Drosophila melanogaster

32 known processes

CG8443 (Dmel_CG8443)

CG8443 gene product from transcript CG8443-RA

(Aliases: clu,Dmel\CG8443,anon-WO0118547.143)

CG8443 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
spermatid development GO:0007286 98 0.874
spermatid differentiation GO:0048515 114 0.619
mitochondrion morphogenesis GO:0070584 8 0.571
germ line stem cell maintenance GO:0030718 50 0.528
regulation of pole plasm oskar mrna localization GO:0007317 27 0.409
negative regulation of response to stimulus GO:0048585 258 0.388
organelle fission GO:0048285 340 0.382
negative regulation of signal transduction GO:0009968 206 0.367
mitochondrion organization GO:0007005 65 0.363
female germ line stem cell asymmetric division GO:0048132 14 0.302
male gamete generation GO:0048232 201 0.296
negative regulation of gene expression GO:0010629 387 0.286
germ line stem cell division GO:0042078 25 0.256
negative regulation of cellular response to oxidative stress GO:1900408 1 0.242
negative regulation of signaling GO:0023057 219 0.213
macromolecule catabolic process GO:0009057 161 0.209
organelle localization GO:0051640 148 0.190
regulation of mitochondrion organization GO:0010821 12 0.178
mitochondrion localization GO:0051646 17 0.173
organelle assembly GO:0070925 198 0.171
negative regulation of cell communication GO:0010648 223 0.161
mitochondrion degradation GO:0000422 8 0.148
purine nucleoside monophosphate metabolic process GO:0009126 50 0.143
autophagy GO:0006914 108 0.137
spermatogenesis GO:0007283 200 0.136
positive regulation of apoptotic signaling pathway GO:2001235 4 0.136
positive regulation of signal transduction GO:0009967 223 0.132
regulation of oocyte development GO:0060281 27 0.131
regulation of cytoskeleton organization GO:0051493 89 0.130
negative regulation of response to oxidative stress GO:1902883 1 0.124
regulation of multicellular organismal development GO:2000026 414 0.124
regulation of cellular component biogenesis GO:0044087 201 0.120
mrna metabolic process GO:0016071 124 0.119
death GO:0016265 284 0.119
posttranscriptional regulation of gene expression GO:0010608 145 0.117
eye development GO:0001654 323 0.117
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.116
production of small rna involved in gene silencing by rna GO:0070918 15 0.113
protein secretion GO:0009306 45 0.109
determination of adult lifespan GO:0008340 137 0.108
female germ line stem cell maintenance GO:0036099 8 0.105
positive regulation of gene expression GO:0010628 290 0.104
regulation of nuclear transcribed mrna poly a tail shortening GO:0060211 4 0.100
protein acetylation GO:0006473 39 0.099
negative regulation of cytoskeleton organization GO:0051494 30 0.097
gene silencing GO:0016458 138 0.097
regulation of growth GO:0040008 233 0.095
programmed cell death GO:0012501 257 0.094
cilium morphogenesis GO:0060271 39 0.093
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.091
actomyosin structure organization GO:0031032 56 0.091
photoreceptor cell fate commitment GO:0046552 41 0.090
targeting of mrna for destruction involved in rna interference GO:0030423 4 0.090
atp metabolic process GO:0046034 49 0.089
regulation of cellular response to insulin stimulus GO:1900076 17 0.086
secretion by cell GO:0032940 101 0.084
gene silencing by mirna GO:0035195 22 0.082
nucleus organization GO:0006997 45 0.082
mitochondrial fission GO:0000266 8 0.081
stem cell differentiation GO:0048863 117 0.081
organic acid metabolic process GO:0006082 103 0.079
positive regulation of response to stimulus GO:0048584 323 0.078
lipid storage GO:0019915 38 0.076
germline stem cell asymmetric division GO:0098728 15 0.075
negative regulation of immune system process GO:0002683 50 0.072
regulation of organelle organization GO:0033043 196 0.072
cytoplasmic transport nurse cell to oocyte GO:0007303 12 0.072
nucleoside metabolic process GO:0009116 127 0.071
stem cell division GO:0017145 69 0.070
sperm mitochondrion organization GO:0030382 7 0.070
aging GO:0007568 143 0.069
cilium assembly GO:0042384 38 0.069
rna catabolic process GO:0006401 37 0.068
response to glucose GO:0009749 2 0.066
single organism membrane fusion GO:0044801 42 0.065
posttranscriptional gene silencing GO:0016441 46 0.065
protein depolymerization GO:0051261 31 0.065
cell death GO:0008219 279 0.064
nucleoside monophosphate metabolic process GO:0009123 52 0.063
positive regulation of cell communication GO:0010647 250 0.063
regulation of tube architecture open tracheal system GO:0035152 68 0.062
nucleoside triphosphate metabolic process GO:0009141 120 0.062
negative regulation of developmental process GO:0051093 201 0.062
negative regulation of phosphorylation GO:0042326 35 0.061
regulation of cell death GO:0010941 173 0.060
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.060
camera type eye development GO:0043010 4 0.059
regulation of cell differentiation GO:0045595 302 0.058
purine nucleoside biosynthetic process GO:0042451 3 0.058
positive regulation of signaling GO:0023056 243 0.057
neurological system process GO:0050877 358 0.056
dna packaging GO:0006323 91 0.056
response to nitrogen compound GO:1901698 90 0.055
glycosyl compound catabolic process GO:1901658 112 0.054
regulation of apoptotic process GO:0042981 130 0.054
oxoacid metabolic process GO:0043436 103 0.054
purine nucleoside triphosphate metabolic process GO:0009144 119 0.053
cell cell signaling involved in cell fate commitment GO:0045168 210 0.053
fusome organization GO:0045478 13 0.052
skeletal muscle adaptation GO:0043501 1 0.052
stem cell maintenance GO:0019827 67 0.052
negative regulation of intracellular signal transduction GO:1902532 57 0.051
rna splicing GO:0008380 83 0.050
small molecule metabolic process GO:0044281 305 0.050
intracellular transport GO:0046907 228 0.050
regulation of programmed cell death GO:0043067 152 0.050
response to organonitrogen compound GO:0010243 75 0.049
insulin receptor signaling pathway GO:0008286 25 0.049
cellular component assembly involved in morphogenesis GO:0010927 151 0.049
vesicle mediated transport GO:0016192 381 0.049
regulation of response to stress GO:0080134 200 0.049
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.049
regulation of defense response GO:0031347 102 0.048
regulation of intracellular signal transduction GO:1902531 236 0.047
purine nucleoside metabolic process GO:0042278 127 0.046
establishment of protein localization GO:0045184 163 0.046
maintenance of location GO:0051235 73 0.045
periodic partitioning GO:0007365 29 0.045
translation GO:0006412 69 0.045
cellular nitrogen compound catabolic process GO:0044270 165 0.044
immune system process GO:0002376 347 0.043
posttranscriptional gene silencing by rna GO:0035194 45 0.043
lipid homeostasis GO:0055088 33 0.043
cellular amino acid metabolic process GO:0006520 61 0.043
imaginal disc pattern formation GO:0007447 91 0.042
response to oxygen containing compound GO:1901700 200 0.042
cell division GO:0051301 248 0.042
oxidation reduction process GO:0055114 123 0.041
wound healing GO:0042060 75 0.041
regulation of cellular response to oxidative stress GO:1900407 4 0.040
positive regulation of organelle organization GO:0010638 65 0.040
cellular response to chemical stimulus GO:0070887 199 0.040
response to organic substance GO:0010033 284 0.040
heterocycle catabolic process GO:0046700 166 0.039
regulation of cellular amino acid metabolic process GO:0006521 0 0.039
regulation of anatomical structure morphogenesis GO:0022603 242 0.038
protein complex disassembly GO:0043241 36 0.038
multicellular organism growth GO:0035264 46 0.038
mrna catabolic process GO:0006402 33 0.037
ribose phosphate metabolic process GO:0019693 145 0.037
cell projection assembly GO:0030031 94 0.037
negative regulation of multicellular organismal process GO:0051241 142 0.037
purine ribonucleoside metabolic process GO:0046128 127 0.037
positive regulation of mitochondrion organization GO:0010822 8 0.036
cilium organization GO:0044782 41 0.036
multicellular organismal aging GO:0010259 140 0.036
regulation of autophagy GO:0010506 62 0.036
cellular response to sterol depletion GO:0071501 3 0.035
regionalization GO:0003002 416 0.035
regulation of membrane potential GO:0042391 35 0.035
regulation of cellular localization GO:0060341 136 0.035
purine ribonucleoside biosynthetic process GO:0046129 3 0.035
organelle fusion GO:0048284 46 0.034
regulation of secretion GO:0051046 44 0.034
cellular protein complex disassembly GO:0043624 35 0.034
energy derivation by oxidation of organic compounds GO:0015980 32 0.034
pole plasm oskar mrna localization GO:0045451 46 0.033
positive regulation of programmed cell death GO:0043068 62 0.033
negative regulation of actin filament depolymerization GO:0030835 2 0.033
positive regulation of biosynthetic process GO:0009891 316 0.033
membrane organization GO:0061024 112 0.033
regulation of molecular function GO:0065009 217 0.032
ribonucleoside monophosphate metabolic process GO:0009161 51 0.032
detection of light stimulus GO:0009583 58 0.032
sensory perception of sound GO:0007605 56 0.031
ovarian fusome organization GO:0030723 11 0.031
regulation of mitochondrial fission GO:0090140 7 0.031
developmental programmed cell death GO:0010623 138 0.031
phosphorylation GO:0016310 294 0.031
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.031
negative regulation of insulin receptor signaling pathway GO:0046627 11 0.031
salivary gland morphogenesis GO:0007435 145 0.031
gland morphogenesis GO:0022612 145 0.029
secretion GO:0046903 109 0.029
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.029
protein localization GO:0008104 284 0.029
cell adhesion GO:0007155 136 0.028
cellular macromolecule catabolic process GO:0044265 136 0.028
synaptic vesicle localization GO:0097479 53 0.028
positive regulation of translation GO:0045727 12 0.027
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.027
morphogenesis of a branching structure GO:0001763 45 0.027
cellular response to nitrogen compound GO:1901699 51 0.027
cellular protein modification process GO:0006464 438 0.027
regulation of meiosis GO:0040020 3 0.027
glycosyl compound metabolic process GO:1901657 127 0.027
reproductive system development GO:0061458 74 0.027
intracellular signal transduction GO:0035556 300 0.026
cellular component disassembly GO:0022411 46 0.026
protein targeting to mitochondrion GO:0006626 1 0.026
regulation of cellular component size GO:0032535 98 0.026
chemotaxis GO:0006935 249 0.025
cellular response to organic substance GO:0071310 132 0.025
ribonucleoside biosynthetic process GO:0042455 3 0.025
regulation of apoptotic signaling pathway GO:2001233 10 0.025
regulation of insulin receptor signaling pathway GO:0046626 17 0.025
organophosphate metabolic process GO:0019637 195 0.025
carboxylic acid metabolic process GO:0019752 92 0.025
nuclear transcribed mrna catabolic process deadenylation dependent decay GO:0000288 14 0.024
establishment of mitochondrion localization GO:0051654 7 0.024
thioester metabolic process GO:0035383 3 0.024
mitochondrial fusion GO:0008053 7 0.024
innate immune response GO:0045087 144 0.024
regulation of cellular ketone metabolic process GO:0010565 3 0.023
detection of external stimulus GO:0009581 66 0.023
regulation of cell maturation GO:1903429 27 0.023
forebrain development GO:0030900 2 0.023
photoreceptor cell differentiation GO:0046530 170 0.023
positive regulation of developmental growth GO:0048639 62 0.023
sulfur compound metabolic process GO:0006790 59 0.023
positive regulation of cellular component organization GO:0051130 156 0.022
regulation of protein phosphorylation GO:0001932 64 0.022
ribonucleoprotein complex subunit organization GO:0071826 28 0.022
organic substance catabolic process GO:1901575 308 0.022
segmentation GO:0035282 207 0.022
rna interference GO:0016246 27 0.022
negative regulation of protein depolymerization GO:1901880 23 0.022
protein phosphorylation GO:0006468 169 0.022
glycosyl compound biosynthetic process GO:1901659 3 0.021
detection of stimulus GO:0051606 156 0.021
production of sirna involved in rna interference GO:0030422 11 0.021
regulation of actin filament depolymerization GO:0030834 3 0.021
regulation of secretion by cell GO:1903530 39 0.021
regulation of response to oxidative stress GO:1902882 4 0.021
intercellular transport GO:0010496 2 0.021
purine ribonucleotide metabolic process GO:0009150 145 0.021
nuclear transcribed mrna catabolic process GO:0000956 24 0.021
oocyte maturation GO:0001556 3 0.021
nucleoside catabolic process GO:0009164 112 0.021
cytoplasm organization GO:0007028 64 0.021
catabolic process GO:0009056 409 0.020
cell cycle arrest GO:0007050 4 0.020
regulation of membrane depolarization GO:0003254 1 0.020
negative regulation of cell differentiation GO:0045596 143 0.020
dorsal ventral pattern formation imaginal disc GO:0007450 51 0.020
cellular response to dsrna GO:0071359 15 0.020
blastoderm segmentation GO:0007350 159 0.020
positive regulation of cellular biosynthetic process GO:0031328 316 0.020
regulation of immune system process GO:0002682 176 0.020
signal release GO:0023061 49 0.020
regulation of actin filament based process GO:0032970 42 0.020
nuclear envelope organization GO:0006998 7 0.020
cellular response to organic cyclic compound GO:0071407 32 0.019
regulation of immune effector process GO:0002697 52 0.019
neuron fate commitment GO:0048663 50 0.019
positive regulation of rna metabolic process GO:0051254 271 0.019
aromatic compound catabolic process GO:0019439 166 0.019
regulation of cell growth GO:0001558 43 0.019
chromosome segregation GO:0007059 157 0.019
protein transport GO:0015031 155 0.019
protein modification process GO:0036211 438 0.019
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.019
positive regulation of developmental process GO:0051094 143 0.018
enzyme linked receptor protein signaling pathway GO:0007167 179 0.018
response to wounding GO:0009611 94 0.018
ribonucleotide metabolic process GO:0009259 145 0.018
regulation of protein complex assembly GO:0043254 42 0.018
regulation of cellular response to stress GO:0080135 89 0.018
purine ribonucleoside catabolic process GO:0046130 112 0.018
response to abiotic stimulus GO:0009628 341 0.018
dorsal ventral pattern formation GO:0009953 133 0.018
negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 29 0.018
purine nucleotide metabolic process GO:0006163 146 0.018
extrinsic apoptotic signaling pathway GO:0097191 1 0.017
exocytosis GO:0006887 28 0.017
regulation of neuron death GO:1901214 26 0.017
salivary gland cell autophagic cell death GO:0035071 83 0.017
negative regulation of cellular metabolic process GO:0031324 382 0.017
biological adhesion GO:0022610 138 0.017
dna conformation change GO:0071103 105 0.017
homeostatic process GO:0042592 199 0.017
regulation of synapse organization GO:0050807 110 0.017
regulation of tor signaling GO:0032006 21 0.017
positive regulation of intracellular signal transduction GO:1902533 116 0.017
ion homeostasis GO:0050801 55 0.017
response to endogenous stimulus GO:0009719 119 0.017
gene silencing by rna GO:0031047 57 0.016
regulation of mrna metabolic process GO:1903311 72 0.016
regulation of response to external stimulus GO:0032101 115 0.016
dsrna fragmentation GO:0031050 15 0.016
positive regulation of cell death GO:0010942 69 0.016
chromosome condensation GO:0030261 41 0.016
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.016
purine containing compound metabolic process GO:0072521 155 0.016
reproductive structure development GO:0048608 74 0.016
regulation of translation GO:0006417 56 0.016
histolysis GO:0007559 102 0.016
response to external biotic stimulus GO:0043207 293 0.016
single organism membrane organization GO:0044802 93 0.016
ovarian nurse cell to oocyte transport GO:0007300 27 0.016
regulation of mitochondrial fusion GO:0010635 5 0.016
regulation of cellular amine metabolic process GO:0033238 3 0.016
gland development GO:0048732 191 0.016
salivary gland development GO:0007431 162 0.015
single organism intracellular transport GO:1902582 207 0.015
ribonucleoside catabolic process GO:0042454 112 0.015
pole plasm assembly GO:0007315 61 0.015
inositol lipid mediated signaling GO:0048017 4 0.015
embryo development ending in birth or egg hatching GO:0009792 152 0.015
nucleoside triphosphate catabolic process GO:0009143 108 0.015
acyl coa metabolic process GO:0006637 3 0.015
negative regulation of cellular component organization GO:0051129 108 0.015
female germ line cyst formation GO:0048135 42 0.015
apoptotic process GO:0006915 159 0.015
actin cytoskeleton organization GO:0030036 206 0.015
nitrogen compound transport GO:0071705 85 0.015
macromolecular complex disassembly GO:0032984 37 0.015
growth GO:0040007 359 0.015
cellular respiration GO:0045333 26 0.015
cellular amine metabolic process GO:0044106 12 0.015
imaginal disc derived wing vein morphogenesis GO:0008586 44 0.015
response to biotic stimulus GO:0009607 294 0.015
cell migration GO:0016477 238 0.015
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.015
hemopoiesis GO:0030097 46 0.015
positive regulation of growth GO:0045927 75 0.014
protein complex assembly GO:0006461 200 0.014
purine nucleoside monophosphate catabolic process GO:0009128 38 0.014
morphogenesis of an epithelium GO:0002009 276 0.014
mitotic sister chromatid segregation GO:0000070 87 0.014
establishment of organelle localization GO:0051656 122 0.014
positive regulation of apoptotic process GO:0043065 47 0.014
reactive oxygen species metabolic process GO:0072593 22 0.014
erbb signaling pathway GO:0038127 58 0.014
mitotic chromosome condensation GO:0007076 22 0.014
ribonucleoprotein complex biogenesis GO:0022613 31 0.014
ribonucleoside monophosphate catabolic process GO:0009158 39 0.014
regulation of embryonic pattern specification GO:1902875 27 0.014
cellular macromolecule localization GO:0070727 220 0.014
cellular response to biotic stimulus GO:0071216 4 0.014
negative regulation of rna metabolic process GO:0051253 251 0.014
kidney development GO:0001822 3 0.014
wing disc pattern formation GO:0035222 66 0.014
nucleoside biosynthetic process GO:0009163 3 0.014
mitochondrion distribution GO:0048311 10 0.014
purine nucleotide catabolic process GO:0006195 109 0.014
golgi organization GO:0007030 66 0.014
positive regulation of multicellular organism growth GO:0040018 21 0.013
cardiovascular system development GO:0072358 82 0.013
negative regulation of gene expression epigenetic GO:0045814 77 0.013
carbohydrate derivative metabolic process GO:1901135 217 0.013
dna methylation GO:0006306 4 0.013
hematopoietic or lymphoid organ development GO:0048534 57 0.013
positive regulation of protein metabolic process GO:0051247 128 0.013
purine ribonucleotide catabolic process GO:0009154 109 0.013
atp catabolic process GO:0006200 38 0.013
purine nucleoside catabolic process GO:0006152 112 0.013
salivary gland histolysis GO:0035070 88 0.013
dna metabolic process GO:0006259 227 0.013
regulation of gene silencing GO:0060968 63 0.013
apoptotic signaling pathway GO:0097190 27 0.013
lipid localization GO:0010876 54 0.013
female sex differentiation GO:0046660 20 0.012
cell motility GO:0048870 251 0.012
mrna splicing via spliceosome GO:0000398 73 0.012
branching morphogenesis of an epithelial tube GO:0048754 45 0.012
ribonucleoside metabolic process GO:0009119 127 0.012
production of mirnas involved in gene silencing by mirna GO:0035196 10 0.012
endocytosis GO:0006897 310 0.012
establishment of localization in cell GO:0051649 402 0.012
establishment of vesicle localization GO:0051650 51 0.012
carbohydrate derivative catabolic process GO:1901136 118 0.012
dephosphorylation GO:0016311 51 0.012
single organism cellular localization GO:1902580 180 0.012
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.012
stem cell development GO:0048864 79 0.012
response to organophosphorus GO:0046683 2 0.012
organic substance transport GO:0071702 257 0.011
embryonic pattern specification GO:0009880 174 0.011
nucleobase containing compound catabolic process GO:0034655 165 0.011
response to bacterium GO:0009617 198 0.011
nucleotide catabolic process GO:0009166 109 0.011
striated muscle tissue development GO:0014706 27 0.011
cellular lipid metabolic process GO:0044255 83 0.011
positive regulation of transport GO:0051050 92 0.011
ncrna metabolic process GO:0034660 43 0.011
compound eye development GO:0048749 307 0.011
generation of precursor metabolites and energy GO:0006091 42 0.011
nucleus localization GO:0051647 34 0.011
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.011
cell proliferation GO:0008283 299 0.011
chaeta development GO:0022416 97 0.011
skeletal muscle organ development GO:0060538 48 0.011
protein localization to mitochondrion GO:0070585 1 0.011
oocyte development GO:0048599 124 0.011
endomembrane system organization GO:0010256 119 0.011
ribonucleoprotein complex assembly GO:0022618 23 0.011
negative regulation of cell proliferation GO:0008285 69 0.011
extracellular structure organization GO:0043062 46 0.011
small rna loading onto risc GO:0070922 6 0.011
regulation of intracellular transport GO:0032386 64 0.011
purine containing compound catabolic process GO:0072523 112 0.011
intracellular protein transport GO:0006886 104 0.011
actin filament depolymerization GO:0030042 5 0.011
tor signaling GO:0031929 32 0.011
regulation of mitochondrial membrane potential GO:0051881 2 0.011
immune system development GO:0002520 57 0.011
defense response to other organism GO:0098542 225 0.011
exocrine system development GO:0035272 162 0.010
purine nucleoside triphosphate catabolic process GO:0009146 108 0.010
nucleoside monophosphate catabolic process GO:0009125 39 0.010
cytoplasmic transport GO:0016482 130 0.010
cellular response to insulin stimulus GO:0032869 28 0.010
positive regulation of rna biosynthetic process GO:1902680 266 0.010
ribonucleotide catabolic process GO:0009261 109 0.010
axon guidance GO:0007411 233 0.010
organonitrogen compound metabolic process GO:1901564 318 0.010
actin filament organization GO:0007015 126 0.010
adult somatic muscle development GO:0007527 14 0.010
gonad development GO:0008406 50 0.010
central nervous system development GO:0007417 201 0.010
macromolecular complex assembly GO:0065003 256 0.010
meiotic nuclear division GO:0007126 151 0.010
germarium derived egg chamber formation GO:0007293 101 0.010
negative regulation of microtubule polymerization or depolymerization GO:0031111 21 0.010
morphogenesis of follicular epithelium GO:0016333 36 0.010

CG8443 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.060
musculoskeletal system disease DOID:17 0 0.060
synucleinopathy DOID:0050890 0 0.020
central nervous system disease DOID:331 0 0.020
neurodegenerative disease DOID:1289 0 0.020
nervous system disease DOID:863 0 0.020
disease of metabolism DOID:0014667 0 0.017
myopathy DOID:423 0 0.016
muscular disease DOID:0080000 0 0.016
muscle tissue disease DOID:66 0 0.016
parkinson s disease DOID:14330 0 0.013
sensory system disease DOID:0050155 0 0.013
eye and adnexa disease DOID:1492 0 0.013