Drosophila melanogaster

25 known processes

defl (Dmel_CG18176)

deflated

(Aliases: CG18176,Dmel\CG18176)

defl biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
chromosome organization GO:0051276 360 0.473
histone acetylation GO:0016573 38 0.365
rna processing GO:0006396 147 0.313
peptidyl amino acid modification GO:0018193 105 0.250
regionalization GO:0003002 416 0.232
ovarian follicle cell development GO:0030707 248 0.224
chromatin organization GO:0006325 207 0.209
oocyte axis specification GO:0007309 108 0.187
cellular protein modification process GO:0006464 438 0.170
oocyte fate determination GO:0030716 27 0.170
columnar cuboidal epithelial cell development GO:0002066 249 0.168
protein acylation GO:0043543 42 0.160
peptidyl lysine acetylation GO:0018394 39 0.156
response to ionizing radiation GO:0010212 32 0.146
negative regulation of peptidyl tyrosine phosphorylation GO:0050732 6 0.143
vesicle mediated transport GO:0016192 381 0.126
Worm
chorion containing eggshell formation GO:0007304 105 0.124
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.123
peptidyl lysine modification GO:0018205 57 0.121
transcription from rna polymerase ii promoter GO:0006366 368 0.121
negative regulation of gene expression GO:0010629 387 0.121
double strand break repair GO:0006302 26 0.120
endocytosis GO:0006897 310 0.115
Worm
transmembrane transport GO:0055085 139 0.114
ncrna 3 end processing GO:0043628 17 0.111
response to abiotic stimulus GO:0009628 341 0.110
protein modification process GO:0036211 438 0.105
epithelial cell development GO:0002064 274 0.105
immune system development GO:0002520 57 0.103
regulation of autophagy GO:0010506 62 0.097
internal protein amino acid acetylation GO:0006475 38 0.094
aromatic compound catabolic process GO:0019439 166 0.092
recombinational repair GO:0000725 13 0.091
cellular nitrogen compound catabolic process GO:0044270 165 0.090
immune system process GO:0002376 347 0.089
cellular macromolecule localization GO:0070727 220 0.089
snrna processing GO:0016180 14 0.088
cellular component assembly involved in morphogenesis GO:0010927 151 0.086
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.082
positive regulation of macromolecule metabolic process GO:0010604 405 0.079
eye morphogenesis GO:0048592 260 0.077
cellular response to dna damage stimulus GO:0006974 223 0.073
positive regulation of transcription dna templated GO:0045893 266 0.073
single organism cellular localization GO:1902580 180 0.073
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.072
cellular ketone metabolic process GO:0042180 24 0.066
snrna metabolic process GO:0016073 14 0.065
positive regulation of biosynthetic process GO:0009891 316 0.061
posttranscriptional gene silencing GO:0016441 46 0.061
regulation of cellular ketone metabolic process GO:0010565 3 0.061
regulation of vesicle mediated transport GO:0060627 59 0.061
protein acetylation GO:0006473 39 0.060
regulation of cellular amine metabolic process GO:0033238 3 0.058
positive regulation of catabolic process GO:0009896 105 0.058
chemical homeostasis GO:0048878 92 0.056
organic cyclic compound catabolic process GO:1901361 168 0.055
positive regulation of response to stimulus GO:0048584 323 0.054
internal peptidyl lysine acetylation GO:0018393 38 0.054
chromatin modification GO:0016568 147 0.053
catabolic process GO:0009056 409 0.052
double strand break repair via homologous recombination GO:0000724 13 0.052
histone modification GO:0016570 106 0.051
single organism intracellular transport GO:1902582 207 0.051
epithelial cell differentiation GO:0030855 322 0.051
dna repair GO:0006281 54 0.050
mrna catabolic process GO:0006402 33 0.050
meiotic cell cycle process GO:1903046 132 0.050
oocyte dorsal ventral axis specification GO:0007310 34 0.050
dna recombination GO:0006310 32 0.049
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.048
regulation of cell death GO:0010941 173 0.047
mrna metabolic process GO:0016071 124 0.047
autophagy GO:0006914 108 0.046
oocyte differentiation GO:0009994 145 0.046
germarium derived oocyte fate determination GO:0007294 26 0.045
hematopoietic or lymphoid organ development GO:0048534 57 0.045
rna catabolic process GO:0006401 37 0.045
innate immune response GO:0045087 144 0.045
organic substance catabolic process GO:1901575 308 0.045
oocyte development GO:0048599 124 0.044
dorsal ventral axis specification GO:0009950 66 0.044
eye pigment metabolic process GO:0042441 33 0.044
regulation of immune system process GO:0002682 176 0.044
rna localization GO:0006403 115 0.041
posttranscriptional regulation of gene expression GO:0010608 145 0.041
macromolecular complex assembly GO:0065003 256 0.041
protein localization GO:0008104 284 0.040
nucleobase containing compound catabolic process GO:0034655 165 0.040
eye development GO:0001654 323 0.040
cellular catabolic process GO:0044248 372 0.039
covalent chromatin modification GO:0016569 106 0.038
negative regulation of cell communication GO:0010648 223 0.037
enzyme linked receptor protein signaling pathway GO:0007167 179 0.037
cytoplasmic transport GO:0016482 130 0.036
regulation of cellular amino acid metabolic process GO:0006521 0 0.036
negative regulation of cell death GO:0060548 81 0.036
dorsal ventral pattern formation GO:0009953 133 0.036
imaginal disc derived wing vein specification GO:0007474 48 0.036
intracellular protein transport GO:0006886 104 0.036
snrna 3 end processing GO:0034472 14 0.035
sensory organ morphogenesis GO:0090596 260 0.034
positive regulation of gene expression GO:0010628 290 0.034
oxoacid metabolic process GO:0043436 103 0.034
oocyte construction GO:0007308 112 0.034
negative regulation of signal transduction GO:0009968 206 0.033
cellular protein localization GO:0034613 160 0.032
ras protein signal transduction GO:0007265 88 0.032
homeostatic process GO:0042592 199 0.031
establishment of localization in cell GO:0051649 402 0.031
regulation of cellular component biogenesis GO:0044087 201 0.031
pigment metabolic process involved in developmental pigmentation GO:0043324 33 0.031
immune response GO:0006955 246 0.031
organic acid metabolic process GO:0006082 103 0.030
response to oxygen containing compound GO:1901700 200 0.030
cellular macromolecular complex assembly GO:0034622 153 0.030
nuclear transcribed mrna catabolic process deadenylation dependent decay GO:0000288 14 0.030
cellular macromolecule catabolic process GO:0044265 136 0.029
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.029
programmed cell death GO:0012501 257 0.029
regulation of mrna metabolic process GO:1903311 72 0.028
extracellular structure organization GO:0043062 46 0.028
small molecule metabolic process GO:0044281 305 0.028
rna transport GO:0050658 46 0.028
gene silencing by rna GO:0031047 57 0.027
positive regulation of mrna processing GO:0050685 4 0.027
heterocycle catabolic process GO:0046700 166 0.027
camera type eye development GO:0043010 4 0.027
actin cytoskeleton organization GO:0030036 206 0.027
defense response GO:0006952 300 0.027
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.026
positive regulation of transport GO:0051050 92 0.026
establishment of protein localization GO:0045184 163 0.026
embryonic pattern specification GO:0009880 174 0.025
protein transport GO:0015031 155 0.025
membrane organization GO:0061024 112 0.025
stem cell differentiation GO:0048863 117 0.025
positive regulation of signaling GO:0023056 243 0.025
mrna processing GO:0006397 104 0.024
actin filament based process GO:0030029 220 0.024
response to radiation GO:0009314 155 0.024
negative regulation of multicellular organismal process GO:0051241 142 0.024
apoptotic process GO:0006915 159 0.024
response to alcohol GO:0097305 95 0.024
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.023
transition metal ion homeostasis GO:0055076 17 0.023
tissue morphogenesis GO:0048729 297 0.023
positive regulation of nucleic acid templated transcription GO:1903508 266 0.023
meiotic cell cycle GO:0051321 171 0.023
regulation of gene expression epigenetic GO:0040029 128 0.023
positive regulation of cellular catabolic process GO:0031331 95 0.023
segmentation GO:0035282 207 0.023
regulation of protein metabolic process GO:0051246 256 0.023
neuron projection guidance GO:0097485 241 0.023
dna biosynthetic process GO:0071897 24 0.022
regulation of cellular localization GO:0060341 136 0.022
regulation of hormone levels GO:0010817 40 0.022
negative regulation of nucleic acid templated transcription GO:1903507 240 0.022
eggshell chorion gene amplification GO:0007307 9 0.022
regulation of apoptotic process GO:0042981 130 0.022
single organism biosynthetic process GO:0044711 206 0.022
amine metabolic process GO:0009308 12 0.022
cellular response to organic substance GO:0071310 132 0.022
response to organic substance GO:0010033 284 0.022
ion transmembrane transport GO:0034220 122 0.022
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.022
regulation of molecular function GO:0065009 217 0.022
nucleobase containing compound transport GO:0015931 56 0.022
chromatin remodeling GO:0006338 72 0.021
axon guidance GO:0007411 233 0.021
regulation of mitotic cell cycle phase transition GO:1901990 130 0.021
cellular amine metabolic process GO:0044106 12 0.021
protein ubiquitination GO:0016567 70 0.021
male gamete generation GO:0048232 201 0.021
negative regulation of response to stimulus GO:0048585 258 0.021
regulation of cell cycle GO:0051726 291 0.021
lateral inhibition GO:0046331 206 0.021
cell migration GO:0016477 238 0.021
regulation of immune response GO:0050776 118 0.021
defense response to bacterium GO:0042742 178 0.020
cellular response to chemical stimulus GO:0070887 199 0.020
imaginal disc derived wing vein morphogenesis GO:0008586 44 0.020
nuclear division GO:0000280 332 0.020
intracellular transport GO:0046907 228 0.020
body morphogenesis GO:0010171 2 0.020
Worm
hemopoiesis GO:0030097 46 0.020
regulation of response to stress GO:0080134 200 0.020
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.020
mitotic cell cycle phase transition GO:0044772 138 0.020
histone h4 k16 acetylation GO:0043984 4 0.020
regulation of programmed cell death GO:0043067 152 0.019
nuclear transport GO:0051169 72 0.019
female meiotic division GO:0007143 70 0.019
regulation of g1 s transition of mitotic cell cycle GO:2000045 23 0.019
positive regulation of cellular biosynthetic process GO:0031328 316 0.019
spermatid development GO:0007286 98 0.019
regulation of catabolic process GO:0009894 170 0.019
ribonucleoside metabolic process GO:0009119 127 0.019
germarium derived egg chamber formation GO:0007293 101 0.019
small gtpase mediated signal transduction GO:0007264 88 0.019
tissue migration GO:0090130 155 0.018
protein dna complex assembly GO:0065004 63 0.018
imaginal disc derived appendage morphogenesis GO:0035114 395 0.018
eggshell formation GO:0030703 105 0.018
negative regulation of rna biosynthetic process GO:1902679 240 0.018
positive regulation of cellular amine metabolic process GO:0033240 0 0.018
positive regulation of mapk cascade GO:0043410 63 0.018
regulation of transport GO:0051049 181 0.018
stem cell development GO:0048864 79 0.018
macromolecule catabolic process GO:0009057 161 0.018
wing disc morphogenesis GO:0007472 344 0.018
nuclear dna replication GO:0033260 1 0.018
negative regulation of rna metabolic process GO:0051253 251 0.018
axis specification GO:0009798 167 0.017
ion homeostasis GO:0050801 55 0.017
cell cycle phase transition GO:0044770 140 0.017
regulation of cellular catabolic process GO:0031329 157 0.017
cell death GO:0008219 279 0.017
positive regulation of rna biosynthetic process GO:1902680 266 0.017
embryo development ending in birth or egg hatching GO:0009792 152 0.017
Worm
response to external biotic stimulus GO:0043207 293 0.017
anterior posterior pattern specification GO:0009952 136 0.017
cellular amino acid metabolic process GO:0006520 61 0.017
positive regulation of nucleotide metabolic process GO:0045981 55 0.016
regulation of mitotic cell cycle GO:0007346 190 0.016
mating behavior GO:0007617 106 0.016
carboxylic acid metabolic process GO:0019752 92 0.016
appendage morphogenesis GO:0035107 397 0.016
single organism membrane organization GO:0044802 93 0.016
stem cell maintenance GO:0019827 67 0.016
positive regulation of rna metabolic process GO:0051254 271 0.016
regulation of membrane potential GO:0042391 35 0.016
regulation of mrna processing GO:0050684 71 0.016
defense response to other organism GO:0098542 225 0.016
regulation of localization GO:0032879 275 0.016
intracellular signal transduction GO:0035556 300 0.015
hematopoietic progenitor cell differentiation GO:0002244 1 0.015
protein modification by small protein conjugation or removal GO:0070647 106 0.015
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.015
localization of cell GO:0051674 257 0.015
protein dna complex subunit organization GO:0071824 86 0.014
positive regulation of cellular component organization GO:0051130 156 0.014
establishment of rna localization GO:0051236 47 0.014
lysosomal transport GO:0007041 13 0.014
compound eye morphogenesis GO:0001745 249 0.014
mitotic nuclear division GO:0007067 213 0.014
positive regulation of intracellular signal transduction GO:1902533 116 0.014
negative regulation of cellular metabolic process GO:0031324 382 0.014
regulation of cellular response to stress GO:0080135 89 0.014
determination of left right symmetry GO:0007368 9 0.014
positive regulation of protein metabolic process GO:0051247 128 0.014
cell proliferation GO:0008283 299 0.013
meiotic nuclear division GO:0007126 151 0.013
erbb signaling pathway GO:0038127 58 0.013
gtp metabolic process GO:0046039 72 0.013
response to ecdysone GO:0035075 34 0.013
response to sterol GO:0036314 34 0.013
chromosome segregation GO:0007059 157 0.013
receptor mediated endocytosis GO:0006898 21 0.013
Worm
positive regulation of signal transduction GO:0009967 223 0.013
negative regulation of developmental process GO:0051093 201 0.012
mesenchymal cell development GO:0014031 1 0.012
regulation of nervous system development GO:0051960 248 0.012
organelle fission GO:0048285 340 0.012
rna 3 end processing GO:0031123 45 0.012
cell aging GO:0007569 2 0.012
response to other organism GO:0051707 293 0.012
epithelial cell migration GO:0010631 148 0.012
positive regulation of cellular component biogenesis GO:0044089 80 0.012
gene silencing GO:0016458 138 0.012
ecdysis chitin based cuticle GO:0018990 8 0.012
cellular homeostasis GO:0019725 80 0.012
transcription initiation from rna polymerase ii promoter GO:0006367 25 0.012
regulation of notch signaling pathway GO:0008593 100 0.012
regulation of protein modification process GO:0031399 112 0.012
cell cycle dna replication GO:0044786 23 0.012
negative regulation of growth GO:0045926 84 0.011
phosphorylation GO:0016310 294 0.011
death GO:0016265 284 0.011
response to monosaccharide GO:0034284 4 0.011
telencephalon development GO:0021537 2 0.011
spermatogenesis GO:0007283 200 0.011
positive regulation of phosphorus metabolic process GO:0010562 139 0.011
purine nucleoside triphosphate catabolic process GO:0009146 108 0.011
positive regulation of cellular protein metabolic process GO:0032270 118 0.011
photoreceptor cell development GO:0042461 96 0.011
positive regulation of multicellular organismal process GO:0051240 143 0.011
negative regulation of cell cycle GO:0045786 116 0.011
protein localization to organelle GO:0033365 82 0.011
dna endoreduplication GO:0042023 22 0.011
negative regulation of receptor activity GO:2000272 3 0.011
regulation of cellular protein metabolic process GO:0032268 243 0.011
embryonic organ development GO:0048568 50 0.011
positive regulation of catalytic activity GO:0043085 118 0.010
positive regulation of immune system process GO:0002684 68 0.010
immune response regulating signaling pathway GO:0002764 2 0.010
purine containing compound catabolic process GO:0072523 112 0.010
single organism catabolic process GO:0044712 228 0.010
negative regulation of biosynthetic process GO:0009890 277 0.010
signal transduction by phosphorylation GO:0023014 107 0.010
protein complex assembly GO:0006461 200 0.010
establishment or maintenance of cell polarity GO:0007163 167 0.010
negative regulation of cellular biosynthetic process GO:0031327 277 0.010
chaeta development GO:0022416 97 0.010
cell fate specification involved in pattern specification GO:0060573 8 0.010

defl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.070
disease of anatomical entity DOID:7 0 0.036
cardiovascular system disease DOID:1287 0 0.036
cancer DOID:162 0 0.032
disease of cellular proliferation DOID:14566 0 0.032
organ system cancer DOID:0050686 0 0.032
inherited metabolic disorder DOID:655 0 0.019
acquired metabolic disease DOID:0060158 0 0.017