Drosophila melanogaster

43 known processes

ko (Dmel_CG10573)

knockout

(Aliases: Dmel\CG10573,CG10573)

ko biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
wing disc morphogenesis GO:0007472 344 0.224
neurological system process GO:0050877 358 0.215
motor neuron axon guidance GO:0008045 58 0.201
locomotory behavior GO:0007626 176 0.198
chemotaxis GO:0006935 249 0.158
appendage development GO:0048736 401 0.149
post embryonic appendage morphogenesis GO:0035120 385 0.147
axonogenesis GO:0007409 290 0.139
appendage morphogenesis GO:0035107 397 0.136
axon guidance GO:0007411 233 0.118
taxis GO:0042330 304 0.116
response to oxidative stress GO:0006979 86 0.114
axon development GO:0061564 297 0.101
cell adhesion involved in heart morphogenesis GO:0061343 12 0.093
cellular amino acid metabolic process GO:0006520 61 0.090
neuron recognition GO:0008038 101 0.088
detection of stimulus GO:0051606 156 0.084
sensory organ morphogenesis GO:0090596 260 0.083
regulation of neurogenesis GO:0050767 158 0.081
imaginal disc derived appendage morphogenesis GO:0035114 395 0.079
hindbrain development GO:0030902 2 0.068
imaginal disc derived appendage development GO:0048737 399 0.067
single organism behavior GO:0044708 391 0.063
adult behavior GO:0030534 137 0.061
sensory perception GO:0007600 196 0.061
learning GO:0007612 75 0.059
oxoacid metabolic process GO:0043436 103 0.058
skeletal muscle fiber development GO:0048741 3 0.057
eye morphogenesis GO:0048592 260 0.056
organelle fission GO:0048285 340 0.055
regulation of multicellular organismal development GO:2000026 414 0.054
learning or memory GO:0007611 141 0.054
cell recognition GO:0008037 102 0.051
synaptic target recognition GO:0008039 45 0.048
cell adhesion GO:0007155 136 0.047
small molecule metabolic process GO:0044281 305 0.047
catabolic process GO:0009056 409 0.046
cognition GO:0050890 141 0.046
eye development GO:0001654 323 0.044
neuron projection guidance GO:0097485 241 0.044
organic acid metabolic process GO:0006082 103 0.043
enzyme linked receptor protein signaling pathway GO:0007167 179 0.043
camera type eye development GO:0043010 4 0.042
synapse organization GO:0050808 196 0.042
response to oxygen containing compound GO:1901700 200 0.041
imaginal disc derived wing morphogenesis GO:0007476 337 0.040
kidney development GO:0001822 3 0.040
adult locomotory behavior GO:0008344 76 0.039
molting cycle chitin based cuticle GO:0007591 56 0.039
amine metabolic process GO:0009308 12 0.039
carboxylic acid metabolic process GO:0019752 92 0.039
regionalization GO:0003002 416 0.038
mesoderm development GO:0007498 78 0.038
actin cytoskeleton organization GO:0030036 206 0.037
negative regulation of cell differentiation GO:0045596 143 0.037
cell maturation GO:0048469 144 0.037
regulation of gene expression epigenetic GO:0040029 128 0.036
acetylcholine metabolic process GO:0008291 2 0.036
positive regulation of cell communication GO:0010647 250 0.035
forebrain development GO:0030900 2 0.035
response to lipopolysaccharide GO:0032496 4 0.034
tube morphogenesis GO:0035239 191 0.033
positive regulation of response to stimulus GO:0048584 323 0.033
embryonic morphogenesis GO:0048598 206 0.032
nephron epithelium development GO:0072009 3 0.032
cellular amine metabolic process GO:0044106 12 0.032
body morphogenesis GO:0010171 2 0.031
tube development GO:0035295 244 0.030
nuclear division GO:0000280 332 0.029
organonitrogen compound metabolic process GO:1901564 318 0.029
positive regulation of macromolecule metabolic process GO:0010604 405 0.029
positive regulation of cellular component organization GO:0051130 156 0.029
positive regulation of signaling GO:0023056 243 0.029
regulation of tube size open tracheal system GO:0035151 43 0.028
response to radiation GO:0009314 155 0.028
compound eye development GO:0048749 307 0.028
regulation of cellular ketone metabolic process GO:0010565 3 0.028
photoreceptor cell axon guidance GO:0072499 23 0.028
photoreceptor cell differentiation GO:0046530 170 0.027
regulation of developmental growth GO:0048638 174 0.027
regulation of neuron differentiation GO:0045664 103 0.027
cellular response to dna damage stimulus GO:0006974 223 0.027
connective tissue development GO:0061448 3 0.027
response to nitrogen compound GO:1901698 90 0.027
apical junction assembly GO:0043297 32 0.026
eye photoreceptor cell differentiation GO:0001754 145 0.026
skeletal muscle organ development GO:0060538 48 0.026
retina development in camera type eye GO:0060041 4 0.026
cellular protein modification process GO:0006464 438 0.026
biological adhesion GO:0022610 138 0.026
notch signaling pathway GO:0007219 120 0.025
cell proliferation GO:0008283 299 0.025
regulation of nervous system development GO:0051960 248 0.025
protein modification process GO:0036211 438 0.025
negative regulation of multicellular organismal process GO:0051241 142 0.024
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.024
gene silencing GO:0016458 138 0.024
establishment of blood brain barrier GO:0060856 16 0.024
eye photoreceptor cell development GO:0042462 81 0.024
organic substance catabolic process GO:1901575 308 0.023
cell migration GO:0016477 238 0.023
positive regulation of signal transduction GO:0009967 223 0.023
acetylcholine catabolic process GO:0006581 1 0.023
positive regulation of cellular amine metabolic process GO:0033240 0 0.022
dorsal ventral pattern formation GO:0009953 133 0.022
response to organic substance GO:0010033 284 0.022
chromatin silencing GO:0006342 76 0.022
aromatic compound catabolic process GO:0019439 166 0.022
regulation of intracellular signal transduction GO:1902531 236 0.022
positive regulation of phosphate metabolic process GO:0045937 139 0.022
response to organonitrogen compound GO:0010243 75 0.021
developmental maturation GO:0021700 172 0.021
positive regulation of intracellular signal transduction GO:1902533 116 0.021
imaginal disc derived wing hair organization GO:0035317 45 0.021
ras protein signal transduction GO:0007265 88 0.021
nephron development GO:0072006 3 0.021
sensory perception of sound GO:0007605 56 0.021
regulation of cytoskeleton organization GO:0051493 89 0.021
cellular catabolic process GO:0044248 372 0.021
regulation of microtubule based process GO:0032886 49 0.021
regulation of cellular component size GO:0032535 98 0.021
negative regulation of nervous system development GO:0051961 92 0.021
establishment of glial blood brain barrier GO:0060857 14 0.020
cell projection assembly GO:0030031 94 0.020
compound eye photoreceptor cell differentiation GO:0001751 140 0.020
actin filament organization GO:0007015 126 0.020
cell division GO:0051301 248 0.020
negative regulation of signaling GO:0023057 219 0.020
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.019
response to ethanol GO:0045471 59 0.019
regulation of cell cycle GO:0051726 291 0.019
synapse assembly GO:0007416 143 0.019
intracellular signal transduction GO:0035556 300 0.019
regulation of response to stress GO:0080134 200 0.019
regulation of cellular amine metabolic process GO:0033238 3 0.019
regulation of protein metabolic process GO:0051246 256 0.019
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.019
hair cell differentiation GO:0035315 47 0.019
phagocytosis GO:0006909 215 0.019
positive regulation of transcription dna templated GO:0045893 266 0.018
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.018
positive regulation of cell motility GO:2000147 3 0.018
nucleobase containing compound catabolic process GO:0034655 165 0.018
sensory perception of mechanical stimulus GO:0050954 72 0.018
muscle structure development GO:0061061 224 0.018
telencephalon development GO:0021537 2 0.018
cell cell junction assembly GO:0007043 38 0.018
cellular ketone metabolic process GO:0042180 24 0.018
establishment of localization in cell GO:0051649 402 0.018
response to alcohol GO:0097305 95 0.017
regulation of actin cytoskeleton organization GO:0032956 42 0.017
acetate ester metabolic process GO:1900619 2 0.017
negative regulation of gene expression epigenetic GO:0045814 77 0.017
positive regulation of cellular component biogenesis GO:0044089 80 0.017
salivary gland development GO:0007431 162 0.017
spermatogenesis GO:0007283 200 0.017
cell cell adhesion via plasma membrane adhesion molecules GO:0098742 26 0.017
eggshell formation GO:0030703 105 0.017
gland development GO:0048732 191 0.017
single organism biosynthetic process GO:0044711 206 0.017
cellular response to ethanol GO:0071361 4 0.016
muscle organ development GO:0007517 127 0.016
positive regulation of cellular biosynthetic process GO:0031328 316 0.016
regulation of tube size GO:0035150 46 0.016
g protein coupled receptor signaling pathway GO:0007186 136 0.016
negative regulation of nucleic acid templated transcription GO:1903507 240 0.016
cellular macromolecule localization GO:0070727 220 0.016
detection of stimulus involved in sensory perception GO:0050906 92 0.016
establishment or maintenance of cell polarity GO:0007163 167 0.016
photoreceptor cell development GO:0042461 96 0.016
morphogenesis of an epithelium GO:0002009 276 0.016
actin filament based process GO:0030029 220 0.016
jak stat cascade GO:0007259 49 0.016
spinal cord development GO:0021510 1 0.016
chromatin modification GO:0016568 147 0.015
septate junction assembly GO:0019991 26 0.015
heart development GO:0007507 82 0.015
negative regulation of response to stimulus GO:0048585 258 0.015
regulation of molecular function GO:0065009 217 0.015
positive regulation of phosphorylation GO:0042327 87 0.015
memory GO:0007613 94 0.015
organic substance transport GO:0071702 257 0.015
anterior posterior pattern specification GO:0009952 136 0.015
glial cell differentiation GO:0010001 35 0.015
regulation of cell differentiation GO:0045595 302 0.015
immune response regulating signaling pathway GO:0002764 2 0.015
multi multicellular organism process GO:0044706 123 0.014
single organism carbohydrate metabolic process GO:0044723 72 0.014
microtubule organizing center organization GO:0031023 168 0.014
negative regulation of gene expression GO:0010629 387 0.014
rhythmic process GO:0048511 106 0.014
positive regulation of neuron differentiation GO:0045666 26 0.014
gliogenesis GO:0042063 80 0.014
outflow tract morphogenesis GO:0003151 4 0.014
negative regulation of cell communication GO:0010648 223 0.014
peptidyl amino acid modification GO:0018193 105 0.014
protein complex biogenesis GO:0070271 201 0.014
response to abiotic stimulus GO:0009628 341 0.014
regulation of cellular component biogenesis GO:0044087 201 0.014
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.014
developmental growth involved in morphogenesis GO:0060560 65 0.014
olfactory learning GO:0008355 56 0.014
negative regulation of cellular biosynthetic process GO:0031327 277 0.013
protein phosphorylation GO:0006468 169 0.013
regulation of localization GO:0032879 275 0.013
carbohydrate derivative metabolic process GO:1901135 217 0.013
localization of cell GO:0051674 257 0.013
regulation of anatomical structure size GO:0090066 163 0.013
inorganic ion transmembrane transport GO:0098660 73 0.013
neurotransmitter metabolic process GO:0042133 2 0.013
single organismal cell cell adhesion GO:0016337 45 0.013
limb morphogenesis GO:0035108 1 0.013
regulation of behavior GO:0050795 75 0.013
lateral inhibition GO:0046331 206 0.013
regulation of microtubule polymerization or depolymerization GO:0031110 27 0.013
cell death GO:0008219 279 0.013
lipopolysaccharide mediated signaling pathway GO:0031663 1 0.013
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.013
cell cell signaling involved in cell fate commitment GO:0045168 210 0.013
limb development GO:0060173 1 0.013
cellular component assembly involved in morphogenesis GO:0010927 151 0.013
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.013
homeostatic process GO:0042592 199 0.013
response to monosaccharide GO:0034284 4 0.013
molting cycle GO:0042303 56 0.013
small gtpase mediated signal transduction GO:0007264 88 0.013
regulation of neuron projection development GO:0010975 69 0.013
axis specification GO:0009798 167 0.013
endocytosis GO:0006897 310 0.012
regulation of protein modification process GO:0031399 112 0.012
negative regulation of rna biosynthetic process GO:1902679 240 0.012
regulation of organelle organization GO:0033043 196 0.012
imaginal disc pattern formation GO:0007447 91 0.012
vesicle mediated transport GO:0016192 381 0.012
microtubule polymerization or depolymerization GO:0031109 39 0.012
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 4 0.012
small molecule catabolic process GO:0044282 21 0.012
single organism catabolic process GO:0044712 228 0.012
organic cyclic compound catabolic process GO:1901361 168 0.012
kidney epithelium development GO:0072073 3 0.012
organelle assembly GO:0070925 198 0.012
purine containing compound metabolic process GO:0072521 155 0.012
negative regulation of rna metabolic process GO:0051253 251 0.012
regulation of epithelial cell differentiation GO:0030856 4 0.012
cellular response to molecule of bacterial origin GO:0071219 3 0.012
kidney morphogenesis GO:0060993 3 0.012
striated muscle cell differentiation GO:0051146 90 0.012
chromatin organization GO:0006325 207 0.012
regulation of cellular protein metabolic process GO:0032268 243 0.012
heterophilic cell cell adhesion via plasma membrane cell adhesion molecules GO:0007157 8 0.012
cell cell junction organization GO:0045216 55 0.012
regulation of membrane potential GO:0042391 35 0.012
positive regulation of molecular function GO:0044093 136 0.012
nucleoside phosphate metabolic process GO:0006753 162 0.012
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.012
substrate adhesion dependent cell spreading GO:0034446 2 0.012
cellular response to lipopolysaccharide GO:0071222 3 0.012
positive regulation of nervous system development GO:0051962 69 0.011
negative regulation of cell development GO:0010721 62 0.011
neuromuscular junction development GO:0007528 149 0.011
gland morphogenesis GO:0022612 145 0.011
cellular response to organonitrogen compound GO:0071417 36 0.011
organophosphate metabolic process GO:0019637 195 0.011
cellular response to nitrogen compound GO:1901699 51 0.011
cellular nitrogen compound catabolic process GO:0044270 165 0.011
regulation of catabolic process GO:0009894 170 0.011
reproductive system development GO:0061458 74 0.011
macromolecular complex assembly GO:0065003 256 0.011
peptidyl threonine phosphorylation GO:0018107 2 0.011
maintenance of location GO:0051235 73 0.011
regulation of gene silencing GO:0060968 63 0.011
tripartite regional subdivision GO:0007351 103 0.011
carbohydrate metabolic process GO:0005975 82 0.011
regulation of cell shape GO:0008360 113 0.011
regulation of synapse organization GO:0050807 110 0.011
chromosome organization GO:0051276 360 0.011
nephron morphogenesis GO:0072028 3 0.011
negative regulation of biosynthetic process GO:0009890 277 0.011
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.011
regulation of microtubule cytoskeleton organization GO:0070507 41 0.011
regulation of cell cycle process GO:0010564 181 0.011
positive regulation of developmental process GO:0051094 143 0.011
axonal defasciculation GO:0007414 12 0.011
regulation of cell proliferation GO:0042127 163 0.011
glial cell development GO:0021782 27 0.011
salivary gland morphogenesis GO:0007435 145 0.011
extrinsic apoptotic signaling pathway GO:0097191 1 0.011
cytoskeleton dependent cytokinesis GO:0061640 81 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.011
sex differentiation GO:0007548 81 0.011
response to other organism GO:0051707 293 0.011
cell junction organization GO:0034330 57 0.010
response to glucose GO:0009749 2 0.010
formation of anatomical boundary GO:0048859 37 0.010
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.010
embryo development ending in birth or egg hatching GO:0009792 152 0.010
anatomical structure homeostasis GO:0060249 97 0.010
positive regulation of multicellular organismal process GO:0051240 143 0.010
developmental programmed cell death GO:0010623 138 0.010
positive regulation of nucleic acid templated transcription GO:1903508 266 0.010
cranial nerve development GO:0021545 1 0.010
intracellular transport GO:0046907 228 0.010
regulation of glial cell differentiation GO:0045685 1 0.010
compound eye photoreceptor development GO:0042051 78 0.010

ko disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.040
nervous system disease DOID:863 0 0.013
bone development disease DOID:0080006 0 0.012
bone disease DOID:0080001 0 0.012
musculoskeletal system disease DOID:17 0 0.012
connective tissue disease DOID:65 0 0.012
sensory system disease DOID:0050155 0 0.011
disease of metabolism DOID:0014667 0 0.010