Drosophila melanogaster

19 known processes

rtGEF (Dmel_CG10043)

rho-type guanine exchange factor

(Aliases: rhoGEF,DrhoGEF,dpix,DrtGEF,RhoGEF,ARHGEF7,beta-PIX,dPix,38C.40,Rho/RacGEF,CG10043,Dmel\CG10043)

rtGEF biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
synaptic transmission GO:0007268 288 0.837
establishment of vesicle localization GO:0051650 51 0.768
synaptic vesicle recycling GO:0036465 28 0.705
synaptic vesicle transport GO:0048489 50 0.696
synapse organization GO:0050808 196 0.667
regulation of multicellular organismal development GO:2000026 414 0.655
signal release GO:0023061 49 0.587
establishment of localization in cell GO:0051649 402 0.551
synaptic vesicle endocytosis GO:0048488 28 0.543
regulation of cell development GO:0060284 215 0.525
Human
neuromuscular junction development GO:0007528 149 0.500
establishment of organelle localization GO:0051656 122 0.462
regulation of neurogenesis GO:0050767 158 0.451
regulation of neuron projection development GO:0010975 69 0.444
regulation of nervous system development GO:0051960 248 0.436
regulation of synaptic growth at neuromuscular junction GO:0008582 89 0.428
protein modification process GO:0036211 438 0.421
organelle localization GO:0051640 148 0.385
regulation of neuron differentiation GO:0045664 103 0.384
regulation of cellular component biogenesis GO:0044087 201 0.372
regulation of cell differentiation GO:0045595 302 0.364
Human
synapse assembly GO:0007416 143 0.361
regulation of synapse organization GO:0050807 110 0.348
synaptic growth at neuromuscular junction GO:0051124 119 0.345
vesicle localization GO:0051648 55 0.341
organonitrogen compound metabolic process GO:1901564 318 0.332
Human Mouse
positive regulation of secretion GO:0051047 22 0.331
establishment of synaptic vesicle localization GO:0097480 50 0.330
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.320
Human Mouse
neurotransmitter transport GO:0006836 37 0.315
tube development GO:0035295 244 0.310
synaptic vesicle exocytosis GO:0016079 16 0.299
axon development GO:0061564 297 0.288
cognition GO:0050890 141 0.278
regulation of cytoskeleton organization GO:0051493 89 0.249
neurotransmitter secretion GO:0007269 35 0.248
epithelial cell migration GO:0010631 148 0.246
learning or memory GO:0007611 141 0.242
tissue migration GO:0090130 155 0.232
negative regulation of cellular component organization GO:0051129 108 0.229
positive regulation of synapse assembly GO:0051965 29 0.228
cellular protein modification process GO:0006464 438 0.220
peptidyl amino acid modification GO:0018193 105 0.218
locomotory behavior GO:0007626 176 0.209
tube morphogenesis GO:0035239 191 0.208
neurological system process GO:0050877 358 0.198
cell motility GO:0048870 251 0.187
Human Rat
positive regulation of cell migration GO:0030335 2 0.179
Human
regulation of synapse assembly GO:0051963 94 0.178
axonogenesis GO:0007409 290 0.173
regulation of anatomical structure morphogenesis GO:0022603 242 0.172
Human
developmental growth GO:0048589 280 0.170
positive regulation of biosynthetic process GO:0009891 316 0.168
g protein coupled receptor signaling pathway GO:0007186 136 0.164
secretion GO:0046903 109 0.163
tissue morphogenesis GO:0048729 297 0.161
ribonucleotide metabolic process GO:0009259 145 0.159
Human Mouse
single organism behavior GO:0044708 391 0.155
axon extension GO:0048675 32 0.153
single organism membrane organization GO:0044802 93 0.153
single organism membrane fusion GO:0044801 42 0.151
positive regulation of exocytosis GO:0045921 4 0.146
positive regulation of transcription dna templated GO:0045893 266 0.139
organophosphate metabolic process GO:0019637 195 0.138
Human Mouse
positive regulation of macromolecule metabolic process GO:0010604 405 0.138
regulation of cell cycle GO:0051726 291 0.137
positive regulation of secretion by cell GO:1903532 20 0.136
intracellular signal transduction GO:0035556 300 0.134
Rat
neuron projection extension GO:1990138 32 0.132
regulation of transport GO:0051049 181 0.132
ameboidal type cell migration GO:0001667 151 0.130
Human
sensory perception GO:0007600 196 0.127
regulation of cell morphogenesis GO:0022604 163 0.126
Human
carbohydrate derivative metabolic process GO:1901135 217 0.125
Human Mouse
synaptic vesicle localization GO:0097479 53 0.125
regulation of cellular localization GO:0060341 136 0.124
regulation of organelle organization GO:0033043 196 0.118
positive regulation of signaling GO:0023056 243 0.118
localization of cell GO:0051674 257 0.118
Human Rat
memory GO:0007613 94 0.114
positive regulation of rna biosynthetic process GO:1902680 266 0.113
rhythmic excitation GO:0043179 1 0.113
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.113
small molecule metabolic process GO:0044281 305 0.112
Human Mouse
regulation of neurotransmitter levels GO:0001505 38 0.111
protein complex biogenesis GO:0070271 201 0.110
nucleobase containing small molecule metabolic process GO:0055086 174 0.110
Human Mouse
epithelium migration GO:0090132 148 0.109
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.109
Human Mouse
positive regulation of rna metabolic process GO:0051254 271 0.108
phosphorylation GO:0016310 294 0.107
vesicle organization GO:0016050 44 0.107
neuron neuron synaptic transmission GO:0007270 14 0.105
regulation of growth GO:0040008 233 0.101
ion transport GO:0006811 145 0.101
detection of stimulus GO:0051606 156 0.101
positive regulation of nucleic acid templated transcription GO:1903508 266 0.100
chromosome organization GO:0051276 360 0.099
protein phosphorylation GO:0006468 169 0.098
regulation of dendrite morphogenesis GO:0048814 28 0.098
regulation of behavior GO:0050795 75 0.098
maintenance of presynaptic active zone structure GO:0048790 8 0.096
regulation of anatomical structure size GO:0090066 163 0.095
single organism intracellular transport GO:1902582 207 0.095
membrane organization GO:0061024 112 0.094
regulation of excitatory postsynaptic membrane potential GO:0060079 3 0.092
positive regulation of cell communication GO:0010647 250 0.092
regulation of secretion by cell GO:1903530 39 0.090
secretion by cell GO:0032940 101 0.089
purine nucleotide metabolic process GO:0006163 146 0.088
Human Mouse
regulation of organ morphogenesis GO:2000027 78 0.088
positive regulation of gene expression GO:0010628 290 0.087
positive regulation of neuromuscular synaptic transmission GO:1900075 4 0.086
regulation of protein metabolic process GO:0051246 256 0.086
embryonic morphogenesis GO:0048598 206 0.086
regulation of neurotransmitter secretion GO:0046928 14 0.085
regulation of catabolic process GO:0009894 170 0.085
Human Mouse
sensory perception of smell GO:0007608 80 0.085
single organism biosynthetic process GO:0044711 206 0.084
taxis GO:0042330 304 0.083
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.083
Human
nuclear division GO:0000280 332 0.083
organelle fusion GO:0048284 46 0.082
regulation of developmental growth GO:0048638 174 0.082
positive regulation of synaptic transmission GO:0050806 15 0.081
single organism catabolic process GO:0044712 228 0.081
Human Mouse
multi organism reproductive behavior GO:0044705 121 0.081
glycosyl compound catabolic process GO:1901658 112 0.081
Human Mouse
detection of stimulus involved in sensory perception GO:0050906 92 0.080
developmental cell growth GO:0048588 52 0.080
long term memory GO:0007616 62 0.079
neuromuscular synaptic transmission GO:0007274 67 0.079
respiratory system development GO:0060541 213 0.079
mitotic nuclear division GO:0007067 213 0.078
cellular catabolic process GO:0044248 372 0.077
Human Mouse
actin filament based process GO:0030029 220 0.077
chemotaxis GO:0006935 249 0.076
regulation of cell projection organization GO:0031344 92 0.075
Human
digestive tract morphogenesis GO:0048546 127 0.075
mesoderm morphogenesis GO:0048332 22 0.075
cell migration GO:0016477 238 0.074
Human Rat
forebrain development GO:0030900 2 0.074
catabolic process GO:0009056 409 0.073
Human Mouse
vesicle mediated transport GO:0016192 381 0.071
growth GO:0040007 359 0.071
cellular ion homeostasis GO:0006873 39 0.070
response to organic substance GO:0010033 284 0.070
organonitrogen compound catabolic process GO:1901565 128 0.069
Human Mouse
regulation of synapse structure and activity GO:0050803 128 0.067
positive regulation of cellular component biogenesis GO:0044089 80 0.067
cyclic purine nucleotide metabolic process GO:0052652 25 0.066
negative regulation of synapse assembly GO:0051964 39 0.066
organelle fission GO:0048285 340 0.066
membrane fusion GO:0061025 42 0.066
cellular chemical homeostasis GO:0055082 40 0.066
positive regulation of cellular biosynthetic process GO:0031328 316 0.065
cation homeostasis GO:0055080 51 0.065
positive regulation of cell motility GO:2000147 3 0.065
Human
mitotic sister chromatid segregation GO:0000070 87 0.065
response to abiotic stimulus GO:0009628 341 0.065
morphogenesis of an epithelium GO:0002009 276 0.064
cellular amine metabolic process GO:0044106 12 0.064
positive regulation of transport GO:0051050 92 0.063
regulation of synaptic transmission GO:0050804 69 0.063
nucleoside phosphate metabolic process GO:0006753 162 0.062
Human Mouse
organonitrogen compound biosynthetic process GO:1901566 117 0.062
imaginal disc derived appendage development GO:0048737 399 0.060
open tracheal system development GO:0007424 204 0.059
negative regulation of developmental growth GO:0048640 64 0.059
sensory organ morphogenesis GO:0090596 260 0.059
carboxylic acid metabolic process GO:0019752 92 0.059
organic substance transport GO:0071702 257 0.059
response to mechanical stimulus GO:0009612 28 0.058
purine containing compound metabolic process GO:0072521 155 0.058
Human Mouse
establishment of spindle orientation GO:0051294 18 0.058
negative regulation of microtubule depolymerization GO:0007026 21 0.058
negative regulation of biosynthetic process GO:0009890 277 0.057
pigment metabolic process GO:0042440 84 0.057
single organism cellular localization GO:1902580 180 0.057
biological adhesion GO:0022610 138 0.057
Human
regulation of phosphorylation GO:0042325 147 0.057
cellular cation homeostasis GO:0030003 38 0.056
axon guidance GO:0007411 233 0.055
ribose phosphate metabolic process GO:0019693 145 0.055
Human Mouse
regulation of protein complex disassembly GO:0043244 29 0.055
negative regulation of response to stimulus GO:0048585 258 0.055
receptor clustering GO:0043113 3 0.054
regulation of neuromuscular synaptic transmission GO:1900073 15 0.054
regulation of cellular amine metabolic process GO:0033238 3 0.053
exocytosis GO:0006887 28 0.053
cellular modified amino acid metabolic process GO:0006575 45 0.052
endocytosis GO:0006897 310 0.052
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.052
embryonic pattern specification GO:0009880 174 0.052
regulation of secretion GO:0051046 44 0.051
endomembrane system organization GO:0010256 119 0.051
sister chromatid segregation GO:0000819 92 0.051
regulation of cell migration GO:0030334 22 0.051
Human
chromosome segregation GO:0007059 157 0.051
organic acid metabolic process GO:0006082 103 0.051
negative regulation of multicellular organismal process GO:0051241 142 0.051
detection of chemical stimulus GO:0009593 93 0.050
regulation of localization GO:0032879 275 0.050
Human
spindle organization GO:0007051 253 0.050
ovarian follicle cell development GO:0030707 248 0.050
larval behavior GO:0030537 42 0.049
positive regulation of phosphate metabolic process GO:0045937 139 0.049
Human Mouse
detection of external stimulus GO:0009581 66 0.049
cellular protein localization GO:0034613 160 0.049
organic substance catabolic process GO:1901575 308 0.049
Human Mouse
synaptic transmission glutamatergic GO:0035249 7 0.048
mating GO:0007618 120 0.048
regulation of dendrite development GO:0050773 37 0.047
nucleoside metabolic process GO:0009116 127 0.047
Human Mouse
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.047
ribonucleoside triphosphate metabolic process GO:0009199 119 0.047
Human Mouse
neuron projection guidance GO:0097485 241 0.047
mapk cascade GO:0000165 107 0.046
negative regulation of nervous system development GO:0051961 92 0.046
nucleoside triphosphate metabolic process GO:0009141 120 0.046
Human Mouse
negative regulation of synaptic growth at neuromuscular junction GO:0045886 39 0.045
cellular homeostasis GO:0019725 80 0.045
meiotic nuclear division GO:0007126 151 0.045
regulation of membrane potential GO:0042391 35 0.045
regulation of mapk cascade GO:0043408 92 0.045
adult locomotory behavior GO:0008344 76 0.044
regulation of catalytic activity GO:0050790 185 0.044
Human Mouse
retina development in camera type eye GO:0060041 4 0.044
negative regulation of cellular metabolic process GO:0031324 382 0.044
regulation of intracellular signal transduction GO:1902531 236 0.044
Human Mouse
urogenital system development GO:0001655 72 0.044
detection of chemical stimulus involved in sensory perception GO:0050907 75 0.043
anterior posterior pattern specification GO:0009952 136 0.043
negative regulation of rna biosynthetic process GO:1902679 240 0.043
negative regulation of growth GO:0045926 84 0.042
homeostatic process GO:0042592 199 0.042
post embryonic appendage morphogenesis GO:0035120 385 0.042
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.041
regulation of cellular component movement GO:0051270 42 0.041
Human
cellular macromolecule localization GO:0070727 220 0.041
regulation of synaptic vesicle exocytosis GO:2000300 3 0.041
positive regulation of response to stimulus GO:0048584 323 0.041
microtubule based transport GO:0010970 42 0.041
regulation of cell division GO:0051302 72 0.040
hindgut morphogenesis GO:0007442 58 0.040
regulation of mitotic cell cycle GO:0007346 190 0.040
carbohydrate derivative catabolic process GO:1901136 118 0.040
Human Mouse
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.040
Human Mouse
intracellular protein transport GO:0006886 104 0.039
positive regulation of synaptic transmission glutamatergic GO:0051968 3 0.039
purine ribonucleoside metabolic process GO:0046128 127 0.039
Human Mouse
positive regulation of cellular component organization GO:0051130 156 0.038
Human
regulation of actin filament based process GO:0032970 42 0.038
positive regulation of synaptic growth at neuromuscular junction GO:0045887 26 0.038
transmembrane transport GO:0055085 139 0.037
epithelial cell development GO:0002064 274 0.037
cytokinesis GO:0000910 90 0.037
heart process GO:0003015 37 0.036
epithelial tube morphogenesis GO:0060562 88 0.036
positive regulation of signal transduction GO:0009967 223 0.036
purine nucleoside triphosphate metabolic process GO:0009144 119 0.036
Human Mouse
establishment of protein localization GO:0045184 163 0.036
regulation of vesicle mediated transport GO:0060627 59 0.036
filopodium assembly GO:0046847 33 0.036
ribonucleotide catabolic process GO:0009261 109 0.036
Human Mouse
negative regulation of developmental process GO:0051093 201 0.036
response to heat GO:0009408 63 0.035
eye development GO:0001654 323 0.035
purine ribonucleotide metabolic process GO:0009150 145 0.035
Human Mouse
digestive tract development GO:0048565 149 0.035
mesoderm formation GO:0001707 21 0.035
associative learning GO:0008306 65 0.035
gtp catabolic process GO:0006184 72 0.035
Human Mouse
regulation of receptor activity GO:0010469 10 0.034
muscle system process GO:0003012 21 0.034
positive regulation of multicellular organismal process GO:0051240 143 0.034
gliogenesis GO:0042063 80 0.034
Rat
guanosine containing compound metabolic process GO:1901068 74 0.034
Human Mouse
cellular divalent inorganic cation homeostasis GO:0072503 23 0.034
intracellular transport GO:0046907 228 0.034
regionalization GO:0003002 416 0.033
ion transmembrane transport GO:0034220 122 0.033
glial cell differentiation GO:0010001 35 0.033
salivary gland development GO:0007431 162 0.033
protein transport GO:0015031 155 0.033
cell proliferation GO:0008283 299 0.033
regulation of cellular response to stress GO:0080135 89 0.033
regulation of epithelial cell migration GO:0010632 12 0.032
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.032
negative regulation of transcription dna templated GO:0045892 237 0.032
macromolecule catabolic process GO:0009057 161 0.032
regulation of cell cycle process GO:0010564 181 0.032
regulation of locomotion GO:0040012 42 0.032
Human
adult behavior GO:0030534 137 0.032
cell division GO:0051301 248 0.032
sensory perception of chemical stimulus GO:0007606 116 0.032
cell death GO:0008219 279 0.032
Human
protein complex assembly GO:0006461 200 0.032
cellular amino acid metabolic process GO:0006520 61 0.032
nucleotide metabolic process GO:0009117 161 0.032
Human Mouse
kidney development GO:0001822 3 0.031
purine ribonucleoside catabolic process GO:0046130 112 0.031
Human Mouse
behavioral response to pain GO:0048266 3 0.031
purine nucleotide catabolic process GO:0006195 109 0.031
Human Mouse
death GO:0016265 284 0.031
Human
nitrogen compound transport GO:0071705 85 0.031
amine metabolic process GO:0009308 12 0.031
detection of visible light GO:0009584 38 0.031
morphogenesis of embryonic epithelium GO:0016331 94 0.031
positive regulation of intracellular signal transduction GO:1902533 116 0.030
regulation of proteolysis GO:0030162 87 0.030
oxoacid metabolic process GO:0043436 103 0.030
microtubule based movement GO:0007018 51 0.030
regulation of molecular function GO:0065009 217 0.030
Human Mouse
response to endogenous stimulus GO:0009719 119 0.030
developmental maturation GO:0021700 172 0.030
axon cargo transport GO:0008088 29 0.030
microtubule depolymerization GO:0007019 25 0.030
mesoderm development GO:0007498 78 0.029
muscle organ development GO:0007517 127 0.029
aromatic compound catabolic process GO:0019439 166 0.029
Human Mouse
cell adhesion GO:0007155 136 0.029
Human
peptide metabolic process GO:0006518 80 0.029
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.029
negative regulation of cell communication GO:0010648 223 0.029
regulation of cell death GO:0010941 173 0.028
Human
columnar cuboidal epithelial cell development GO:0002066 249 0.028
larval locomotory behavior GO:0008345 27 0.028
plasma membrane organization GO:0007009 26 0.028
dendrite development GO:0016358 204 0.028
small gtpase mediated signal transduction GO:0007264 88 0.028
Rat
meiotic cell cycle GO:0051321 171 0.028
regulation of nuclear division GO:0051783 58 0.028
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.028
positive regulation of phosphorus metabolic process GO:0010562 139 0.028
Human Mouse
macromolecular complex assembly GO:0065003 256 0.028
developmental programmed cell death GO:0010623 138 0.027
actin filament organization GO:0007015 126 0.027
regulation of phosphorus metabolic process GO:0051174 210 0.027
Human Mouse
developmental growth involved in morphogenesis GO:0060560 65 0.027
cellular metal ion homeostasis GO:0006875 31 0.027
regulation of programmed cell death GO:0043067 152 0.027
Human
compound eye development GO:0048749 307 0.027
segmentation GO:0035282 207 0.027
purine containing compound biosynthetic process GO:0072522 30 0.026
camera type eye development GO:0043010 4 0.026
response to oxygen containing compound GO:1901700 200 0.026
divalent inorganic cation transport GO:0072511 30 0.026
metal ion transport GO:0030001 74 0.026
regulation of g protein coupled receptor protein signaling pathway GO:0008277 23 0.026
autophagy GO:0006914 108 0.026
muscle contraction GO:0006936 13 0.026
eye morphogenesis GO:0048592 260 0.026
actin cytoskeleton organization GO:0030036 206 0.025
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.025
positive regulation of catabolic process GO:0009896 105 0.025
Human Mouse
positive regulation of synaptic vesicle recycling GO:1903423 4 0.025
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.025
Human Mouse
negative regulation of nucleic acid templated transcription GO:1903507 240 0.025
transcription from rna polymerase ii promoter GO:0006366 368 0.025
mitotic cytokinesis GO:0000281 50 0.025
l amino acid import GO:0043092 2 0.025
purine nucleoside triphosphate catabolic process GO:0009146 108 0.025
Human Mouse
protein alkylation GO:0008213 43 0.024
cellular ketone metabolic process GO:0042180 24 0.024
cytosolic calcium ion homeostasis GO:0051480 11 0.024
aging GO:0007568 143 0.024
regulation of purine nucleotide metabolic process GO:1900542 62 0.024
Human Mouse
programmed cell death GO:0012501 257 0.024
Human
brain development GO:0007420 120 0.024
gastrulation GO:0007369 70 0.024
cellular amide metabolic process GO:0043603 80 0.024
purine nucleoside catabolic process GO:0006152 112 0.024
Human Mouse
ribonucleoside catabolic process GO:0042454 112 0.024
Human Mouse
dendrite morphogenesis GO:0048813 199 0.024
ribonucleoside triphosphate catabolic process GO:0009203 108 0.024
Human Mouse
inorganic ion transmembrane transport GO:0098660 73 0.024
regulation of tube size GO:0035150 46 0.024
cellular component disassembly GO:0022411 46 0.024
regulation of hormone levels GO:0010817 40 0.024
response to radiation GO:0009314 155 0.023
microtubule polymerization or depolymerization GO:0031109 39 0.023
appendage morphogenesis GO:0035107 397 0.023
anatomical structure homeostasis GO:0060249 97 0.023
inter male aggressive behavior GO:0002121 60 0.023
positive regulation of jun kinase activity GO:0043507 4 0.023
actin filament bundle assembly GO:0051017 26 0.023
defense response to gram negative bacterium GO:0050829 94 0.023
covalent chromatin modification GO:0016569 106 0.023
negative regulation of organelle organization GO:0010639 56 0.023
cellular response to chemical stimulus GO:0070887 199 0.023
positive regulation of programmed cell death GO:0043068 62 0.023
Human
signal transduction by phosphorylation GO:0023014 107 0.023
hindbrain development GO:0030902 2 0.022
nucleotide catabolic process GO:0009166 109 0.022
Human Mouse
response to organophosphorus GO:0046683 2 0.022
protein heterooligomerization GO:0051291 4 0.022
cortical cytoskeleton organization GO:0030865 29 0.022
imaginal disc derived appendage morphogenesis GO:0035114 395 0.022
protein catabolic process GO:0030163 101 0.022
regulation of phosphate metabolic process GO:0019220 210 0.022
Human Mouse
purine nucleoside metabolic process GO:0042278 127 0.022
Human Mouse
multi multicellular organism process GO:0044706 123 0.022
organic hydroxy compound metabolic process GO:1901615 83 0.021
regulation of cell motility GO:2000145 23 0.021
Human
establishment or maintenance of cell polarity GO:0007163 167 0.021
ethanolamine containing compound metabolic process GO:0042439 4 0.021
positive regulation of cell death GO:0010942 69 0.021
Human
single organism cell adhesion GO:0098602 47 0.021
Human
response to light stimulus GO:0009416 124 0.021
ribonucleoside metabolic process GO:0009119 127 0.021
Human Mouse
protein complex disassembly GO:0043241 36 0.021
regulation of mitosis GO:0007088 56 0.021
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.021
heart contraction GO:0060047 26 0.021
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 17 0.021
organic cyclic compound catabolic process GO:1901361 168 0.021
Human Mouse
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.021
inorganic cation transmembrane transport GO:0098662 61 0.021
regulation of immune system process GO:0002682 176 0.021
regulation of response to stress GO:0080134 200 0.020
regulation of cell proliferation GO:0042127 163 0.020
purine containing compound catabolic process GO:0072523 112 0.020
Human Mouse
positive regulation of developmental growth GO:0048639 62 0.020
regulation of synaptic vesicle transport GO:1902803 10 0.020
positive regulation of phosphorylation GO:0042327 87 0.020
regulation of synaptic plasticity GO:0048167 14 0.020
negative regulation of cell differentiation GO:0045596 143 0.020
establishment of cell polarity GO:0030010 40 0.020
cellular protein complex disassembly GO:0043624 35 0.020
cell migration involved in gastrulation GO:0042074 9 0.020
myotube cell development GO:0014904 3 0.020
rhythmic synaptic transmission GO:0060024 2 0.020
response to extracellular stimulus GO:0009991 116 0.020
immune system process GO:0002376 347 0.020
Mouse
central nervous system development GO:0007417 201 0.020
negative regulation of protein complex disassembly GO:0043242 23 0.020
body morphogenesis GO:0010171 2 0.020
telencephalon development GO:0021537 2 0.020
generation of precursor metabolites and energy GO:0006091 42 0.020
calcium ion homeostasis GO:0055074 23 0.020
mitotic cell cycle phase transition GO:0044772 138 0.020
metal ion homeostasis GO:0055065 44 0.019
cellular macromolecule catabolic process GO:0044265 136 0.019
imaginal disc derived wing morphogenesis GO:0007476 337 0.019
negative regulation of homeostatic process GO:0032845 2 0.019
wing disc morphogenesis GO:0007472 344 0.019
oxidation reduction process GO:0055114 123 0.019
cell growth GO:0016049 108 0.019
regulation of neurotransmitter transport GO:0051588 14 0.019
positive regulation of synaptic vesicle endocytosis GO:1900244 4 0.019
tripartite regional subdivision GO:0007351 103 0.019
regulation of heart rate GO:0002027 11 0.019
cytoskeleton dependent intracellular transport GO:0030705 44 0.019
response to hexose GO:0009746 3 0.019
positive regulation of neurotransmitter secretion GO:0001956 2 0.019
regulation of immune response GO:0050776 118 0.019
cellular response to organic substance GO:0071310 132 0.019
determination of adult lifespan GO:0008340 137 0.019
golgi organization GO:0007030 66 0.018
rna processing GO:0006396 147 0.018
sensory perception of mechanical stimulus GO:0050954 72 0.018
positive regulation of protein metabolic process GO:0051247 128 0.018
regulation of system process GO:0044057 36 0.018
protein localization GO:0008104 284 0.018
regulation of gene expression epigenetic GO:0040029 128 0.018
exocrine system development GO:0035272 162 0.018
reproductive behavior GO:0019098 122 0.018
multi organism behavior GO:0051705 175 0.018
vesicle fusion GO:0006906 19 0.018
cell fate determination GO:0001709 91 0.018
dorsal ventral pattern formation GO:0009953 133 0.018
negative regulation of protein depolymerization GO:1901880 23 0.018
protein maturation GO:0051604 71 0.018
cytoskeleton dependent cytokinesis GO:0061640 81 0.017
heart development GO:0007507 82 0.017
protein localization to plasma membrane GO:0072659 13 0.017
regulation of cellular amino acid metabolic process GO:0006521 0 0.017
organophosphate catabolic process GO:0046434 112 0.017
Human Mouse
regulation of blood circulation GO:1903522 21 0.017
response to temperature stimulus GO:0009266 106 0.017
cellular macromolecular complex assembly GO:0034622 153 0.017
response to lipopolysaccharide GO:0032496 4 0.017
regulation of neuronal synaptic plasticity GO:0048168 8 0.017

rtGEF disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.145
vascular disease DOID:178 0 0.069
cardiovascular system disease DOID:1287 0 0.069
disease of cellular proliferation DOID:14566 0 0.063
hypertension DOID:10763 0 0.032
artery disease DOID:0050828 0 0.032
cancer DOID:162 0 0.028
organ system cancer DOID:0050686 0 0.028
nervous system disease DOID:863 0 0.027
essential hypertension DOID:10825 0 0.024
disease of metabolism DOID:0014667 0 0.022
inherited metabolic disorder DOID:655 0 0.022
central nervous system disease DOID:331 0 0.019