Drosophila melanogaster

148 known processes

step (Dmel_CG11628)

steppke

(Aliases: cytohesin/GRP1,GPH,l(2)k08110,l(2)SH0323,CG11633,stepk,CG11628,GRP1/cytohesin 1,l(2)SH2 0323,Grp1,GRP1,CYH1,Dmel\CG11628)

step biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
phosphorylation GO:0016310 294 0.784
regulation of synaptic growth at neuromuscular junction GO:0008582 89 0.752
neuromuscular junction development GO:0007528 149 0.751
tissue morphogenesis GO:0048729 297 0.718
negative regulation of cell communication GO:0010648 223 0.707
synapse organization GO:0050808 196 0.628
regulation of growth GO:0040008 233 0.610
regulation of developmental growth GO:0048638 174 0.534
protein phosphorylation GO:0006468 169 0.430
growth GO:0040007 359 0.425
synaptic growth at neuromuscular junction GO:0051124 119 0.390
intracellular signal transduction GO:0035556 300 0.350
negative regulation of signal transduction GO:0009968 206 0.322
imaginal disc derived appendage development GO:0048737 399 0.310
morphogenesis of an epithelium GO:0002009 276 0.306
intracellular transport GO:0046907 228 0.274
Human
organic substance catabolic process GO:1901575 308 0.271
Human Mouse
chemical homeostasis GO:0048878 92 0.250
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.243
post embryonic appendage morphogenesis GO:0035120 385 0.238
autophagy GO:0006914 108 0.233
regionalization GO:0003002 416 0.232
regulation of synapse structure and activity GO:0050803 128 0.225
imaginal disc derived appendage morphogenesis GO:0035114 395 0.224
actin cytoskeleton organization GO:0030036 206 0.218
cellular protein catabolic process GO:0044257 83 0.214
macromolecule catabolic process GO:0009057 161 0.212
negative regulation of response to stimulus GO:0048585 258 0.212
regulation of cellular component biogenesis GO:0044087 201 0.210
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.209
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.186
regulation of cellular amino acid metabolic process GO:0006521 0 0.183
cation transport GO:0006812 110 0.179
regulation of catabolic process GO:0009894 170 0.175
Human Mouse
regulation of notch signaling pathway GO:0008593 100 0.175
gland development GO:0048732 191 0.170
multicellular organism growth GO:0035264 46 0.167
negative regulation of signaling GO:0023057 219 0.164
salivary gland morphogenesis GO:0007435 145 0.163
appendage development GO:0048736 401 0.162
regulation of lipid metabolic process GO:0019216 15 0.161
gland morphogenesis GO:0022612 145 0.160
modification dependent protein catabolic process GO:0019941 78 0.157
positive regulation of signaling GO:0023056 243 0.155
programmed cell death GO:0012501 257 0.154
modification dependent macromolecule catabolic process GO:0043632 79 0.153
embryonic development via the syncytial blastoderm GO:0001700 148 0.149
ubiquitin dependent protein catabolic process GO:0006511 78 0.146
inositol lipid mediated signaling GO:0048017 4 0.142
positive regulation of developmental growth GO:0048639 62 0.141
positive regulation of synaptic growth at neuromuscular junction GO:0045887 26 0.138
imaginal disc derived wing morphogenesis GO:0007476 337 0.133
death GO:0016265 284 0.133
regulation of nervous system development GO:0051960 248 0.133
carbohydrate derivative metabolic process GO:1901135 217 0.129
Human Mouse
cellular catabolic process GO:0044248 372 0.129
Human Mouse
regulation of intracellular signal transduction GO:1902531 236 0.125
nucleobase containing compound catabolic process GO:0034655 165 0.124
Human Mouse
regulation of cellular ketone metabolic process GO:0010565 3 0.123
protein modification process GO:0036211 438 0.122
regulation of multicellular organism growth GO:0040014 40 0.121
tor signaling GO:0031929 32 0.118
regulation of multicellular organismal development GO:2000026 414 0.116
synapse assembly GO:0007416 143 0.115
purine nucleoside triphosphate metabolic process GO:0009144 119 0.114
Human Mouse
localization of cell GO:0051674 257 0.111
aromatic compound catabolic process GO:0019439 166 0.110
Human Mouse
nucleoside triphosphate metabolic process GO:0009141 120 0.109
Human Mouse
regulation of cell death GO:0010941 173 0.107
phosphatidylinositol mediated signaling GO:0048015 4 0.106
regulation of cellular localization GO:0060341 136 0.106
proteolysis GO:0006508 192 0.106
response to radiation GO:0009314 155 0.104
establishment of localization in cell GO:0051649 402 0.104
Human
positive regulation of cell communication GO:0010647 250 0.102
positive regulation of cellular component biogenesis GO:0044089 80 0.101
single organism biosynthetic process GO:0044711 206 0.100
erbb signaling pathway GO:0038127 58 0.098
embryonic morphogenesis GO:0048598 206 0.096
macroautophagy GO:0016236 42 0.096
actin filament based process GO:0030029 220 0.093
wing disc morphogenesis GO:0007472 344 0.093
regulation of programmed cell death GO:0043067 152 0.091
catabolic process GO:0009056 409 0.089
Human Mouse
organelle fusion GO:0048284 46 0.089
single organism intracellular transport GO:1902582 207 0.088
Human
cell death GO:0008219 279 0.086
nitrogen compound transport GO:0071705 85 0.086
appendage morphogenesis GO:0035107 397 0.084
regulation of proteolysis GO:0030162 87 0.083
lipid biosynthetic process GO:0008610 46 0.083
regulation of epidermal growth factor receptor signaling pathway GO:0042058 42 0.083
negative regulation of autophagy GO:0010507 16 0.082
determination of adult lifespan GO:0008340 137 0.081
peptidyl threonine phosphorylation GO:0018107 2 0.080
protein catabolic process GO:0030163 101 0.080
regulation of cell cycle process GO:0010564 181 0.079
actin filament organization GO:0007015 126 0.079
cell motility GO:0048870 251 0.077
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.076
developmental growth GO:0048589 280 0.075
negative regulation of synaptic growth at neuromuscular junction GO:0045886 39 0.075
autophagic cell death GO:0048102 83 0.075
nucleotide metabolic process GO:0009117 161 0.074
Human Mouse
nucleoside metabolic process GO:0009116 127 0.074
Human Mouse
response to organic substance GO:0010033 284 0.072
exocrine system development GO:0035272 162 0.067
negative regulation of fibroblast growth factor receptor signaling pathway GO:0040037 2 0.067
leg disc development GO:0035218 92 0.065
regulation of apoptotic process GO:0042981 130 0.065
negative regulation of multicellular organismal process GO:0051241 142 0.062
positive regulation of phosphate metabolic process GO:0045937 139 0.062
notch signaling pathway GO:0007219 120 0.061
single organism catabolic process GO:0044712 228 0.061
Human Mouse
lipid metabolic process GO:0006629 121 0.060
multicellular organismal aging GO:0010259 140 0.059
body morphogenesis GO:0010171 2 0.059
regulation of localization GO:0032879 275 0.056
cellular ketone metabolic process GO:0042180 24 0.056
response to abiotic stimulus GO:0009628 341 0.055
forebrain development GO:0030900 2 0.055
positive regulation of cellular protein metabolic process GO:0032270 118 0.055
organonitrogen compound metabolic process GO:1901564 318 0.054
Human Mouse
phosphatidylinositol 3 kinase signaling GO:0014065 4 0.054
negative regulation of cellular metabolic process GO:0031324 382 0.054
negative regulation of cell death GO:0060548 81 0.053
negative regulation of synapse assembly GO:0051964 39 0.052
male gamete generation GO:0048232 201 0.052
regulation of phosphorus metabolic process GO:0051174 210 0.052
cell migration GO:0016477 238 0.052
cell cycle checkpoint GO:0000075 95 0.051
intracellular protein transport GO:0006886 104 0.051
organic substance transport GO:0071702 257 0.051
secretion by cell GO:0032940 101 0.050
cellular response to nutrient levels GO:0031669 62 0.050
positive regulation of phosphorylation GO:0042327 87 0.048
regulation of transport GO:0051049 181 0.048
regulation of phosphate metabolic process GO:0019220 210 0.047
cellular protein modification process GO:0006464 438 0.047
regulation of protein metabolic process GO:0051246 256 0.046
cellular macromolecule catabolic process GO:0044265 136 0.046
mapk cascade GO:0000165 107 0.046
central nervous system development GO:0007417 201 0.046
organelle assembly GO:0070925 198 0.046
cellular response to insulin stimulus GO:0032869 28 0.046
instar larval development GO:0002168 55 0.045
ion transmembrane transport GO:0034220 122 0.044
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.044
Human Mouse
regulation of locomotion GO:0040012 42 0.043
synaptic transmission GO:0007268 288 0.043
regulation of cell cycle GO:0051726 291 0.043
epidermal growth factor receptor signaling pathway GO:0007173 58 0.042
apoptotic process GO:0006915 159 0.041
regulation of synapse organization GO:0050807 110 0.041
salivary gland development GO:0007431 162 0.041
regulation of vesicle mediated transport GO:0060627 59 0.041
negative regulation of phosphorylation GO:0042326 35 0.040
cellular amino acid metabolic process GO:0006520 61 0.040
regulation of cell development GO:0060284 215 0.040
regulation of synaptic transmission GO:0050804 69 0.039
regulation of phosphorylation GO:0042325 147 0.038
cation transmembrane transport GO:0098655 88 0.038
immune effector process GO:0002252 98 0.038
chorion containing eggshell formation GO:0007304 105 0.038
establishment of tissue polarity GO:0007164 87 0.038
calcium ion transport GO:0006816 24 0.037
regulation of cellular amine metabolic process GO:0033238 3 0.037
enzyme linked receptor protein signaling pathway GO:0007167 179 0.037
larval development GO:0002164 104 0.036
mitotic spindle organization GO:0007052 220 0.035
cognition GO:0050890 141 0.035
organic cyclic compound catabolic process GO:1901361 168 0.035
Human Mouse
extrinsic apoptotic signaling pathway GO:0097191 1 0.034
purine containing compound catabolic process GO:0072523 112 0.034
Human Mouse
protein modification by small protein conjugation GO:0032446 79 0.034
purine ribonucleoside catabolic process GO:0046130 112 0.034
Human Mouse
ribonucleoside metabolic process GO:0009119 127 0.034
Human Mouse
heterocycle catabolic process GO:0046700 166 0.033
Human Mouse
protein localization GO:0008104 284 0.033
nucleoside phosphate catabolic process GO:1901292 110 0.033
Human Mouse
cell cycle phase transition GO:0044770 140 0.033
proteasomal protein catabolic process GO:0010498 59 0.033
actin filament polymerization GO:0030041 27 0.033
positive regulation of cellular component organization GO:0051130 156 0.033
oxoacid metabolic process GO:0043436 103 0.032
cellular lipid metabolic process GO:0044255 83 0.032
spinal cord patterning GO:0021511 1 0.031
anterior posterior axis specification GO:0009948 109 0.031
ribonucleoside triphosphate metabolic process GO:0009199 119 0.031
Human Mouse
nuclear division GO:0000280 332 0.031
regulation of response to external stimulus GO:0032101 115 0.031
spermatogenesis GO:0007283 200 0.030
regulation of cell migration GO:0030334 22 0.030
positive regulation of secretion GO:0051047 22 0.030
epithelial cell differentiation GO:0030855 322 0.030
regulation of actin filament length GO:0030832 27 0.030
positive regulation of tor signaling GO:0032008 13 0.030
cellular amine metabolic process GO:0044106 12 0.030
secretion GO:0046903 109 0.029
salivary gland cell autophagic cell death GO:0035071 83 0.029
neurological system process GO:0050877 358 0.029
positive regulation of signal transduction GO:0009967 223 0.029
segmentation GO:0035282 207 0.029
regulation of purine nucleotide metabolic process GO:1900542 62 0.029
Human Mouse
neuron recognition GO:0008038 101 0.029
heart contraction GO:0060047 26 0.029
ribose phosphate metabolic process GO:0019693 145 0.029
Human Mouse
phagocytosis GO:0006909 215 0.028
regulation of protein catabolic process GO:0042176 55 0.028
regulation of cellular catabolic process GO:0031329 157 0.028
Human Mouse
nucleoside triphosphate catabolic process GO:0009143 108 0.028
Human Mouse
positive regulation of phosphorus metabolic process GO:0010562 139 0.027
embryo development ending in birth or egg hatching GO:0009792 152 0.027
glycosyl compound metabolic process GO:1901657 127 0.027
Human Mouse
amine metabolic process GO:0009308 12 0.027
purine ribonucleotide catabolic process GO:0009154 109 0.026
Human Mouse
regulation of cell growth GO:0001558 43 0.026
regulation of protein modification process GO:0031399 112 0.026
salivary gland histolysis GO:0035070 88 0.026
regulation of tor signaling GO:0032006 21 0.026
blastoderm segmentation GO:0007350 159 0.025
negative regulation of erbb signaling pathway GO:1901185 29 0.025
regulation of synapse assembly GO:0051963 94 0.025
regulation of actin polymerization or depolymerization GO:0008064 27 0.025
cell adhesion GO:0007155 136 0.024
Human Mouse
regulation of embryonic development GO:0045995 68 0.024
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.024
positive regulation of macromolecule metabolic process GO:0010604 405 0.024
positive regulation of catabolic process GO:0009896 105 0.024
Human Mouse
homeostatic process GO:0042592 199 0.024
epithelial cell development GO:0002064 274 0.023
regulation of protein localization GO:0032880 76 0.023
regulation of anatomical structure morphogenesis GO:0022603 242 0.023
dna catabolic process GO:0006308 16 0.023
imaginal disc derived leg morphogenesis GO:0007480 80 0.023
positive regulation of protein metabolic process GO:0051247 128 0.023
peptidyl threonine modification GO:0018210 3 0.022
cytoplasmic transport GO:0016482 130 0.022
regulation of wound healing GO:0061041 13 0.022
regulation of neurogenesis GO:0050767 158 0.022
digestive tract development GO:0048565 149 0.022
establishment of protein localization GO:0045184 163 0.022
germarium derived egg chamber formation GO:0007293 101 0.022
eye development GO:0001654 323 0.022
regulation of autophagy GO:0010506 62 0.022
biological adhesion GO:0022610 138 0.021
Human Mouse
carboxylic acid metabolic process GO:0019752 92 0.021
inorganic cation transmembrane transport GO:0098662 61 0.021
regulation of cellular protein metabolic process GO:0032268 243 0.021
regulation of cell cycle phase transition GO:1901987 130 0.021
negative regulation of cellular component organization GO:0051129 108 0.021
regulation of protein phosphorylation GO:0001932 64 0.021
cellular chemical homeostasis GO:0055082 40 0.021
positive regulation of developmental process GO:0051094 143 0.021
neuron apoptotic process GO:0051402 17 0.021
establishment or maintenance of cytoskeleton polarity GO:0030952 44 0.021
regulation of cellular component size GO:0032535 98 0.021
positive regulation of nucleotide metabolic process GO:0045981 55 0.021
Human Mouse
hemopoiesis GO:0030097 46 0.021
spermatid development GO:0007286 98 0.020
regulation of response to nutrient levels GO:0032107 18 0.020
regulation of proteasomal protein catabolic process GO:0061136 39 0.020
locomotory behavior GO:0007626 176 0.020
positive regulation of cell migration GO:0030335 2 0.020
positive regulation of cell death GO:0010942 69 0.020
positive regulation of intracellular signal transduction GO:1902533 116 0.020
organophosphate biosynthetic process GO:0090407 46 0.020
metal ion homeostasis GO:0055065 44 0.020
regulation of response to stress GO:0080134 200 0.020
nucleoside catabolic process GO:0009164 112 0.020
Human Mouse
negative regulation of phosphorus metabolic process GO:0010563 45 0.020
positive regulation of molecular function GO:0044093 136 0.020
regulation of cellular component movement GO:0051270 42 0.020
ribonucleoside triphosphate catabolic process GO:0009203 108 0.019
Human Mouse
signal transduction by phosphorylation GO:0023014 107 0.019
response to insulin GO:0032868 29 0.019
protein ubiquitination GO:0016567 70 0.019
regulation of mitotic cell cycle phase transition GO:1901990 130 0.019
response to wounding GO:0009611 94 0.019
stress activated protein kinase signaling cascade GO:0031098 55 0.019
regulation of anatomical structure size GO:0090066 163 0.018
response to oxygen containing compound GO:1901700 200 0.018
epidermis development GO:0008544 65 0.018
positive regulation of protein catabolic process GO:0045732 34 0.018
purine nucleoside metabolic process GO:0042278 127 0.018
Human Mouse
positive regulation of multicellular organism growth GO:0040018 21 0.018
regulation of peptidyl tyrosine phosphorylation GO:0050730 10 0.018
mitotic sister chromatid segregation GO:0000070 87 0.018
protein complex assembly GO:0006461 200 0.018
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.018
Human Mouse
border follicle cell migration GO:0007298 113 0.018
tissue migration GO:0090130 155 0.017
larval behavior GO:0030537 42 0.017
cell growth GO:0016049 108 0.017
regulation of catalytic activity GO:0050790 185 0.017
metal ion transport GO:0030001 74 0.017
negative regulation of programmed cell death GO:0043069 72 0.017
ras protein signal transduction GO:0007265 88 0.017
regulation of actin filament polymerization GO:0030833 25 0.017
regulation of small gtpase mediated signal transduction GO:0051056 93 0.016
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 24 0.016
monovalent inorganic cation transport GO:0015672 40 0.016
peripheral nervous system development GO:0007422 52 0.016
cellular response to organic substance GO:0071310 132 0.016
cation homeostasis GO:0055080 51 0.016
negative regulation of protein metabolic process GO:0051248 85 0.015
negative regulation of catabolic process GO:0009895 36 0.015
convergent extension involved in gastrulation GO:0060027 2 0.015
regulation of gtpase activity GO:0043087 44 0.015
Human Mouse
purine nucleotide metabolic process GO:0006163 146 0.015
Human Mouse
nuclear export GO:0051168 24 0.015
nuclear transport GO:0051169 72 0.015
aging GO:0007568 143 0.015
digestive tract morphogenesis GO:0048546 127 0.015
negative regulation of cellular protein metabolic process GO:0032269 85 0.015
regulation of cellular protein catabolic process GO:1903362 44 0.015
protein transport GO:0015031 155 0.015
negative regulation of protein phosphorylation GO:0001933 17 0.015
induction of programmed cell death GO:0012502 12 0.015
cellular response to peptide hormone stimulus GO:0071375 28 0.015
negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 29 0.015
gliogenesis GO:0042063 80 0.015
positive regulation of growth GO:0045927 75 0.015
protein kinase b signaling GO:0043491 1 0.014
sister chromatid segregation GO:0000819 92 0.014
endocytosis GO:0006897 310 0.014
cellular metal ion homeostasis GO:0006875 31 0.014
associative learning GO:0008306 65 0.014
regulation of erbb signaling pathway GO:1901184 42 0.014
imaginal disc fusion GO:0046528 19 0.014
establishment or maintenance of cell polarity GO:0007163 167 0.014
Mouse
inorganic ion transmembrane transport GO:0098660 73 0.013
autophagic vacuole assembly GO:0000045 2 0.013
ion homeostasis GO:0050801 55 0.013
positive regulation of transport GO:0051050 92 0.013
regulation of cell proliferation GO:0042127 163 0.013
response to organonitrogen compound GO:0010243 75 0.013
cellular nitrogen compound catabolic process GO:0044270 165 0.013
Human Mouse
response to ecdysone GO:0035075 34 0.013
photoreceptor cell development GO:0042461 96 0.013
negative regulation of phosphate metabolic process GO:0045936 45 0.013
regulation of phosphatidylinositol 3 kinase activity GO:0043551 2 0.013
learning or memory GO:0007611 141 0.013
learning GO:0007612 75 0.012
response to osmotic stress GO:0006970 14 0.012
histolysis GO:0007559 102 0.012
negative regulation of notch signaling pathway GO:0045746 41 0.012
morphogenesis of a polarized epithelium GO:0001738 93 0.012
hematopoietic progenitor cell differentiation GO:0002244 1 0.012
cell recognition GO:0008037 102 0.012
negative regulation of intracellular signal transduction GO:1902532 57 0.012
skeletal muscle fiber development GO:0048741 3 0.012
positive regulation of response to stimulus GO:0048584 323 0.012
cell maturation GO:0048469 144 0.012
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 19 0.012
organophosphate metabolic process GO:0019637 195 0.012
Human Mouse
purine nucleotide catabolic process GO:0006195 109 0.012
Human Mouse
positive regulation of lipid metabolic process GO:0045834 4 0.012
mitotic cell cycle phase transition GO:0044772 138 0.012
regulation of establishment of protein localization GO:0070201 61 0.012
regulation of erk1 and erk2 cascade GO:0070372 39 0.012
regulation of macroautophagy GO:0016241 15 0.012
regulation of endocytosis GO:0030100 37 0.012
actin polymerization or depolymerization GO:0008154 31 0.012
response to extracellular stimulus GO:0009991 116 0.012
negative regulation of developmental process GO:0051093 201 0.011
cellular cation homeostasis GO:0030003 38 0.011
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.011
Human Mouse
ovarian follicle cell development GO:0030707 248 0.011
positive regulation of cell development GO:0010720 61 0.011
protein complex localization GO:0031503 4 0.011
positive regulation of hydrolase activity GO:0051345 78 0.011
Human Mouse
regulation of stress activated protein kinase signaling cascade GO:0070302 42 0.011
regulation of stress activated mapk cascade GO:0032872 41 0.011
positive regulation of cellular protein catabolic process GO:1903364 24 0.011
mrna metabolic process GO:0016071 124 0.011
multicellular organismal reproductive behavior GO:0033057 110 0.011
regulation of purine nucleotide catabolic process GO:0033121 48 0.011
Human Mouse
brain development GO:0007420 120 0.011
gtp metabolic process GO:0046039 72 0.010
Human Mouse
establishment of organelle localization GO:0051656 122 0.010
regulation of phosphatase activity GO:0010921 3 0.010
tissue death GO:0016271 102 0.010
protein modification by small protein conjugation or removal GO:0070647 106 0.010
ribonucleoside catabolic process GO:0042454 112 0.010
Human Mouse
purine containing compound metabolic process GO:0072521 155 0.010
Human Mouse
wound healing GO:0042060 75 0.010
response to nutrient levels GO:0031667 114 0.010
cell fate determination GO:0001709 91 0.010

step disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org