Drosophila melanogaster

72 known processes

eIF4G (Dmel_CG10811)

eukaryotic translation initiation factor 4G

(Aliases: p200,deIF4G,Dmel\CG10811,eIF-4G,CG10811,Eif4G,eIF4g)

eIF4G biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of gene expression GO:0010629 387 0.423
catabolic process GO:0009056 409 0.355
locomotory behavior GO:0007626 176 0.231
biological adhesion GO:0022610 138 0.213
vesicle mediated transport GO:0016192 381 0.195
organic cyclic compound catabolic process GO:1901361 168 0.193
homeostatic process GO:0042592 199 0.161
translation GO:0006412 69 0.157
nuclear division GO:0000280 332 0.155
organophosphate metabolic process GO:0019637 195 0.150
nucleobase containing compound catabolic process GO:0034655 165 0.146
anion transmembrane transport GO:0098656 26 0.143
rna catabolic process GO:0006401 37 0.129
organelle fission GO:0048285 340 0.123
regulation of multicellular organism growth GO:0040014 40 0.120
golgi to plasma membrane transport GO:0006893 8 0.116
body morphogenesis GO:0010171 2 0.110
dna damage checkpoint GO:0000077 78 0.108
response to biotic stimulus GO:0009607 294 0.107
cell migration GO:0016477 238 0.093
organic substance catabolic process GO:1901575 308 0.093
intracellular transport GO:0046907 228 0.093
ion transmembrane transport GO:0034220 122 0.092
regulation of translation GO:0006417 56 0.090
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.085
regulation of localization GO:0032879 275 0.082
multicellular organism growth GO:0035264 46 0.079
cellular response to dna damage stimulus GO:0006974 223 0.077
cell cycle phase transition GO:0044770 140 0.076
cellular macromolecule catabolic process GO:0044265 136 0.072
establishment of protein localization to membrane GO:0090150 11 0.071
purine nucleoside metabolic process GO:0042278 127 0.067
regulation of growth GO:0040008 233 0.065
meiotic cell cycle GO:0051321 171 0.065
negative regulation of cellular biosynthetic process GO:0031327 277 0.064
positive regulation of cellular component biogenesis GO:0044089 80 0.064
nucleoside metabolic process GO:0009116 127 0.063
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.063
mrna metabolic process GO:0016071 124 0.062
endomembrane system organization GO:0010256 119 0.062
response to organic substance GO:0010033 284 0.061
cellular nitrogen compound catabolic process GO:0044270 165 0.059
programmed cell death GO:0012501 257 0.059
microtubule organizing center organization GO:0031023 168 0.058
telencephalon development GO:0021537 2 0.058
transmembrane transport GO:0055085 139 0.055
drug transmembrane transport GO:0006855 2 0.054
heterocycle catabolic process GO:0046700 166 0.054
macromolecular complex assembly GO:0065003 256 0.054
macromolecule catabolic process GO:0009057 161 0.054
organic substance transport GO:0071702 257 0.053
regulation of mitotic cell cycle GO:0007346 190 0.053
protein import GO:0017038 55 0.053
mitotic spindle elongation GO:0000022 81 0.052
cellular homeostasis GO:0019725 80 0.048
single organism membrane fusion GO:0044801 42 0.048
negative regulation of biosynthetic process GO:0009890 277 0.047
nucleocytoplasmic transport GO:0006913 72 0.047
cell motility GO:0048870 251 0.047
regulation of cell cycle process GO:0010564 181 0.047
nucleoside phosphate metabolic process GO:0006753 162 0.047
plasma membrane organization GO:0007009 26 0.046
developmental growth GO:0048589 280 0.045
regulation of tube diameter GO:0035296 14 0.044
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.044
response to endogenous stimulus GO:0009719 119 0.044
regulation of protein complex assembly GO:0043254 42 0.043
regulation of cellular localization GO:0060341 136 0.042
negative regulation of cellular metabolic process GO:0031324 382 0.042
regulation of erbb signaling pathway GO:1901184 42 0.042
cell adhesion GO:0007155 136 0.041
cellular macromolecule localization GO:0070727 220 0.041
positive regulation of biosynthetic process GO:0009891 316 0.041
positive regulation of multicellular organism growth GO:0040018 21 0.041
protein localization GO:0008104 284 0.041
cellular component assembly involved in morphogenesis GO:0010927 151 0.040
reproductive structure development GO:0048608 74 0.040
protein transport GO:0015031 155 0.040
single organism cellular localization GO:1902580 180 0.040
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.040
purine nucleotide catabolic process GO:0006195 109 0.040
centrosome cycle GO:0007098 137 0.039
nuclear transport GO:0051169 72 0.039
compound eye development GO:0048749 307 0.039
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.038
cellular response to chemical stimulus GO:0070887 199 0.038
anterior posterior axis specification GO:0009948 109 0.038
response to organonitrogen compound GO:0010243 75 0.038
cell death GO:0008219 279 0.037
organelle fusion GO:0048284 46 0.037
regulation of protein metabolic process GO:0051246 256 0.037
mrna catabolic process GO:0006402 33 0.037
hindbrain development GO:0030902 2 0.036
nucleobase containing small molecule metabolic process GO:0055086 174 0.036
cellular response to hormone stimulus GO:0032870 44 0.035
membrane organization GO:0061024 112 0.035
cell cycle checkpoint GO:0000075 95 0.034
multi organism behavior GO:0051705 175 0.034
positive regulation of cell migration GO:0030335 2 0.034
single organism catabolic process GO:0044712 228 0.034
blastoderm segmentation GO:0007350 159 0.034
response to oxygen containing compound GO:1901700 200 0.033
growth GO:0040007 359 0.033
central nervous system development GO:0007417 201 0.033
response to metal ion GO:0010038 23 0.032
cytoplasmic transport GO:0016482 130 0.032
maternal determination of anterior posterior axis embryo GO:0008358 74 0.032
establishment of protein localization GO:0045184 163 0.032
regulation of protein transport GO:0051223 57 0.032
protein complex biogenesis GO:0070271 201 0.032
organelle assembly GO:0070925 198 0.032
cellular catabolic process GO:0044248 372 0.031
single organism behavior GO:0044708 391 0.031
response to drug GO:0042493 17 0.031
forebrain development GO:0030900 2 0.031
posttranscriptional regulation of gene expression GO:0010608 145 0.030
response to hormone GO:0009725 45 0.030
embryonic pattern specification GO:0009880 174 0.030
positive regulation of macromolecule metabolic process GO:0010604 405 0.030
cellular protein localization GO:0034613 160 0.030
enzyme linked receptor protein signaling pathway GO:0007167 179 0.029
response to peptide GO:1901652 29 0.029
multi organism reproductive behavior GO:0044705 121 0.029
multicellular organismal reproductive behavior GO:0033057 110 0.029
negative regulation of cellular protein metabolic process GO:0032269 85 0.028
axis specification GO:0009798 167 0.028
regulation of apoptotic process GO:0042981 130 0.028
neurological system process GO:0050877 358 0.028
rna localization GO:0006403 115 0.028
mitotic spindle organization GO:0007052 220 0.028
tripartite regional subdivision GO:0007351 103 0.028
positive regulation of cell motility GO:2000147 3 0.028
carboxylic acid metabolic process GO:0019752 92 0.028
establishment of localization in cell GO:0051649 402 0.028
cellularization GO:0007349 90 0.027
dna metabolic process GO:0006259 227 0.027
endocytosis GO:0006897 310 0.027
adult behavior GO:0030534 137 0.027
protein targeting GO:0006605 64 0.027
regulation of anatomical structure size GO:0090066 163 0.027
intracellular protein transport GO:0006886 104 0.027
innate immune response GO:0045087 144 0.026
cellular amino acid metabolic process GO:0006520 61 0.026
regulation of immune system process GO:0002682 176 0.026
centrosome organization GO:0051297 163 0.026
organophosphate catabolic process GO:0046434 112 0.026
regulation of organelle organization GO:0033043 196 0.026
intracellular mrna localization GO:0008298 66 0.026
response to organic cyclic compound GO:0014070 89 0.026
positive regulation of rna biosynthetic process GO:1902680 266 0.025
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.025
cellular protein modification process GO:0006464 438 0.025
purine ribonucleoside catabolic process GO:0046130 112 0.025
gtp catabolic process GO:0006184 72 0.025
regulation of intracellular transport GO:0032386 64 0.025
carbohydrate derivative metabolic process GO:1901135 217 0.024
proteolysis GO:0006508 192 0.024
protein modification process GO:0036211 438 0.024
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.024
negative regulation of translation GO:0017148 28 0.024
organonitrogen compound metabolic process GO:1901564 318 0.024
regulation of cellular protein metabolic process GO:0032268 243 0.023
single organism intracellular transport GO:1902582 207 0.023
purine containing compound metabolic process GO:0072521 155 0.023
death GO:0016265 284 0.023
cellular protein complex assembly GO:0043623 71 0.023
regulation of catabolic process GO:0009894 170 0.023
regulation of transport GO:0051049 181 0.023
oxoacid metabolic process GO:0043436 103 0.023
ribonucleotide metabolic process GO:0009259 145 0.022
spindle elongation GO:0051231 83 0.022
regulation of cytoplasmic transport GO:1903649 47 0.022
regulation of establishment of protein localization GO:0070201 61 0.022
immune system process GO:0002376 347 0.022
purine ribonucleotide catabolic process GO:0009154 109 0.022
positive regulation of signaling GO:0023056 243 0.022
maintenance of location GO:0051235 73 0.022
oocyte differentiation GO:0009994 145 0.022
purine ribonucleoside metabolic process GO:0046128 127 0.022
regulation of nucleocytoplasmic transport GO:0046822 35 0.021
regulation of vesicle mediated transport GO:0060627 59 0.021
cell cell signaling involved in cell fate commitment GO:0045168 210 0.021
nephron tubule development GO:0072080 3 0.021
regulation of intracellular protein transport GO:0033157 46 0.021
g2 dna damage checkpoint GO:0031572 69 0.021
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.021
ribonucleoside triphosphate catabolic process GO:0009203 108 0.021
photoreceptor cell differentiation GO:0046530 170 0.021
eye antennal disc development GO:0035214 60 0.021
response to inorganic substance GO:0010035 44 0.020
regulation of proteolysis GO:0030162 87 0.020
cell cycle arrest GO:0007050 4 0.020
nucleotide catabolic process GO:0009166 109 0.020
positive regulation of nucleic acid templated transcription GO:1903508 266 0.020
nucleotide metabolic process GO:0009117 161 0.020
cilium morphogenesis GO:0060271 39 0.020
histone modification GO:0016570 106 0.020
protein complex assembly GO:0006461 200 0.019
phagocytosis GO:0006909 215 0.019
brain development GO:0007420 120 0.019
cellular macromolecular complex assembly GO:0034622 153 0.019
response to lipopolysaccharide GO:0032496 4 0.019
ribonucleoprotein complex subunit organization GO:0071826 28 0.019
response to peptide hormone GO:0043434 29 0.019
purine nucleoside triphosphate catabolic process GO:0009146 108 0.019
regulation of programmed cell death GO:0043067 152 0.019
membrane fusion GO:0061025 42 0.019
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.019
regulation of hydrolase activity GO:0051336 97 0.019
regulation of cell cycle phase transition GO:1901987 130 0.018
positive regulation of catabolic process GO:0009896 105 0.018
cell proliferation GO:0008283 299 0.018
purine nucleoside catabolic process GO:0006152 112 0.018
nuclear transcribed mrna catabolic process GO:0000956 24 0.018
localization of cell GO:0051674 257 0.018
cellular response to organic substance GO:0071310 132 0.018
nucleoside phosphate catabolic process GO:1901292 110 0.018
nucleoside triphosphate catabolic process GO:0009143 108 0.018
embryonic axis specification GO:0000578 107 0.018
positive regulation of gene expression GO:0010628 290 0.018
oocyte development GO:0048599 124 0.018
glycosyl compound catabolic process GO:1901658 112 0.018
organic acid metabolic process GO:0006082 103 0.017
response to bacterium GO:0009617 198 0.017
cellular response to insulin stimulus GO:0032869 28 0.017
response to hypoxia GO:0001666 53 0.017
regulation of protein catabolic process GO:0042176 55 0.017
response to axon injury GO:0048678 12 0.017
anterior posterior pattern specification GO:0009952 136 0.017
dorsal ventral pattern formation GO:0009953 133 0.017
multi multicellular organism process GO:0044706 123 0.017
axonogenesis GO:0007409 290 0.016
oocyte anterior posterior axis specification GO:0007314 72 0.016
positive regulation of response to stimulus GO:0048584 323 0.016
regulation of cell death GO:0010941 173 0.016
oocyte construction GO:0007308 112 0.016
chemical homeostasis GO:0048878 92 0.016
establishment of protein localization to plasma membrane GO:0090002 9 0.016
nuclear transcribed mrna catabolic process deadenylation dependent decay GO:0000288 14 0.016
ribonucleoside catabolic process GO:0042454 112 0.016
regulation of microtubule cytoskeleton organization GO:0070507 41 0.016
rna transport GO:0050658 46 0.016
nucleoside triphosphate metabolic process GO:0009141 120 0.016
segmentation GO:0035282 207 0.016
cell recognition GO:0008037 102 0.016
ribonucleotide catabolic process GO:0009261 109 0.016
aging GO:0007568 143 0.016
inorganic ion transmembrane transport GO:0098660 73 0.016
negative regulation of cell cycle process GO:0010948 109 0.016
regulation of epithelial cell differentiation GO:0030856 4 0.016
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.016
cell maturation GO:0048469 144 0.016
posttranscriptional gene silencing by rna GO:0035194 45 0.016
protein modification by small protein conjugation or removal GO:0070647 106 0.015
purine ribonucleotide metabolic process GO:0009150 145 0.015
protein localization to organelle GO:0033365 82 0.015
purine nucleoside monophosphate metabolic process GO:0009126 50 0.015
small molecule metabolic process GO:0044281 305 0.015
regulation of nuclear division GO:0051783 58 0.015
purine nucleoside triphosphate metabolic process GO:0009144 119 0.015
centrosome duplication GO:0051298 121 0.015
response to oxygen levels GO:0070482 59 0.015
cellular response to decreased oxygen levels GO:0036294 30 0.015
dna integrity checkpoint GO:0031570 81 0.015
response to abiotic stimulus GO:0009628 341 0.015
chromosome organization GO:0051276 360 0.015
cholesterol homeostasis GO:0042632 3 0.015
regulation of protein localization GO:0032880 76 0.015
nephron tubule morphogenesis GO:0072078 3 0.015
response to organophosphorus GO:0046683 2 0.015
positive regulation of developmental growth GO:0048639 62 0.015
intracellular signal transduction GO:0035556 300 0.015
response to decreased oxygen levels GO:0036293 58 0.015
meiotic nuclear division GO:0007126 151 0.014
positive regulation of cellular biosynthetic process GO:0031328 316 0.014
male gamete generation GO:0048232 201 0.014
oocyte axis specification GO:0007309 108 0.014
actin cytoskeleton organization GO:0030036 206 0.014
anterior posterior axis specification embryo GO:0008595 103 0.014
response to wounding GO:0009611 94 0.014
centriole replication GO:0007099 24 0.014
cellular response to peptide hormone stimulus GO:0071375 28 0.014
positive regulation of transcription dna templated GO:0045893 266 0.014
response to nitrogen compound GO:1901698 90 0.014
regulation of developmental growth GO:0048638 174 0.014
trna aminoacylation GO:0043039 2 0.014
positive regulation of catalytic activity GO:0043085 118 0.014
eye morphogenesis GO:0048592 260 0.014
response to extracellular stimulus GO:0009991 116 0.014
compound eye morphogenesis GO:0001745 249 0.013
insulin receptor signaling pathway GO:0008286 25 0.013
head development GO:0060322 135 0.013
gene silencing GO:0016458 138 0.013
regulation of cellular component biogenesis GO:0044087 201 0.013
cell division GO:0051301 248 0.013
cation transport GO:0006812 110 0.013
aromatic compound catabolic process GO:0019439 166 0.013
protein heterooligomerization GO:0051291 4 0.013
negative regulation of cell cycle GO:0045786 116 0.013
positive regulation of protein complex assembly GO:0031334 22 0.013
protein localization to nucleus GO:0034504 55 0.013
cell cycle g1 s phase transition GO:0044843 31 0.013
cellular response to organonitrogen compound GO:0071417 36 0.013
development of primary sexual characteristics GO:0045137 50 0.013
maintenance of location in cell GO:0051651 28 0.013
nucleoside catabolic process GO:0009164 112 0.013
positive regulation of protein localization to plasma membrane GO:1903078 3 0.013
single organism membrane organization GO:0044802 93 0.012
molting cycle chitin based cuticle GO:0007591 56 0.012
negative regulation of mitotic cell cycle GO:0045930 109 0.012
positive regulation of establishment of protein localization to plasma membrane GO:0090004 3 0.012
mitotic dna integrity checkpoint GO:0044774 75 0.012
negative regulation of rna metabolic process GO:0051253 251 0.012
connective tissue development GO:0061448 3 0.012
phosphorylation GO:0016310 294 0.012
cellular response to nitrogen compound GO:1901699 51 0.012
chemosensory behavior GO:0007635 106 0.012
anatomical structure homeostasis GO:0060249 97 0.012
spermatid differentiation GO:0048515 114 0.012
lipid localization GO:0010876 54 0.011
regulation of gene expression epigenetic GO:0040029 128 0.011
developmental maturation GO:0021700 172 0.011
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.011
positive regulation of developmental process GO:0051094 143 0.011
positive regulation of protein transport GO:0051222 37 0.011
regulation of cell division GO:0051302 72 0.011
negative regulation of transcription dna templated GO:0045892 237 0.011
spermatogenesis GO:0007283 200 0.011
divalent inorganic cation homeostasis GO:0072507 29 0.011
negative regulation of protein metabolic process GO:0051248 85 0.011
gland development GO:0048732 191 0.011
cellular response to endogenous stimulus GO:0071495 80 0.011
nucleoside monophosphate metabolic process GO:0009123 52 0.011
protein localization to membrane GO:0072657 19 0.010
protein maturation GO:0051604 71 0.010
positive regulation of intracellular transport GO:0032388 42 0.010
translational initiation GO:0006413 11 0.010
nuclear transcribed mrna poly a tail shortening GO:0000289 12 0.010
wound healing GO:0042060 75 0.010
single organism biosynthetic process GO:0044711 206 0.010
response to calcium ion GO:0051592 1 0.010

eIF4G disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.115
disease of metabolism DOID:0014667 0 0.024
nervous system disease DOID:863 0 0.022
cardiovascular system disease DOID:1287 0 0.019
central nervous system disease DOID:331 0 0.012