Drosophila melanogaster

137 known processes

Cdk8 (Dmel_CG10572)

Cyclin-dependent kinase 8

(Aliases: Dmel\CG10572,CG10572,DmCdk8,cdk8,p58,dTRAP56,CDK8)

Cdk8 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
transcription from rna polymerase ii promoter GO:0006366 368 0.487
Yeast
axonogenesis GO:0007409 290 0.244
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.209
Yeast
sex comb development GO:0045498 8 0.182
regulation of cell differentiation GO:0045595 302 0.175
regulation of nervous system development GO:0051960 248 0.164
multi organism reproductive behavior GO:0044705 121 0.155
regulation of neural precursor cell proliferation GO:2000177 35 0.130
peptidyl lysine modification GO:0018205 57 0.127
positive regulation of transcription dna templated GO:0045893 266 0.122
Yeast
negative regulation of developmental process GO:0051093 201 0.110
Worm
cell cycle phase transition GO:0044770 140 0.108
negative regulation of stem cell proliferation GO:2000647 30 0.107
muscle structure development GO:0061061 224 0.099
positive regulation of cellular biosynthetic process GO:0031328 316 0.097
Yeast
regulation of neuroblast proliferation GO:1902692 34 0.093
multi organism behavior GO:0051705 175 0.093
mitotic cell cycle phase transition GO:0044772 138 0.091
dendrite development GO:0016358 204 0.087
positive regulation of macromolecule metabolic process GO:0010604 405 0.085
Yeast
multicellular organismal reproductive behavior GO:0033057 110 0.082
post embryonic appendage morphogenesis GO:0035120 385 0.082
negative regulation of neural precursor cell proliferation GO:2000178 27 0.078
multi multicellular organism process GO:0044706 123 0.076
compound eye development GO:0048749 307 0.074
negative regulation of multicellular organismal process GO:0051241 142 0.070
Worm
cellular response to dna damage stimulus GO:0006974 223 0.070
negative regulation of nervous system development GO:0051961 92 0.069
regulation of cell development GO:0060284 215 0.068
protein modification process GO:0036211 438 0.068
regulation of neurogenesis GO:0050767 158 0.067
stem cell maintenance GO:0019827 67 0.067
negative regulation of neuroblast proliferation GO:0007406 27 0.065
positive regulation of nucleic acid templated transcription GO:1903508 266 0.065
Yeast
regionalization GO:0003002 416 0.063
neuron projection guidance GO:0097485 241 0.060
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.058
Yeast
regulation of immune system process GO:0002682 176 0.058
peptidyl lysine acetylation GO:0018394 39 0.057
tissue morphogenesis GO:0048729 297 0.055
body morphogenesis GO:0010171 2 0.055
Worm
regulation of cellular component biogenesis GO:0044087 201 0.053
regulation of cell cycle GO:0051726 291 0.053
cell cycle checkpoint GO:0000075 95 0.052
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.052
salivary gland cell autophagic cell death GO:0035071 83 0.051
segmentation GO:0035282 207 0.051
taxis GO:0042330 304 0.051
mitotic g2 dna damage checkpoint GO:0007095 69 0.050
regulation of tor signaling GO:0032006 21 0.049
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.049
Yeast
positive regulation of cell communication GO:0010647 250 0.048
mitotic dna integrity checkpoint GO:0044774 75 0.043
mitotic nuclear division GO:0007067 213 0.043
muscle organ development GO:0007517 127 0.042
negative regulation of cellular metabolic process GO:0031324 382 0.042
Yeast
negative regulation of cell cycle GO:0045786 116 0.041
regulation of stem cell proliferation GO:0072091 40 0.041
leg disc morphogenesis GO:0007478 80 0.040
negative regulation of biosynthetic process GO:0009890 277 0.040
Yeast
chromatin organization GO:0006325 207 0.040
growth GO:0040007 359 0.039
Yeast
regulation of protein modification by small protein conjugation or removal GO:1903320 25 0.039
organ growth GO:0035265 56 0.038
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.038
Yeast
negative regulation of cellular biosynthetic process GO:0031327 277 0.037
Yeast
positive regulation of response to stimulus GO:0048584 323 0.037
negative regulation of gene expression GO:0010629 387 0.036
Yeast
cellular protein modification process GO:0006464 438 0.035
negative regulation of rna biosynthetic process GO:1902679 240 0.035
Yeast
eye development GO:0001654 323 0.035
regulation of wnt signaling pathway GO:0030111 68 0.035
response to oxygen containing compound GO:1901700 200 0.034
macromolecule catabolic process GO:0009057 161 0.032
Yeast
dna repair GO:0006281 54 0.032
negative regulation of transcription dna templated GO:0045892 237 0.032
Yeast
negative regulation of cell cycle phase transition GO:1901988 103 0.031
negative regulation of response to stimulus GO:0048585 258 0.031
nuclear division GO:0000280 332 0.031
regulation of immune response GO:0050776 118 0.031
positive regulation of gene expression GO:0010628 290 0.030
Yeast
imaginal disc derived appendage morphogenesis GO:0035114 395 0.030
appendage segmentation GO:0035285 26 0.030
regulation of protein metabolic process GO:0051246 256 0.030
appendage development GO:0048736 401 0.029
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.029
Yeast
negative regulation of cell cycle process GO:0010948 109 0.028
appendage morphogenesis GO:0035107 397 0.028
dna integrity checkpoint GO:0031570 81 0.028
protein acetylation GO:0006473 39 0.028
chromatin modification GO:0016568 147 0.027
response to ecdysone GO:0035075 34 0.027
mitotic g2 m transition checkpoint GO:0044818 70 0.027
imaginal disc derived leg segmentation GO:0036011 26 0.027
response to heat GO:0009408 63 0.026
neuroblast proliferation GO:0007405 74 0.026
axon guidance GO:0007411 233 0.026
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.026
Yeast
regulation of intracellular signal transduction GO:1902531 236 0.026
cellular component assembly involved in morphogenesis GO:0010927 151 0.026
negative regulation of cell development GO:0010721 62 0.025
negative regulation of cell differentiation GO:0045596 143 0.025
camera type eye development GO:0043010 4 0.025
response to light stimulus GO:0009416 124 0.025
positive regulation of signaling GO:0023056 243 0.025
negative regulation of mitotic cell cycle GO:0045930 109 0.025
protein localization GO:0008104 284 0.025
regulation of synapse assembly GO:0051963 94 0.024
compound eye morphogenesis GO:0001745 249 0.024
exocrine system development GO:0035272 162 0.024
stem cell proliferation GO:0072089 88 0.024
gland development GO:0048732 191 0.024
regulation of response to stress GO:0080134 200 0.024
leg disc development GO:0035218 92 0.023
morphogenesis of an epithelium GO:0002009 276 0.022
imaginal disc pattern formation GO:0007447 91 0.022
internal protein amino acid acetylation GO:0006475 38 0.022
establishment or maintenance of cell polarity GO:0007163 167 0.022
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.021
Yeast
response to abiotic stimulus GO:0009628 341 0.021
wing disc morphogenesis GO:0007472 344 0.021
sensory organ morphogenesis GO:0090596 260 0.021
male gamete generation GO:0048232 201 0.020
kidney development GO:0001822 3 0.020
cellular protein complex assembly GO:0043623 71 0.020
reproductive behavior GO:0019098 122 0.020
cellular ketone metabolic process GO:0042180 24 0.020
negative regulation of nucleic acid templated transcription GO:1903507 240 0.020
Yeast
regulation of multicellular organismal development GO:2000026 414 0.020
Worm
protein ubiquitination GO:0016567 70 0.020
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.019
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.019
Yeast
snrna 3 end processing GO:0034472 14 0.019
positive regulation of signal transduction GO:0009967 223 0.019
developmental programmed cell death GO:0010623 138 0.019
imaginal disc derived wing morphogenesis GO:0007476 337 0.019
proteolysis GO:0006508 192 0.018
histolysis GO:0007559 102 0.018
regulation of organ morphogenesis GO:2000027 78 0.018
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.018
Yeast
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.018
Yeast
gland morphogenesis GO:0022612 145 0.018
cell cell signaling involved in cell fate commitment GO:0045168 210 0.018
peptidyl amino acid modification GO:0018193 105 0.017
cellular macromolecular complex assembly GO:0034622 153 0.017
regulation of catalytic activity GO:0050790 185 0.017
autophagic cell death GO:0048102 83 0.017
positive regulation of protein deacetylation GO:0090312 2 0.017
central nervous system development GO:0007417 201 0.017
tor signaling GO:0031929 32 0.017
negative regulation of rna metabolic process GO:0051253 251 0.017
Yeast
protein phosphorylation GO:0006468 169 0.017
chromosome organization GO:0051276 360 0.017
regulation of humoral immune response GO:0002920 51 0.017
negative regulation of signal transduction GO:0009968 206 0.017
developmental growth GO:0048589 280 0.017
protein complex biogenesis GO:0070271 201 0.017
organelle assembly GO:0070925 198 0.017
regulation of antimicrobial humoral response GO:0002759 50 0.016
histone modification GO:0016570 106 0.016
salivary gland development GO:0007431 162 0.016
protein alkylation GO:0008213 43 0.016
salivary gland histolysis GO:0035070 88 0.016
regulation of molecular function GO:0065009 217 0.015
photoreceptor cell differentiation GO:0046530 170 0.015
mitotic cell cycle checkpoint GO:0007093 88 0.015
regulation of notch signaling pathway GO:0008593 100 0.015
striated muscle myosin thick filament assembly GO:0071688 3 0.015
imaginal disc derived appendage development GO:0048737 399 0.015
macromolecular complex assembly GO:0065003 256 0.015
dna endoreduplication GO:0042023 22 0.015
intracellular signal transduction GO:0035556 300 0.015
embryonic axis specification GO:0000578 107 0.015
positive regulation of biosynthetic process GO:0009891 316 0.015
Yeast
mitotic cell cycle embryonic GO:0045448 38 0.015
positive regulation of protein metabolic process GO:0051247 128 0.014
regulation of cellular protein metabolic process GO:0032268 243 0.014
cell cycle dna replication GO:0044786 23 0.014
striated muscle cell differentiation GO:0051146 90 0.014
negative regulation of cell communication GO:0010648 223 0.014
regulation of protein deacetylation GO:0090311 2 0.014
sex differentiation GO:0007548 81 0.014
positive regulation of cellular component biogenesis GO:0044089 80 0.014
protein modification by small protein conjugation GO:0032446 79 0.014
response to organic substance GO:0010033 284 0.014
regulation of protein modification process GO:0031399 112 0.014
positive regulation of rna biosynthetic process GO:1902680 266 0.014
Yeast
embryonic pattern specification GO:0009880 174 0.014
dna dependent dna replication GO:0006261 17 0.014
dna damage checkpoint GO:0000077 78 0.014
regulation of cell projection organization GO:0031344 92 0.014
retina development in camera type eye GO:0060041 4 0.013
blastoderm segmentation GO:0007350 159 0.013
response to biotic stimulus GO:0009607 294 0.013
cell proliferation GO:0008283 299 0.013
response to external biotic stimulus GO:0043207 293 0.013
mitotic dna damage checkpoint GO:0044773 74 0.013
negative regulation of neurogenesis GO:0050768 53 0.013
methylation GO:0032259 47 0.013
embryo development ending in birth or egg hatching GO:0009792 152 0.013
Worm
oxoacid metabolic process GO:0043436 103 0.013
covalent chromatin modification GO:0016569 106 0.013
regulation of epithelial cell differentiation GO:0030856 4 0.013
response to other organism GO:0051707 293 0.012
chaeta development GO:0022416 97 0.012
vesicle mediated transport GO:0016192 381 0.012
dna metabolic process GO:0006259 227 0.012
catabolic process GO:0009056 409 0.012
Yeast
cell maturation GO:0048469 144 0.012
axon development GO:0061564 297 0.012
eye morphogenesis GO:0048592 260 0.012
carboxylic acid metabolic process GO:0019752 92 0.012
regulation of innate immune response GO:0045088 71 0.012
intracellular transport GO:0046907 228 0.012
regulation of multi organism process GO:0043900 131 0.012
neural retina development GO:0003407 4 0.012
enzyme linked receptor protein signaling pathway GO:0007167 179 0.012
response to temperature stimulus GO:0009266 106 0.012
response to organic cyclic compound GO:0014070 89 0.012
modification dependent protein catabolic process GO:0019941 78 0.012
locomotory behavior GO:0007626 176 0.012
lateral inhibition GO:0046331 206 0.012
salivary gland morphogenesis GO:0007435 145 0.012
mrna metabolic process GO:0016071 124 0.012
Yeast
ncrna metabolic process GO:0034660 43 0.012
dorsal ventral pattern formation GO:0009953 133 0.012
dendrite morphogenesis GO:0048813 199 0.012
organonitrogen compound metabolic process GO:1901564 318 0.012
histone acetylation GO:0016573 38 0.011
negative regulation of signaling GO:0023057 219 0.011
oviposition GO:0018991 19 0.011
dorsal ventral pattern formation imaginal disc GO:0007450 51 0.011
regulation of cell cycle phase transition GO:1901987 130 0.011
immune system process GO:0002376 347 0.011
neurological system process GO:0050877 358 0.011
antimicrobial peptide production GO:0002775 46 0.011
positive regulation of catalytic activity GO:0043085 118 0.011
internal peptidyl lysine acetylation GO:0018393 38 0.011
regulation of mitotic cell cycle phase transition GO:1901990 130 0.011
jak stat cascade GO:0007259 49 0.011
heterochromatin organization GO:0070828 25 0.011
protein processing GO:0016485 68 0.011
wing disc pattern formation GO:0035222 66 0.011
cellular response to organic cyclic compound GO:0071407 32 0.011
notch signaling pathway GO:0007219 120 0.011
reproductive structure development GO:0048608 74 0.011
morphogenesis of a polarized epithelium GO:0001738 93 0.011
cellular response to organic substance GO:0071310 132 0.011
sensory perception of pain GO:0019233 4 0.011
intracellular receptor signaling pathway GO:0030522 19 0.011
regulation of erbb signaling pathway GO:1901184 42 0.011
purine ribonucleoside catabolic process GO:0046130 112 0.010
wnt signaling pathway GO:0016055 98 0.010
regulation of anatomical structure size GO:0090066 163 0.010
cell death GO:0008219 279 0.010
developmental growth involved in morphogenesis GO:0060560 65 0.010
stem cell development GO:0048864 79 0.010
anterior posterior pattern specification GO:0009952 136 0.010
defense response to other organism GO:0098542 225 0.010
organelle fission GO:0048285 340 0.010
muscle cell differentiation GO:0042692 103 0.010

Cdk8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 0 0.010
disease of anatomical entity DOID:7 0 0.010
nervous system disease DOID:863 0 0.010