Drosophila melanogaster

36 known processes

Hcs (Dmel_CG14670)

Holocarboxylase synthetase

(Aliases: HCS,Dmel\CG14670,CG14670,NEST:bs27h05)

Hcs biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein modification process GO:0036211 438 0.055
organonitrogen compound metabolic process GO:1901564 318 0.032
organic substance catabolic process GO:1901575 308 0.032
carbohydrate derivative metabolic process GO:1901135 217 0.032
nucleobase containing compound catabolic process GO:0034655 165 0.032
cellular catabolic process GO:0044248 372 0.032
heterocycle catabolic process GO:0046700 166 0.030
ribonucleoside catabolic process GO:0042454 112 0.030
nucleoside phosphate metabolic process GO:0006753 162 0.029
regulation of cellular amine metabolic process GO:0033238 3 0.029
aromatic compound catabolic process GO:0019439 166 0.028
small molecule metabolic process GO:0044281 305 0.028
negative regulation of gene expression GO:0010629 387 0.028
cellular nitrogen compound catabolic process GO:0044270 165 0.027
imaginal disc derived appendage development GO:0048737 399 0.026
purine ribonucleotide catabolic process GO:0009154 109 0.026
purine containing compound metabolic process GO:0072521 155 0.025
post embryonic appendage morphogenesis GO:0035120 385 0.025
nucleoside phosphate catabolic process GO:1901292 110 0.025
regulation of anatomical structure size GO:0090066 163 0.025
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.025
appendage morphogenesis GO:0035107 397 0.024
ribonucleotide metabolic process GO:0009259 145 0.024
neurological system process GO:0050877 358 0.024
morphogenesis of an epithelium GO:0002009 276 0.024
organic cyclic compound catabolic process GO:1901361 168 0.023
small gtpase mediated signal transduction GO:0007264 88 0.023
regulation of intracellular signal transduction GO:1902531 236 0.023
regulation of catabolic process GO:0009894 170 0.023
regionalization GO:0003002 416 0.023
ras protein signal transduction GO:0007265 88 0.023
compound eye development GO:0048749 307 0.022
cellular protein modification process GO:0006464 438 0.022
single organism catabolic process GO:0044712 228 0.022
purine nucleotide catabolic process GO:0006195 109 0.022
phagocytosis GO:0006909 215 0.022
imaginal disc derived wing morphogenesis GO:0007476 337 0.022
carboxylic acid metabolic process GO:0019752 92 0.022
phosphorylation GO:0016310 294 0.022
amine metabolic process GO:0009308 12 0.022
intracellular signal transduction GO:0035556 300 0.021
organophosphate metabolic process GO:0019637 195 0.021
appendage development GO:0048736 401 0.021
ribonucleoside metabolic process GO:0009119 127 0.021
protein complex biogenesis GO:0070271 201 0.021
catabolic process GO:0009056 409 0.021
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.021
single organism behavior GO:0044708 391 0.021
vesicle mediated transport GO:0016192 381 0.021
purine nucleotide metabolic process GO:0006163 146 0.021
body morphogenesis GO:0010171 2 0.021
purine ribonucleoside catabolic process GO:0046130 112 0.021
organonitrogen compound biosynthetic process GO:1901566 117 0.021
single organism biosynthetic process GO:0044711 206 0.020
cellular amine metabolic process GO:0044106 12 0.020
negative regulation of response to stimulus GO:0048585 258 0.020
regulation of cellular catabolic process GO:0031329 157 0.020
epithelial cell development GO:0002064 274 0.020
connective tissue development GO:0061448 3 0.020
regulation of ras protein signal transduction GO:0046578 93 0.020
negative regulation of cellular metabolic process GO:0031324 382 0.020
regulation of molecular function GO:0065009 217 0.020
transcription from rna polymerase ii promoter GO:0006366 368 0.020
regulation of cellular component biogenesis GO:0044087 201 0.020
positive regulation of cellular biosynthetic process GO:0031328 316 0.020
purine ribonucleoside metabolic process GO:0046128 127 0.020
regulation of small gtpase mediated signal transduction GO:0051056 93 0.019
nucleoside triphosphate metabolic process GO:0009141 120 0.019
nucleoside triphosphate catabolic process GO:0009143 108 0.019
regulation of catalytic activity GO:0050790 185 0.019
purine nucleoside triphosphate catabolic process GO:0009146 108 0.019
purine nucleoside catabolic process GO:0006152 112 0.019
regulation of phosphorus metabolic process GO:0051174 210 0.019
biological adhesion GO:0022610 138 0.019
cellular amino acid metabolic process GO:0006520 61 0.019
endocytosis GO:0006897 310 0.019
endomembrane system organization GO:0010256 119 0.019
wing disc morphogenesis GO:0007472 344 0.019
camera type eye development GO:0043010 4 0.018
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.018
regulation of nucleotide catabolic process GO:0030811 48 0.018
gland development GO:0048732 191 0.018
response to organic substance GO:0010033 284 0.018
developmental growth GO:0048589 280 0.018
regulation of localization GO:0032879 275 0.018
eye morphogenesis GO:0048592 260 0.018
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.018
regulation of cellular ketone metabolic process GO:0010565 3 0.018
eye development GO:0001654 323 0.018
organonitrogen compound catabolic process GO:1901565 128 0.018
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.018
purine ribonucleotide metabolic process GO:0009150 145 0.018
positive regulation of cell communication GO:0010647 250 0.018
organic acid metabolic process GO:0006082 103 0.017
open tracheal system development GO:0007424 204 0.017
gene silencing GO:0016458 138 0.017
ribonucleotide catabolic process GO:0009261 109 0.017
protein phosphorylation GO:0006468 169 0.017
macromolecule catabolic process GO:0009057 161 0.017
cell death GO:0008219 279 0.017
nucleobase containing small molecule metabolic process GO:0055086 174 0.017
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.017
ribonucleoside triphosphate metabolic process GO:0009199 119 0.017
nucleoside catabolic process GO:0009164 112 0.017
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.017
salivary gland development GO:0007431 162 0.017
positive regulation of catalytic activity GO:0043085 118 0.017
regulation of transport GO:0051049 181 0.017
axonogenesis GO:0007409 290 0.017
death GO:0016265 284 0.017
regulation of cellular amino acid metabolic process GO:0006521 0 0.016
ribose phosphate metabolic process GO:0019693 145 0.016
negative regulation of cellular biosynthetic process GO:0031327 277 0.016
ribonucleoside triphosphate catabolic process GO:0009203 108 0.016
regulation of programmed cell death GO:0043067 152 0.016
gtp catabolic process GO:0006184 72 0.016
negative regulation of signal transduction GO:0009968 206 0.016
golgi organization GO:0007030 66 0.016
rna processing GO:0006396 147 0.016
nucleotide catabolic process GO:0009166 109 0.016
positive regulation of phosphorus metabolic process GO:0010562 139 0.016
response to abiotic stimulus GO:0009628 341 0.016
regulation of cellular component size GO:0032535 98 0.016
sensory organ morphogenesis GO:0090596 260 0.016
embryonic pattern specification GO:0009880 174 0.016
neuron projection guidance GO:0097485 241 0.016
glycosyl compound metabolic process GO:1901657 127 0.016
response to lipopolysaccharide GO:0032496 4 0.015
compound eye morphogenesis GO:0001745 249 0.015
oxoacid metabolic process GO:0043436 103 0.015
segmentation GO:0035282 207 0.015
regulation of protein metabolic process GO:0051246 256 0.015
imaginal disc derived appendage morphogenesis GO:0035114 395 0.015
positive regulation of cellular catabolic process GO:0031331 95 0.015
positive regulation of nucleoside metabolic process GO:0045979 47 0.015
positive regulation of hydrolase activity GO:0051345 78 0.015
regulation of response to stress GO:0080134 200 0.015
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.015
respiratory system development GO:0060541 213 0.015
gtp metabolic process GO:0046039 72 0.015
nucleoside metabolic process GO:0009116 127 0.015
positive regulation of molecular function GO:0044093 136 0.015
organophosphate catabolic process GO:0046434 112 0.015
carbohydrate metabolic process GO:0005975 82 0.014
guanosine containing compound catabolic process GO:1901069 74 0.014
cell proliferation GO:0008283 299 0.014
forebrain development GO:0030900 2 0.014
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.014
columnar cuboidal epithelial cell development GO:0002066 249 0.014
response to oxygen containing compound GO:1901700 200 0.014
regulation of ras gtpase activity GO:0032318 38 0.014
positive regulation of cell migration GO:0030335 2 0.014
cellular ketone metabolic process GO:0042180 24 0.014
response to starvation GO:0042594 97 0.014
positive regulation of catabolic process GO:0009896 105 0.014
negative regulation of developmental process GO:0051093 201 0.014
regulation of multicellular organismal development GO:2000026 414 0.014
salivary gland morphogenesis GO:0007435 145 0.014
actin filament based process GO:0030029 220 0.014
positive regulation of gene expression GO:0010628 290 0.014
gland morphogenesis GO:0022612 145 0.014
programmed cell death GO:0012501 257 0.014
establishment of localization in cell GO:0051649 402 0.014
photoreceptor cell development GO:0042461 96 0.014
positive regulation of cellular amine metabolic process GO:0033240 0 0.014
negative regulation of rna metabolic process GO:0051253 251 0.014
positive regulation of macromolecule metabolic process GO:0010604 405 0.014
compound eye photoreceptor cell differentiation GO:0001751 140 0.014
positive regulation of rna metabolic process GO:0051254 271 0.014
regulation of mitotic cell cycle GO:0007346 190 0.014
actin cytoskeleton organization GO:0030036 206 0.014
posttranscriptional regulation of gene expression GO:0010608 145 0.014
positive regulation of biosynthetic process GO:0009891 316 0.014
cuticle development GO:0042335 86 0.014
positive regulation of response to stimulus GO:0048584 323 0.014
taxis GO:0042330 304 0.013
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.013
response to extracellular stimulus GO:0009991 116 0.013
regulation of anatomical structure morphogenesis GO:0022603 242 0.013
locomotory behavior GO:0007626 176 0.013
single organism carbohydrate metabolic process GO:0044723 72 0.013
positive regulation of ras gtpase activity GO:0032320 36 0.013
glycosyl compound catabolic process GO:1901658 112 0.013
organic substance transport GO:0071702 257 0.013
protein complex assembly GO:0006461 200 0.013
tissue morphogenesis GO:0048729 297 0.013
negative regulation of biosynthetic process GO:0009890 277 0.013
blastoderm segmentation GO:0007350 159 0.013
macromolecular complex assembly GO:0065003 256 0.013
cellular response to chemical stimulus GO:0070887 199 0.013
positive regulation of cell motility GO:2000147 3 0.013
regulation of cell substrate adhesion GO:0010810 2 0.012
regulation of gtp catabolic process GO:0033124 44 0.012
ovarian follicle cell development GO:0030707 248 0.012
negative regulation of multicellular organismal process GO:0051241 142 0.012
positive regulation of nucleic acid templated transcription GO:1903508 266 0.012
regulation of phosphate metabolic process GO:0019220 210 0.012
retina development in camera type eye GO:0060041 4 0.012
purine nucleoside metabolic process GO:0042278 127 0.012
autophagic cell death GO:0048102 83 0.012
negative regulation of cell communication GO:0010648 223 0.012
exocrine system development GO:0035272 162 0.012
eggshell formation GO:0030703 105 0.012
positive regulation of rna biosynthetic process GO:1902680 266 0.012
negative regulation of nervous system development GO:0051961 92 0.012
positive regulation of phosphate metabolic process GO:0045937 139 0.012
cellular component assembly involved in morphogenesis GO:0010927 151 0.012
epithelial cell differentiation GO:0030855 322 0.012
establishment of vesicle localization GO:0051650 51 0.012
negative regulation of signaling GO:0023057 219 0.012
defense response GO:0006952 300 0.012
histolysis GO:0007559 102 0.012
cell cycle phase transition GO:0044770 140 0.012
regulation of gene silencing GO:0060968 63 0.012
nucleotide metabolic process GO:0009117 161 0.012
regulation of purine nucleotide catabolic process GO:0033121 48 0.012
protein modification by small protein conjugation or removal GO:0070647 106 0.012
regulation of mitotic cell cycle phase transition GO:1901990 130 0.012
pigmentation GO:0043473 75 0.012
neuron recognition GO:0008038 101 0.012
sensory perception GO:0007600 196 0.012
positive regulation of nucleotide metabolic process GO:0045981 55 0.012
homeostatic process GO:0042592 199 0.012
xenobiotic catabolic process GO:0042178 1 0.012
developmental programmed cell death GO:0010623 138 0.012
regulation of organelle organization GO:0033043 196 0.012
protein localization GO:0008104 284 0.012
positive regulation of gtpase activity GO:0043547 43 0.012
positive regulation of nucleotide catabolic process GO:0030813 46 0.012
steroid catabolic process GO:0006706 1 0.012
chemotaxis GO:0006935 249 0.012
peptidyl amino acid modification GO:0018193 105 0.012
purine nucleoside triphosphate metabolic process GO:0009144 119 0.012
aging GO:0007568 143 0.012
telencephalon development GO:0021537 2 0.012
synapse organization GO:0050808 196 0.012
photoreceptor cell differentiation GO:0046530 170 0.012
purine containing compound catabolic process GO:0072523 112 0.011
regulation of epithelial cell proliferation GO:0050678 4 0.011
vesicle organization GO:0016050 44 0.011
growth GO:0040007 359 0.011
regulation of cell death GO:0010941 173 0.011
regulation of gtpase activity GO:0043087 44 0.011
positive regulation of signal transduction GO:0009967 223 0.011
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.011
regulation of hydrolase activity GO:0051336 97 0.011
enzyme linked receptor protein signaling pathway GO:0007167 179 0.011
cellular response to organic substance GO:0071310 132 0.011
tissue death GO:0016271 102 0.011
organelle fission GO:0048285 340 0.011
regulation of cellular protein metabolic process GO:0032268 243 0.011
defense response to bacterium GO:0042742 178 0.011
embryonic axis specification GO:0000578 107 0.011
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.011
anion homeostasis GO:0055081 3 0.011
negative regulation of gene expression epigenetic GO:0045814 77 0.011
camera type eye morphogenesis GO:0048593 2 0.011
eye photoreceptor cell differentiation GO:0001754 145 0.011
lateral inhibition GO:0046331 206 0.011
cellular response to dna damage stimulus GO:0006974 223 0.011
negative regulation of cell differentiation GO:0045596 143 0.011
actin filament organization GO:0007015 126 0.011
hindbrain development GO:0030902 2 0.011
salivary gland histolysis GO:0035070 88 0.011
axon guidance GO:0007411 233 0.011
proteolysis GO:0006508 192 0.011
pigment metabolic process GO:0042440 84 0.011
regulation of gene expression epigenetic GO:0040029 128 0.011
limb development GO:0060173 1 0.011
guanosine containing compound metabolic process GO:1901068 74 0.011
cellular response to starvation GO:0009267 61 0.011
imaginal disc derived leg morphogenesis GO:0007480 80 0.011
hormone catabolic process GO:0042447 3 0.011
response to bacterium GO:0009617 198 0.011
regulation of cell cycle GO:0051726 291 0.011
wnt signaling pathway GO:0016055 98 0.011
organelle assembly GO:0070925 198 0.011
central nervous system development GO:0007417 201 0.011
axon development GO:0061564 297 0.011
regulation of microtubule polymerization or depolymerization GO:0031110 27 0.011
regulation of nucleoside metabolic process GO:0009118 50 0.011
negative regulation of nucleic acid templated transcription GO:1903507 240 0.010
erbb signaling pathway GO:0038127 58 0.010
axis specification GO:0009798 167 0.010
response to hexose GO:0009746 3 0.010
negative regulation of transcription dna templated GO:0045892 237 0.010
peptidyl threonine modification GO:0018210 3 0.010
dorsal ventral pattern formation GO:0009953 133 0.010
cell recognition GO:0008037 102 0.010
response to external biotic stimulus GO:0043207 293 0.010
embryonic morphogenesis GO:0048598 206 0.010
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 4 0.010
response to nitrogen compound GO:1901698 90 0.010
response to monosaccharide GO:0034284 4 0.010
response to other organism GO:0051707 293 0.010
cellular macromolecule catabolic process GO:0044265 136 0.010
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.010
positive regulation of signaling GO:0023056 243 0.010
positive regulation of cell death GO:0010942 69 0.010

Hcs disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.044
nervous system disease DOID:863 0 0.025
cardiovascular system disease DOID:1287 0 0.012
central nervous system disease DOID:331 0 0.012
musculoskeletal system disease DOID:17 0 0.011
neurodegenerative disease DOID:1289 0 0.011
disease of metabolism DOID:0014667 0 0.011
disease of cellular proliferation DOID:14566 0 0.011