Drosophila melanogaster

87 known processes

CTCF (Dmel_CG8591)

CG8591 gene product from transcript CG8591-RA

(Aliases: dCTCF,Dmel\CG8591,CG8591)

CTCF biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of gene expression epigenetic GO:0045814 77 1.000
chromatin silencing GO:0006342 76 1.000
gene silencing GO:0016458 138 1.000
negative regulation of biosynthetic process GO:0009890 277 0.999
negative regulation of transcription dna templated GO:0045892 237 0.999
regulation of gene expression epigenetic GO:0040029 128 0.999
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.999
negative regulation of rna metabolic process GO:0051253 251 0.999
negative regulation of cellular biosynthetic process GO:0031327 277 0.999
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.998
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.997
negative regulation of rna biosynthetic process GO:1902679 240 0.996
negative regulation of gene expression GO:0010629 387 0.993
heterochromatin organization GO:0070828 25 0.989
negative regulation of nucleic acid templated transcription GO:1903507 240 0.988
chromosome organization GO:0051276 360 0.975
negative regulation of cellular metabolic process GO:0031324 382 0.968
positive regulation of rna metabolic process GO:0051254 271 0.959
Human Mouse
transcription from rna polymerase ii promoter GO:0006366 368 0.912
Human Mouse
positive regulation of transcription dna templated GO:0045893 266 0.899
Human Mouse
chromatin remodeling GO:0006338 72 0.883
positive regulation of macromolecule metabolic process GO:0010604 405 0.866
Human Mouse
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.856
Human Mouse
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.845
chromatin organization GO:0006325 207 0.826
Human Mouse
regulation of chromatin silencing GO:0031935 36 0.785
response to external biotic stimulus GO:0043207 293 0.781
positive regulation of rna biosynthetic process GO:1902680 266 0.780
Human Mouse
positive regulation of gene expression GO:0010628 290 0.773
Human Mouse
protein acetylation GO:0006473 39 0.763
Mouse
regulation of gene silencing GO:0060968 63 0.744
meiotic nuclear division GO:0007126 151 0.721
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.713
Human Mouse
single organism behavior GO:0044708 391 0.709
embryonic morphogenesis GO:0048598 206 0.703
chromatin modification GO:0016568 147 0.636
Human Mouse
positive regulation of biosynthetic process GO:0009891 316 0.630
Human Mouse
organelle fission GO:0048285 340 0.612
taxis GO:0042330 304 0.580
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.579
Human Mouse
positive regulation of cellular biosynthetic process GO:0031328 316 0.562
Human Mouse
heterochromatin organization involved in chromatin silencing GO:0070868 9 0.476
gene silencing by rna GO:0031047 57 0.448
histone modification GO:0016570 106 0.428
Human Mouse
response to biotic stimulus GO:0009607 294 0.426
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.404
Human Mouse
tube development GO:0035295 244 0.401
positive regulation of nucleic acid templated transcription GO:1903508 266 0.397
Human Mouse
compound eye photoreceptor cell differentiation GO:0001751 140 0.368
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.351
Human Mouse
digestive tract morphogenesis GO:0048546 127 0.345
regulation of heterochromatin assembly GO:0031445 8 0.333
dna metabolic process GO:0006259 227 0.331
nuclear division GO:0000280 332 0.329
anatomical structure homeostasis GO:0060249 97 0.311
chromatin mediated maintenance of transcription GO:0048096 7 0.311
localization of cell GO:0051674 257 0.310
chromatin assembly GO:0031497 48 0.303
Human
digestive tract development GO:0048565 149 0.290
retina development in camera type eye GO:0060041 4 0.288
epidermis development GO:0008544 65 0.284
defense response to other organism GO:0098542 225 0.253
posttranscriptional gene silencing by rna GO:0035194 45 0.247
protein acylation GO:0043543 42 0.246
Mouse
appendage morphogenesis GO:0035107 397 0.244
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.238
Human Mouse
negative regulation of response to stimulus GO:0048585 258 0.236
response to bacterium GO:0009617 198 0.233
internal protein amino acid acetylation GO:0006475 38 0.229
Mouse
neuron projection guidance GO:0097485 241 0.213
posttranscriptional gene silencing GO:0016441 46 0.212
endocytosis GO:0006897 310 0.208
chromosome segregation GO:0007059 157 0.208
imaginal disc derived appendage morphogenesis GO:0035114 395 0.193
cell fate specification GO:0001708 71 0.190
imaginal disc derived appendage development GO:0048737 399 0.187
regulation of transcription by chromatin organization GO:0034401 3 0.175
response to other organism GO:0051707 293 0.174
immune system process GO:0002376 347 0.173
covalent chromatin modification GO:0016569 106 0.167
Human Mouse
positive regulation of response to stimulus GO:0048584 323 0.166
dna replication GO:0006260 48 0.164
ribonucleoside monophosphate catabolic process GO:0009158 39 0.164
chemotaxis GO:0006935 249 0.158
protein modification process GO:0036211 438 0.156
Human Mouse
negative regulation of chromatin silencing GO:0031936 9 0.155
positive regulation of chromatin silencing GO:0031937 16 0.153
dna packaging GO:0006323 91 0.151
Human
regulation of chromatin modification GO:1903308 28 0.147
Human Mouse
positive regulation of cellular component organization GO:0051130 156 0.141
embryonic development via the syncytial blastoderm GO:0001700 148 0.141
nucleosome mobilization GO:0042766 9 0.133
appendage development GO:0048736 401 0.131
dna methylation or demethylation GO:0044728 4 0.131
Mouse
digestive system development GO:0055123 149 0.124
histone h4 acetylation GO:0043967 13 0.123
genital disc development GO:0035215 44 0.121
positive regulation of developmental process GO:0051094 143 0.119
regionalization GO:0003002 416 0.118
wing disc morphogenesis GO:0007472 344 0.117
regulation of dna metabolic process GO:0051052 34 0.114
internal peptidyl lysine acetylation GO:0018393 38 0.114
Mouse
atp dependent chromatin remodeling GO:0043044 22 0.114
positive regulation of gene expression epigenetic GO:0045815 16 0.111
embryo development ending in birth or egg hatching GO:0009792 152 0.109
peptidyl lysine acetylation GO:0018394 39 0.105
Mouse
gland development GO:0048732 191 0.100
histone methylation GO:0016571 40 0.099
Human Mouse
sex differentiation GO:0007548 81 0.098
histone acetylation GO:0016573 38 0.097
Mouse
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.097
cellular response to oxygen containing compound GO:1901701 79 0.097
defense response to bacterium GO:0042742 178 0.095
meiotic cell cycle GO:0051321 171 0.094
cell proliferation GO:0008283 299 0.091
protein localization GO:0008104 284 0.091
purine nucleoside monophosphate catabolic process GO:0009128 38 0.087
dna alkylation GO:0006305 4 0.085
Mouse
imaginal disc derived wing morphogenesis GO:0007476 337 0.080
skin development GO:0043588 65 0.080
chromatin assembly or disassembly GO:0006333 52 0.077
Human
heterochromatin assembly GO:0031507 13 0.077
peptidyl lysine modification GO:0018205 57 0.077
Mouse
organelle assembly GO:0070925 198 0.077
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 15 0.074
response to endogenous stimulus GO:0009719 119 0.073
neurological system process GO:0050877 358 0.073
atp metabolic process GO:0046034 49 0.072
regulation of multi organism process GO:0043900 131 0.071
cell migration GO:0016477 238 0.070
cell motility GO:0048870 251 0.069
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.068
regulation of cellular component biogenesis GO:0044087 201 0.068
dna methylation GO:0006306 4 0.067
Mouse
histone h3 k27 methylation GO:0070734 6 0.067
regulation of cell fate specification GO:0042659 27 0.067
negative regulation of cellular component organization GO:0051129 108 0.067
ribonucleoside monophosphate metabolic process GO:0009161 51 0.066
meiosis i GO:0007127 59 0.066
cellular macromolecular complex assembly GO:0034622 153 0.066
post embryonic appendage morphogenesis GO:0035120 385 0.065
camera type eye development GO:0043010 4 0.065
dna templated transcription elongation GO:0006354 18 0.064
rna interference GO:0016246 27 0.064
axon development GO:0061564 297 0.064
salivary gland development GO:0007431 162 0.063
respiratory system development GO:0060541 213 0.062
embryonic hindgut morphogenesis GO:0048619 48 0.062
gastrulation GO:0007369 70 0.061
epithelial cell differentiation GO:0030855 322 0.061
defense response GO:0006952 300 0.060
salivary gland histolysis GO:0035070 88 0.060
histone h3 k9 acetylation GO:0043970 3 0.059
regulation of cell cycle process GO:0010564 181 0.059
production of small rna involved in gene silencing by rna GO:0070918 15 0.059
regulation of intracellular signal transduction GO:1902531 236 0.059
cellular amine metabolic process GO:0044106 12 0.058
regulation of cell cycle GO:0051726 291 0.058
regulation of cellular amino acid metabolic process GO:0006521 0 0.057
regulation of dna replication GO:0006275 13 0.057
ribonucleoprotein complex assembly GO:0022618 23 0.057
blastoderm segmentation GO:0007350 159 0.057
regulation of chromatin organization GO:1902275 32 0.056
Human Mouse
regulation of meiosis GO:0040020 3 0.056
ribonucleoprotein complex subunit organization GO:0071826 28 0.055
negative regulation of cell cycle GO:0045786 116 0.055
regulation of defense response GO:0031347 102 0.054
regulation of immune system process GO:0002682 176 0.053
axon guidance GO:0007411 233 0.052
sister chromatid segregation GO:0000819 92 0.051
negative regulation of small gtpase mediated signal transduction GO:0051058 13 0.051
rna processing GO:0006396 147 0.050
regulation of chromosome organization GO:0033044 64 0.050
Human Mouse
chromosome condensation GO:0030261 41 0.049
protein complex biogenesis GO:0070271 201 0.048
regulation of mrna processing GO:0050684 71 0.047
vesicle mediated transport GO:0016192 381 0.047
positive regulation of mrna processing GO:0050685 4 0.047
response to dsrna GO:0043331 15 0.046
nucleoside monophosphate catabolic process GO:0009125 39 0.046
response to oxygen containing compound GO:1901700 200 0.046
gene silencing by mirna GO:0035195 22 0.045
regulation of chromatin assembly GO:0010847 9 0.045
sensory organ morphogenesis GO:0090596 260 0.044
regulation of protein metabolic process GO:0051246 256 0.043
Human Mouse
anterior posterior pattern specification GO:0009952 136 0.043
homeostatic process GO:0042592 199 0.042
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.042
cellular response to endogenous stimulus GO:0071495 80 0.042
regulation of mitotic cell cycle GO:0007346 190 0.041
protein complex assembly GO:0006461 200 0.041
programmed cell death GO:0012501 257 0.041
response to organic substance GO:0010033 284 0.041
organonitrogen compound catabolic process GO:1901565 128 0.040
exocrine system development GO:0035272 162 0.039
ubiquitin dependent protein catabolic process GO:0006511 78 0.039
dsrna fragmentation GO:0031050 15 0.038
purine ribonucleoside monophosphate catabolic process GO:0009169 38 0.038
cellular response to organic substance GO:0071310 132 0.038
segmentation GO:0035282 207 0.037
atp catabolic process GO:0006200 38 0.037
regulation of cell death GO:0010941 173 0.036
dna dependent dna replication GO:0006261 17 0.035
purine nucleoside monophosphate metabolic process GO:0009126 50 0.035
cellular response to chemical stimulus GO:0070887 199 0.035
organophosphate metabolic process GO:0019637 195 0.034
negative regulation of signal transduction GO:0009968 206 0.033
cellular protein modification process GO:0006464 438 0.032
Human Mouse
dna conformation change GO:0071103 105 0.032
Human
meiotic chromosome segregation GO:0045132 59 0.031
regulation of cell proliferation GO:0042127 163 0.031
regulation of multicellular organismal development GO:2000026 414 0.031
protein alkylation GO:0008213 43 0.031
Human Mouse
spindle organization GO:0007051 253 0.031
defense response to gram negative bacterium GO:0050829 94 0.030
proteolysis GO:0006508 192 0.029
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.029
tube morphogenesis GO:0035239 191 0.029
transcription elongation from rna polymerase ii promoter GO:0006368 18 0.029
regulation of cell development GO:0060284 215 0.029
purine ribonucleoside metabolic process GO:0046128 127 0.029
regulation of mrna metabolic process GO:1903311 72 0.029
apoptotic signaling pathway GO:0097190 27 0.028
maternal specification of dorsal ventral axis oocyte germ line encoded GO:0007311 4 0.028
morphogenesis of an epithelium GO:0002009 276 0.028
axis specification GO:0009798 167 0.027
body morphogenesis GO:0010171 2 0.027
cellular response to dna damage stimulus GO:0006974 223 0.027
regulation of dna templated transcription elongation GO:0032784 17 0.027
mitotic cell cycle embryonic GO:0045448 38 0.027
histone h4 k20 methylation GO:0034770 4 0.026
nucleoside triphosphate metabolic process GO:0009141 120 0.026
positive regulation of multicellular organismal process GO:0051240 143 0.025
cellular response to dsrna GO:0071359 15 0.025
purine containing compound metabolic process GO:0072521 155 0.025
regulation of nuclear division GO:0051783 58 0.025
hindbrain development GO:0030902 2 0.025
embryonic organ development GO:0048568 50 0.025
positive regulation of signal transduction GO:0009967 223 0.024
embryonic axis specification GO:0000578 107 0.024
histone h3 acetylation GO:0043966 11 0.024
eye photoreceptor cell differentiation GO:0001754 145 0.024
mitotic sister chromatid segregation GO:0000070 87 0.024
cellular macromolecule catabolic process GO:0044265 136 0.024
positive regulation of cellular component biogenesis GO:0044089 80 0.023
death GO:0016265 284 0.023
regulation of cell differentiation GO:0045595 302 0.023
ribose phosphate metabolic process GO:0019693 145 0.023
regulation of mitotic sister chromatid segregation GO:0033047 28 0.023
regulation of phosphatase activity GO:0010921 3 0.023
regulation of compound eye cone cell fate specification GO:0042682 4 0.023
regulation of cellular protein metabolic process GO:0032268 243 0.022
Human Mouse
response to alcohol GO:0097305 95 0.022
axonogenesis GO:0007409 290 0.022
regulation of transferase activity GO:0051338 58 0.022
posttranscriptional regulation of gene expression GO:0010608 145 0.022
response to temperature stimulus GO:0009266 106 0.022
negative regulation of developmental process GO:0051093 201 0.022
response to nitrogen compound GO:1901698 90 0.021
production of mirnas involved in gene silencing by mirna GO:0035196 10 0.021
positive regulation of cellular amine metabolic process GO:0033240 0 0.021
cell division GO:0051301 248 0.021
positive regulation of cell differentiation GO:0045597 64 0.021
muscle organ development GO:0007517 127 0.020
sex determination GO:0007530 18 0.020
phagocytosis GO:0006909 215 0.020
regulation of response to dna damage stimulus GO:2001020 23 0.020
phosphorylation GO:0016310 294 0.020
regulation of cell fate commitment GO:0010453 29 0.020
regulation of protein localization to nucleus GO:1900180 29 0.020
histone exchange GO:0043486 21 0.020
peptidyl amino acid modification GO:0018193 105 0.020
Mouse
proteasomal protein catabolic process GO:0010498 59 0.020
memory GO:0007613 94 0.020
positive regulation of cell development GO:0010720 61 0.019
double strand break repair GO:0006302 26 0.019
regulation of cell division GO:0051302 72 0.019
regulation of organelle organization GO:0033043 196 0.019
Human Mouse
response to ionizing radiation GO:0010212 32 0.019
wnt signaling pathway GO:0016055 98 0.019
organonitrogen compound metabolic process GO:1901564 318 0.019
multi organism behavior GO:0051705 175 0.019
positive regulation of cell cycle process GO:0090068 28 0.019
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 15 0.019
cellular response to nitrogen compound GO:1901699 51 0.019
sister chromatid cohesion GO:0007062 18 0.019
dna recombination GO:0006310 32 0.019
protein phosphorylation GO:0006468 169 0.018
macromolecular complex assembly GO:0065003 256 0.018
Human
salivary gland morphogenesis GO:0007435 145 0.018
compound eye cone cell fate commitment GO:0042676 5 0.018
jak stat cascade GO:0007259 49 0.018
dna repair GO:0006281 54 0.018
cell cycle checkpoint GO:0000075 95 0.018
positive regulation of molecular function GO:0044093 136 0.018
muscle structure development GO:0061061 224 0.018
negative regulation of signaling GO:0023057 219 0.018
nucleoside phosphate metabolic process GO:0006753 162 0.018
regulation of cellular ketone metabolic process GO:0010565 3 0.017
positive regulation of cell communication GO:0010647 250 0.017
histone h4 k12 acetylation GO:0043983 2 0.017
developmental pigmentation GO:0048066 68 0.017
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.017
regulation of sister chromatid cohesion GO:0007063 2 0.017
learning or memory GO:0007611 141 0.017
apoptotic process GO:0006915 159 0.017
nucleoside monophosphate metabolic process GO:0009123 52 0.017
positive regulation of cell cycle GO:0045787 43 0.017
protein maturation GO:0051604 71 0.017
histone h4 k16 acetylation GO:0043984 4 0.016
modification dependent protein catabolic process GO:0019941 78 0.016
regulation of protein import into nucleus GO:0042306 28 0.016
syncytial blastoderm mitotic cell cycle GO:0035186 21 0.016
hematopoietic or lymphoid organ development GO:0048534 57 0.016
regeneration GO:0031099 16 0.016
eye development GO:0001654 323 0.016
regulation of histone h3 k27 methylation GO:0061085 3 0.016
cellular catabolic process GO:0044248 372 0.016
nucleobase containing compound catabolic process GO:0034655 165 0.016
multicellular organismal reproductive behavior GO:0033057 110 0.016
immune system development GO:0002520 57 0.016
hindgut morphogenesis GO:0007442 58 0.015
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.015
positive regulation of cellular protein metabolic process GO:0032270 118 0.015
regulation of rna splicing GO:0043484 69 0.015
cellular amino acid metabolic process GO:0006520 61 0.015
response to organic cyclic compound GO:0014070 89 0.015
negative regulation of ras protein signal transduction GO:0046580 13 0.015
developmental programmed cell death GO:0010623 138 0.015
regulation of glial cell differentiation GO:0045685 1 0.015
regulation of cellular amine metabolic process GO:0033238 3 0.014
connective tissue development GO:0061448 3 0.014
production of sirna involved in rna interference GO:0030422 11 0.014
regulation of mapk cascade GO:0043408 92 0.014
dna endoreduplication GO:0042023 22 0.014
chromosome organization involved in meiosis GO:0070192 10 0.014
regulation of protein modification process GO:0031399 112 0.014
Human Mouse
ncrna processing GO:0034470 30 0.014
receptor mediated endocytosis GO:0006898 21 0.014
mitotic chromosome condensation GO:0007076 22 0.014
regulation of apoptotic process GO:0042981 130 0.014
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.014
developmental growth GO:0048589 280 0.014
regulation of response to stress GO:0080134 200 0.014
reproductive structure development GO:0048608 74 0.014
response to hormone GO:0009725 45 0.013
terminal region determination GO:0007362 25 0.013
antennal development GO:0007469 25 0.013
morphogenesis of a branching epithelium GO:0061138 45 0.013
response to lipopolysaccharide GO:0032496 4 0.013
photoreceptor cell differentiation GO:0046530 170 0.013
leg disc development GO:0035218 92 0.013
eye pigmentation GO:0048069 43 0.013
positive regulation of multi organism process GO:0043902 40 0.013
regulation of cell shape GO:0008360 113 0.013
protein localization to organelle GO:0033365 82 0.013
establishment or maintenance of bipolar cell polarity GO:0061245 34 0.013
salivary gland cell autophagic cell death GO:0035071 83 0.013
embryonic pattern specification GO:0009880 174 0.012
regulation of phosphorylation GO:0042325 147 0.012
mitotic dna damage checkpoint GO:0044773 74 0.012
positive regulation of transferase activity GO:0051347 26 0.012
negative regulation of chromosome organization GO:2001251 19 0.012
branching morphogenesis of an epithelial tube GO:0048754 45 0.012
negative regulation of g1 s transition of mitotic cell cycle GO:2000134 13 0.012
nucleotide metabolic process GO:0009117 161 0.012
gland morphogenesis GO:0022612 145 0.012
positive regulation of immune system process GO:0002684 68 0.012
regulation of mrna splicing via spliceosome GO:0048024 64 0.012
negative regulation of immune system process GO:0002683 50 0.012
meiotic cell cycle process GO:1903046 132 0.012
nucleosome organization GO:0034728 59 0.012
Human
negative regulation of sister chromatid segregation GO:0033046 13 0.012
negative regulation of cardiac cell fate specification GO:2000044 7 0.011
regulation of phosphate metabolic process GO:0019220 210 0.011
purine nucleoside triphosphate metabolic process GO:0009144 119 0.011
mitotic spindle organization GO:0007052 220 0.011
establishment or maintenance of apical basal cell polarity GO:0035088 34 0.011
regulation of programmed cell death GO:0043067 152 0.011
reproductive system development GO:0061458 74 0.011
oocyte dorsal ventral axis specification GO:0007310 34 0.011
ribonucleoside triphosphate metabolic process GO:0009199 119 0.011
small molecule metabolic process GO:0044281 305 0.011
regulation of cellular response to stress GO:0080135 89 0.011
regulation of meiotic cell cycle GO:0051445 9 0.011
negative regulation of cell communication GO:0010648 223 0.011
regulation of embryonic development GO:0045995 68 0.011
regulation of molecular function GO:0065009 217 0.011
Human
embryonic organ morphogenesis GO:0048562 5 0.011
cell type specific apoptotic process GO:0097285 38 0.011
regulation of localization GO:0032879 275 0.010
eye morphogenesis GO:0048592 260 0.010
mrna processing GO:0006397 104 0.010
negative regulation of apoptotic process GO:0043066 63 0.010
aromatic compound catabolic process GO:0019439 166 0.010
nucleoside triphosphate catabolic process GO:0009143 108 0.010
compound eye photoreceptor fate commitment GO:0001752 36 0.010
hindgut development GO:0061525 58 0.010
enzyme linked receptor protein signaling pathway GO:0007167 179 0.010
oxoacid metabolic process GO:0043436 103 0.010
regulation of gene silencing by mirna GO:0060964 8 0.010
positive regulation of nervous system development GO:0051962 69 0.010
purine containing compound catabolic process GO:0072523 112 0.010
chemosensory behavior GO:0007635 106 0.010
cell cycle comprising mitosis without cytokinesis GO:0033301 25 0.010
negative regulation of cellular protein metabolic process GO:0032269 85 0.010

CTCF disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.073
disease of cellular proliferation DOID:14566 0 0.073
organ system cancer DOID:0050686 0 0.073
disease of anatomical entity DOID:7 0 0.013