Drosophila melanogaster

79 known processes

HtrA2 (Dmel_CG8464)

CG8464 gene product from transcript CG8464-RA

(Aliases: dOmi,CG8464,Dmel\CG8464,domi,DmHtrA2,Omi,HtrA2/Omi)

HtrA2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
sperm individualization GO:0007291 48 0.981
spermatid differentiation GO:0048515 114 0.956
spermatid development GO:0007286 98 0.923
spermatogenesis GO:0007283 200 0.835
male gamete generation GO:0048232 201 0.669
cellularization GO:0007349 90 0.654
apoptotic signaling pathway GO:0097190 27 0.378
Human Mouse
regionalization GO:0003002 416 0.353
sensory organ morphogenesis GO:0090596 260 0.322
epithelial cell differentiation GO:0030855 322 0.277
cell projection assembly GO:0030031 94 0.270
regulation of response to stress GO:0080134 200 0.226
developmental maturation GO:0021700 172 0.190
blastoderm segmentation GO:0007350 159 0.184
regulation of autophagy GO:0010506 62 0.182
neurological system process GO:0050877 358 0.181
adult behavior GO:0030534 137 0.180
Mouse
pole plasm assembly GO:0007315 61 0.175
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.173
cell division GO:0051301 248 0.166
autophagy GO:0006914 108 0.165
eye development GO:0001654 323 0.165
learning or memory GO:0007611 141 0.163
organelle localization GO:0051640 148 0.162
cellular component assembly involved in morphogenesis GO:0010927 151 0.160
microtubule bundle formation GO:0001578 27 0.159
locomotory behavior GO:0007626 176 0.158
Mouse
regulation of apoptotic process GO:0042981 130 0.158
positive regulation of cell communication GO:0010647 250 0.156
Human
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 23 0.155
Human
regulation of cell death GO:0010941 173 0.154
immune system process GO:0002376 347 0.152
establishment of localization in cell GO:0051649 402 0.149
intrinsic apoptotic signaling pathway GO:0097193 16 0.143
Human Mouse
response to abiotic stimulus GO:0009628 341 0.139
Human
cell maturation GO:0048469 144 0.137
organelle fusion GO:0048284 46 0.131
axis specification GO:0009798 167 0.131
lateral inhibition GO:0046331 206 0.130
positive regulation of macromolecule metabolic process GO:0010604 405 0.125
single organism cellular localization GO:1902580 180 0.124
epithelial cell development GO:0002064 274 0.124
rna localization GO:0006403 115 0.123
single organism behavior GO:0044708 391 0.123
Mouse
imaginal disc derived wing morphogenesis GO:0007476 337 0.122
anterior posterior axis specification GO:0009948 109 0.119
single organism intracellular transport GO:1902582 207 0.118
localization of cell GO:0051674 257 0.118
regulation of pole plasm oskar mrna localization GO:0007317 27 0.112
synaptic transmission GO:0007268 288 0.111
positive regulation of biosynthetic process GO:0009891 316 0.111
regulation of multicellular organismal development GO:2000026 414 0.108
columnar cuboidal epithelial cell development GO:0002066 249 0.106
compound eye development GO:0048749 307 0.104
regulation of microtubule based process GO:0032886 49 0.103
muscle structure development GO:0061061 224 0.102
regulation of anatomical structure morphogenesis GO:0022603 242 0.100
protein maturation GO:0051604 71 0.099
axon development GO:0061564 297 0.098
proteolysis GO:0006508 192 0.095
regulation of multi organism process GO:0043900 131 0.094
appendage morphogenesis GO:0035107 397 0.093
regulation of protein metabolic process GO:0051246 256 0.093
intracellular signal transduction GO:0035556 300 0.093
Human Mouse
regulation of localization GO:0032879 275 0.093
cognition GO:0050890 141 0.093
protein catabolic process GO:0030163 101 0.092
Human
macromolecular complex assembly GO:0065003 256 0.092
negative regulation of organelle organization GO:0010639 56 0.092
positive regulation of cysteine type endopeptidase activity GO:2001056 24 0.087
appendage development GO:0048736 401 0.087
ectopic germ cell programmed cell death GO:0035234 8 0.086
anatomical structure homeostasis GO:0060249 97 0.085
programmed cell death GO:0012501 257 0.085
activation of cysteine type endopeptidase activity GO:0097202 17 0.085
regulation of programmed cell death GO:0043067 152 0.083
positive regulation of transcription dna templated GO:0045893 266 0.082
pole plasm mrna localization GO:0019094 49 0.081
negative regulation of programmed cell death GO:0043069 72 0.080
positive regulation of protein metabolic process GO:0051247 128 0.078
positive regulation of programmed cell death GO:0043068 62 0.077
oocyte differentiation GO:0009994 145 0.076
regulation of cysteine type endopeptidase activity GO:2000116 27 0.076
pole plasm rna localization GO:0007316 52 0.075
single organism membrane fusion GO:0044801 42 0.075
mitochondrial fusion GO:0008053 7 0.074
hair cell differentiation GO:0035315 47 0.074
positive regulation of signal transduction GO:0009967 223 0.074
Human
cellular response to chemical stimulus GO:0070887 199 0.072
Human Zebrafish Mouse
negative regulation of cellular response to oxidative stress GO:1900408 1 0.072
compound eye morphogenesis GO:0001745 249 0.070
oocyte construction GO:0007308 112 0.070
embryonic axis specification GO:0000578 107 0.069
negative regulation of apoptotic process GO:0043066 63 0.069
phosphorylation GO:0016310 294 0.069
cell cell signaling involved in cell fate commitment GO:0045168 210 0.069
regulation of intracellular signal transduction GO:1902531 236 0.067
eye morphogenesis GO:0048592 260 0.067
embryonic pattern specification GO:0009880 174 0.067
oocyte development GO:0048599 124 0.067
mapk cascade GO:0000165 107 0.066
regulation of cellular localization GO:0060341 136 0.066
protein localization GO:0008104 284 0.065
post embryonic appendage morphogenesis GO:0035120 385 0.065
homeostatic process GO:0042592 199 0.065
positive regulation of cellular biosynthetic process GO:0031328 316 0.064
positive regulation of signaling GO:0023056 243 0.064
Human
cytoplasm organization GO:0007028 64 0.064
skin development GO:0043588 65 0.063
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.063
Mouse
anterior posterior pattern specification GO:0009952 136 0.062
chorion containing eggshell formation GO:0007304 105 0.062
oocyte axis specification GO:0007309 108 0.062
adult locomotory behavior GO:0008344 76 0.060
Mouse
melanin metabolic process GO:0006582 47 0.059
regulation of cellular response to stress GO:0080135 89 0.058
negative regulation of cell communication GO:0010648 223 0.058
Mouse
positive regulation of cell death GO:0010942 69 0.058
imaginal disc derived appendage development GO:0048737 399 0.057
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 25 0.057
Human
response to oxygen containing compound GO:1901700 200 0.056
Human
cellular protein modification process GO:0006464 438 0.056
multicellular organismal aging GO:0010259 140 0.056
morphogenesis of an epithelium GO:0002009 276 0.056
regulation of cell development GO:0060284 215 0.056
protein complex biogenesis GO:0070271 201 0.055
regulation of microtubule cytoskeleton organization GO:0070507 41 0.054
regulation of reproductive process GO:2000241 54 0.054
response to oxidative stress GO:0006979 86 0.054
regulation of organelle organization GO:0033043 196 0.054
single organism membrane organization GO:0044802 93 0.054
embryonic morphogenesis GO:0048598 206 0.053
regulation of molecular function GO:0065009 217 0.053
protein phosphorylation GO:0006468 169 0.052
dna metabolic process GO:0006259 227 0.051
positive regulation of apoptotic process GO:0043065 47 0.050
negative regulation of signaling GO:0023057 219 0.050
Mouse
ameboidal type cell migration GO:0001667 151 0.049
protein modification process GO:0036211 438 0.049
negative regulation of cellular metabolic process GO:0031324 382 0.049
eye photoreceptor cell differentiation GO:0001754 145 0.049
cellular catabolic process GO:0044248 372 0.049
Human
embryonic development via the syncytial blastoderm GO:0001700 148 0.048
positive regulation of proteolysis GO:0045862 52 0.048
zymogen activation GO:0031638 20 0.047
regulation of mitotic cell cycle GO:0007346 190 0.047
positive regulation of cellular protein metabolic process GO:0032270 118 0.047
positive regulation of response to stimulus GO:0048584 323 0.047
Human
regulation of embryonic pattern specification GO:1902875 27 0.047
positive regulation of developmental process GO:0051094 143 0.046
cellular macromolecular complex assembly GO:0034622 153 0.046
developmental programmed cell death GO:0010623 138 0.046
ovarian follicle cell development GO:0030707 248 0.046
sperm motility GO:0030317 12 0.046
regulation of mitochondrial fusion GO:0010635 5 0.046
positive regulation of rna biosynthetic process GO:1902680 266 0.046
cell motility GO:0048870 251 0.045
death GO:0016265 284 0.045
regulation of catalytic activity GO:0050790 185 0.045
chromosome organization GO:0051276 360 0.045
epidermal cell differentiation GO:0009913 51 0.045
secondary metabolic process GO:0019748 75 0.045
cellular macromolecule localization GO:0070727 220 0.044
oocyte anterior posterior axis specification GO:0007314 72 0.044
positive regulation of intracellular signal transduction GO:1902533 116 0.044
maintenance of gastrointestinal epithelium GO:0030277 3 0.043
positive regulation of apoptotic signaling pathway GO:2001235 4 0.043
Human
nucleus organization GO:0006997 45 0.043
brain development GO:0007420 120 0.042
Mouse
protein transport GO:0015031 155 0.042
negative regulation of cellular biosynthetic process GO:0031327 277 0.042
defense response GO:0006952 300 0.042
response to organic substance GO:0010033 284 0.042
Human Zebrafish Mouse
defense response to other organism GO:0098542 225 0.041
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.041
epidermis development GO:0008544 65 0.041
regulation of cellular catabolic process GO:0031329 157 0.041
regulation of phosphorylation GO:0042325 147 0.041
muscle cell differentiation GO:0042692 103 0.041
intracellular mrna localization involved in anterior posterior axis specification GO:0060811 53 0.041
cytoskeleton dependent cytokinesis GO:0061640 81 0.041
axonogenesis GO:0007409 290 0.040
axoneme assembly GO:0035082 18 0.040
protein complex assembly GO:0006461 200 0.040
signal transduction by phosphorylation GO:0023014 107 0.040
hindbrain development GO:0030902 2 0.039
negative regulation of immune system process GO:0002683 50 0.039
positive regulation of nucleic acid templated transcription GO:1903508 266 0.039
rna processing GO:0006396 147 0.039
response to bacterium GO:0009617 198 0.039
pole plasm oskar mrna localization GO:0045451 46 0.039
protein complex disassembly GO:0043241 36 0.038
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.038
negative regulation of developmental process GO:0051093 201 0.038
negative regulation of cell cycle GO:0045786 116 0.038
sperm axoneme assembly GO:0007288 13 0.038
endocytosis GO:0006897 310 0.038
negative regulation of signal transduction GO:0009968 206 0.038
Mouse
actin filament based process GO:0030029 220 0.038
positive regulation of peptidase activity GO:0010952 29 0.037
protein localization to organelle GO:0033365 82 0.037
cilium morphogenesis GO:0060271 39 0.037
regulation of cytoskeleton organization GO:0051493 89 0.036
sperm mitochondrion organization GO:0030382 7 0.036
posttranscriptional gene silencing GO:0016441 46 0.036
dorsal appendage formation GO:0046843 47 0.036
regulation of cell cycle GO:0051726 291 0.036
catabolic process GO:0009056 409 0.036
Human
regulation of proteolysis GO:0030162 87 0.036
phenol containing compound metabolic process GO:0018958 57 0.035
microtubule based transport GO:0010970 42 0.035
regulation of cellular response to oxidative stress GO:1900407 4 0.035
apoptotic process GO:0006915 159 0.035
actin filament organization GO:0007015 126 0.034
positive regulation of transport GO:0051050 92 0.034
regulation of phosphorus metabolic process GO:0051174 210 0.034
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.034
tripartite regional subdivision GO:0007351 103 0.034
apoptotic process involved in development GO:1902742 20 0.034
tissue migration GO:0090130 155 0.034
negative regulation of reactive oxygen species metabolic process GO:2000378 1 0.034
embryo development ending in birth or egg hatching GO:0009792 152 0.033
cellular protein catabolic process GO:0044257 83 0.033
Human
cell growth GO:0016049 108 0.032
segmentation GO:0035282 207 0.032
positive regulation of rna metabolic process GO:0051254 271 0.032
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.032
membrane organization GO:0061024 112 0.032
membrane fusion GO:0061025 42 0.032
vesicle mediated transport GO:0016192 381 0.032
regulation of microtubule polymerization or depolymerization GO:0031110 27 0.032
anterior posterior axis specification embryo GO:0008595 103 0.032
microtubule based movement GO:0007018 51 0.031
cellular amide metabolic process GO:0043603 80 0.031
regulation of endopeptidase activity GO:0052548 36 0.031
intracellular mrna localization involved in pattern specification process GO:0060810 56 0.031
intracellular transport GO:0046907 228 0.031
sensory perception of mechanical stimulus GO:0050954 72 0.031
developmental growth GO:0048589 280 0.031
Mouse
negative regulation of cell death GO:0060548 81 0.031
regulation of cellular component biogenesis GO:0044087 201 0.030
immune response GO:0006955 246 0.030
immune effector process GO:0002252 98 0.030
determination of adult lifespan GO:0008340 137 0.030
establishment of protein localization GO:0045184 163 0.029
response to other organism GO:0051707 293 0.029
positive regulation of cell differentiation GO:0045597 64 0.029
regulation of intracellular transport GO:0032386 64 0.029
necrotic cell death GO:0070265 1 0.029
regulation of mapk cascade GO:0043408 92 0.028
regulation of phosphate metabolic process GO:0019220 210 0.028
regulation of macroautophagy GO:0016241 15 0.028
regulation of immune system process GO:0002682 176 0.027
regulation of response to external stimulus GO:0032101 115 0.027
multi multicellular organism process GO:0044706 123 0.027
cell death GO:0008219 279 0.027
eggshell chorion assembly GO:0007306 66 0.027
tissue homeostasis GO:0001894 36 0.027
innate immune response GO:0045087 144 0.027
hemopoiesis GO:0030097 46 0.027
wing disc morphogenesis GO:0007472 344 0.027
pigment metabolic process GO:0042440 84 0.026
regulation of cellular protein metabolic process GO:0032268 243 0.026
response to radiation GO:0009314 155 0.026
regulation of cellular amine metabolic process GO:0033238 3 0.026
nitrogen compound transport GO:0071705 85 0.025
peptide metabolic process GO:0006518 80 0.025
regulation of cell division GO:0051302 72 0.025
cytoskeleton dependent intracellular transport GO:0030705 44 0.025
transcription from rna polymerase ii promoter GO:0006366 368 0.025
organic hydroxy compound metabolic process GO:1901615 83 0.025
cellular response to organic substance GO:0071310 132 0.025
Human Zebrafish Mouse
tissue morphogenesis GO:0048729 297 0.025
regulation of apoptotic signaling pathway GO:2001233 10 0.024
Human
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.024
positive regulation of phosphorus metabolic process GO:0010562 139 0.024
negative regulation of cytoskeleton organization GO:0051494 30 0.024
axon cargo transport GO:0008088 29 0.024
negative regulation of cellular protein metabolic process GO:0032269 85 0.024
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 4 0.024
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.024
cellular protein complex disassembly GO:0043624 35 0.024
cell type specific apoptotic process GO:0097285 38 0.024
positive regulation of macroautophagy GO:0016239 8 0.023
endomembrane system organization GO:0010256 119 0.023
rna splicing GO:0008380 83 0.023
organic substance transport GO:0071702 257 0.023
regulation of nervous system development GO:0051960 248 0.023
small molecule metabolic process GO:0044281 305 0.023
establishment or maintenance of cell polarity GO:0007163 167 0.023
regulation of cell cycle process GO:0010564 181 0.023
regulation of cell differentiation GO:0045595 302 0.023
regulation of cellular ketone metabolic process GO:0010565 3 0.023
positive regulation of phosphorylation GO:0042327 87 0.023
intracellular protein transport GO:0006886 104 0.023
synaptic transmission dopaminergic GO:0001963 2 0.023
protein processing GO:0016485 68 0.022
response to gravity GO:0009629 26 0.022
positive regulation of i kappab kinase nf kappab signaling GO:0043123 1 0.022
cytoplasmic transport GO:0016482 130 0.022
chromosome separation GO:0051304 42 0.022
negative regulation of intracellular signal transduction GO:1902532 57 0.022
positive regulation of cell motility GO:2000147 3 0.022
melanization defense response GO:0035006 45 0.021
negative regulation of cell cycle process GO:0010948 109 0.021
cellular response to dna damage stimulus GO:0006974 223 0.021
Human
negative regulation of response to oxidative stress GO:1902883 1 0.021
organonitrogen compound metabolic process GO:1901564 318 0.021
phagocytosis GO:0006909 215 0.021
negative regulation of biosynthetic process GO:0009890 277 0.021
protein import GO:0017038 55 0.021
morphogenesis of a polarized epithelium GO:0001738 93 0.021
immune response activating signal transduction GO:0002757 2 0.021
cilium organization GO:0044782 41 0.021
macroautophagy GO:0016236 42 0.021
negative regulation of microtubule depolymerization GO:0007026 21 0.021
negative regulation of response to stimulus GO:0048585 258 0.021
Mouse
protein targeting to nucleus GO:0044744 51 0.021
oxidation reduction process GO:0055114 123 0.021
regulation of transport GO:0051049 181 0.021
regulation of immune response GO:0050776 118 0.021
establishment of planar polarity GO:0001736 87 0.021
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.020
zinc ion homeostasis GO:0055069 6 0.020
epithelium migration GO:0090132 148 0.020
nuclear transport GO:0051169 72 0.020
positive regulation of cellular amine metabolic process GO:0033240 0 0.020
regulation of mitochondrial fission GO:0090140 7 0.020
transmembrane transport GO:0055085 139 0.020
regulation of protein modification process GO:0031399 112 0.020
immune response regulating signaling pathway GO:0002764 2 0.020
negative regulation of cellular component organization GO:0051129 108 0.020
regulation of innate immune response GO:0045088 71 0.020
positive regulation of gene expression GO:0010628 290 0.020
positive regulation of molecular function GO:0044093 136 0.020
regulation of intracellular protein transport GO:0033157 46 0.020
eye antennal disc development GO:0035214 60 0.020
response to external biotic stimulus GO:0043207 293 0.020
ion transport GO:0006811 145 0.019
microtubule organizing center organization GO:0031023 168 0.019
cell cycle arrest GO:0007050 4 0.019
organophosphate metabolic process GO:0019637 195 0.019
protein localization to nucleus GO:0034504 55 0.019
protein modification by small protein conjugation or removal GO:0070647 106 0.019
regulation of epithelial cell differentiation GO:0030856 4 0.019
cellular response to starvation GO:0009267 61 0.019
cation transmembrane transport GO:0098655 88 0.019
forebrain development GO:0030900 2 0.019
Mouse
positive regulation of cellular catabolic process GO:0031331 95 0.019
regulation of response to oxidative stress GO:1902882 4 0.019
single organism catabolic process GO:0044712 228 0.019
nucleocytoplasmic transport GO:0006913 72 0.019
hematopoietic or lymphoid organ development GO:0048534 57 0.019
response to endogenous stimulus GO:0009719 119 0.019
Zebrafish Mouse
compound eye photoreceptor cell differentiation GO:0001751 140 0.019
salivary gland morphogenesis GO:0007435 145 0.019
taxis GO:0042330 304 0.019
nuclear import GO:0051170 51 0.019
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 11 0.018
Human
multicellular organismal homeostasis GO:0048871 41 0.018
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 41 0.018
spindle organization GO:0007051 253 0.018
epidermal growth factor receptor signaling pathway GO:0007173 58 0.018
response to endoplasmic reticulum stress GO:0034976 28 0.018
hematopoietic progenitor cell differentiation GO:0002244 1 0.018
imaginal disc derived wing vein specification GO:0007474 48 0.018
mitochondrial fission GO:0000266 8 0.018
regulation of alternative mrna splicing via spliceosome GO:0000381 60 0.018
erbb signaling pathway GO:0038127 58 0.018
cytoplasmic transport nurse cell to oocyte GO:0007303 12 0.018
regulation of protein depolymerization GO:1901879 27 0.018
regulation of defense response GO:0031347 102 0.018
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.017
modification dependent macromolecule catabolic process GO:0043632 79 0.017
regulation of anatomical structure size GO:0090066 163 0.017
cellular response to nutrient levels GO:0031669 62 0.017
imaginal disc derived appendage morphogenesis GO:0035114 395 0.017
mesenchymal cell differentiation GO:0048762 1 0.017
oocyte microtubule cytoskeleton organization GO:0016325 35 0.017
cellular macromolecule catabolic process GO:0044265 136 0.017
Human
myofibril assembly GO:0030239 36 0.017
response to organic cyclic compound GO:0014070 89 0.017
cilium assembly GO:0042384 38 0.017
digestive system development GO:0055123 149 0.017
developmental pigmentation GO:0048066 68 0.017
negative regulation of gene expression GO:0010629 387 0.017
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 4 0.017
cellular protein localization GO:0034613 160 0.017
mesenchymal cell development GO:0014031 1 0.017
salivary gland histolysis GO:0035070 88 0.016
response to nutrient levels GO:0031667 114 0.016
positive regulation of intracellular transport GO:0032388 42 0.016
cell aging GO:0007569 2 0.016
immune system development GO:0002520 57 0.016
negative regulation of multicellular organismal process GO:0051241 142 0.016
regulation of neurogenesis GO:0050767 158 0.016
jnk cascade GO:0007254 50 0.016
positive regulation of phosphate metabolic process GO:0045937 139 0.016
positive regulation of cellular component organization GO:0051130 156 0.016
cell migration GO:0016477 238 0.016
centrosome organization GO:0051297 163 0.016
cellular response to heat GO:0034605 24 0.016
Human
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.016
Mouse
posttranscriptional regulation of gene expression GO:0010608 145 0.016
oxoacid metabolic process GO:0043436 103 0.016
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.016
negative regulation of nervous system development GO:0051961 92 0.016
response to lipopolysaccharide GO:0032496 4 0.016
positive regulation of organelle organization GO:0010638 65 0.016
stress activated mapk cascade GO:0051403 52 0.016
mitotic nuclear division GO:0007067 213 0.015
organic substance catabolic process GO:1901575 308 0.015
Human
single organism nuclear import GO:1902593 51 0.015
sarcomere organization GO:0045214 26 0.015
axon guidance GO:0007411 233 0.015
head development GO:0060322 135 0.015
Mouse
endosomal transport GO:0016197 44 0.015
stress activated protein kinase signaling cascade GO:0031098 55 0.015
response to alcohol GO:0097305 95 0.015
response to starvation GO:0042594 97 0.015
compound eye retinal cell programmed cell death GO:0046667 23 0.015
regulation of developmental pigmentation GO:0048070 24 0.015
imaginal disc derived wing hair organization GO:0035317 45 0.015
photoreceptor cell differentiation GO:0046530 170 0.015
regulation of cellular amino acid metabolic process GO:0006521 0 0.015
cellular lipid metabolic process GO:0044255 83 0.015
defense response to bacterium GO:0042742 178 0.014
germ line stem cell maintenance GO:0030718 50 0.014
positive regulation of retinal cell programmed cell death GO:0046670 9 0.014
behavioral response to ethanol GO:0048149 49 0.014
response to nitrogen compound GO:1901698 90 0.014
respiratory system development GO:0060541 213 0.014
exocrine system development GO:0035272 162 0.014
tube development GO:0035295 244 0.014
positive regulation of protein transport GO:0051222 37 0.014
regulation of catabolic process GO:0009894 170 0.014
digestive tract development GO:0048565 149 0.014
establishment or maintenance of cytoskeleton polarity GO:0030952 44 0.014
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.014
central nervous system development GO:0007417 201 0.014
Mouse
protein k48 linked ubiquitination GO:0070936 3 0.014
sensory perception GO:0007600 196 0.014
cytokinesis GO:0000910 90 0.014
negative regulation of molecular function GO:0044092 51 0.014
non sensory hair organization GO:0035316 47 0.014
signal transduction in response to dna damage GO:0042770 3 0.014
ribonucleotide metabolic process GO:0009259 145 0.014
ribonucleoprotein complex subunit organization GO:0071826 28 0.014
regulation of compound eye retinal cell programmed cell death GO:0046669 18 0.014
chromatin organization GO:0006325 207 0.014
protein targeting GO:0006605 64 0.014
nucleoside phosphate metabolic process GO:0006753 162 0.014
asymmetric cell division GO:0008356 37 0.014
proteasomal protein catabolic process GO:0010498 59 0.014
macromolecule catabolic process GO:0009057 161 0.014
Human
aging GO:0007568 143 0.014
regulation of vesicle mediated transport GO:0060627 59 0.014
striated muscle cell development GO:0055002 50 0.013
chemical homeostasis GO:0048878 92 0.013
cell fate determination GO:0001709 91 0.013
response to biotic stimulus GO:0009607 294 0.013
mitochondrion degradation GO:0000422 8 0.013
cellular response to oxidative stress GO:0034599 28 0.013
positive regulation of neuron apoptotic process GO:0043525 1 0.013
neurotransmitter transport GO:0006836 37 0.013
response to extracellular stimulus GO:0009991 116 0.013
regulation of cellular component size GO:0032535 98 0.013
mitotic cell cycle checkpoint GO:0007093 88 0.013
translation GO:0006412 69 0.013
gland morphogenesis GO:0022612 145 0.013
regulation of translation GO:0006417 56 0.013
negative regulation of cell differentiation GO:0045596 143 0.013
regulation of cytoplasmic transport GO:1903649 47 0.013
establishment of tissue polarity GO:0007164 87 0.013
regulation of protein transport GO:0051223 57 0.013
body morphogenesis GO:0010171 2 0.013
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.013
Zebrafish
ion transmembrane transport GO:0034220 122 0.013
positive regulation of endopeptidase activity GO:0010950 26 0.013
energy derivation by oxidation of organic compounds GO:0015980 32 0.013
regulation of notch signaling pathway GO:0008593 100 0.013
eggshell formation GO:0030703 105 0.013
lipid metabolic process GO:0006629 121 0.013
wnt signaling pathway GO:0016055 98 0.013
organic acid metabolic process GO:0006082 103 0.013
cellular response to hormone stimulus GO:0032870 44 0.013
heterochromatin organization GO:0070828 25 0.012
photoreceptor cell development GO:0042461 96 0.012
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.012
cell adhesion GO:0007155 136 0.012

HtrA2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.054
Human
parkinson s disease DOID:14330 0 0.041
Human
synucleinopathy DOID:0050890 0 0.041
Human
central nervous system disease DOID:331 0 0.041
Human
neurodegenerative disease DOID:1289 0 0.041
Human
nervous system disease DOID:863 0 0.041
Human
disease of cellular proliferation DOID:14566 0 0.013