Drosophila melanogaster

124 known processes

Frq1 (Dmel_CG5744)

Frequenin 1

(Aliases: HL-II,frq1,CG5744,frq,Dmel\CG5744,Frq)

Frq1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
synaptic transmission GO:0007268 288 0.993
neuromuscular junction development GO:0007528 149 0.928
neurotransmitter transport GO:0006836 37 0.918
regulation of neurotransmitter secretion GO:0046928 14 0.810
Fly
regulation of synapse structure and activity GO:0050803 128 0.746
regulation of neurotransmitter levels GO:0001505 38 0.683
signal release GO:0023061 49 0.664
regulation of synaptic transmission GO:0050804 69 0.622
Fly
establishment of localization in cell GO:0051649 402 0.615
cation transport GO:0006812 110 0.606
Rat
synapse organization GO:0050808 196 0.603
secretion by cell GO:0032940 101 0.500
regulation of secretion by cell GO:1903530 39 0.484
Rat Fly
neurotransmitter secretion GO:0007269 35 0.466
establishment of vesicle localization GO:0051650 51 0.450
secretion GO:0046903 109 0.446
synaptic growth at neuromuscular junction GO:0051124 119 0.439
regulation of synapse organization GO:0050807 110 0.386
regulation of neurotransmitter transport GO:0051588 14 0.366
Fly
metal ion transport GO:0030001 74 0.315
Rat
ion transmembrane transport GO:0034220 122 0.287
Rat
regulation of transport GO:0051049 181 0.274
Rat Fly
regulation of secretion GO:0051046 44 0.273
Rat Fly
regulation of synaptic growth at neuromuscular junction GO:0008582 89 0.271
cgmp biosynthetic process GO:0006182 8 0.264
regulation of multicellular organismal development GO:2000026 414 0.250
Rat
synaptic vesicle transport GO:0048489 50 0.228
synapse assembly GO:0007416 143 0.224
neuromuscular synaptic transmission GO:0007274 67 0.218
regulation of membrane potential GO:0042391 35 0.215
response to abiotic stimulus GO:0009628 341 0.195
neuron neuron synaptic transmission GO:0007270 14 0.192
synaptic vesicle recycling GO:0036465 28 0.187
regulation of synapse assembly GO:0051963 94 0.181
regulation of nervous system development GO:0051960 248 0.167
Rat
single organism behavior GO:0044708 391 0.166
single organism membrane fusion GO:0044801 42 0.163
regulation of excitatory postsynaptic membrane potential GO:0060079 3 0.161
axonogenesis GO:0007409 290 0.159
regulation of cell differentiation GO:0045595 302 0.159
Rat
synaptic vesicle localization GO:0097479 53 0.156
ion transport GO:0006811 145 0.151
Rat
locomotory behavior GO:0007626 176 0.139
vesicle mediated transport GO:0016192 381 0.133
Rat
vitamin transport GO:0051180 2 0.121
growth GO:0040007 359 0.117
regulation of cellular component biogenesis GO:0044087 201 0.114
regulation of localization GO:0032879 275 0.113
Rat Fly
establishment of synaptic vesicle localization GO:0097480 50 0.112
axon development GO:0061564 297 0.104
positive regulation of cgmp metabolic process GO:0030825 1 0.102
synaptic transmission glutamatergic GO:0035249 7 0.101
membrane organization GO:0061024 112 0.098
adult locomotory behavior GO:0008344 76 0.092
cellular homeostasis GO:0019725 80 0.091
transmembrane transport GO:0055085 139 0.091
Rat
negative regulation of cell communication GO:0010648 223 0.091
single organism membrane organization GO:0044802 93 0.087
developmental growth GO:0048589 280 0.084
inorganic cation transmembrane transport GO:0098662 61 0.082
Rat
regulation of cellular localization GO:0060341 136 0.081
Rat Fly
regulation of transmembrane transport GO:0034762 27 0.080
Rat
multi organism behavior GO:0051705 175 0.078
cellular protein modification process GO:0006464 438 0.077
neurotransmitter metabolic process GO:0042133 2 0.076
tube morphogenesis GO:0035239 191 0.075
Zebrafish
nitrogen compound transport GO:0071705 85 0.075
terminal button organization GO:0072553 19 0.072
camera type eye development GO:0043010 4 0.071
positive regulation of synapse assembly GO:0051965 29 0.070
positive regulation of synaptic transmission GO:0050806 15 0.069
regulation of neurogenesis GO:0050767 158 0.064
Rat
catabolic process GO:0009056 409 0.064
regulation of neuromuscular synaptic transmission GO:1900073 15 0.064
muscle structure development GO:0061061 224 0.062
potassium ion transport GO:0006813 20 0.061
positive regulation of cell communication GO:0010647 250 0.058
calcium ion transmembrane transport GO:0070588 17 0.057
Rat
muscle system process GO:0003012 21 0.057
positive regulation of signaling GO:0023056 243 0.057
organic substance transport GO:0071702 257 0.056
developmental maturation GO:0021700 172 0.056
regulation of developmental growth GO:0048638 174 0.056
eye development GO:0001654 323 0.055
rhythmic excitation GO:0043179 1 0.055
small molecule metabolic process GO:0044281 305 0.055
tube development GO:0035295 244 0.054
Zebrafish
exocytosis GO:0006887 28 0.054
Rat
chemotaxis GO:0006935 249 0.054
homeostatic process GO:0042592 199 0.053
regulation of terminal button organization GO:2000331 11 0.053
positive regulation of exocytosis GO:0045921 4 0.053
Rat
cellular macromolecule localization GO:0070727 220 0.052
cellular protein localization GO:0034613 160 0.050
acetate ester metabolic process GO:1900619 2 0.049
cellular component assembly involved in morphogenesis GO:0010927 151 0.049
regulation of synaptic transmission glutamatergic GO:0051966 5 0.048
neuron maturation GO:0042551 31 0.047
negative regulation of signaling GO:0023057 219 0.047
endocytosis GO:0006897 310 0.047
synaptic vesicle endocytosis GO:0048488 28 0.047
rhythmic synaptic transmission GO:0060024 2 0.046
cell maturation GO:0048469 144 0.046
regulation of glutamate receptor signaling pathway GO:1900449 1 0.045
vesicle localization GO:0051648 55 0.045
male courtship behavior veined wing extension GO:0048065 22 0.045
positive regulation of synaptic vesicle endocytosis GO:1900244 4 0.044
regulation of growth GO:0040008 233 0.043
membrane depolarization GO:0051899 4 0.043
single organism cellular localization GO:1902580 180 0.042
associative learning GO:0008306 65 0.042
regulation of ion transmembrane transport GO:0034765 27 0.042
Rat
negative regulation of response to stimulus GO:0048585 258 0.041
positive regulation of cellular component organization GO:0051130 156 0.041
cell recognition GO:0008037 102 0.041
regulation of cell development GO:0060284 215 0.040
Rat
positive regulation of transport GO:0051050 92 0.040
Rat
divalent inorganic cation transport GO:0072511 30 0.040
Rat
neuron projection guidance GO:0097485 241 0.039
endoplasmic reticulum organization GO:0007029 13 0.038
single organism catabolic process GO:0044712 228 0.036
cell projection assembly GO:0030031 94 0.035
negative regulation of synaptic growth at neuromuscular junction GO:0045886 39 0.035
positive regulation of synaptic vesicle recycling GO:1903423 4 0.034
acetylcholine metabolic process GO:0008291 2 0.034
muscle cell differentiation GO:0042692 103 0.034
response to biotic stimulus GO:0009607 294 0.033
response to radiation GO:0009314 155 0.033
regulation of vesicle mediated transport GO:0060627 59 0.033
Rat
regulation of cell projection organization GO:0031344 92 0.032
Rat
carbohydrate derivative metabolic process GO:1901135 217 0.032
membrane fusion GO:0061025 42 0.032
organelle assembly GO:0070925 198 0.032
organonitrogen compound metabolic process GO:1901564 318 0.031
positive regulation of developmental process GO:0051094 143 0.031
protein localization GO:0008104 284 0.031
axon guidance GO:0007411 233 0.031
striated muscle cell development GO:0055002 50 0.031
programmed cell death GO:0012501 257 0.031
organelle localization GO:0051640 148 0.031
positive regulation of synaptic transmission glutamatergic GO:0051968 3 0.030
neuron recognition GO:0008038 101 0.030
organic substance catabolic process GO:1901575 308 0.030
negative regulation of signal transduction GO:0009968 206 0.029
nucleoside catabolic process GO:0009164 112 0.029
phagocytosis GO:0006909 215 0.029
purine nucleoside triphosphate catabolic process GO:0009146 108 0.028
purine containing compound metabolic process GO:0072521 155 0.028
macromolecular complex assembly GO:0065003 256 0.028
positive regulation of cellular component biogenesis GO:0044089 80 0.028
purine ribonucleotide catabolic process GO:0009154 109 0.028
endomembrane system organization GO:0010256 119 0.028
carboxylic acid metabolic process GO:0019752 92 0.028
hindbrain development GO:0030902 2 0.027
positive regulation of synaptic growth at neuromuscular junction GO:0045887 26 0.027
nucleobase containing small molecule metabolic process GO:0055086 174 0.027
regulation of cell proliferation GO:0042127 163 0.027
regulation of synaptic vesicle endocytosis GO:1900242 7 0.027
synaptic vesicle exocytosis GO:0016079 16 0.027
regionalization GO:0003002 416 0.026
response to external biotic stimulus GO:0043207 293 0.026
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.026
regulation of synaptic vesicle exocytosis GO:2000300 3 0.026
regulation of embryonic pattern specification GO:1902875 27 0.026
establishment of protein localization GO:0045184 163 0.025
nucleoside phosphate catabolic process GO:1901292 110 0.025
monovalent inorganic cation transport GO:0015672 40 0.024
single organism biosynthetic process GO:0044711 206 0.024
anatomical structure homeostasis GO:0060249 97 0.024
cellular amine metabolic process GO:0044106 12 0.024
purine ribonucleotide metabolic process GO:0009150 145 0.024
retina development in camera type eye GO:0060041 4 0.024
cellular response to organic substance GO:0071310 132 0.023
positive regulation of response to stimulus GO:0048584 323 0.023
protein heterooligomerization GO:0051291 4 0.023
regulation of ion transport GO:0043269 39 0.023
Rat
chromatin modification GO:0016568 147 0.023
regulation of synaptic activity GO:0060025 9 0.023
membrane biogenesis GO:0044091 8 0.023
sensory organ morphogenesis GO:0090596 260 0.023
Zebrafish
dendrite development GO:0016358 204 0.023
purine nucleotide metabolic process GO:0006163 146 0.022
cell proliferation GO:0008283 299 0.022
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.022
response to mechanical stimulus GO:0009612 28 0.022
axis specification GO:0009798 167 0.022
positive regulation of cell death GO:0010942 69 0.022
mushroom body development GO:0016319 70 0.022
organophosphate metabolic process GO:0019637 195 0.022
immune system process GO:0002376 347 0.022
embryonic pattern specification GO:0009880 174 0.022
myotube cell development GO:0014904 3 0.021
chromatin organization GO:0006325 207 0.021
cellular response to lipopolysaccharide GO:0071222 3 0.021
positive regulation of molecular function GO:0044093 136 0.021
carbohydrate derivative catabolic process GO:1901136 118 0.021
intracellular signal transduction GO:0035556 300 0.021
Rat
regulation of dendrite development GO:0050773 37 0.021
positive regulation of cell migration GO:0030335 2 0.021
protein depolymerization GO:0051261 31 0.020
positive regulation of protein metabolic process GO:0051247 128 0.020
organonitrogen compound catabolic process GO:1901565 128 0.020
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.020
transcription from rna polymerase ii promoter GO:0006366 368 0.020
cognition GO:0050890 141 0.020
sarcomere organization GO:0045214 26 0.020
purine ribonucleoside metabolic process GO:0046128 127 0.020
sensory perception of sound GO:0007605 56 0.020
segmentation GO:0035282 207 0.020
positive regulation of catalytic activity GO:0043085 118 0.019
positive regulation of biosynthetic process GO:0009891 316 0.019
cyclic nucleotide metabolic process GO:0009187 28 0.019
appendage development GO:0048736 401 0.019
regulation of cell projection assembly GO:0060491 30 0.019
organic acid metabolic process GO:0006082 103 0.019
cellular protein complex disassembly GO:0043624 35 0.019
ribonucleoside triphosphate catabolic process GO:0009203 108 0.019
regulation of phosphorus metabolic process GO:0051174 210 0.019
adult behavior GO:0030534 137 0.019
cellular catabolic process GO:0044248 372 0.019
cation transmembrane transport GO:0098655 88 0.018
Rat
carbohydrate derivative biosynthetic process GO:1901137 85 0.018
positive regulation of cgmp biosynthetic process GO:0030828 1 0.018
camera type eye morphogenesis GO:0048593 2 0.018
regulation of cytoskeleton organization GO:0051493 89 0.018
regulation of behavior GO:0050795 75 0.018
learning GO:0007612 75 0.018
single organism carbohydrate metabolic process GO:0044723 72 0.018
aging GO:0007568 143 0.018
regulation of wnt signaling pathway GO:0030111 68 0.018
positive regulation of multicellular organismal process GO:0051240 143 0.018
positive regulation of neurotransmitter secretion GO:0001956 2 0.018
positive regulation of nervous system development GO:0051962 69 0.018
wnt signaling pathway GO:0016055 98 0.017
regulation of cell death GO:0010941 173 0.017
cell growth GO:0016049 108 0.017
peripheral nervous system development GO:0007422 52 0.017
regulation of system process GO:0044057 36 0.017
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.017
learning or memory GO:0007611 141 0.017
neuroblast proliferation GO:0007405 74 0.017
establishment of organelle localization GO:0051656 122 0.017
action potential GO:0001508 13 0.017
regulation of synaptic plasticity GO:0048167 14 0.017
protein complex assembly GO:0006461 200 0.017
negative regulation of multicellular organismal process GO:0051241 142 0.017
branching involved in open tracheal system development GO:0060446 45 0.017
striated muscle cell differentiation GO:0051146 90 0.017
response to nutrient levels GO:0031667 114 0.017
dendrite morphogenesis GO:0048813 199 0.017
cell death GO:0008219 279 0.017
chemical homeostasis GO:0048878 92 0.017
negative regulation of developmental process GO:0051093 201 0.017
regulation of anatomical structure size GO:0090066 163 0.016
purine ribonucleoside catabolic process GO:0046130 112 0.016
skeletal muscle fiber development GO:0048741 3 0.016
positive regulation of growth GO:0045927 75 0.016
proteolysis GO:0006508 192 0.016
positive regulation of phosphate metabolic process GO:0045937 139 0.016
positive regulation of apoptotic signaling pathway GO:2001235 4 0.016
cell adhesion GO:0007155 136 0.016
blastoderm segmentation GO:0007350 159 0.016
positive regulation of programmed cell death GO:0043068 62 0.016
chromatin remodeling GO:0006338 72 0.016
neuron projection extension GO:1990138 32 0.015
nuclear division GO:0000280 332 0.015
nucleoside triphosphate catabolic process GO:0009143 108 0.015
protein complex biogenesis GO:0070271 201 0.015
muscle cell development GO:0055001 50 0.015
photoreceptor cell development GO:0042461 96 0.015
forebrain development GO:0030900 2 0.015
regulation of multi organism process GO:0043900 131 0.015
positive regulation of signal transduction GO:0009967 223 0.015
photoreceptor cell differentiation GO:0046530 170 0.015
regulation of defense response GO:0031347 102 0.015
negative regulation of synapse assembly GO:0051964 39 0.015
axon extension GO:0048675 32 0.015
nucleoside metabolic process GO:0009116 127 0.015
positive regulation of cell differentiation GO:0045597 64 0.015
dna metabolic process GO:0006259 227 0.014
regulation of phosphate metabolic process GO:0019220 210 0.014
heterocycle catabolic process GO:0046700 166 0.014
spermatogenesis GO:0007283 200 0.014
intracellular protein transport GO:0006886 104 0.014
cellular amino acid metabolic process GO:0006520 61 0.014
synapse maturation GO:0060074 7 0.014
protein catabolic process GO:0030163 101 0.014
response to monosaccharide GO:0034284 4 0.014
divalent metal ion transport GO:0070838 26 0.014
Rat
cellular nitrogen compound catabolic process GO:0044270 165 0.014
kidney development GO:0001822 3 0.014
appendage morphogenesis GO:0035107 397 0.014
ribonucleoside metabolic process GO:0009119 127 0.014
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.014
cellular potassium ion transport GO:0071804 18 0.014
multicellular organismal aging GO:0010259 140 0.014
ribose phosphate metabolic process GO:0019693 145 0.014
regulation of mitotic cell cycle GO:0007346 190 0.014
ribonucleoside catabolic process GO:0042454 112 0.014
glycosyl compound metabolic process GO:1901657 127 0.014
apoptotic process GO:0006915 159 0.014
detection of light stimulus GO:0009583 58 0.014
body morphogenesis GO:0010171 2 0.014
oxoacid metabolic process GO:0043436 103 0.014
epithelial tube morphogenesis GO:0060562 88 0.014
regulation of cell cycle process GO:0010564 181 0.014
cytoplasmic transport GO:0016482 130 0.013
response to organic substance GO:0010033 284 0.013
taxis GO:0042330 304 0.013
multicellular organism growth GO:0035264 46 0.013
positive regulation of phosphorus metabolic process GO:0010562 139 0.013
motor neuron axon guidance GO:0008045 58 0.013
nucleotide metabolic process GO:0009117 161 0.013
organelle fission GO:0048285 340 0.013
aromatic compound catabolic process GO:0019439 166 0.013
purine nucleoside catabolic process GO:0006152 112 0.013
ribonucleotide metabolic process GO:0009259 145 0.013
calcium ion transport GO:0006816 24 0.013
Rat
circulatory system process GO:0003013 37 0.013
muscle organ development GO:0007517 127 0.013
positive regulation of organelle organization GO:0010638 65 0.013
stem cell development GO:0048864 79 0.013
cellular biogenic amine catabolic process GO:0042402 1 0.013
embryonic organ development GO:0048568 50 0.013
Zebrafish
regulation of endocytosis GO:0030100 37 0.013
maternal determination of anterior posterior axis embryo GO:0008358 74 0.012
response to lipopolysaccharide GO:0032496 4 0.012
nucleoside phosphate metabolic process GO:0006753 162 0.012
regulation of immune system process GO:0002682 176 0.012
purine nucleoside triphosphate metabolic process GO:0009144 119 0.012
mesenchymal cell development GO:0014031 1 0.012
embryonic axis specification GO:0000578 107 0.012
protein modification by small protein conjugation or removal GO:0070647 106 0.012
post embryonic appendage morphogenesis GO:0035120 385 0.012
response to toxic substance GO:0009636 22 0.012
positive regulation of catabolic process GO:0009896 105 0.012
rna processing GO:0006396 147 0.012
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.012
neuron remodeling GO:0016322 29 0.012
mitotic nuclear division GO:0007067 213 0.012
stem cell proliferation GO:0072089 88 0.012
courtship behavior GO:0007619 68 0.012
bmp signaling pathway GO:0030509 27 0.012
muscle contraction GO:0006936 13 0.012
eye morphogenesis GO:0048592 260 0.012
cytokinesis GO:0000910 90 0.012
pattern recognition receptor signaling pathway GO:0002221 2 0.012
isoprenoid transport GO:0046864 2 0.012
actin filament based process GO:0030029 220 0.012
response to hexose GO:0009746 3 0.012
positive regulation of hydrolase activity GO:0051345 78 0.012
detection of stimulus GO:0051606 156 0.012
response to other organism GO:0051707 293 0.012
vesicle organization GO:0016050 44 0.012
imaginal disc derived appendage morphogenesis GO:0035114 395 0.012
larval locomotory behavior GO:0008345 27 0.012
potassium ion transmembrane transport GO:0071805 18 0.011
skin development GO:0043588 65 0.011
organic cyclic compound catabolic process GO:1901361 168 0.011
posttranscriptional regulation of gene expression GO:0010608 145 0.011
positive regulation of purine nucleotide biosynthetic process GO:1900373 10 0.011
presynaptic membrane organization GO:0097090 4 0.011
neuron cell cell adhesion GO:0007158 1 0.011
regulation of intracellular signal transduction GO:1902531 236 0.011
neural precursor cell proliferation GO:0061351 75 0.011
regulation of synaptic vesicle transport GO:1902803 10 0.011
calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules GO:0016339 9 0.011
filopodium assembly GO:0046847 33 0.011
regulation of programmed cell death GO:0043067 152 0.011
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.011
cellular response to chemical stimulus GO:0070887 199 0.011
positive regulation of cell motility GO:2000147 3 0.011
cranial nerve development GO:0021545 1 0.011
death GO:0016265 284 0.011
visual learning GO:0008542 4 0.011
positive regulation of nucleotide biosynthetic process GO:0030810 10 0.011
dna packaging GO:0006323 91 0.011
striated muscle contraction GO:0006941 5 0.011
regulation of gene expression epigenetic GO:0040029 128 0.011
terpenoid transport GO:0046865 2 0.011
regulation of catabolic process GO:0009894 170 0.011
ribonucleoside triphosphate metabolic process GO:0009199 119 0.011
gtp catabolic process GO:0006184 72 0.011
regulation of organelle organization GO:0033043 196 0.011
synaptic vesicle fusion to presynaptic membrane GO:0031629 7 0.011
chromosome organization GO:0051276 360 0.010
open tracheal system development GO:0007424 204 0.010
actin filament based movement GO:0030048 26 0.010
biological adhesion GO:0022610 138 0.010
regulation of protein kinase a signaling GO:0010738 2 0.010
mating GO:0007618 120 0.010
single organismal cell cell adhesion GO:0016337 45 0.010
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.010
positive regulation of cell development GO:0010720 61 0.010
regulation of hydrolase activity GO:0051336 97 0.010
compound eye development GO:0048749 307 0.010
organelle fusion GO:0048284 46 0.010
protein transport GO:0015031 155 0.010
positive regulation of cellular protein metabolic process GO:0032270 118 0.010
regulation of cellular ketone metabolic process GO:0010565 3 0.010
limb development GO:0060173 1 0.010
imaginal disc derived wing morphogenesis GO:0007476 337 0.010
necrotic cell death GO:0070265 1 0.010
regulation of innate immune response GO:0045088 71 0.010
purine containing compound catabolic process GO:0072523 112 0.010

Frq1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.055
cardiovascular system disease DOID:1287 0 0.024
artery disease DOID:0050828 0 0.017
vascular disease DOID:178 0 0.017
disease of metabolism DOID:0014667 0 0.015
diabetes mellitus DOID:9351 0 0.012
carbohydrate metabolism disease DOID:0050013 0 0.012
glucose metabolism disease DOID:4194 0 0.012
acquired metabolic disease DOID:0060158 0 0.012
cancer DOID:162 0 0.012
disease of cellular proliferation DOID:14566 0 0.012
organ system cancer DOID:0050686 0 0.011