Drosophila melanogaster

34 known processes

Pros25 (Dmel_CG5266)

Proteasome 25kD subunit

(Aliases: CG5266,Su(DTS),153303_at,dalpha2,PSA2_DROME,PROS Dm25,alpha2_dm,PROS-Dm25g,PRC3,Prosalpha2,Dmel\CG5266,Su(DTS)-1)

Pros25 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
modification dependent macromolecule catabolic process GO:0043632 79 0.907
Yeast
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.731
mitotic spindle elongation GO:0000022 81 0.651
spindle organization GO:0007051 253 0.635
gastrulation involving germ band extension GO:0010004 36 0.281
organelle assembly GO:0070925 198 0.274
ventral furrow formation GO:0007370 17 0.255
microtubule cytoskeleton organization involved in mitosis GO:1902850 52 0.221
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 24 0.217
body morphogenesis GO:0010171 2 0.212
cellular response to dna damage stimulus GO:0006974 223 0.202
positive regulation of macromolecule metabolic process GO:0010604 405 0.201
spindle assembly involved in mitosis GO:0090307 50 0.195
cellular catabolic process GO:0044248 372 0.189
Yeast
cellular macromolecule catabolic process GO:0044265 136 0.183
Yeast
positive regulation of proteasomal protein catabolic process GO:1901800 20 0.171
gastrulation with mouth forming first GO:0001703 36 0.167
mitotic spindle organization GO:0007052 220 0.165
mitotic nuclear division GO:0007067 213 0.164
protein catabolic process GO:0030163 101 0.157
Yeast
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.152
Yeast
cellular protein catabolic process GO:0044257 83 0.144
Yeast
spindle assembly GO:0051225 80 0.137
proteolysis GO:0006508 192 0.136
Yeast
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.128
embryonic morphogenesis GO:0048598 206 0.123
positive regulation of nucleic acid templated transcription GO:1903508 266 0.118
catabolic process GO:0009056 409 0.112
Yeast
embryo development ending in birth or egg hatching GO:0009792 152 0.108
Worm
larval development GO:0002164 104 0.098
Worm
positive regulation of transcription dna templated GO:0045893 266 0.097
spindle elongation GO:0051231 83 0.094
organelle fission GO:0048285 340 0.088
microtubule organizing center organization GO:0031023 168 0.085
regulation of molecular function GO:0065009 217 0.080
macromolecule catabolic process GO:0009057 161 0.072
Yeast
positive regulation of catabolic process GO:0009896 105 0.067
positive regulation of proteolysis GO:0045862 52 0.067
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.066
nuclear division GO:0000280 332 0.066
aging GO:0007568 143 0.065
positive regulation of rna metabolic process GO:0051254 271 0.061
proteasome assembly GO:0043248 2 0.061
positive regulation of rna biosynthetic process GO:1902680 266 0.059
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.057
multicellular organismal aging GO:0010259 140 0.056
proteasomal protein catabolic process GO:0010498 59 0.054
Yeast
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.053
Yeast
regionalization GO:0003002 416 0.053
gastrulation GO:0007369 70 0.052
macromolecular complex assembly GO:0065003 256 0.051
regulation of proteasomal protein catabolic process GO:0061136 39 0.047
regulation of cellular protein metabolic process GO:0032268 243 0.047
cell proliferation GO:0008283 299 0.047
transcription from rna polymerase ii promoter GO:0006366 368 0.046
tube development GO:0035295 244 0.046
regulation of catalytic activity GO:0050790 185 0.045
regulation of cellular catabolic process GO:0031329 157 0.044
ubiquitin dependent protein catabolic process GO:0006511 78 0.044
Yeast
modification dependent protein catabolic process GO:0019941 78 0.044
Yeast
lateral inhibition GO:0046331 206 0.042
cellular macromolecular complex assembly GO:0034622 153 0.040
digestive system development GO:0055123 149 0.040
stem cell differentiation GO:0048863 117 0.039
positive regulation of cellular catabolic process GO:0031331 95 0.039
digestive tract development GO:0048565 149 0.039
positive regulation of cellular protein metabolic process GO:0032270 118 0.038
mitotic cell cycle phase transition GO:0044772 138 0.038
cell cycle phase transition GO:0044770 140 0.038
regulation of cell cycle GO:0051726 291 0.036
positive regulation of peptidase activity GO:0010952 29 0.035
regulation of cell cycle process GO:0010564 181 0.035
cell cell signaling involved in cell fate commitment GO:0045168 210 0.034
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 19 0.033
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.032
positive regulation of signaling GO:0023056 243 0.029
cellular protein complex assembly GO:0043623 71 0.029
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 20 0.029
appendage morphogenesis GO:0035107 397 0.029
regulation of catabolic process GO:0009894 170 0.028
protein complex assembly GO:0006461 200 0.028
cell death GO:0008219 279 0.028
negative regulation of cellular metabolic process GO:0031324 382 0.028
purine nucleoside catabolic process GO:0006152 112 0.028
regulation of cell cycle phase transition GO:1901987 130 0.027
determination of adult lifespan GO:0008340 137 0.026
regulation of proteolysis GO:0030162 87 0.026
aromatic compound catabolic process GO:0019439 166 0.025
cell motility GO:0048870 251 0.025
response to nitrogen compound GO:1901698 90 0.025
centrosome organization GO:0051297 163 0.025
eye morphogenesis GO:0048592 260 0.025
death GO:0016265 284 0.024
nucleoside catabolic process GO:0009164 112 0.024
digestive tract morphogenesis GO:0048546 127 0.024
regulation of cellular protein catabolic process GO:1903362 44 0.024
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.024
organophosphate metabolic process GO:0019637 195 0.023
dorsal ventral pattern formation GO:0009953 133 0.023
positive regulation of cellular biosynthetic process GO:0031328 316 0.023
lamellipodium assembly GO:0030032 21 0.022
ribonucleoside triphosphate catabolic process GO:0009203 108 0.022
camera type eye development GO:0043010 4 0.022
synaptic transmission GO:0007268 288 0.022
organic substance catabolic process GO:1901575 308 0.022
Yeast
positive regulation of biosynthetic process GO:0009891 316 0.022
imaginal disc derived appendage development GO:0048737 399 0.021
positive regulation of catalytic activity GO:0043085 118 0.021
positive regulation of molecular function GO:0044093 136 0.021
carbohydrate derivative catabolic process GO:1901136 118 0.021
cell division GO:0051301 248 0.020
cell migration GO:0016477 238 0.020
positive regulation of cellular component organization GO:0051130 156 0.020
purine ribonucleoside catabolic process GO:0046130 112 0.020
regulation of mitotic cell cycle GO:0007346 190 0.020
purine nucleoside triphosphate catabolic process GO:0009146 108 0.019
mrna processing GO:0006397 104 0.019
protein modification process GO:0036211 438 0.019
negative regulation of developmental process GO:0051093 201 0.019
cellular nitrogen compound catabolic process GO:0044270 165 0.019
nucleotide metabolic process GO:0009117 161 0.018
ribonucleoside catabolic process GO:0042454 112 0.018
positive regulation of gene expression GO:0010628 290 0.018
regulation of cell shape GO:0008360 113 0.018
regulation of cellular component biogenesis GO:0044087 201 0.018
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.018
negative regulation of cellular biosynthetic process GO:0031327 277 0.017
organophosphate catabolic process GO:0046434 112 0.017
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.017
secretion by cell GO:0032940 101 0.017
purine nucleotide metabolic process GO:0006163 146 0.017
ribonucleotide catabolic process GO:0009261 109 0.017
regulation of cellular ketone metabolic process GO:0010565 3 0.017
mitotic g2 m transition checkpoint GO:0044818 70 0.016
organonitrogen compound metabolic process GO:1901564 318 0.016
small molecule metabolic process GO:0044281 305 0.016
protein phosphorylation GO:0006468 169 0.016
regulation of mitotic cell cycle phase transition GO:1901990 130 0.016
heterocycle catabolic process GO:0046700 166 0.016
nucleoside phosphate catabolic process GO:1901292 110 0.016
morphogenesis of an epithelium GO:0002009 276 0.015
positive regulation of cellular protein catabolic process GO:1903364 24 0.015
purine nucleoside monophosphate catabolic process GO:0009128 38 0.015
regulation of phosphorus metabolic process GO:0051174 210 0.015
regulation of mrna metabolic process GO:1903311 72 0.015
embryonic development via the syncytial blastoderm GO:0001700 148 0.015
organic substance transport GO:0071702 257 0.015
appendage development GO:0048736 401 0.014
imaginal disc pattern formation GO:0007447 91 0.014
cellular component assembly involved in morphogenesis GO:0010927 151 0.014
nucleoside metabolic process GO:0009116 127 0.014
chromatin modification GO:0016568 147 0.014
purine ribonucleotide catabolic process GO:0009154 109 0.014
positive regulation of cell communication GO:0010647 250 0.014
cellular response to xenobiotic stimulus GO:0071466 5 0.014
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 4 0.013
epithelial tube morphogenesis GO:0060562 88 0.013
er associated ubiquitin dependent protein catabolic process GO:0030433 3 0.013
purine nucleotide catabolic process GO:0006195 109 0.013
single organism catabolic process GO:0044712 228 0.013
regulation of protein metabolic process GO:0051246 256 0.012
cytokinesis GO:0000910 90 0.012
positive regulation of protein catabolic process GO:0045732 34 0.012
dna templated transcription initiation GO:0006352 25 0.012
purine nucleoside metabolic process GO:0042278 127 0.012
apoptotic process GO:0006915 159 0.012
cellular protein modification process GO:0006464 438 0.012
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.012
negative regulation of rna metabolic process GO:0051253 251 0.012
regulation of synapse structure and activity GO:0050803 128 0.012
organonitrogen compound catabolic process GO:1901565 128 0.012
nucleoside triphosphate catabolic process GO:0009143 108 0.012
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.012
organic cyclic compound catabolic process GO:1901361 168 0.012
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 1 0.012
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.012
membrane depolarization GO:0051899 4 0.012
nucleoside phosphate metabolic process GO:0006753 162 0.011
cellular lipid metabolic process GO:0044255 83 0.011
positive regulation of protein metabolic process GO:0051247 128 0.011
purine ribonucleoside metabolic process GO:0046128 127 0.011
purine containing compound metabolic process GO:0072521 155 0.011
flight behavior GO:0007629 26 0.011
purine nucleoside triphosphate metabolic process GO:0009144 119 0.011
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.011
neurological system process GO:0050877 358 0.011
gland development GO:0048732 191 0.011
purine ribonucleotide metabolic process GO:0009150 145 0.011
localization of cell GO:0051674 257 0.011
single organism behavior GO:0044708 391 0.011
protein localization GO:0008104 284 0.011
nucleotide catabolic process GO:0009166 109 0.010
response to organonitrogen compound GO:0010243 75 0.010
positive regulation of cellular component biogenesis GO:0044089 80 0.010
morphogenesis of follicular epithelium GO:0016333 36 0.010

Pros25 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.034
disease of metabolism DOID:0014667 0 0.017