Drosophila melanogaster

91 known processes

Rbf2 (Dmel_CG5083)

Retinoblastoma-family protein 2

(Aliases: CG5083,RBF2,Dmel\CG5083,rbf2)

Rbf2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of transcription dna templated GO:0045892 237 0.532
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.517
negative regulation of rna biosynthetic process GO:1902679 240 0.457
dna metabolic process GO:0006259 227 0.450
Fly
cell cycle dna replication GO:0044786 23 0.399
Fly
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.398
negative regulation of biosynthetic process GO:0009890 277 0.345
negative regulation of nucleic acid templated transcription GO:1903507 240 0.234
transcription from rna polymerase ii promoter GO:0006366 368 0.226
negative regulation of gene expression GO:0010629 387 0.211
mitotic spindle organization GO:0007052 220 0.206
dna damage checkpoint GO:0000077 78 0.194
Fly
nuclear division GO:0000280 332 0.178
Fly
negative regulation of rna metabolic process GO:0051253 251 0.171
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.171
negative regulation of cellular metabolic process GO:0031324 382 0.168
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.166
negative regulation of cellular biosynthetic process GO:0031327 277 0.151
intracellular signal transduction GO:0035556 300 0.149
Fly
regulation of cell differentiation GO:0045595 302 0.140
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.135
small molecule metabolic process GO:0044281 305 0.131
epithelial cell development GO:0002064 274 0.130
programmed cell death GO:0012501 257 0.120
Fly
mitotic nuclear division GO:0007067 213 0.119
Fly
spindle organization GO:0007051 253 0.115
regulation of mitotic cell cycle phase transition GO:1901990 130 0.106
cell motility GO:0048870 251 0.103
negative regulation of response to stimulus GO:0048585 258 0.101
nuclear dna replication GO:0033260 1 0.100
ras protein signal transduction GO:0007265 88 0.095
positive regulation of macromolecule metabolic process GO:0010604 405 0.095
organelle fission GO:0048285 340 0.093
Fly
columnar cuboidal epithelial cell development GO:0002066 249 0.089
mitotic dna integrity checkpoint GO:0044774 75 0.087
Fly
epithelial cell differentiation GO:0030855 322 0.086
segmentation GO:0035282 207 0.086
ovarian follicle cell development GO:0030707 248 0.085
regulation of cell development GO:0060284 215 0.083
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.082
centrosome organization GO:0051297 163 0.082
single organism biosynthetic process GO:0044711 206 0.080
Fly
regionalization GO:0003002 416 0.074
regulation of cell cycle GO:0051726 291 0.074
morphogenesis of an epithelium GO:0002009 276 0.071
blastoderm segmentation GO:0007350 159 0.071
embryonic pattern specification GO:0009880 174 0.070
cell proliferation GO:0008283 299 0.070
Fly
purine containing compound metabolic process GO:0072521 155 0.069
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.068
chromosome organization GO:0051276 360 0.067
Fly
regulation of multicellular organismal development GO:2000026 414 0.067
eggshell chorion assembly GO:0007306 66 0.066
oocyte differentiation GO:0009994 145 0.066
tissue morphogenesis GO:0048729 297 0.066
mitotic cell cycle checkpoint GO:0007093 88 0.064
Fly
macromolecular complex assembly GO:0065003 256 0.062
regulation of intracellular signal transduction GO:1902531 236 0.062
cellular response to dna damage stimulus GO:0006974 223 0.061
Fly
positive regulation of multicellular organismal process GO:0051240 143 0.060
small gtpase mediated signal transduction GO:0007264 88 0.059
negative regulation of signaling GO:0023057 219 0.058
purine nucleotide metabolic process GO:0006163 146 0.057
cell cycle phase transition GO:0044770 140 0.056
gene silencing GO:0016458 138 0.055
regulation of small gtpase mediated signal transduction GO:0051056 93 0.052
dorsal ventral pattern formation GO:0009953 133 0.049
sister chromatid segregation GO:0000819 92 0.049
Fly
cellular nitrogen compound catabolic process GO:0044270 165 0.047
microtubule organizing center organization GO:0031023 168 0.047
response to biotic stimulus GO:0009607 294 0.047
regulation of programmed cell death GO:0043067 152 0.046
Fly
single organism cellular localization GO:1902580 180 0.046
Fly
single organism catabolic process GO:0044712 228 0.045
positive regulation of developmental process GO:0051094 143 0.045
phosphorylation GO:0016310 294 0.045
Human
protein complex assembly GO:0006461 200 0.045
mitotic cell cycle phase transition GO:0044772 138 0.044
regulation of mitotic cell cycle GO:0007346 190 0.044
cellular macromolecular complex assembly GO:0034622 153 0.044
tube development GO:0035295 244 0.042
nucleoside phosphate metabolic process GO:0006753 162 0.042
positive regulation of cellular amine metabolic process GO:0033240 0 0.042
dendrite morphogenesis GO:0048813 199 0.041
axis specification GO:0009798 167 0.041
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.041
positive regulation of programmed cell death GO:0043068 62 0.040
regulation of gene expression epigenetic GO:0040029 128 0.040
stem cell proliferation GO:0072089 88 0.040
nucleobase containing compound catabolic process GO:0034655 165 0.040
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.040
body morphogenesis GO:0010171 2 0.040
mitotic dna damage checkpoint GO:0044773 74 0.039
Fly
regulation of protein metabolic process GO:0051246 256 0.039
mitotic sister chromatid segregation GO:0000070 87 0.039
Fly
nucleobase containing small molecule metabolic process GO:0055086 174 0.039
purine ribonucleotide metabolic process GO:0009150 145 0.039
organophosphate metabolic process GO:0019637 195 0.039
stem cell division GO:0017145 69 0.038
regulation of phosphate metabolic process GO:0019220 210 0.038
Human
protein dna complex assembly GO:0065004 63 0.038
eggshell formation GO:0030703 105 0.037
dna packaging GO:0006323 91 0.037
neuroblast proliferation GO:0007405 74 0.037
neural precursor cell proliferation GO:0061351 75 0.036
cell division GO:0051301 248 0.036
leg disc development GO:0035218 92 0.036
mitotic g2 m transition checkpoint GO:0044818 70 0.035
Fly
response to external biotic stimulus GO:0043207 293 0.035
regulation of apoptotic process GO:0042981 130 0.035
Fly
organic substance transport GO:0071702 257 0.035
mitotic g2 dna damage checkpoint GO:0007095 69 0.035
Fly
organic cyclic compound catabolic process GO:1901361 168 0.034
organonitrogen compound metabolic process GO:1901564 318 0.034
regulation of ras protein signal transduction GO:0046578 93 0.034
aromatic compound catabolic process GO:0019439 166 0.034
developmental maturation GO:0021700 172 0.033
eye development GO:0001654 323 0.033
positive regulation of rna metabolic process GO:0051254 271 0.032
negative regulation of cell communication GO:0010648 223 0.032
regulation of cell cycle process GO:0010564 181 0.031
tube morphogenesis GO:0035239 191 0.030
anterior posterior pattern specification GO:0009952 136 0.030
negative regulation of cell cycle process GO:0010948 109 0.030
negative regulation of signal transduction GO:0009968 206 0.030
apoptotic process GO:0006915 159 0.030
Fly
negative regulation of mitotic cell cycle GO:0045930 109 0.030
purine ribonucleoside metabolic process GO:0046128 127 0.030
cell fate determination GO:0001709 91 0.030
nucleotide metabolic process GO:0009117 161 0.030
regulation of localization GO:0032879 275 0.030
Fly
positive regulation of nucleic acid templated transcription GO:1903508 266 0.029
regulation of anatomical structure morphogenesis GO:0022603 242 0.029
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.029
cellular component assembly involved in morphogenesis GO:0010927 151 0.029
regulation of cellular protein metabolic process GO:0032268 243 0.028
localization of cell GO:0051674 257 0.028
digestive tract development GO:0048565 149 0.028
cell fate specification GO:0001708 71 0.028
ribose phosphate metabolic process GO:0019693 145 0.028
neuroblast division GO:0055057 35 0.028
meiotic cell cycle GO:0051321 171 0.027
cell cycle checkpoint GO:0000075 95 0.027
Fly
regulation of immune system process GO:0002682 176 0.026
response to oxygen containing compound GO:1901700 200 0.026
positive regulation of gene expression GO:0010628 290 0.026
purine containing compound catabolic process GO:0072523 112 0.026
ribonucleoside catabolic process GO:0042454 112 0.026
organelle assembly GO:0070925 198 0.026
notch signaling pathway GO:0007219 120 0.025
dendrite development GO:0016358 204 0.025
response to abiotic stimulus GO:0009628 341 0.025
embryonic axis specification GO:0000578 107 0.025
cellular protein modification process GO:0006464 438 0.025
embryonic morphogenesis GO:0048598 206 0.024
ribonucleoside metabolic process GO:0009119 127 0.024
positive regulation of transcription dna templated GO:0045893 266 0.024
wound healing GO:0042060 75 0.024
response to organic substance GO:0010033 284 0.024
death GO:0016265 284 0.023
Fly
positive regulation of phosphorus metabolic process GO:0010562 139 0.023
chromosome segregation GO:0007059 157 0.023
Fly
purine nucleotide catabolic process GO:0006195 109 0.023
cell maturation GO:0048469 144 0.023
dna integrity checkpoint GO:0031570 81 0.023
Fly
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.023
actin cytoskeleton organization GO:0030036 206 0.023
nucleoside catabolic process GO:0009164 112 0.023
organic substance catabolic process GO:1901575 308 0.022
purine nucleoside triphosphate metabolic process GO:0009144 119 0.022
heterocycle catabolic process GO:0046700 166 0.022
oocyte anterior posterior axis specification GO:0007314 72 0.022
camera type eye development GO:0043010 4 0.021
positive regulation of cell death GO:0010942 69 0.021
establishment of localization in cell GO:0051649 402 0.021
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.021
ribonucleotide metabolic process GO:0009259 145 0.021
regulation of multi organism process GO:0043900 131 0.020
brain development GO:0007420 120 0.020
glycosyl compound metabolic process GO:1901657 127 0.020
appendage morphogenesis GO:0035107 397 0.020
regulation of cell death GO:0010941 173 0.020
Fly
immune response GO:0006955 246 0.020
cell death GO:0008219 279 0.020
Fly
positive regulation of phosphate metabolic process GO:0045937 139 0.020
purine nucleoside catabolic process GO:0006152 112 0.020
regulation of cellular ketone metabolic process GO:0010565 3 0.020
positive regulation of biosynthetic process GO:0009891 316 0.020
regulation of phosphorylation GO:0042325 147 0.020
Human
protein dna complex subunit organization GO:0071824 86 0.019
purine nucleoside metabolic process GO:0042278 127 0.019
protein acylation GO:0043543 42 0.019
spindle assembly GO:0051225 80 0.019
chromatin remodeling GO:0006338 72 0.019
cellular amine metabolic process GO:0044106 12 0.019
regulation of cellular amino acid metabolic process GO:0006521 0 0.019
meiotic cell cycle process GO:1903046 132 0.019
negative regulation of gene expression epigenetic GO:0045814 77 0.019
ameboidal type cell migration GO:0001667 151 0.019
nucleoside triphosphate catabolic process GO:0009143 108 0.019
peptidyl lysine acetylation GO:0018394 39 0.018
regulation of cell shape GO:0008360 113 0.018
response to alcohol GO:0097305 95 0.018
regulation of catabolic process GO:0009894 170 0.018
asymmetric stem cell division GO:0098722 49 0.017
organonitrogen compound catabolic process GO:1901565 128 0.017
phagocytosis GO:0006909 215 0.017
leg disc morphogenesis GO:0007478 80 0.017
meiotic nuclear division GO:0007126 151 0.017
negative regulation of cell cycle phase transition GO:1901988 103 0.017
regulation of nervous system development GO:0051960 248 0.017
embryonic development via the syncytial blastoderm GO:0001700 148 0.017
regulation of cellular amine metabolic process GO:0033238 3 0.017
cellular catabolic process GO:0044248 372 0.017
protein ubiquitination GO:0016567 70 0.016
carboxylic acid metabolic process GO:0019752 92 0.016
regulation of neurogenesis GO:0050767 158 0.016
tissue migration GO:0090130 155 0.016
positive regulation of catalytic activity GO:0043085 118 0.016
histone mrna metabolic process GO:0008334 8 0.016
protein complex biogenesis GO:0070271 201 0.016
gland development GO:0048732 191 0.016
regulation of phosphorus metabolic process GO:0051174 210 0.016
Human
response to other organism GO:0051707 293 0.016
cellular protein complex assembly GO:0043623 71 0.016
catabolic process GO:0009056 409 0.016
developmental programmed cell death GO:0010623 138 0.016
taxis GO:0042330 304 0.016
negative regulation of ras protein signal transduction GO:0046580 13 0.016
regulation of cellular catabolic process GO:0031329 157 0.016
histone modification GO:0016570 106 0.015
carbohydrate derivative metabolic process GO:1901135 217 0.015
purine ribonucleoside catabolic process GO:0046130 112 0.015
internal peptidyl lysine acetylation GO:0018393 38 0.015
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.015
organophosphate catabolic process GO:0046434 112 0.015
microtubule anchoring GO:0034453 11 0.015
regulation of hydrolase activity GO:0051336 97 0.015
regulation of gene silencing GO:0060968 63 0.015
mitotic chromosome condensation GO:0007076 22 0.015
epithelial tube morphogenesis GO:0060562 88 0.015
axon guidance GO:0007411 233 0.015
purine nucleoside monophosphate metabolic process GO:0009126 50 0.015
digestive system development GO:0055123 149 0.015
regulation of response to stress GO:0080134 200 0.015
nucleoside triphosphate metabolic process GO:0009141 120 0.015
nucleotide catabolic process GO:0009166 109 0.014
regulation of chromosome organization GO:0033044 64 0.014
Fly
glycosyl compound catabolic process GO:1901658 112 0.014
compound eye development GO:0048749 307 0.014
regulation of molecular function GO:0065009 217 0.014
Human Fly
purine nucleoside triphosphate catabolic process GO:0009146 108 0.014
cell migration GO:0016477 238 0.014
response to wounding GO:0009611 94 0.014
anterior posterior axis specification GO:0009948 109 0.014
carbohydrate derivative catabolic process GO:1901136 118 0.014
mapk cascade GO:0000165 107 0.014
spindle assembly involved in mitosis GO:0090307 50 0.014
negative regulation of cell cycle GO:0045786 116 0.014
cellular protein localization GO:0034613 160 0.014
Fly
chromatin modification GO:0016568 147 0.014
mitotic spindle elongation GO:0000022 81 0.014
positive regulation of cellular component biogenesis GO:0044089 80 0.014
single organism intracellular transport GO:1902582 207 0.014
ribonucleoside triphosphate metabolic process GO:0009199 119 0.013
g2 dna damage checkpoint GO:0031572 69 0.013
Fly
positive regulation of cell development GO:0010720 61 0.013
head development GO:0060322 135 0.013
positive regulation of protein complex assembly GO:0031334 22 0.013
nucleoside phosphate catabolic process GO:1901292 110 0.013
regulation of notch signaling pathway GO:0008593 100 0.013
protein modification process GO:0036211 438 0.013
ribonucleoside triphosphate catabolic process GO:0009203 108 0.013
positive regulation of signal transduction GO:0009967 223 0.013
chromosome condensation GO:0030261 41 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.013
response to endogenous stimulus GO:0009719 119 0.013
negative regulation of apoptotic process GO:0043066 63 0.013
Fly
g1 s transition of mitotic cell cycle GO:0000082 31 0.013
regulation of organelle organization GO:0033043 196 0.013
Fly
nucleoside metabolic process GO:0009116 127 0.013
positive regulation of cellular catabolic process GO:0031331 95 0.013
actin filament based process GO:0030029 220 0.013
regulation of nucleotide catabolic process GO:0030811 48 0.013
oxoacid metabolic process GO:0043436 103 0.012
g protein coupled receptor signaling pathway GO:0007186 136 0.012
dna conformation change GO:0071103 105 0.012
mrna 3 end processing GO:0031124 28 0.012
regulation of proteolysis GO:0030162 87 0.012
appendage development GO:0048736 401 0.012
purine ribonucleotide catabolic process GO:0009154 109 0.012
regulation of cellular component biogenesis GO:0044087 201 0.012
response to lipopolysaccharide GO:0032496 4 0.012
ribonucleotide catabolic process GO:0009261 109 0.012
regulation of mapk cascade GO:0043408 92 0.012
dorsal appendage formation GO:0046843 47 0.012
imaginal disc derived leg morphogenesis GO:0007480 80 0.012
response to oxygen levels GO:0070482 59 0.012
regulation of cell cycle phase transition GO:1901987 130 0.012
regulation of catalytic activity GO:0050790 185 0.012
Human
regulation of neuron differentiation GO:0045664 103 0.012
cell type specific apoptotic process GO:0097285 38 0.012
posttranscriptional regulation of gene expression GO:0010608 145 0.011
positive regulation of response to stimulus GO:0048584 323 0.011
protein acetylation GO:0006473 39 0.011
positive regulation of cellular protein metabolic process GO:0032270 118 0.011
nucleoside monophosphate metabolic process GO:0009123 52 0.011
establishment or maintenance of cell polarity GO:0007163 167 0.011
neuronal stem cell division GO:0036445 35 0.011
positive regulation of cell proliferation GO:0008284 47 0.011
positive regulation of multi organism process GO:0043902 40 0.011
regulation of reproductive process GO:2000241 54 0.011
organic acid metabolic process GO:0006082 103 0.011
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.011
positive regulation of protein metabolic process GO:0051247 128 0.011
central nervous system development GO:0007417 201 0.011
post embryonic appendage morphogenesis GO:0035120 385 0.011
developmental growth GO:0048589 280 0.011
regulation of histone modification GO:0031056 20 0.011
positive regulation of cell differentiation GO:0045597 64 0.010
positive regulation of molecular function GO:0044093 136 0.010
covalent chromatin modification GO:0016569 106 0.010
establishment of protein localization to organelle GO:0072594 62 0.010
regulation of cell cycle g1 s phase transition GO:1902806 23 0.010
nucleocytoplasmic transport GO:0006913 72 0.010
oocyte development GO:0048599 124 0.010
atp metabolic process GO:0046034 49 0.010
telencephalon development GO:0021537 2 0.010

Rbf2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.021