Drosophila melanogaster

156 known processes

Cul-3 (Dmel_CG42616)

Cullin-3

(Aliases: Dmel\CG42616,gft,gft/dCul-3,dCul-3,mds,br34,cul3,Dmel_CG31829,CG31829,Dmel_CG11861,guftagu,l(2)br34,BG:DS07851.2,CUL3,DMcul-3,CG11861,dCul3,CG42616,l(2)35Cd,l35Cd,cul-3,Cul3,l(2)06430)

Cul-3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein modification by small protein conjugation or removal GO:0070647 106 0.987
appendage morphogenesis GO:0035107 397 0.868
cellular protein modification process GO:0006464 438 0.866
striated muscle cell differentiation GO:0051146 90 0.851
circadian rhythm GO:0007623 105 0.844
negative regulation of response to stimulus GO:0048585 258 0.811
appendage development GO:0048736 401 0.774
synapse organization GO:0050808 196 0.756
positive regulation of macromolecule metabolic process GO:0010604 405 0.756
rhythmic process GO:0048511 106 0.697
cytoskeleton dependent cytokinesis GO:0061640 81 0.659
imaginal disc derived wing hair organization GO:0035317 45 0.648
post embryonic appendage morphogenesis GO:0035120 385 0.641
protein modification by small protein conjugation GO:0032446 79 0.631
dorsal ventral pattern formation GO:0009953 133 0.630
imaginal disc derived appendage morphogenesis GO:0035114 395 0.616
hair cell differentiation GO:0035315 47 0.588
positive regulation of gene expression GO:0010628 290 0.575
imaginal disc derived wing morphogenesis GO:0007476 337 0.564
regionalization GO:0003002 416 0.548
muscle structure development GO:0061061 224 0.537
circadian sleep wake cycle process GO:0022410 24 0.534
cell division GO:0051301 248 0.531
cellular macromolecule catabolic process GO:0044265 136 0.468
intracellular signal transduction GO:0035556 300 0.464
proteolysis GO:0006508 192 0.459
embryo development ending in birth or egg hatching GO:0009792 152 0.455
negative regulation of gene expression GO:0010629 387 0.440
regulation of cell development GO:0060284 215 0.421
male gamete generation GO:0048232 201 0.420
regulation of circadian rhythm GO:0042752 49 0.418
nucleocytoplasmic transport GO:0006913 72 0.411
regulation of cell differentiation GO:0045595 302 0.404
rhythmic behavior GO:0007622 76 0.391
actin filament based process GO:0030029 220 0.388
regulation of cell cycle GO:0051726 291 0.385
sperm individualization GO:0007291 48 0.376
mushroom body development GO:0016319 70 0.362
protein maturation GO:0051604 71 0.357
protein modification process GO:0036211 438 0.353
spermatid differentiation GO:0048515 114 0.352
circadian sleep wake cycle GO:0042745 28 0.332
regulation of molecular function GO:0065009 217 0.328
tissue morphogenesis GO:0048729 297 0.327
regulation of protein metabolic process GO:0051246 256 0.319
programmed cell death GO:0012501 257 0.319
death GO:0016265 284 0.316
regulation of nervous system development GO:0051960 248 0.310
negative regulation of signaling GO:0023057 219 0.291
regulation of cell cycle phase transition GO:1901987 130 0.290
negative regulation of developmental process GO:0051093 201 0.288
negative regulation of cell cycle phase transition GO:1901988 103 0.285
dorsal ventral axis specification GO:0009950 66 0.284
negative regulation of cell communication GO:0010648 223 0.275
modification dependent protein catabolic process GO:0019941 78 0.272
head development GO:0060322 135 0.269
protein ubiquitination GO:0016567 70 0.266
regulation of multicellular organismal development GO:2000026 414 0.265
sarcomere organization GO:0045214 26 0.265
transcription from rna polymerase ii promoter GO:0006366 368 0.259
regulation of synapse organization GO:0050807 110 0.242
cellular component assembly involved in morphogenesis GO:0010927 151 0.232
epithelial cell differentiation GO:0030855 322 0.231
regulation of localization GO:0032879 275 0.230
imaginal disc derived appendage development GO:0048737 399 0.227
macromolecule catabolic process GO:0009057 161 0.225
organic substance catabolic process GO:1901575 308 0.215
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.215
protein localization GO:0008104 284 0.214
regulation of catalytic activity GO:0050790 185 0.208
non sensory hair organization GO:0035316 47 0.205
oocyte construction GO:0007308 112 0.205
oocyte dorsal ventral axis specification GO:0007310 34 0.201
single organism cellular localization GO:1902580 180 0.200
cell death GO:0008219 279 0.195
cytoplasmic transport nurse cell to oocyte GO:0007303 12 0.194
epidermal cell differentiation GO:0009913 51 0.188
negative regulation of cellular biosynthetic process GO:0031327 277 0.186
circadian behavior GO:0048512 76 0.179
dna repair GO:0006281 54 0.173
positive regulation of signal transduction GO:0009967 223 0.172
compound eye morphogenesis GO:0001745 249 0.171
positive regulation of rna biosynthetic process GO:1902680 266 0.171
negative regulation of mitotic cell cycle GO:0045930 109 0.170
cytokinesis GO:0000910 90 0.169
positive regulation of protein metabolic process GO:0051247 128 0.168
multi organism behavior GO:0051705 175 0.166
cell cycle phase transition GO:0044770 140 0.165
morphogenesis of an epithelium GO:0002009 276 0.165
regulation of neuron differentiation GO:0045664 103 0.164
positive regulation of response to stimulus GO:0048584 323 0.160
negative regulation of cell cycle GO:0045786 116 0.159
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.156
protein targeting to nucleus GO:0044744 51 0.156
positive regulation of protein import into nucleus GO:0042307 21 0.153
positive regulation of cellular protein metabolic process GO:0032270 118 0.149
protein import into nucleus GO:0006606 51 0.142
myotube differentiation GO:0014902 46 0.141
protein targeting GO:0006605 64 0.139
nuclear transport GO:0051169 72 0.138
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.137
protein import GO:0017038 55 0.136
microtubule organizing center organization GO:0031023 168 0.135
regulation of circadian sleep wake cycle GO:0042749 25 0.134
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.133
negative regulation of cellular metabolic process GO:0031324 382 0.133
response to temperature stimulus GO:0009266 106 0.127
segment polarity determination GO:0007367 25 0.124
mitotic cell cycle phase transition GO:0044772 138 0.122
larval development GO:0002164 104 0.121
eye morphogenesis GO:0048592 260 0.120
regulation of programmed cell death GO:0043067 152 0.116
cellular macromolecule localization GO:0070727 220 0.115
establishment of planar polarity GO:0001736 87 0.113
actin cytoskeleton organization GO:0030036 206 0.113
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.110
negative regulation of nucleic acid templated transcription GO:1903507 240 0.108
regulation of cytoskeleton organization GO:0051493 89 0.108
positive regulation of cell death GO:0010942 69 0.107
positive regulation of mrna metabolic process GO:1903313 5 0.107
oocyte development GO:0048599 124 0.104
oocyte axis specification GO:0007309 108 0.103
positive regulation of protein localization to nucleus GO:1900182 21 0.103
regulation of anatomical structure morphogenesis GO:0022603 242 0.098
response to oxidative stress GO:0006979 86 0.093
stem cell development GO:0048864 79 0.092
skeletal muscle organ development GO:0060538 48 0.091
muscle organ development GO:0007517 127 0.090
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.089
epithelial cell development GO:0002064 274 0.085
segmentation GO:0035282 207 0.084
positive regulation of transcription dna templated GO:0045893 266 0.083
nuclear division GO:0000280 332 0.083
establishment of localization in cell GO:0051649 402 0.083
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.082
immune system process GO:0002376 347 0.082
regulation of mitotic cell cycle phase transition GO:1901990 130 0.082
cell maturation GO:0048469 144 0.081
cell motility GO:0048870 251 0.081
ubiquitin dependent protein catabolic process GO:0006511 78 0.080
digestive system development GO:0055123 149 0.080
positive regulation of multicellular organismal process GO:0051240 143 0.080
regulation of neurogenesis GO:0050767 158 0.079
smoothened signaling pathway GO:0007224 49 0.077
wing disc morphogenesis GO:0007472 344 0.077
nephron development GO:0072006 3 0.077
protein transport GO:0015031 155 0.077
skeletal muscle fiber development GO:0048741 3 0.077
spermatogenesis GO:0007283 200 0.077
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.076
positive regulation of phosphate metabolic process GO:0045937 139 0.075
mrna metabolic process GO:0016071 124 0.074
mitotic cytokinesis GO:0000281 50 0.072
positive regulation of nucleocytoplasmic transport GO:0046824 24 0.070
mrna processing GO:0006397 104 0.069
body morphogenesis GO:0010171 2 0.069
single organism intracellular transport GO:1902582 207 0.069
retina development in camera type eye GO:0060041 4 0.069
embryonic pattern specification GO:0009880 174 0.069
negative regulation of multicellular organismal process GO:0051241 142 0.068
positive regulation of nucleic acid templated transcription GO:1903508 266 0.067
spermatid development GO:0007286 98 0.066
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.066
protein localization to nucleus GO:0034504 55 0.064
regulation of protein import into nucleus GO:0042306 28 0.063
regulation of intracellular signal transduction GO:1902531 236 0.061
single organism behavior GO:0044708 391 0.059
positive regulation of cell communication GO:0010647 250 0.059
regulation of smoothened signaling pathway GO:0008589 28 0.059
microtubule anchoring GO:0034453 11 0.058
regulation of circadian sleep wake cycle sleep GO:0045187 21 0.057
organelle fission GO:0048285 340 0.056
multi multicellular organism process GO:0044706 123 0.056
regulation of endopeptidase activity GO:0052548 36 0.056
eye photoreceptor cell development GO:0042462 81 0.056
actomyosin structure organization GO:0031032 56 0.054
intracellular protein transport GO:0006886 104 0.054
regulation of organelle organization GO:0033043 196 0.053
apoptotic signaling pathway GO:0097190 27 0.053
regulation of cell cycle process GO:0010564 181 0.053
positive regulation of cellular biosynthetic process GO:0031328 316 0.052
regulation of synapse structure and activity GO:0050803 128 0.052
eye development GO:0001654 323 0.052
cellular protein catabolic process GO:0044257 83 0.052
nuclear import GO:0051170 51 0.051
multicellular organismal reproductive behavior GO:0033057 110 0.051
stem cell differentiation GO:0048863 117 0.050
dendrite morphogenesis GO:0048813 199 0.050
negative regulation of transcription dna templated GO:0045892 237 0.050
modification dependent macromolecule catabolic process GO:0043632 79 0.050
regulation of mitotic cell cycle GO:0007346 190 0.049
epidermis development GO:0008544 65 0.049
compound eye development GO:0048749 307 0.048
anatomical structure homeostasis GO:0060249 97 0.048
circulatory system development GO:0072359 82 0.048
regulation of notch signaling pathway GO:0008593 100 0.048
maintenance of protein location in cell GO:0032507 26 0.048
endocytosis GO:0006897 310 0.048
nephron tubule morphogenesis GO:0072078 3 0.047
germline ring canal formation GO:0030725 13 0.047
negative regulation of notch signaling pathway GO:0045746 41 0.047
establishment of protein localization to organelle GO:0072594 62 0.046
regulation of embryonic pattern specification GO:1902875 27 0.046
regulation of response to dna damage stimulus GO:2001020 23 0.045
regulation of hydrolase activity GO:0051336 97 0.045
brain development GO:0007420 120 0.045
regulation of cellular protein metabolic process GO:0032268 243 0.044
organonitrogen compound metabolic process GO:1901564 318 0.044
muscle cell differentiation GO:0042692 103 0.044
actin filament organization GO:0007015 126 0.044
blastoderm segmentation GO:0007350 159 0.044
nephron morphogenesis GO:0072028 3 0.042
sensory organ morphogenesis GO:0090596 260 0.042
myofibril assembly GO:0030239 36 0.042
response to organic substance GO:0010033 284 0.041
renal system process GO:0003014 12 0.041
developmental maturation GO:0021700 172 0.041
negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 29 0.041
establishment of imaginal disc derived wing hair orientation GO:0001737 24 0.041
response to nitrogen compound GO:1901698 90 0.041
negative regulation of smoothened signaling pathway GO:0045879 16 0.040
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.039
nephron epithelium morphogenesis GO:0072088 3 0.038
cardiovascular system development GO:0072358 82 0.038
ovarian nurse cell to oocyte transport GO:0007300 27 0.038
skin development GO:0043588 65 0.038
response to abiotic stimulus GO:0009628 341 0.038
cellular catabolic process GO:0044248 372 0.037
striated muscle cell development GO:0055002 50 0.037
positive regulation of programmed cell death GO:0043068 62 0.037
cytoplasmic transport GO:0016482 130 0.036
positive regulation of transcription factor import into nucleus GO:0042993 19 0.036
imaginal disc derived wing vein specification GO:0007474 48 0.036
central nervous system development GO:0007417 201 0.036
imaginal disc derived wing vein morphogenesis GO:0008586 44 0.036
regulation of proteolysis GO:0030162 87 0.035
regulation of protein catabolic process GO:0042176 55 0.035
negative regulation of intracellular signal transduction GO:1902532 57 0.035
regulation of nucleocytoplasmic transport GO:0046822 35 0.035
regulation of phosphorus metabolic process GO:0051174 210 0.035
skeletal muscle tissue development GO:0007519 13 0.035
regulation of proteasomal protein catabolic process GO:0061136 39 0.035
immune response GO:0006955 246 0.034
cellular response to organic substance GO:0071310 132 0.034
carbohydrate derivative metabolic process GO:1901135 217 0.034
eye photoreceptor cell differentiation GO:0001754 145 0.033
positive regulation of signaling GO:0023056 243 0.033
cellular response to endogenous stimulus GO:0071495 80 0.033
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.033
regulation of transcription factor import into nucleus GO:0042990 22 0.033
response to endogenous stimulus GO:0009719 119 0.032
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.032
cellular protein localization GO:0034613 160 0.032
neuroblast division GO:0055057 35 0.032
compound eye photoreceptor cell differentiation GO:0001751 140 0.032
gastrulation GO:0007369 70 0.031
response to light stimulus GO:0009416 124 0.031
regulation of cysteine type endopeptidase activity GO:2000116 27 0.031
apoptotic process GO:0006915 159 0.031
morphogenesis of a branching epithelium GO:0061138 45 0.031
regulation of organ morphogenesis GO:2000027 78 0.031
negative regulation of cell cycle process GO:0010948 109 0.031
membrane protein proteolysis GO:0033619 6 0.030
notch signaling pathway GO:0007219 120 0.030
neurological system process GO:0050877 358 0.030
protein localization to organelle GO:0033365 82 0.030
organelle assembly GO:0070925 198 0.029
positive regulation of proteolysis GO:0045862 52 0.029
anterior posterior pattern specification GO:0009952 136 0.029
establishment of protein localization GO:0045184 163 0.029
mitotic dna damage checkpoint GO:0044773 74 0.029
protein processing GO:0016485 68 0.029
regulation of membrane potential GO:0042391 35 0.028
spindle assembly GO:0051225 80 0.028
locomotory behavior GO:0007626 176 0.028
localization of cell GO:0051674 257 0.028
oocyte differentiation GO:0009994 145 0.028
regulation of protein modification process GO:0031399 112 0.028
imaginal disc derived leg segmentation GO:0036011 26 0.028
positive regulation of biosynthetic process GO:0009891 316 0.027
positive regulation of rna metabolic process GO:0051254 271 0.027
centrosome separation GO:0051299 20 0.027
chromosome organization GO:0051276 360 0.027
female germline ring canal formation GO:0007301 9 0.027
proteasomal protein catabolic process GO:0010498 59 0.027
regulation of multi organism process GO:0043900 131 0.027
organic substance transport GO:0071702 257 0.026
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 41 0.026
mating GO:0007618 120 0.026
mitotic g2 dna damage checkpoint GO:0007095 69 0.026
response to organic cyclic compound GO:0014070 89 0.026
negative regulation of cellular protein metabolic process GO:0032269 85 0.026
regulation of nuclear transcribed mrna poly a tail shortening GO:0060211 4 0.026
axis specification GO:0009798 167 0.026
response to oxygen containing compound GO:1901700 200 0.026
negative regulation of cell death GO:0060548 81 0.026
negative regulation of developmental growth GO:0048640 64 0.025
open tracheal system development GO:0007424 204 0.025
positive regulation of protein transport GO:0051222 37 0.025
positive regulation of intracellular protein transport GO:0090316 30 0.025
regulation of cellular response to stress GO:0080135 89 0.025
positive regulation of transport GO:0051050 92 0.025
heart morphogenesis GO:0003007 32 0.025
humoral immune response GO:0006959 117 0.025
renal system development GO:0072001 72 0.024
meiotic spindle organization GO:0000212 36 0.024
regulation of phosphate metabolic process GO:0019220 210 0.024
intercellular bridge organization GO:0043063 14 0.024
positive regulation of phosphorus metabolic process GO:0010562 139 0.024
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.024
enzyme linked receptor protein signaling pathway GO:0007167 179 0.024
regulation of anatomical structure size GO:0090066 163 0.024
heart development GO:0007507 82 0.024
cell cycle checkpoint GO:0000075 95 0.023
establishment of cell polarity GO:0030010 40 0.023
ion transport GO:0006811 145 0.023
regulation of neuron death GO:1901214 26 0.023
regulation of cellular protein catabolic process GO:1903362 44 0.023
cellularization GO:0007349 90 0.023
hematopoietic or lymphoid organ development GO:0048534 57 0.023
response to external biotic stimulus GO:0043207 293 0.023
negative regulation of protein metabolic process GO:0051248 85 0.022
synaptic transmission dopaminergic GO:0001963 2 0.022
mitotic cell cycle checkpoint GO:0007093 88 0.022
mitotic nuclear division GO:0007067 213 0.022
cell adhesion GO:0007155 136 0.022
mesenchymal cell differentiation GO:0048762 1 0.022
regulation of protein modification by small protein conjugation or removal GO:1903320 25 0.021
gliogenesis GO:0042063 80 0.021
hematopoietic progenitor cell differentiation GO:0002244 1 0.021
positive regulation of cellular catabolic process GO:0031331 95 0.021
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.021
tube morphogenesis GO:0035239 191 0.021
immune system development GO:0002520 57 0.021
neuronal stem cell division GO:0036445 35 0.021
mitochondrial fission GO:0000266 8 0.021
intracellular distribution of mitochondria GO:0048312 5 0.021
positive regulation of phosphorylation GO:0042327 87 0.021
synaptic vesicle localization GO:0097479 53 0.021
neuron remodeling GO:0016322 29 0.020
spinal cord development GO:0021510 1 0.020
negative regulation of ras protein signal transduction GO:0046580 13 0.020
regulation of cellular component biogenesis GO:0044087 201 0.020
protein catabolic process GO:0030163 101 0.020
dorsal ventral pattern formation imaginal disc GO:0007450 51 0.020
regulation of cellular component size GO:0032535 98 0.020
positive regulation of intracellular transport GO:0032388 42 0.019
oocyte microtubule cytoskeleton organization GO:0016325 35 0.019
oocyte nucleus localization involved in oocyte dorsal ventral axis specification GO:0051663 12 0.019
regulation of actin cytoskeleton organization GO:0032956 42 0.019
negative regulation of cellular component organization GO:0051129 108 0.019
regulation of protein localization to nucleus GO:1900180 29 0.019
negative regulation of biosynthetic process GO:0009890 277 0.019
targeting of mrna for destruction involved in rna interference GO:0030423 4 0.019
sister chromatid segregation GO:0000819 92 0.019
intracellular receptor signaling pathway GO:0030522 19 0.019
establishment of spindle localization GO:0051293 22 0.019
regulation of mrna metabolic process GO:1903311 72 0.019
dna integrity checkpoint GO:0031570 81 0.018
positive regulation of developmental process GO:0051094 143 0.018
positive regulation of cellular amine metabolic process GO:0033240 0 0.018
regulation of cell morphogenesis GO:0022604 163 0.018
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 19 0.018
imaginal disc fusion thorax closure GO:0046529 19 0.018
convergent extension GO:0060026 2 0.018
organonitrogen compound biosynthetic process GO:1901566 117 0.018
oocyte microtubule cytoskeleton polarization GO:0008103 22 0.018
positive regulation of apoptotic signaling pathway GO:2001235 4 0.018
regulation of nuclear division GO:0051783 58 0.018
mitotic g2 m transition checkpoint GO:0044818 70 0.018
regulation of wnt signaling pathway GO:0030111 68 0.017
positive regulation of catalytic activity GO:0043085 118 0.017
nuclear transcribed mrna poly a tail shortening GO:0000289 12 0.017
regulation of rna splicing GO:0043484 69 0.017
regulation of cell death GO:0010941 173 0.017
nitrogen compound transport GO:0071705 85 0.017
multicellular organismal aging GO:0010259 140 0.017
negative regulation of cell differentiation GO:0045596 143 0.017
compound eye photoreceptor development GO:0042051 78 0.017
cellular response to dna damage stimulus GO:0006974 223 0.017
regulation of intracellular protein transport GO:0033157 46 0.017
dendrite development GO:0016358 204 0.017
nephron epithelium development GO:0072009 3 0.016
positive regulation of molecular function GO:0044093 136 0.016
response to virus GO:0009615 28 0.016
cellular response to chemical stimulus GO:0070887 199 0.016
regulation of cellular localization GO:0060341 136 0.016
sleep GO:0030431 49 0.016
male meiosis cytokinesis GO:0007112 26 0.016
regulation of cytoplasmic transport GO:1903649 47 0.016
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 17 0.016
establishment of organelle localization GO:0051656 122 0.016
response to organonitrogen compound GO:0010243 75 0.015
catabolic process GO:0009056 409 0.015
germarium derived oocyte fate determination GO:0007294 26 0.015
adult locomotory behavior GO:0008344 76 0.015
negative regulation of proteasomal protein catabolic process GO:1901799 16 0.015
regulation of intracellular transport GO:0032386 64 0.015
response to radiation GO:0009314 155 0.015
imaginal disc derived wing margin morphogenesis GO:0008587 41 0.015
protein complex assembly GO:0006461 200 0.015
neuronal action potential GO:0019228 10 0.015
syncytium formation GO:0006949 43 0.015
wing disc dorsal ventral pattern formation GO:0048190 47 0.015
positive regulation of apoptotic process GO:0043065 47 0.015
antimicrobial humoral response GO:0019730 99 0.015
hindbrain development GO:0030902 2 0.015
response to other organism GO:0051707 293 0.015
regulation of synaptic transmission GO:0050804 69 0.015
regulation of nf kappab import into nucleus GO:0042345 1 0.015
regulation of mrna processing GO:0050684 71 0.015
regulation of actin polymerization or depolymerization GO:0008064 27 0.014
regulation of phosphorylation GO:0042325 147 0.014
negative regulation of proteolysis GO:0045861 31 0.014
positive regulation of nervous system development GO:0051962 69 0.014
negative regulation of imaginal disc growth GO:0045571 8 0.014
protein complex biogenesis GO:0070271 201 0.014
regulation of cell proliferation GO:0042127 163 0.014
negative regulation of rna biosynthetic process GO:1902679 240 0.014
germarium derived female germ line cyst encapsulation GO:0030708 8 0.014
camera type eye development GO:0043010 4 0.014
dephosphorylation GO:0016311 51 0.014
inositol phosphate mediated signaling GO:0048016 3 0.014
negative regulation of nervous system development GO:0051961 92 0.013
cell proliferation GO:0008283 299 0.013
cellular response to organic cyclic compound GO:0071407 32 0.013
substrate dependent cell migration GO:0006929 3 0.013
maintenance of location GO:0051235 73 0.013
erbb signaling pathway GO:0038127 58 0.013
striated muscle tissue development GO:0014706 27 0.013
synaptic transmission GO:0007268 288 0.013
single organism nuclear import GO:1902593 51 0.013
positive regulation of nf kappab import into nucleus GO:0042346 1 0.013
ectodermal placode morphogenesis GO:0071697 4 0.013
wing disc pattern formation GO:0035222 66 0.013
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.013
membrane protein ectodomain proteolysis GO:0006509 5 0.013
negative regulation of dendrite development GO:2000171 2 0.013
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 25 0.013
regulation of protein targeting GO:1903533 29 0.013
negative regulation of tor signaling GO:0032007 5 0.013
mrna 3 end processing GO:0031124 28 0.013
cellular protein complex assembly GO:0043623 71 0.013
epithelial tube morphogenesis GO:0060562 88 0.013
regulation of cell maturation GO:1903429 27 0.013
amine metabolic process GO:0009308 12 0.013
regulation of ras protein signal transduction GO:0046578 93 0.012
asymmetric neuroblast division GO:0055059 33 0.012
spinal cord patterning GO:0021511 1 0.012
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 16 0.012
negative regulation of signal transduction GO:0009968 206 0.012
negative regulation of programmed cell death GO:0043069 72 0.012
synapse assembly GO:0007416 143 0.012
asymmetric stem cell division GO:0098722 49 0.012
connective tissue development GO:0061448 3 0.012
negative regulation of protein maturation GO:1903318 31 0.012
multi organism reproductive behavior GO:0044705 121 0.012
syncytium formation by plasma membrane fusion GO:0000768 43 0.012
heterocycle catabolic process GO:0046700 166 0.012
protein modification by small protein removal GO:0070646 28 0.012
imaginal disc pattern formation GO:0007447 91 0.012
regulation of protein dephosphorylation GO:0035304 5 0.012
gland development GO:0048732 191 0.012
maintenance of location in cell GO:0051651 28 0.012
stem cell maintenance GO:0019827 67 0.012
cellular response to oxygen containing compound GO:1901701 79 0.012
regulation of dendrite morphogenesis GO:0048814 28 0.011
neural precursor cell proliferation GO:0061351 75 0.011
regulation of actin filament polymerization GO:0030833 25 0.011
cell growth GO:0016049 108 0.011
nucleoside phosphate metabolic process GO:0006753 162 0.011
gene silencing by mirna GO:0035195 22 0.011
establishment of tissue polarity GO:0007164 87 0.011
regulation of response to stress GO:0080134 200 0.011
carbohydrate metabolic process GO:0005975 82 0.011
circadian regulation of gene expression GO:0032922 5 0.011
columnar cuboidal epithelial cell development GO:0002066 249 0.011
negative regulation of rna metabolic process GO:0051253 251 0.011
histone modification GO:0016570 106 0.011
somatic muscle development GO:0007525 66 0.011
meiotic cytokinesis GO:0033206 33 0.011
negative regulation of dendrite morphogenesis GO:0050774 2 0.011
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.011
regulation of immune response GO:0050776 118 0.011
cellular amine metabolic process GO:0044106 12 0.011
muscle cell development GO:0055001 50 0.011

Cul-3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.101
nervous system disease DOID:863 0 0.081
auditory system disease DOID:2742 0 0.056
autosomal dominant nonsyndromic deafness DOID:0050564 0 0.056
nonsyndromic deafness DOID:0050563 0 0.056
sensory system disease DOID:0050155 0 0.056
cancer DOID:162 0 0.021
disease of cellular proliferation DOID:14566 0 0.021
central nervous system disease DOID:331 0 0.012
musculoskeletal system disease DOID:17 0 0.011
connective tissue disease DOID:65 0 0.011
physical disorder DOID:0080015 0 0.011
congenital nervous system abnormality DOID:2490 0 0.011