Drosophila melanogaster

12 known processes

Spn88Eb (Dmel_CG6687)

Serpin 88Eb

(Aliases: CG6687,Dmel\CG6687)

Spn88Eb biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
defense response to gram positive bacterium GO:0050830 41 0.228
pattern recognition receptor signaling pathway GO:0002221 2 0.180
response to external biotic stimulus GO:0043207 293 0.176
antibacterial humoral response GO:0019731 44 0.165
response to biotic stimulus GO:0009607 294 0.128
activation of innate immune response GO:0002218 4 0.120
defense response to other organism GO:0098542 225 0.102
immune system process GO:0002376 347 0.100
defense response GO:0006952 300 0.100
antimicrobial peptide production GO:0002775 46 0.100
response to other organism GO:0051707 293 0.085
regulation of immune system process GO:0002682 176 0.084
defense response to bacterium GO:0042742 178 0.083
response to bacterium GO:0009617 198 0.078
humoral immune response GO:0006959 117 0.070
antimicrobial humoral response GO:0019730 99 0.070
defense response to fungus GO:0050832 48 0.069
organonitrogen compound metabolic process GO:1901564 318 0.068
positive regulation of defense response GO:0031349 59 0.068
carbohydrate derivative metabolic process GO:1901135 217 0.060
response to lipopolysaccharide GO:0032496 4 0.060
defense response to gram negative bacterium GO:0050829 94 0.057
positive regulation of response to stimulus GO:0048584 323 0.056
innate immune response activating signal transduction GO:0002758 2 0.055
positive regulation of immune system process GO:0002684 68 0.055
immune response activating signal transduction GO:0002757 2 0.051
immune response regulating signaling pathway GO:0002764 2 0.047
small molecule metabolic process GO:0044281 305 0.046
cellular modified amino acid metabolic process GO:0006575 45 0.045
cell cell signaling involved in cell fate commitment GO:0045168 210 0.044
organonitrogen compound biosynthetic process GO:1901566 117 0.043
regulation of antimicrobial peptide biosynthetic process GO:0002805 38 0.042
regulation of defense response GO:0031347 102 0.041
positive regulation of antibacterial peptide production GO:0002803 20 0.041
glycosyl compound metabolic process GO:1901657 127 0.039
nucleoside metabolic process GO:0009116 127 0.038
regulation of response to stress GO:0080134 200 0.038
immune response GO:0006955 246 0.037
positive regulation of biosynthetic process of antibacterial peptides active against gram negative bacteria GO:0006964 12 0.036
regulation of multi organism process GO:0043900 131 0.036
nucleobase containing small molecule metabolic process GO:0055086 174 0.036
oxoacid metabolic process GO:0043436 103 0.036
organic acid metabolic process GO:0006082 103 0.036
regulation of immune response GO:0050776 118 0.035
purine containing compound metabolic process GO:0072521 155 0.035
axis specification GO:0009798 167 0.035
purine nucleoside metabolic process GO:0042278 127 0.035
cellular response to lipopolysaccharide GO:0071222 3 0.034
catabolic process GO:0009056 409 0.034
positive regulation of immune response GO:0050778 63 0.034
dorsal ventral pattern formation GO:0009953 133 0.034
compound eye development GO:0048749 307 0.033
lipopolysaccharide mediated signaling pathway GO:0031663 1 0.033
intracellular signal transduction GO:0035556 300 0.032
negative regulation of cell communication GO:0010648 223 0.031
Fly
regulation of antibacterial peptide production GO:0002786 22 0.031
cell proliferation GO:0008283 299 0.030
phagocytosis GO:0006909 215 0.030
phosphorylation GO:0016310 294 0.029
peptidoglycan catabolic process GO:0009253 3 0.029
organic substance catabolic process GO:1901575 308 0.029
mating behavior GO:0007617 106 0.029
macromolecule catabolic process GO:0009057 161 0.027
regulation of biosynthetic process of antibacterial peptides active against gram negative bacteria GO:0002813 14 0.027
positive regulation of cellular biosynthetic process GO:0031328 316 0.027
peptidoglycan metabolic process GO:0000270 3 0.027
innate immune response GO:0045087 144 0.027
amide biosynthetic process GO:0043604 42 0.026
positive regulation of biosynthetic process GO:0009891 316 0.025
vesicle mediated transport GO:0016192 381 0.025
regulation of phosphorus metabolic process GO:0051174 210 0.025
glycosaminoglycan catabolic process GO:0006027 3 0.025
production of molecular mediator of immune response GO:0002440 46 0.025
compound eye morphogenesis GO:0001745 249 0.024
regulation of antimicrobial peptide production GO:0002784 44 0.024
imaginal disc derived appendage development GO:0048737 399 0.024
Fly
negative regulation of signaling GO:0023057 219 0.024
Fly
endocytosis GO:0006897 310 0.024
negative regulation of signal transduction GO:0009968 206 0.023
Fly
cellular response to molecule of bacterial origin GO:0071219 3 0.023
regulation of phosphate metabolic process GO:0019220 210 0.023
antibacterial peptide production GO:0002778 22 0.023
carboxylic acid metabolic process GO:0019752 92 0.023
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.023
cellular response to external stimulus GO:0071496 66 0.023
melanization defense response GO:0035006 45 0.023
protein modification process GO:0036211 438 0.023
neurological system process GO:0050877 358 0.023
dorsal ventral axis specification GO:0009950 66 0.023
regulation of innate immune response GO:0045088 71 0.023
response to fungus GO:0009620 50 0.022
negative regulation of response to stimulus GO:0048585 258 0.022
Fly
cellular response to chemical stimulus GO:0070887 199 0.022
ion transport GO:0006811 145 0.022
sensory organ morphogenesis GO:0090596 260 0.022
cellular protein modification process GO:0006464 438 0.022
carbohydrate derivative catabolic process GO:1901136 118 0.022
eye development GO:0001654 323 0.022
biosynthetic process of antibacterial peptides active against gram positive bacteria GO:0002815 3 0.021
appendage morphogenesis GO:0035107 397 0.021
Fly
regulation of cell proliferation GO:0042127 163 0.021
regulation of intracellular signal transduction GO:1902531 236 0.021
response to peptidoglycan GO:0032494 2 0.021
positive regulation of antimicrobial humoral response GO:0002760 28 0.021
regulation of response to external stimulus GO:0032101 115 0.021
secondary metabolic process GO:0019748 75 0.021
negative regulation of cellular metabolic process GO:0031324 382 0.020
regulation of response to biotic stimulus GO:0002831 63 0.020
antimicrobial peptide biosynthetic process GO:0002777 38 0.020
eye morphogenesis GO:0048592 260 0.020
response to oxygen containing compound GO:1901700 200 0.020
stress activated mapk cascade GO:0051403 52 0.019
positive regulation of cell motility GO:2000147 3 0.019
regulation of molecular function GO:0065009 217 0.019
peptide biosynthetic process GO:0043043 42 0.019
regulation of antimicrobial humoral response GO:0002759 50 0.019
cellular response to extracellular stimulus GO:0031668 64 0.019
regulation of defense response to bacterium GO:1900424 30 0.019
cellular response to biotic stimulus GO:0071216 4 0.018
regulation of humoral immune response GO:0002920 51 0.018
cellular response to organic substance GO:0071310 132 0.018
positive regulation of signal transduction GO:0009967 223 0.018
regulation of anatomical structure morphogenesis GO:0022603 242 0.018
wing disc morphogenesis GO:0007472 344 0.018
Fly
antibacterial peptide biosynthetic process GO:0002780 22 0.018
positive regulation of cell migration GO:0030335 2 0.018
organelle fission GO:0048285 340 0.018
cellular catabolic process GO:0044248 372 0.018
body morphogenesis GO:0010171 2 0.018
taxis GO:0042330 304 0.018
positive regulation of production of molecular mediator of immune response GO:0002702 28 0.018
biosynthetic process of antibacterial peptides active against gram negative bacteria GO:0002812 14 0.018
appendage development GO:0048736 401 0.017
Fly
positive regulation of antibacterial peptide biosynthetic process GO:0006963 20 0.017
lateral inhibition GO:0046331 206 0.017
positive regulation of humoral immune response GO:0002922 28 0.017
reproductive behavior GO:0019098 122 0.017
response to nutrient levels GO:0031667 114 0.017
regulation of protein metabolic process GO:0051246 256 0.017
cellular amino acid metabolic process GO:0006520 61 0.017
secondary metabolite biosynthetic process GO:0044550 24 0.017
death GO:0016265 284 0.017
immune effector process GO:0002252 98 0.017
cellular response to starvation GO:0009267 61 0.017
imaginal disc derived wing morphogenesis GO:0007476 337 0.017
Fly
organonitrogen compound catabolic process GO:1901565 128 0.016
positive regulation of cell communication GO:0010647 250 0.016
negative regulation of gene expression GO:0010629 387 0.016
positive regulation of signaling GO:0023056 243 0.016
cation transport GO:0006812 110 0.016
proteolysis GO:0006508 192 0.016
multicellular organismal reproductive behavior GO:0033057 110 0.016
cellular ketone metabolic process GO:0042180 24 0.016
regulation of production of molecular mediator of immune response GO:0002700 44 0.016
regulation of cellular protein metabolic process GO:0032268 243 0.015
gene silencing GO:0016458 138 0.015
response to organic substance GO:0010033 284 0.015
homeostatic process GO:0042592 199 0.015
extracellular structure organization GO:0043062 46 0.015
spindle organization GO:0007051 253 0.015
cell death GO:0008219 279 0.015
jnk cascade GO:0007254 50 0.015
regulation of multicellular organismal development GO:2000026 414 0.015
mitotic nuclear division GO:0007067 213 0.015
single organism biosynthetic process GO:0044711 206 0.015
regulation of cellular response to stress GO:0080135 89 0.015
positive regulation of multi organism process GO:0043902 40 0.015
regulation of antibacterial peptide biosynthetic process GO:0002808 22 0.015
regionalization GO:0003002 416 0.015
cellular amide metabolic process GO:0043603 80 0.015
positive regulation of innate immune response GO:0045089 38 0.015
negative regulation of developmental process GO:0051093 201 0.014
regulation of catalytic activity GO:0050790 185 0.014
protein phosphorylation GO:0006468 169 0.014
regulation of cell cycle GO:0051726 291 0.014
establishment of localization in cell GO:0051649 402 0.014
regulation of cellular amide metabolic process GO:0034248 39 0.014
post embryonic appendage morphogenesis GO:0035120 385 0.014
Fly
regulation of cellular ketone metabolic process GO:0010565 3 0.014
negative regulation of peptidoglycan recognition protein signaling pathway GO:0061060 3 0.014
chemotaxis GO:0006935 249 0.014
response to abiotic stimulus GO:0009628 341 0.014
positive regulation of melanization defense response GO:0035008 1 0.014
mating GO:0007618 120 0.014
nuclear division GO:0000280 332 0.014
single organism catabolic process GO:0044712 228 0.014
response to organophosphorus GO:0046683 2 0.014
axon development GO:0061564 297 0.013
organic substance transport GO:0071702 257 0.013
melanin metabolic process GO:0006582 47 0.013
response to organonitrogen compound GO:0010243 75 0.013
positive regulation of antimicrobial peptide production GO:0002225 28 0.013
neuropeptide signaling pathway GO:0007218 45 0.013
regulation of phosphorylation GO:0042325 147 0.013
cellular response to oxygen containing compound GO:1901701 79 0.013
developmental maturation GO:0021700 172 0.013
positive regulation of defense response to bacterium GO:1900426 23 0.013
very long chain fatty acid metabolic process GO:0000038 4 0.013
regulation of mapk cascade GO:0043408 92 0.013
amino sugar catabolic process GO:0046348 3 0.013
chemical homeostasis GO:0048878 92 0.013
response to glucose GO:0009749 2 0.013
negative regulation of cellular protein metabolic process GO:0032269 85 0.013
positive regulation of phosphorus metabolic process GO:0010562 139 0.013
mapk cascade GO:0000165 107 0.013
protein maturation GO:0051604 71 0.013
cellular response to nutrient levels GO:0031669 62 0.013
intracellular transport GO:0046907 228 0.012
gene silencing by rna GO:0031047 57 0.012
antifungal humoral response GO:0019732 12 0.012
ribonucleoside metabolic process GO:0009119 127 0.012
cellular nitrogen compound catabolic process GO:0044270 165 0.012
ras protein signal transduction GO:0007265 88 0.012
regulation of cell morphogenesis GO:0022604 163 0.012
meiotic cell cycle GO:0051321 171 0.012
segmentation GO:0035282 207 0.012
alpha amino acid metabolic process GO:1901605 20 0.012
mitotic spindle organization GO:0007052 220 0.012
signal transduction by phosphorylation GO:0023014 107 0.012
genital disc development GO:0035215 44 0.012
negative regulation of protein metabolic process GO:0051248 85 0.012
toll signaling pathway GO:0008063 25 0.012
Fly
negative regulation of cell differentiation GO:0045596 143 0.012
cell maturation GO:0048469 144 0.012
amine metabolic process GO:0009308 12 0.012
macromolecular complex assembly GO:0065003 256 0.012
tripartite regional subdivision GO:0007351 103 0.012
transcription from rna polymerase ii promoter GO:0006366 368 0.012
positive regulation of cellular amide metabolic process GO:0034250 26 0.012
forebrain development GO:0030900 2 0.012
peptide metabolic process GO:0006518 80 0.012
programmed cell death GO:0012501 257 0.012
imaginal disc derived appendage morphogenesis GO:0035114 395 0.012
Fly
camera type eye development GO:0043010 4 0.012
regulation of cellular amine metabolic process GO:0033238 3 0.012
regulation of localization GO:0032879 275 0.012
chromosome segregation GO:0007059 157 0.012
pigment metabolic process GO:0042440 84 0.011
connective tissue development GO:0061448 3 0.011
stress activated protein kinase signaling cascade GO:0031098 55 0.011
positive regulation of macromolecule metabolic process GO:0010604 405 0.011
autophagic cell death GO:0048102 83 0.011
ovarian follicle cell development GO:0030707 248 0.011
regulation of cell substrate adhesion GO:0010810 2 0.011
actin filament based process GO:0030029 220 0.011
blastoderm segmentation GO:0007350 159 0.011
neuron projection guidance GO:0097485 241 0.011
biological adhesion GO:0022610 138 0.011
small gtpase mediated signal transduction GO:0007264 88 0.011
axonogenesis GO:0007409 290 0.011
wound healing GO:0042060 75 0.011
positive regulation of phosphate metabolic process GO:0045937 139 0.011
cell adhesion GO:0007155 136 0.011
regulation of cell differentiation GO:0045595 302 0.011
purine ribonucleoside metabolic process GO:0046128 127 0.011
kidney development GO:0001822 3 0.011
positive regulation of catalytic activity GO:0043085 118 0.011
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.011
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.011
cellular amine metabolic process GO:0044106 12 0.011
cellular macromolecule catabolic process GO:0044265 136 0.011
aromatic compound catabolic process GO:0019439 166 0.011
cellular macromolecule localization GO:0070727 220 0.011
localization of cell GO:0051674 257 0.011
g protein coupled receptor signaling pathway GO:0007186 136 0.011
negative regulation of phosphorylation GO:0042326 35 0.011
posttranscriptional regulation of gene expression GO:0010608 145 0.011
protein heterooligomerization GO:0051291 4 0.010
single organism cell adhesion GO:0098602 47 0.010
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.010
regulation of peptidoglycan recognition protein signaling pathway GO:0061058 4 0.010
positive regulation of hemocyte proliferation GO:0035208 4 0.010
oocyte construction GO:0007308 112 0.010
regulation of cell death GO:0010941 173 0.010
response to monosaccharide GO:0034284 4 0.010
developmental growth GO:0048589 280 0.010
Fly
regulation of cell development GO:0060284 215 0.010
developmental programmed cell death GO:0010623 138 0.010
regulation of nervous system development GO:0051960 248 0.010
organophosphate metabolic process GO:0019637 195 0.010
regulation of cell cycle process GO:0010564 181 0.010
negative regulation of immune system process GO:0002683 50 0.010
axon guidance GO:0007411 233 0.010
cell migration GO:0016477 238 0.010
peptidoglycan recognition protein signaling pathway GO:0061057 16 0.010
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.010
positive regulation of gene expression GO:0010628 290 0.010
long chain fatty acid metabolic process GO:0001676 3 0.010
xenobiotic catabolic process GO:0042178 1 0.010
organic hydroxy compound metabolic process GO:1901615 83 0.010

Spn88Eb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.028
nervous system disease DOID:863 0 0.014
cardiovascular system disease DOID:1287 0 0.011