366
single organism behavior GO:0044708 391 0.365
Human Mouse
oocyte localization involved in germarium derived egg chamber formation GO:0030720 12 0.363
axon cargo transport GO:0008088 29 0.362
purine ribonucleotide metabolic process GO:0009150 145 0.342
Mouse
regulation of localization GO:0032879 275 0.337
response to other organism GO:0051707 293 0.336
establishment or maintenance of cell polarity GO:0007163 167 0.334
Human Worm
chorion containing eggshell formation GO:0007304 105 0.333
death GO:0016265 284 0.329
synaptic transmission GO:0007268 288 0.329
Mouse Worm
positive regulation of signal transduction GO:0009967 223 0.328
Mouse
single organism membrane organization GO:0044802 93 0.325
Mouse
chromosome organization GO:0051276 360 0.323
asymmetric protein localization GO:0008105 33 0.322
Zebrafish
neural precursor cell proliferation GO:0061351 75 0.319
gonad development GO:0008406 50 0.315
stem cell development GO:0048864 79 0.315
positive regulation of developmental process GO:0051094 143 0.313
Rat
regulation of response to biotic stimulus GO:0002831 63 0.311
ribonucleoside metabolic process GO:0009119 127 0.308
Mouse
muscle structure development GO:0061061 224 0.300
actin cytoskeleton reorganization GO:0031532 22 0.299
embryonic axis specification GO:0000578 107 0.297
regulation of immune response GO:0050776 118 0.291
cell adhesion GO:0007155 136 0.291
dendrite morphogenesis GO:0048813 199 0.291
protein complex biogenesis GO:0070271 201 0.290
ribonucleotide metabolic process GO:0009259 145 0.288
Mouse
stem cell differentiation GO:0048863 117 0.288
intracellular mrna localization GO:0008298 66 0.283
regulation of phosphorus metabolic process GO:0051174 210 0.274
Mouse
female germ line cyst formation GO:0048135 42 0.274
cytokinetic process GO:0032506 27 0.270
organic cyclic compound catabolic process GO:1901361 168 0.265
Mouse
positive regulation of cell differentiation GO:0045597 64 0.264
Rat
compound eye development GO:0048749 307 0.262
photoreceptor cell development GO:0042461 96 0.262
eye photoreceptor cell development GO:0042462 81 0.262
negative regulation of response to stimulus GO:0048585 258 0.259
Mouse
nucleoside metabolic process GO:0009116 127 0.257
Mouse
central nervous system development GO:0007417 201 0.256
pseudocleavage involved in syncytial blastoderm formation GO:0030589 9 0.255
regulation of phosphorylation GO:0042325 147 0.255
Mouse
positive regulation of molecular function GO:0044093 136 0.253
asymmetric cell division GO:0008356 37 0.253
protein targeting GO:0006605 64 0.250
cellular component assembly involved in morphogenesis GO:0010927 151 0.250
sister chromatid segregation GO:0000819 92 0.248
germ line cyst formation GO:0048134 44 0.248
establishment of protein localization GO:0045184 163 0.246
dorsal appendage formation GO:0046843 47 0.245
establishment or maintenance of apical basal cell polarity GO:0035088 34 0.242
establishment or maintenance of bipolar cell polarity GO:0061245 34 0.240
microtubule based transport GO:0010970 42 0.235
regulation of organ morphogenesis GO:2000027 78 0.233
positive regulation of phosphorus metabolic process GO:0010562 139 0.232
mitotic cytokinesis GO:0000281 50 0.232
macromolecular complex assembly GO:0065003 256 0.231
regulation of protein polymerization GO:0032271 28 0.230
negative regulation of immune system process GO:0002683 50 0.229
homeostatic process GO:0042592 199 0.227
positive regulation of cellular component biogenesis GO:0044089 80 0.225
muscle cell differentiation GO:0042692 103 0.222
protein modification process GO:0036211 438 0.222
positive regulation of rna metabolic process GO:0051254 271 0.209
regulation of immune effector process GO:0002697 52 0.208
regulation of synapse organization GO:0050807 110 0.206
filopodium assembly GO:0046847 33 0.206
phenol containing compound metabolic process GO:0018958 57 0.205
regulation of molecular function GO:0065009 217 0.205
Mouse
tissue migration GO:0090130 155 0.204
vesicle localization GO:0051648 55 0.203
Mouse Worm
establishment of epithelial cell polarity GO:0090162 13 0.202
intracellular protein transport GO:0006886 104 0.200
defense response to other organism GO:0098542 225 0.199
hematopoietic or lymphoid organ development GO:0048534 57 0.197
Mouse
response to virus GO:0009615 28 0.197
learning or memory GO:0007611 141 0.193
Mouse
regulation of cell cycle GO:0051726 291 0.192
nucleoside phosphate catabolic process GO:1901292 110 0.191
Mouse
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.191
organophosphate metabolic process GO:0019637 195 0.186
Mouse
secondary metabolic process GO:0019748 75 0.184
regulation of anatomical structure size GO:0090066 163 0.184
Rat
phosphorylation GO:0016310 294 0.181
Mouse
positive regulation of multicellular organismal process GO:0051240 143 0.178
Rat
establishment or maintenance of epithelial cell apical basal polarity GO:0045197 24 0.177
purine containing compound catabolic process GO:0072523 112 0.176
Mouse
microtubule organizing center organization GO:0031023 168 0.176
body morphogenesis GO:0010171 2 0.175
microtubule depolymerization GO:0007019 25 0.174
organelle transport along microtubule GO:0072384 7 0.174
purine nucleoside triphosphate metabolic process GO:0009144 119 0.169
Mouse
positive regulation of gene expression GO:0010628 290 0.168
positive regulation of phosphorylation GO:0042327 87 0.168
regulation of axonogenesis GO:0050770 32 0.168
Rat
positive regulation of axonogenesis GO:0050772 2 0.167
Rat
dendrite development GO:0016358 204 0.167
nucleoside catabolic process GO:0009164 112 0.165
Mouse
mapk cascade GO:0000165 107 0.162
Mouse
compound eye photoreceptor development GO:0042051 78 0.158
regulation of defense response to virus GO:0050688 14 0.156
regulation of protein modification process GO:0031399 112 0.154
response to bacterium GO:0009617 198 0.154
regulation of embryonic development GO:0045995 68 0.153
negative regulation of gene expression GO:0010629 387 0.153
small gtpase mediated signal transduction GO:0007264 88 0.152
regulation of synapse structure and activity GO:0050803 128 0.147
positive regulation of cell development GO:0010720 61 0.145
Rat
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.145
cell cycle phase transition GO:0044770 140 0.144
cytoplasmic transport GO:0016482 130 0.141
small molecule metabolic process GO:0044281 305 0.141
Mouse
regulation of actin cytoskeleton organization GO:0032956 42 0.140
synaptic growth at neuromuscular junction GO:0051124 119 0.140
regulation of microtubule polymerization or depolymerization GO:0031110 27 0.139
protein localization to organelle GO:0033365 82 0.139
purine nucleotide catabolic process GO:0006195 109 0.137
Mouse
regulation of microtubule depolymerization GO:0031114 24 0.134
nucleobase containing compound catabolic process GO:0034655 165 0.132
Mouse
anterior posterior axis specification GO:0009948 109 0.131
spermatid differentiation GO:0048515 114 0.130
Mouse
camera type eye development GO:0043010 4 0.128
intracellular transport GO:0046907 228 0.128
response to endogenous stimulus GO:0009719 119 0.127
telencephalon development GO:0021537 2 0.125
Human Mouse
endomembrane system organization GO:0010256 119 0.123
Mouse
negative regulation of developmental process GO:0051093 201 0.123
germ line stem cell division GO:0042078 25 0.123
endosomal transport GO:0016197 44 0.122
nuclear division GO:0000280 332 0.121
Worm
nucleocytoplasmic transport GO:0006913 72 0.121
positive regulation of cell projection organization GO:0031346 29 0.120
Rat
chemical homeostasis GO:0048878 92 0.119
regulation of small gtpase mediated signal transduction GO:0051056 93 0.118
Mouse
development of primary sexual characteristics GO:0045137 50 0.116
protein polymerization GO:0051258 42 0.116
positive regulation of transport GO:0051050 92 0.116
cellular response to oxygen containing compound GO:1901701 79 0.115
positive regulation of nervous system development GO:0051962 69 0.114
Rat
regulation of compound eye retinal cell programmed cell death GO:0046669 18 0.114
reproductive system development GO:0061458 74 0.112
reproductive structure development GO:0048608 74 0.112
nucleus organization GO:0006997 45 0.111
Mouse
glycosyl compound catabolic process GO:1901658 112 0.111
Mouse
meiotic cell cycle process GO:1903046 132 0.110
Worm
establishment of mitochondrion localization microtubule mediated GO:0034643 6 0.110
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.109
response to heat GO:0009408 63 0.109
retrograde axon cargo transport GO:0008090 9 0.109
membrane tubulation GO:0097320 4 0.108
male meiosis cytokinesis GO:0007112 26 0.108
axon extension GO:0048675 32 0.108
Rat
regulation of phosphatase activity GO:0010921 3 0.108
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.107
Mouse
positive regulation of neurogenesis GO:0050769 41 0.107
Rat
response to oxygen containing compound GO:1901700 200 0.105
regulation of cell size GO:0008361 63 0.105
Rat
meiotic cytokinesis GO:0033206 33 0.105
nuclear transport GO:0051169 72 0.102
centrosome organization GO:0051297 163 0.102
purine nucleoside metabolic process GO:0042278 127 0.102
Mouse
organophosphate catabolic process GO:0046434 112 0.102
Mouse
positive regulation of programmed cell death GO:0043068 62 0.101
compound eye retinal cell programmed cell death GO:0046667 23 0.101
cellular response to abiotic stimulus GO:0071214 58 0.101
spindle assembly GO:0051225 80 0.100
striated muscle cell development GO:0055002 50 0.100
eye photoreceptor cell differentiation GO:0001754 145 0.100
purine nucleoside catabolic process GO:0006152 112 0.100
Mouse
establishment of mitochondrion localization GO:0051654 7 0.099
protein localization to plasma membrane GO:0072659 13 0.099
protein phosphorylation GO:0006468 169 0.098
regulation of cellular amine metabolic process GO:0033238 3 0.097
cellular catabolic process GO:0044248 372 0.097
Mouse
regulation of actin polymerization or depolymerization GO:0008064 27 0.097
microtubule polymerization GO:0046785 15 0.096
positive regulation of growth GO:0045927 75 0.096
Rat
stem cell proliferation GO:0072089 88 0.096
biological adhesion GO:0022610 138 0.095
regulation of cellular protein metabolic process GO:0032268 243 0.093
positive regulation of neuron differentiation GO:0045666 26 0.093
Rat
regulation of protein complex disassembly GO:0043244 29 0.093
positive regulation of apoptotic process GO:0043065 47 0.093
purine nucleotide metabolic process GO:0006163 146 0.091
Mouse
positive regulation of cellular protein metabolic process GO:0032270 118 0.091
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.090
establishment of protein localization to organelle GO:0072594 62 0.090
melanin metabolic process GO:0006582 47 0.090
cellular protein complex disassembly GO:0043624 35 0.090
response to ionizing radiation GO:0010212 32 0.089
vesicle organization GO:0016050 44 0.088
Mouse
ribonucleoside triphosphate catabolic process GO:0009203 108 0.087
Mouse
cellular response to endogenous stimulus GO:0071495 80 0.087
positive regulation of mapk cascade GO:0043410 63 0.086
germarium derived female germ line cyst encapsulation GO:0030708 8 0.086
positive regulation of dendrite morphogenesis GO:0050775 9 0.086
positive regulation of cell size GO:0045793 21 0.084
regulation of growth GO:0040008 233 0.083
Rat
regulation of cell division GO:0051302 72 0.083
digestive tract development GO:0048565 149 0.082
cell type specific apoptotic process GO:0097285 38 0.082
regulation of synaptic transmission GO:0050804 69 0.081
developmental cell growth GO:0048588 52 0.081
Rat
stem cell maintenance GO:0019827 67 0.080
regulation of defense response GO:0031347 102 0.080
meiotic cell cycle GO:0051321 171 0.078
Worm
nucleotide catabolic process GO:0009166 109 0.078
Mouse
positive regulation of cell death GO:0010942 69 0.078
negative regulation of rna metabolic process GO:0051253 251 0.077
positive regulation of axon extension GO:0045773 2 0.076
Rat
negative regulation of cellular metabolic process GO:0031324 382 0.076
Mouse
membrane organization GO:0061024 112 0.075
Mouse Worm
regulation of catalytic activity GO:0050790 185 0.075
Mouse
regulation of oocyte development GO:0060281 27 0.075
regulation of transport GO:0051049 181 0.074
mitotic cell cycle embryonic GO:0045448 38 0.073
regulation of cellular catabolic process GO:0031329 157 0.072
Mouse
retinal cell programmed cell death GO:0046666 25 0.072
salivary gland development GO:0007431 162 0.071
cellular amino acid metabolic process GO:0006520 61 0.071
regulation of response to external stimulus GO:0032101 115 0.071
protein import GO:0017038 55 0.070
catabolic process GO:0009056 409 0.070
Mouse
regulation of cell projection assembly GO:0060491 30 0.069
molting cycle GO:0042303 56 0.068
response to wounding GO:0009611 94 0.067
regulation of cellular component biogenesis GO:0044087 201 0.067
peptidyl amino acid modification GO:0018193 105 0.066
cellular amine metabolic process GO:0044106 12 0.066
regulation of apoptotic process GO:0042981 130 0.066
regulation of protein localization GO:0032880 76 0.066
carbohydrate derivative metabolic process GO:1901135 217 0.066
Mouse
negative regulation of cell cycle phase transition GO:1901988 103 0.066
regulation of cell maturation GO:1903429 27 0.066
aging GO:0007568 143 0.065
posttranscriptional regulation of gene expression GO:0010608 145 0.065
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.064
striated muscle cell differentiation GO:0051146 90 0.064
amine metabolic process GO:0009308 12 0.064
rhythmic process GO:0048511 106 0.064
meiotic spindle organization GO:0000212 36 0.063
dorsal ventral axis specification GO:0009950 66 0.063
forebrain development GO:0030900 2 0.062
Human Mouse Rat
negative regulation of mitotic cell cycle GO:0045930 109 0.062
defense response to virus GO:0051607 23 0.060
positive regulation of response to external stimulus GO:0032103 44 0.060
positive regulation of transcription dna templated GO:0045893 266 0.060
pigmentation GO:0043473 75 0.059
nucleoside phosphate metabolic process GO:0006753 162 0.059
Mouse
regulation of ras protein signal transduction GO:0046578 93 0.058
Mouse
purine nucleoside triphosphate catabolic process GO:0009146 108 0.058
Mouse
positive regulation of cellular amine metabolic process GO:0033240 0 0.057
chromosome segregation GO:0007059 157 0.057
protein import into nucleus GO:0006606 51 0.057
negative regulation of neurogenesis GO:0050768 53 0.057
Rat
mitotic metaphase plate congression GO:0007080 13 0.057
positive regulation of multicellular organism growth GO:0040018 21 0.057
cell fate determination GO:0001709 91 0.056
regulation of actin filament length GO:0030832 27 0.056
morphogenesis of embryonic epithelium GO:0016331 94 0.056
microtubule based movement GO:0007018 51 0.056
establishment of spindle localization GO:0051293 22 0.055
Human Worm
regulation of cell death GO:0010941 173 0.055
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.055
axis specification GO:0009798 167 0.055
regulation of intracellular transport GO:0032386 64 0.054
negative regulation of microtubule polymerization or depolymerization GO:0031111 21 0.054
positive regulation of apoptotic signaling pathway GO:2001235 4 0.054
hemocyte differentiation GO:0042386 38 0.053
actin filament bundle organization GO:0061572 28 0.053
regulation of nucleocytoplasmic transport GO:0046822 35 0.052
regulation of programmed cell death GO:0043067 152 0.052
cell growth GO:0016049 108 0.051
Rat
regulation of multicellular organism growth GO:0040014 40 0.051
positive regulation of erk1 and erk2 cascade GO:0070374 36 0.050
ribonucleotide catabolic process GO:0009261 109 0.050
Mouse
regulation of cytoskeleton organization GO:0051493 89 0.050
cytoplasmic microtubule organization GO:0031122 22 0.049
regulation of multi organism process GO:0043900 131 0.049
mitotic cell cycle phase transition GO:0044772 138 0.049
regulation of protein localization to nucleus GO:1900180 29 0.048
cellular nitrogen compound catabolic process GO:0044270 165 0.048
Mouse
mitotic sister chromatid segregation GO:0000070 87 0.048
positive regulation of cell cycle process GO:0090068 28 0.047
positive regulation of cellular biosynthetic process GO:0031328 316 0.047
negative regulation of protein metabolic process GO:0051248 85 0.047
imaginal disc derived appendage development GO:0048737 399 0.047
nucleoside monophosphate catabolic process GO:0009125 39 0.047
regulation of proteolysis GO:0030162 87 0.046
stem cell division GO:0017145 69 0.046
Rat
protein complex disassembly GO:0043241 36 0.045
regulation of protein import into nucleus GO:0042306 28 0.044
neuron apoptotic process GO:0051402 17 0.044
macromolecular complex disassembly GO:0032984 37 0.044
positive regulation of neuron projection development GO:0010976 14 0.044
Rat
regulation of cytoplasmic transport GO:1903649 47 0.044
organonitrogen compound biosynthetic process GO:1901566 117 0.044
positive regulation of neuron apoptotic process GO:0043525 1 0.043
single organism catabolic process GO:0044712 228 0.043
Mouse
protein depolymerization GO:0051261 31 0.043
cardiovascular system development GO:0072358 82 0.042
apical constriction GO:0003383 18 0.042
regulation of centrosome cycle GO:0046605 7 0.042
phagocytosis engulfment GO:0006911 11 0.042
Worm
cellularization GO:0007349 90 0.042
protein transport GO:0015031 155 0.041
ribonucleoside monophosphate catabolic process GO:0009158 39 0.041
cellular macromolecular complex assembly GO:0034622 153 0.041
muscle cell development GO:0055001 50 0.041
apoptotic signaling pathway GO:0097190 27 0.041
sperm individualization GO:0007291 48 0.041
cell projection assembly GO:0030031 94 0.040
negative regulation of transcription dna templated GO:0045892 237 0.040
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.040
engulfment of apoptotic cell GO:0043652 6 0.040
Worm
protein targeting to nucleus GO:0044744 51 0.040
asymmetric protein localization involved in cell fate determination GO:0045167 9 0.039
regulation of lamellipodium organization GO:1902743 15 0.038
nuclear import GO:0051170 51 0.038
regulation of protein dephosphorylation GO:0035304 5 0.038
actin polymerization or depolymerization GO:0008154 31 0.037
regulation of neuron death GO:1901214 26 0.037
signal transduction by phosphorylation GO:0023014 107 0.037
Mouse
negative regulation of cell differentiation GO:0045596 143 0.037
appendage development GO:0048736 401 0.037
response to nutrient levels GO:0031667 114 0.037

Lis-1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.181
neuromuscular disease DOID:440 0 0.058
charcot marie tooth disease type 2 DOID:0050539 0 0.058
charcot marie tooth disease DOID:10595 0 0.058
nervous system disease DOID:863 0 0.058
neuropathy DOID:870 0 0.058