Drosophila melanogaster

183 known processes

polo (Dmel_CG12306)

CG12306 gene product from transcript CG12306-RA

(Aliases: Dmel\CG12306,l(3)77Aa,Polo,POLO/PLK1,CG12306,l(3)S025604,0256/04,l(3)S132408,l(3)01673,POLO,anon-WO0172774.3,1324/08)

polo biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
meiotic cell cycle process GO:1903046 132 1.000
organelle fission GO:0048285 340 1.000
nuclear division GO:0000280 332 1.000
meiotic cell cycle GO:0051321 171 1.000
chromosome organization GO:0051276 360 1.000
Human Yeast
meiotic nuclear division GO:0007126 151 1.000
meiosis i GO:0007127 59 1.000
Yeast Worm
meiotic spindle organization GO:0000212 36 1.000
chromosome segregation GO:0007059 157 0.999
Human Yeast Worm
spermatogenesis GO:0007283 200 0.999
cell division GO:0051301 248 0.999
spindle organization GO:0007051 253 0.999
male meiosis GO:0007140 52 0.999
mitotic sister chromatid separation GO:0051306 30 0.998
Human
organelle assembly GO:0070925 198 0.995
spindle assembly involved in meiosis GO:0090306 20 0.995
cytokinesis GO:0000910 90 0.991
male gamete generation GO:0048232 201 0.990
mitotic nuclear division GO:0007067 213 0.987
mitotic spindle organization GO:0007052 220 0.984
development of primary sexual characteristics GO:0045137 50 0.984
Worm
dna conformation change GO:0071103 105 0.978
regulation of mitotic cell cycle GO:0007346 190 0.977
Human
gonad development GO:0008406 50 0.975
Worm
regulation of neurogenesis GO:0050767 158 0.971
microtubule organizing center organization GO:0031023 168 0.968
spermatid differentiation GO:0048515 114 0.964
single fertilization GO:0007338 24 0.944
regulation of cell cycle phase transition GO:1901987 130 0.933
Human
regulation of cell cycle GO:0051726 291 0.923
Human Yeast Worm
centrosome duplication GO:0051298 121 0.920
cell cycle phase transition GO:0044770 140 0.914
Human
cytoskeleton dependent cytokinesis GO:0061640 81 0.914
oocyte maturation GO:0001556 3 0.895
reproductive system development GO:0061458 74 0.881
Worm
cellular component assembly involved in morphogenesis GO:0010927 151 0.872
neuroblast proliferation GO:0007405 74 0.869
reproductive structure development GO:0048608 74 0.859
Worm
meiotic chromosome segregation GO:0045132 59 0.853
Yeast Worm
centrosome cycle GO:0007098 137 0.841
Worm
chromosome separation GO:0051304 42 0.830
Human Yeast
negative regulation of gene expression GO:0010629 387 0.830
Human
negative regulation of cell cycle GO:0045786 116 0.829
Human
mitotic cell cycle phase transition GO:0044772 138 0.824
Human
regulation of microtubule based process GO:0032886 49 0.824
Yeast
female meiotic division GO:0007143 70 0.802
negative regulation of cellular biosynthetic process GO:0031327 277 0.799
Human
spindle assembly involved in female meiosis GO:0007056 14 0.791
regulation of cell cycle process GO:0010564 181 0.791
Human Yeast Worm
regulation of organelle organization GO:0033043 196 0.789
Human Yeast Worm
mitotic cell cycle checkpoint GO:0007093 88 0.784
Human
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.773
Human
nucleus organization GO:0006997 45 0.769
positive regulation of protein metabolic process GO:0051247 128 0.759
Human
sister chromatid segregation GO:0000819 92 0.736
Human
protein modification process GO:0036211 438 0.731
neural precursor cell proliferation GO:0061351 75 0.730
regulation of mitosis GO:0007088 56 0.720
Human
chromosome condensation GO:0030261 41 0.713
spindle assembly involved in mitosis GO:0090307 50 0.693
regulation of meiosis GO:0040020 3 0.687
Worm
centrosome organization GO:0051297 163 0.682
actomyosin structure organization GO:0031032 56 0.677
mitotic sister chromatid segregation GO:0000070 87 0.675
Human
regulation of neuroblast proliferation GO:1902692 34 0.673
regulation of growth GO:0040008 233 0.668
cell death GO:0008219 279 0.665
Human Worm
meiosis ii GO:0007135 23 0.663
cellular protein modification process GO:0006464 438 0.642
body morphogenesis GO:0010171 2 0.640
regulation of protein metabolic process GO:0051246 256 0.636
Human
mitotic spindle stabilization GO:0043148 6 0.635
spindle assembly GO:0051225 80 0.629
sex differentiation GO:0007548 81 0.616
Worm
regulation of multicellular organismal development GO:2000026 414 0.614
negative regulation of biosynthetic process GO:0009890 277 0.612
Human
phosphorylation GO:0016310 294 0.605
negative regulation of rna biosynthetic process GO:1902679 240 0.599
Human
stem cell maintenance GO:0019827 67 0.599
chromatin modification GO:0016568 147 0.595
spermatid development GO:0007286 98 0.595
establishment of cell polarity GO:0030010 40 0.582
positive regulation of macromolecule metabolic process GO:0010604 405 0.571
Human
positive regulation of developmental process GO:0051094 143 0.568
stem cell differentiation GO:0048863 117 0.566
female meiosis i GO:0007144 8 0.564
regulation of cytoskeleton organization GO:0051493 89 0.545
Yeast
regulation of proteasomal protein catabolic process GO:0061136 39 0.545
Human
embryo development ending in birth or egg hatching GO:0009792 152 0.542
Worm
positive regulation of cellular protein metabolic process GO:0032270 118 0.542
Human
regulation of cell differentiation GO:0045595 302 0.541
ubiquitin dependent protein catabolic process GO:0006511 78 0.534
Human
cellular protein complex disassembly GO:0043624 35 0.521
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.504
Human
modification dependent protein catabolic process GO:0019941 78 0.494
Human
regulation of mitotic spindle organization GO:0060236 9 0.461
positive regulation of transcription dna templated GO:0045893 266 0.453
regulation of chromosome segregation GO:0051983 32 0.445
Human
positive regulation of neurogenesis GO:0050769 41 0.438
regulation of mitotic sister chromatid segregation GO:0033047 28 0.426
Human
fertilization GO:0009566 26 0.417
cellular component disassembly GO:0022411 46 0.412
Yeast Worm
establishment of localization in cell GO:0051649 402 0.398
regulation of cell proliferation GO:0042127 163 0.395
chromatin organization GO:0006325 207 0.369
meiotic sister chromatid segregation GO:0045144 6 0.363
mitotic cytokinesis GO:0000281 50 0.361
Human
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.356
Human
regulation of microtubule cytoskeleton organization GO:0070507 41 0.348
Yeast
regulation of developmental growth GO:0048638 174 0.343
spindle stabilization GO:0043146 14 0.331
positive regulation of multicellular organismal process GO:0051240 143 0.327
regulation of cell division GO:0051302 72 0.327
Human Worm
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.326
Human
regulation of cell death GO:0010941 173 0.316
Human
embryonic morphogenesis GO:0048598 206 0.316
asymmetric cell division GO:0008356 37 0.316
tube development GO:0035295 244 0.313
negative regulation of developmental process GO:0051093 201 0.305
modification dependent macromolecule catabolic process GO:0043632 79 0.305
Human
positive regulation of cell development GO:0010720 61 0.304
regulation of mitotic cell cycle phase transition GO:1901990 130 0.293
Human
macromolecular complex disassembly GO:0032984 37 0.292
dendrite development GO:0016358 204 0.280
stem cell division GO:0017145 69 0.270
imaginal disc derived appendage morphogenesis GO:0035114 395 0.266
protein complex biogenesis GO:0070271 201 0.264
cystoblast division GO:0007282 10 0.262
asymmetric stem cell division GO:0098722 49 0.259
regulation of mitotic sister chromatid separation GO:0010965 28 0.255
Human
cell migration GO:0016477 238 0.252
meiotic cytokinesis GO:0033206 33 0.249
rna localization GO:0006403 115 0.248
regulation of cell development GO:0060284 215 0.247
regulation of protein complex disassembly GO:0043244 29 0.244
neuroblast division GO:0055057 35 0.241
negative regulation of transcription dna templated GO:0045892 237 0.240
Human
apoptotic process GO:0006915 159 0.239
Human Worm
negative regulation of protein metabolic process GO:0051248 85 0.232
Human
pronuclear migration GO:0035046 4 0.227
positive regulation of nervous system development GO:0051962 69 0.223
death GO:0016265 284 0.222
Human Worm
negative regulation of multicellular organismal process GO:0051241 142 0.222
regulation of localization GO:0032879 275 0.221
regulation of nuclear division GO:0051783 58 0.219
Human Worm
metaphase anaphase transition of cell cycle GO:0044784 28 0.219
Human
endocytosis GO:0006897 310 0.216
nuclear migration GO:0007097 20 0.215
protein complex assembly GO:0006461 200 0.210
gene silencing GO:0016458 138 0.208
regulation of neuron differentiation GO:0045664 103 0.208
regulation of phosphate metabolic process GO:0019220 210 0.201
Human
stem cell proliferation GO:0072089 88 0.193
programmed cell death GO:0012501 257 0.192
Human Worm
regulation of nervous system development GO:0051960 248 0.189
protein complex disassembly GO:0043241 36 0.188
cell motility GO:0048870 251 0.187
larval development GO:0002164 104 0.182
Worm
microtubule cytoskeleton organization involved in mitosis GO:1902850 52 0.180
cellular macromolecule localization GO:0070727 220 0.174
protein depolymerization GO:0051261 31 0.169
dna packaging GO:0006323 91 0.168
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.165
Human
single organism intracellular transport GO:1902582 207 0.165
canonical wnt signaling pathway GO:0060070 21 0.163
regulation of proteolysis GO:0030162 87 0.163
Human
negative regulation of cellular component organization GO:0051129 108 0.163
Human
nuclear import GO:0051170 51 0.161
synaptonemal complex organization GO:0070193 5 0.157
Yeast
regulation of meiotic cell cycle GO:0051445 9 0.155
Worm
neuronal stem cell division GO:0036445 35 0.155
mitotic chromosome condensation GO:0007076 22 0.154
maintenance of location GO:0051235 73 0.154
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.154
Human
regulation of wnt signaling pathway GO:0030111 68 0.148
developmental maturation GO:0021700 172 0.145
regulation of cellular response to stress GO:0080135 89 0.143
establishment or maintenance of cell polarity GO:0007163 167 0.143
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.142
Human
regulation of protein localization GO:0032880 76 0.141
macromolecule catabolic process GO:0009057 161 0.140
Human
single organism cellular localization GO:1902580 180 0.135
cellular response to dna damage stimulus GO:0006974 223 0.132
Human
regulation of sister chromatid segregation GO:0033045 28 0.131
Human
establishment of spindle orientation GO:0051294 18 0.130
negative regulation of mitotic sister chromatid separation GO:2000816 13 0.130
Human
neuron projection guidance GO:0097485 241 0.130
meiotic cell cycle phase transition GO:0044771 4 0.129
protein phosphorylation GO:0006468 169 0.126
cellular macromolecule catabolic process GO:0044265 136 0.126
Human
positive regulation of mitotic cell cycle GO:0045931 34 0.125
Human
positive regulation of cell proliferation GO:0008284 47 0.124
axon guidance GO:0007411 233 0.120
regulation of phosphorus metabolic process GO:0051174 210 0.120
Human
genitalia development GO:0048806 26 0.119
Worm
positive regulation of programmed cell death GO:0043068 62 0.119
regulation of canonical wnt signaling pathway GO:0060828 15 0.114
developmental programmed cell death GO:0010623 138 0.113
digestive tract development GO:0048565 149 0.112
immune system development GO:0002520 57 0.112
wing disc morphogenesis GO:0007472 344 0.110
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.109
Human
negative regulation of cell division GO:0051782 17 0.109
Human
germ line stem cell division GO:0042078 25 0.109
macromolecular complex assembly GO:0065003 256 0.108
regulation of nucleocytoplasmic transport GO:0046822 35 0.107
microtubule depolymerization GO:0007019 25 0.106
myofibril assembly GO:0030239 36 0.106
negative regulation of protein complex disassembly GO:0043242 23 0.103
negative regulation of microtubule depolymerization GO:0007026 21 0.102
female meiosis chromosome segregation GO:0016321 33 0.101
purine nucleoside triphosphate catabolic process GO:0009146 108 0.100
positive regulation of metaphase anaphase transition of cell cycle GO:1902101 10 0.099
Human
regulation of catalytic activity GO:0050790 185 0.099
Human Yeast
axon development GO:0061564 297 0.098
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.096
Human
establishment of spindle localization GO:0051293 22 0.096
negative regulation of mitotic cell cycle GO:0045930 109 0.092
Human
mitotic g2 m transition checkpoint GO:0044818 70 0.092
immune system process GO:0002376 347 0.092
negative regulation of nucleic acid templated transcription GO:1903507 240 0.092
Human
asymmetric neuroblast division GO:0055059 33 0.092
appendage development GO:0048736 401 0.088
regulation of cellular protein metabolic process GO:0032268 243 0.088
Human
negative regulation of cellular protein metabolic process GO:0032269 85 0.088
Human
dna amplification GO:0006277 11 0.087
nucleus localization GO:0051647 34 0.087
protein localization GO:0008104 284 0.086
epithelial cell differentiation GO:0030855 322 0.085
maintenance of location in cell GO:0051651 28 0.085
positive regulation of cellular catabolic process GO:0031331 95 0.083
Human
cytoplasmic transport GO:0016482 130 0.082
photoreceptor cell differentiation GO:0046530 170 0.081
positive regulation of cell differentiation GO:0045597 64 0.081
stem cell development GO:0048864 79 0.081
regulation of phosphorylation GO:0042325 147 0.080
Human
positive regulation of nucleic acid templated transcription GO:1903508 266 0.079
mitotic g2 dna damage checkpoint GO:0007095 69 0.079
regulation of protein catabolic process GO:0042176 55 0.078
Human
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.077
Human
oocyte development GO:0048599 124 0.076
cellular protein catabolic process GO:0044257 83 0.076
Human
protein modification by small protein conjugation or removal GO:0070647 106 0.074
Human
positive regulation of proteolysis GO:0045862 52 0.074
Human
membrane disassembly GO:0030397 4 0.071
Worm
regulation of cellular protein catabolic process GO:1903362 44 0.071
Human
regulation of intracellular protein transport GO:0033157 46 0.069
protein dna complex subunit organization GO:0071824 86 0.068
negative regulation of cell proliferation GO:0008285 69 0.068
positive regulation of protein import into nucleus GO:0042307 21 0.067
dendrite morphogenesis GO:0048813 199 0.066
negative regulation of cell development GO:0010721 62 0.066
regulation of microtubule depolymerization GO:0031114 24 0.065
metaphase anaphase transition of mitotic cell cycle GO:0007091 28 0.065
Human
malpighian tubule morphogenesis GO:0007443 44 0.065
aromatic compound catabolic process GO:0019439 166 0.064
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.064
histoblast morphogenesis GO:0007488 9 0.063
muscle organ development GO:0007517 127 0.063
compound eye morphogenesis GO:0001745 249 0.063
establishment of organelle localization GO:0051656 122 0.062
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.062
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.061
Human
regulation of protein kinase activity GO:0045859 51 0.061
Human
proteolysis GO:0006508 192 0.060
Human
negative regulation of protein depolymerization GO:1901880 23 0.059
proteasomal protein catabolic process GO:0010498 59 0.059
Human
mitotic spindle assembly checkpoint GO:0007094 11 0.059
Human
regulation of chromosome organization GO:0033044 64 0.059
Human
regulation of response to stress GO:0080134 200 0.058
positive regulation of gene expression GO:0010628 290 0.058
negative regulation of cellular metabolic process GO:0031324 382 0.057
Human
axonogenesis GO:0007409 290 0.055
negative regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032435 16 0.055
Human
organic substance transport GO:0071702 257 0.054
membrane organization GO:0061024 112 0.054
Worm
regulation of protein modification process GO:0031399 112 0.053
Human
mitotic cell cycle embryonic GO:0045448 38 0.052
positive regulation of phosphorylation GO:0042327 87 0.051
Human
mrna metabolic process GO:0016071 124 0.051
hematopoietic or lymphoid organ development GO:0048534 57 0.050
negative regulation of rna metabolic process GO:0051253 251 0.049
Human
regulation of spindle organization GO:0090224 17 0.049
regulation of molecular function GO:0065009 217 0.049
Human Yeast
organonitrogen compound metabolic process GO:1901564 318 0.048
dna integrity checkpoint GO:0031570 81 0.048
Human
response to radiation GO:0009314 155 0.047
neuron recognition GO:0008038 101 0.047
somatic stem cell division GO:0048103 37 0.047
regulation of programmed cell death GO:0043067 152 0.046
Human
positive regulation of transcription factor import into nucleus GO:0042993 19 0.046
negative regulation of cell differentiation GO:0045596 143 0.046
central nervous system development GO:0007417 201 0.046
protein localization to organelle GO:0033365 82 0.045
Human
eye development GO:0001654 323 0.045
renal tubule development GO:0061326 64 0.045
imaginal disc derived appendage development GO:0048737 399 0.044
morphogenesis of an epithelium GO:0002009 276 0.044
hindgut development GO:0061525 58 0.044
positive regulation of biosynthetic process GO:0009891 316 0.044
positive regulation of catabolic process GO:0009896 105 0.043
Human
posttranscriptional regulation of gene expression GO:0010608 145 0.043
Human
sensory organ precursor cell division GO:0045035 10 0.042
establishment of mitotic spindle localization GO:0040001 17 0.042
appendage morphogenesis GO:0035107 397 0.042
establishment of mitotic spindle orientation GO:0000132 13 0.042
nuclear transport GO:0051169 72 0.042
organelle localization GO:0051640 148 0.042
cellular catabolic process GO:0044248 372 0.041
Human
regulation of protein localization to nucleus GO:1900180 29 0.041
receptor mediated endocytosis GO:0006898 21 0.041
protein import into nucleus GO:0006606 51 0.041
regulation of dendrite development GO:0050773 37 0.040
wnt signaling pathway GO:0016055 98 0.040
atp metabolic process GO:0046034 49 0.040
nuclear envelope organization GO:0006998 7 0.040
Worm
regulation of dna metabolic process GO:0051052 34 0.040
eggshell formation GO:0030703 105 0.040
negative regulation of cell cycle process GO:0010948 109 0.039
Human
regulation of rac gtpase activity GO:0032314 1 0.039
ovarian follicle cell development GO:0030707 248 0.039
positive regulation of response to stimulus GO:0048584 323 0.039
regulation of protein phosphatase type 2a activity GO:0034047 2 0.038
chromosome organization involved in meiosis GO:0070192 10 0.038
negative regulation of organelle organization GO:0010639 56 0.038
Human
dna metabolic process GO:0006259 227 0.037
Yeast
negative regulation of mitotic sister chromatid segregation GO:0033048 13 0.037
Human
positive regulation of cellular biosynthetic process GO:0031328 316 0.037
spindle assembly involved in female meiosis i GO:0007057 5 0.037
positive regulation of cell communication GO:0010647 250 0.037
purine nucleoside triphosphate metabolic process GO:0009144 119 0.037
oocyte microtubule cytoskeleton organization GO:0016325 35 0.037
embryonic development via the syncytial blastoderm GO:0001700 148 0.036
endomembrane system organization GO:0010256 119 0.036
Worm
regulation of chromatin binding GO:0035561 3 0.035
defense response GO:0006952 300 0.035
negative regulation of cell cycle phase transition GO:1901988 103 0.035
Human
cell cycle g1 s phase transition GO:0044843 31 0.035
positive regulation of cell death GO:0010942 69 0.035
regulation of protein depolymerization GO:1901879 27 0.034
brain development GO:0007420 120 0.034
positive regulation of mitotic cell cycle phase transition GO:1901992 20 0.033
Human
regulation of transferase activity GO:0051338 58 0.033
Human
oxoacid metabolic process GO:0043436 103 0.033
oocyte differentiation GO:0009994 145 0.033
regulation of neuron projection development GO:0010975 69 0.032
protein targeting to nucleus GO:0044744 51 0.032
positive regulation of mitotic sister chromatid separation GO:1901970 10 0.031
Human
digestive system development GO:0055123 149 0.031
spindle localization GO:0051653 22 0.031
epithelial cell development GO:0002064 274 0.031
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.031
Human
translation GO:0006412 69 0.031
tube morphogenesis GO:0035239 191 0.031
protein ubiquitination GO:0016567 70 0.031
Human
mitotic dna integrity checkpoint GO:0044774 75 0.030
cellular macromolecular complex assembly GO:0034622 153 0.030
response to endogenous stimulus GO:0009719 119 0.030
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 24 0.030
Human
regulation of cellular component biogenesis GO:0044087 201 0.029
positive regulation of growth GO:0045927 75 0.029
g2 dna damage checkpoint GO:0031572 69 0.029
Human
protein localization to nucleus GO:0034504 55 0.029
nucleocytoplasmic transport GO:0006913 72 0.029
regulation of mitotic spindle elongation GO:0032888 1 0.029
negative regulation of metaphase anaphase transition of cell cycle GO:1902100 13 0.029
Human
actin filament based process GO:0030029 220 0.028
negative regulation of purine nucleotide catabolic process GO:0033122 1 0.028
actin cytoskeleton organization GO:0030036 206 0.028
determination of adult lifespan GO:0008340 137 0.028
wing disc pattern formation GO:0035222 66 0.028
regulation of catabolic process GO:0009894 170 0.028
Human
cardiovascular system development GO:0072358 82 0.028
microtubule polymerization or depolymerization GO:0031109 39 0.028
meiotic sister chromatid cohesion GO:0051177 6 0.027
regulation of response to dna damage stimulus GO:2001020 23 0.027
assembly of actomyosin apparatus involved in cytokinesis GO:0000912 11 0.027
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.026
growth GO:0040007 359 0.026
dna damage checkpoint GO:0000077 78 0.026
Human
protein catabolic process GO:0030163 101 0.025
Human
cellular response to oxygen containing compound GO:1901701 79 0.025
multicellular organismal aging GO:0010259 140 0.025
neuronal stem cell maintenance GO:0097150 4 0.025
eggshell chorion gene amplification GO:0007307 9 0.025
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.024
sensory organ morphogenesis GO:0090596 260 0.024
chorion containing eggshell formation GO:0007304 105 0.024
regulation of exit from mitosis GO:0007096 7 0.024
negative regulation of programmed cell death GO:0043069 72 0.024
Human
hindgut morphogenesis GO:0007442 58 0.024
establishment of nucleus localization GO:0040023 26 0.024
regulation of microtubule polymerization or depolymerization GO:0031110 27 0.024
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 30 0.023
Human
protein modification by small protein conjugation GO:0032446 79 0.023
Human
icosanoid biosynthetic process GO:0046456 1 0.023
cell fate determination GO:0001709 91 0.023
regulation of synapse structure and activity GO:0050803 128 0.023
purine nucleotide metabolic process GO:0006163 146 0.023
negative regulation of microtubule polymerization or depolymerization GO:0031111 21 0.023
positive regulation of developmental growth GO:0048639 62 0.022
embryonic axis specification GO:0000578 107 0.022
regulation of intracellular signal transduction GO:1902531 236 0.022
regulation of apoptotic process GO:0042981 130 0.022
Human
single organism biosynthetic process GO:0044711 206 0.022
syncytial blastoderm mitotic cell cycle GO:0035186 21 0.022
nucleotide metabolic process GO:0009117 161 0.022
cellular nitrogen compound catabolic process GO:0044270 165 0.022
dna dependent dna replication GO:0006261 17 0.021
response to organic substance GO:0010033 284 0.021
dna replication GO:0006260 48 0.021
cell proliferation GO:0008283 299 0.021
catabolic process GO:0009056 409 0.021
Human
purine nucleoside catabolic process GO:0006152 112 0.021
developmental growth GO:0048589 280 0.020
epithelial tube morphogenesis GO:0060562 88 0.020
positive regulation of transferase activity GO:0051347 26 0.020
Human
nucleoside triphosphate metabolic process GO:0009141 120 0.020
mitotic dna damage checkpoint GO:0044773 74 0.020
regulation of intracellular transport GO:0032386 64 0.020
regulation of neural precursor cell proliferation GO:2000177 35 0.020
synaptic transmission GO:0007268 288 0.020
negative regulation of nervous system development GO:0051961 92 0.020
positive regulation of signal transduction GO:0009967 223 0.019
male meiosis cytokinesis GO:0007112 26 0.019
regulation of protein import into nucleus GO:0042306 28 0.019
macromolecule methylation GO:0043414 45 0.019
regulation of organ morphogenesis GO:2000027 78 0.019
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.019
cytokinetic cell separation GO:0000920 1 0.019
negative regulation of cellular catabolic process GO:0031330 34 0.018
Human
negative regulation of meiotic cell cycle GO:0051447 2 0.018
positive regulation of cell cycle GO:0045787 43 0.018
Human Yeast
intercellular bridge organization GO:0043063 14 0.018
positive regulation of catalytic activity GO:0043085 118 0.018
Human Yeast
establishment of meiotic spindle orientation GO:0051296 2 0.018
oocyte morphogenesis GO:0048601 3 0.018
single organism membrane organization GO:0044802 93 0.018
Worm
microtubule anchoring GO:0034453 11 0.018
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 19 0.018
Human
negative regulation of proteolysis GO:0045861 31 0.017
Human
response to nitrogen compound GO:1901698 90 0.017
negative regulation of mitotic metaphase anaphase transition GO:0045841 13 0.017
Human
transcription from rna polymerase ii promoter GO:0006366 368 0.017
Human
columnar cuboidal epithelial cell development GO:0002066 249 0.017
positive regulation of stem cell maintenance GO:1902459 1 0.017
sister chromatid cohesion GO:0007062 18 0.017
cellular protein localization GO:0034613 160 0.016
negative regulation of nuclear division GO:0051784 17 0.016
Human
centriole replication GO:0007099 24 0.016
chromosome movement towards spindle pole GO:0051305 4 0.016
kinetochore organization GO:0051383 9 0.016
gland development GO:0048732 191 0.016
regulation of sister chromatid cohesion GO:0007063 2 0.016
regulation of transport GO:0051049 181 0.016
positive regulation of nucleocytoplasmic transport GO:0046824 24 0.016
striated muscle cell development GO:0055002 50 0.016
positive regulation of protein phosphorylation GO:0001934 34 0.016
Human
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.016
response to ionizing radiation GO:0010212 32 0.016
tissue morphogenesis GO:0048729 297 0.015
positive regulation of neuron differentiation GO:0045666 26 0.015
dendrite regeneration GO:0031104 2 0.015
organic substance catabolic process GO:1901575 308 0.015
Human
regulation of cytoplasmic transport GO:1903649 47 0.015
organonitrogen compound catabolic process GO:1901565 128 0.015
positive regulation of immune system process GO:0002684 68 0.015
establishment of meiotic spindle localization GO:0051295 3 0.015
positive regulation of cellular component organization GO:0051130 156 0.015
Human Yeast
positive regulation of hydrolase activity GO:0051345 78 0.015
spindle elongation GO:0051231 83 0.015
multi multicellular organism process GO:0044706 123 0.014
covalent chromatin modification GO:0016569 106 0.014
meiotic g2 mi transition GO:0008315 3 0.014
meiotic chromosome condensation GO:0010032 3 0.014
regulation of cytokinesis GO:0032465 3 0.014
negative regulation of catalytic activity GO:0043086 42 0.014
Human
dna recombination GO:0006310 32 0.014
Yeast
regulation of protein transport GO:0051223 57 0.014
negative regulation of response to stimulus GO:0048585 258 0.014
circulatory system development GO:0072359 82 0.014
ribonucleoside triphosphate catabolic process GO:0009203 108 0.014
female germ line cyst formation GO:0048135 42 0.014
ribonucleoside monophosphate metabolic process GO:0009161 51 0.014
vesicle mediated transport GO:0016192 381 0.014
protein import GO:0017038 55 0.014
purine ribonucleoside catabolic process GO:0046130 112 0.014
taxis GO:0042330 304 0.014
compound eye development GO:0048749 307 0.014
synaptic growth at neuromuscular junction GO:0051124 119 0.014
cellular response to organic substance GO:0071310 132 0.013

polo disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.052
nervous system disease DOID:863 0 0.052
disease of cellular proliferation DOID:14566 0 0.043
immune system cancer DOID:0060083 0 0.026
hematologic cancer DOID:2531 0 0.026
cancer DOID:162 0 0.026
organ system cancer DOID:0050686 0 0.026
bone marrow cancer DOID:4960 0 0.026