Drosophila melanogaster

11 known processes

Sema-1b (Dmel_CG6446)

CG6446 gene product from transcript CG6446-RA

(Aliases: Dmel\CG6446,Sema 1b,BcDNA:GH03186,D-semaIII,Sema1b,sema-III,CG6446,Sema III)

Sema-1b biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
taxis GO:0042330 304 0.853
Zebrafish Rat Fly
morphogenesis of an epithelium GO:0002009 276 0.813
axon development GO:0061564 297 0.761
Rat Fly
axonogenesis GO:0007409 290 0.667
Rat Fly
immune response activating signal transduction GO:0002757 2 0.596
neuron projection guidance GO:0097485 241 0.550
Rat Fly
cell growth GO:0016049 108 0.518
defense response to virus GO:0051607 23 0.510
cellular protein modification process GO:0006464 438 0.494
regulation of synapse organization GO:0050807 110 0.492
axon guidance GO:0007411 233 0.398
Rat Fly
immune response regulating signaling pathway GO:0002764 2 0.380
regulation of cell morphogenesis GO:0022604 163 0.347
Fly
positive regulation of response to stimulus GO:0048584 323 0.344
developmental growth GO:0048589 280 0.338
morphogenesis of embryonic epithelium GO:0016331 94 0.335
protein modification process GO:0036211 438 0.324
regulation of intracellular signal transduction GO:1902531 236 0.320
regionalization GO:0003002 416 0.311
positive regulation of signal transduction GO:0009967 223 0.311
negative regulation of response to stimulus GO:0048585 258 0.304
response to organic substance GO:0010033 284 0.281
response to virus GO:0009615 28 0.278
synapse assembly GO:0007416 143 0.271
Fly
chemotaxis GO:0006935 249 0.260
Zebrafish Rat Fly
activation of immune response GO:0002253 5 0.251
immune response GO:0006955 246 0.246
negative regulation of cell communication GO:0010648 223 0.236
tissue morphogenesis GO:0048729 297 0.232
phosphorylation GO:0016310 294 0.230
photoreceptor cell axon guidance GO:0072499 23 0.227
positive regulation of cellular component organization GO:0051130 156 0.224
regulation of response to external stimulus GO:0032101 115 0.211
Fly
embryo development ending in birth or egg hatching GO:0009792 152 0.208
synapse organization GO:0050808 196 0.208
Fly
regulation of synapse structure and activity GO:0050803 128 0.202
positive regulation of intracellular signal transduction GO:1902533 116 0.186
positive regulation of cell communication GO:0010647 250 0.183
neuron projection extension GO:1990138 32 0.180
intracellular signal transduction GO:0035556 300 0.177
protein phosphorylation GO:0006468 169 0.176
negative regulation of signal transduction GO:0009968 206 0.170
cell motility GO:0048870 251 0.166
regulation of immune response GO:0050776 118 0.164
biological adhesion GO:0022610 138 0.160
regulation of neuron projection development GO:0010975 69 0.158
Fly
regulation of phosphorylation GO:0042325 147 0.152
regulation of response to stress GO:0080134 200 0.151
Fly
columnar cuboidal epithelial cell development GO:0002066 249 0.149
positive regulation of multicellular organismal process GO:0051240 143 0.144
microtubule organizing center organization GO:0031023 168 0.143
negative regulation of gene expression GO:0010629 387 0.131
developmental growth involved in morphogenesis GO:0060560 65 0.131
negative regulation of signaling GO:0023057 219 0.131
dendrite development GO:0016358 204 0.128
Fly
negative regulation of response to external stimulus GO:0032102 22 0.128
positive regulation of immune response GO:0050778 63 0.127
appendage development GO:0048736 401 0.127
positive regulation of signaling GO:0023056 243 0.126
regulation of immune effector process GO:0002697 52 0.125
positive regulation of macromolecule metabolic process GO:0010604 405 0.117
regulation of neurogenesis GO:0050767 158 0.111
Fly
growth GO:0040007 359 0.110
regulation of nervous system development GO:0051960 248 0.108
Fly
cardiovascular system development GO:0072358 82 0.107
embryonic pattern specification GO:0009880 174 0.105
endocytosis GO:0006897 310 0.105
photoreceptor cell differentiation GO:0046530 170 0.098
cell recognition GO:0008037 102 0.097
Fly
compound eye photoreceptor cell differentiation GO:0001751 140 0.097
cell death GO:0008219 279 0.095
ovarian follicle cell development GO:0030707 248 0.093
regulation of synapse assembly GO:0051963 94 0.089
gland development GO:0048732 191 0.089
Fly
regulation of programmed cell death GO:0043067 152 0.087
cellular protein localization GO:0034613 160 0.087
axon extension GO:0048675 32 0.085
regulation of protein metabolic process GO:0051246 256 0.084
developmental cell growth GO:0048588 52 0.084
semaphorin plexin signaling pathway involved in regulation of photoreceptor cell axon guidance GO:2000305 2 0.082
Fly
actin filament based process GO:0030029 220 0.080
compound eye photoreceptor development GO:0042051 78 0.080
immune effector process GO:0002252 98 0.079
innate immune response GO:0045087 144 0.079
positive regulation of protein metabolic process GO:0051247 128 0.079
regulation of growth GO:0040008 233 0.078
mapk cascade GO:0000165 107 0.077
response to external biotic stimulus GO:0043207 293 0.075
cellular catabolic process GO:0044248 372 0.072
chromosome organization GO:0051276 360 0.072
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.071
homeostatic process GO:0042592 199 0.071
cell adhesion GO:0007155 136 0.070
negative regulation of immune system process GO:0002683 50 0.070
cytoplasmic transport GO:0016482 130 0.070
regulation of behavior GO:0050795 75 0.068
Fly
eye photoreceptor cell differentiation GO:0001754 145 0.068
regulation of response to biotic stimulus GO:0002831 63 0.065
regulation of cell development GO:0060284 215 0.063
Fly
segmentation GO:0035282 207 0.063
body morphogenesis GO:0010171 2 0.062
posttranscriptional gene silencing GO:0016441 46 0.059
olfactory bulb axon guidance GO:0071678 3 0.059
Fly
single organism cellular localization GO:1902580 180 0.058
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.058
posttranscriptional gene silencing by rna GO:0035194 45 0.058
death GO:0016265 284 0.057
chromosome segregation GO:0007059 157 0.057
single organismal cell cell adhesion GO:0016337 45 0.057
programmed cell death GO:0012501 257 0.057
regulation of defense response GO:0031347 102 0.057
cellular response to chemical stimulus GO:0070887 199 0.056
circulatory system development GO:0072359 82 0.056
transcription from rna polymerase ii promoter GO:0006366 368 0.056
oxoacid metabolic process GO:0043436 103 0.055
regulation of neuron differentiation GO:0045664 103 0.054
Fly
protein transport GO:0015031 155 0.054
immune system process GO:0002376 347 0.054
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.053
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.053
positive regulation of transcription dna templated GO:0045893 266 0.052
response to abiotic stimulus GO:0009628 341 0.052
Fly
positive regulation of nucleic acid templated transcription GO:1903508 266 0.052
positive regulation of programmed cell death GO:0043068 62 0.052
positive regulation of nervous system development GO:0051962 69 0.051
posttranscriptional regulation of gene expression GO:0010608 145 0.049
regulation of cell differentiation GO:0045595 302 0.049
Fly
single organism biosynthetic process GO:0044711 206 0.049
organic substance catabolic process GO:1901575 308 0.049
embryonic axis specification GO:0000578 107 0.049
germ cell migration GO:0008354 43 0.048
extracellular structure organization GO:0043062 46 0.047
positive regulation of rna biosynthetic process GO:1902680 266 0.047
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.047
Fly
respiratory system development GO:0060541 213 0.046
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.044
regulation of immune system process GO:0002682 176 0.044
localization of cell GO:0051674 257 0.044
protein catabolic process GO:0030163 101 0.043
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.043
carboxylic acid metabolic process GO:0019752 92 0.042
response to other organism GO:0051707 293 0.042
negative regulation of cellular metabolic process GO:0031324 382 0.042
digestive system development GO:0055123 149 0.042
signal transduction by phosphorylation GO:0023014 107 0.041
appendage morphogenesis GO:0035107 397 0.041
enzyme linked receptor protein signaling pathway GO:0007167 179 0.041
lipid metabolic process GO:0006629 121 0.040
cellular macromolecule localization GO:0070727 220 0.040
chromatin organization GO:0006325 207 0.039
cell migration GO:0016477 238 0.039
regulation of multi organism process GO:0043900 131 0.039
positive regulation of cellular component biogenesis GO:0044089 80 0.039
regulation of apoptotic process GO:0042981 130 0.039
epithelial cell migration GO:0010631 148 0.039
small molecule metabolic process GO:0044281 305 0.039
positive regulation of cysteine type endopeptidase activity GO:2001056 24 0.039
epithelium migration GO:0090132 148 0.038
blastoderm segmentation GO:0007350 159 0.038
compound eye development GO:0048749 307 0.038
axonal defasciculation GO:0007414 12 0.038
regulation of cellular protein metabolic process GO:0032268 243 0.037
regulation of anatomical structure size GO:0090066 163 0.037
Fly
single organism intracellular transport GO:1902582 207 0.037
positive regulation of apoptotic process GO:0043065 47 0.037
regulation of cysteine type endopeptidase activity GO:2000116 27 0.037
regulation of cell projection organization GO:0031344 92 0.037
Fly
positive regulation of developmental process GO:0051094 143 0.036
single organism behavior GO:0044708 391 0.036
Fly
ameboidal type cell migration GO:0001667 151 0.035
photoreceptor cell development GO:0042461 96 0.035
response to endogenous stimulus GO:0009719 119 0.035
eye development GO:0001654 323 0.035
response to biotic stimulus GO:0009607 294 0.035
nuclear division GO:0000280 332 0.034
regulation of mitotic cell cycle GO:0007346 190 0.034
organic acid metabolic process GO:0006082 103 0.034
positive regulation of immune system process GO:0002684 68 0.034
innate immune response activating signal transduction GO:0002758 2 0.033
organonitrogen compound metabolic process GO:1901564 318 0.033
regulation of mapk cascade GO:0043408 92 0.033
apoptotic process GO:0006915 159 0.033
apoptotic signaling pathway GO:0097190 27 0.032
protein localization GO:0008104 284 0.032
ovarian follicle cell migration GO:0007297 121 0.031
cellular amine metabolic process GO:0044106 12 0.031
proteolysis GO:0006508 192 0.031
activation of innate immune response GO:0002218 4 0.031
positive regulation of cellular biosynthetic process GO:0031328 316 0.030
multi organism behavior GO:0051705 175 0.030
limb development GO:0060173 1 0.029
spermatid differentiation GO:0048515 114 0.029
humoral immune response GO:0006959 117 0.029
regulation of cellular component biogenesis GO:0044087 201 0.029
central nervous system development GO:0007417 201 0.029
Fly
positive regulation of rna metabolic process GO:0051254 271 0.029
positive regulation of cellular protein metabolic process GO:0032270 118 0.028
forebrain development GO:0030900 2 0.028
regulation of organ morphogenesis GO:2000027 78 0.028
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.028
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.028
regulation of protein modification process GO:0031399 112 0.028
regulation of axon extension involved in axon guidance GO:0048841 4 0.027
defense response GO:0006952 300 0.027
amine metabolic process GO:0009308 12 0.027
cellular response to peptide hormone stimulus GO:0071375 28 0.026
tube development GO:0035295 244 0.026
macromolecular complex assembly GO:0065003 256 0.026
regulation of cellular response to stress GO:0080135 89 0.026
Fly
nuclear transport GO:0051169 72 0.026
regulation of molecular function GO:0065009 217 0.026
regulation of phosphorus metabolic process GO:0051174 210 0.026
eye morphogenesis GO:0048592 260 0.025
peptidyl threonine phosphorylation GO:0018107 2 0.025
modification dependent macromolecule catabolic process GO:0043632 79 0.024
cell division GO:0051301 248 0.024
regulation of protein phosphorylation GO:0001932 64 0.024
epithelial tube morphogenesis GO:0060562 88 0.024
vesicle mediated transport GO:0016192 381 0.024
neurological system process GO:0050877 358 0.024
Fly
ras protein signal transduction GO:0007265 88 0.024
positive regulation of growth GO:0045927 75 0.024
protein targeting to nucleus GO:0044744 51 0.024
neuron recognition GO:0008038 101 0.023
Fly
somatic muscle development GO:0007525 66 0.023
mesenchymal cell differentiation GO:0048762 1 0.023
positive regulation of cellular amine metabolic process GO:0033240 0 0.023
intracellular transport GO:0046907 228 0.023
catabolic process GO:0009056 409 0.023
cellular macromolecule catabolic process GO:0044265 136 0.023
endomembrane system organization GO:0010256 119 0.023
negative regulation of cell death GO:0060548 81 0.023
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.023
mrna catabolic process GO:0006402 33 0.022
single organism nuclear import GO:1902593 51 0.022
regulation of developmental growth GO:0048638 174 0.022
positive regulation of proteolysis GO:0045862 52 0.022
macromolecule catabolic process GO:0009057 161 0.021
regulation of anatomical structure morphogenesis GO:0022603 242 0.021
Fly
nucleocytoplasmic transport GO:0006913 72 0.021
post embryonic appendage morphogenesis GO:0035120 385 0.021
activation of protein kinase activity GO:0032147 12 0.021
cellular response to organic cyclic compound GO:0071407 32 0.021
response to oxygen containing compound GO:1901700 200 0.020
gene silencing by rna GO:0031047 57 0.020
developmental maturation GO:0021700 172 0.020
cellular ketone metabolic process GO:0042180 24 0.020
embryonic morphogenesis GO:0048598 206 0.020
phagocytosis GO:0006909 215 0.020
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.020
heart development GO:0007507 82 0.020
tissue migration GO:0090130 155 0.020
single organism membrane organization GO:0044802 93 0.020
zymogen activation GO:0031638 20 0.020
regulation of bmp signaling pathway GO:0030510 23 0.020
cellular response to dna damage stimulus GO:0006974 223 0.020
Fly
regulation of cell cycle process GO:0010564 181 0.020
cellular response to nitrogen compound GO:1901699 51 0.020
protein acylation GO:0043543 42 0.019
cell junction assembly GO:0034329 42 0.019
actin cytoskeleton reorganization GO:0031532 22 0.019
cellular response to organic substance GO:0071310 132 0.019
negative regulation of intracellular signal transduction GO:1902532 57 0.018
imaginal disc derived appendage development GO:0048737 399 0.018
positive regulation of gene expression GO:0010628 290 0.018
cellular response to endogenous stimulus GO:0071495 80 0.018
mating behavior GO:0007617 106 0.018
positive regulation of phosphorus metabolic process GO:0010562 139 0.018
regulation of cell death GO:0010941 173 0.018
negative regulation of programmed cell death GO:0043069 72 0.018
sensory organ morphogenesis GO:0090596 260 0.018
regulation of axon extension GO:0030516 8 0.017
establishment of protein localization GO:0045184 163 0.017
positive regulation of cell death GO:0010942 69 0.017
regulation of phosphate metabolic process GO:0019220 210 0.017
open tracheal system development GO:0007424 204 0.017
nephron development GO:0072006 3 0.017
cellular response to oxygen containing compound GO:1901701 79 0.017
motor neuron axon guidance GO:0008045 58 0.017
Fly
negative regulation of protein metabolic process GO:0051248 85 0.017
compound eye morphogenesis GO:0001745 249 0.016
ubiquitin dependent protein catabolic process GO:0006511 78 0.016
salivary gland development GO:0007431 162 0.016
Fly
dendrite morphogenesis GO:0048813 199 0.016
Fly
regulation of innate immune response GO:0045088 71 0.016
dna metabolic process GO:0006259 227 0.016
exocrine system development GO:0035272 162 0.016
Fly
response to growth factor GO:0070848 31 0.016
response to protozoan GO:0001562 3 0.016
epithelial cell development GO:0002064 274 0.016
organic substance transport GO:0071702 257 0.016
pigment metabolic process GO:0042440 84 0.016
negative regulation of multi organism process GO:0043901 29 0.015
regulation of protein targeting GO:1903533 29 0.015
establishment or maintenance of cell polarity GO:0007163 167 0.015
regulation of wnt signaling pathway GO:0030111 68 0.015
bmp signaling pathway GO:0030509 27 0.015
embryonic organ development GO:0048568 50 0.015
determination of adult lifespan GO:0008340 137 0.015
defense response to other organism GO:0098542 225 0.015
cellular amino acid metabolic process GO:0006520 61 0.015
tube morphogenesis GO:0035239 191 0.015
intracellular protein transport GO:0006886 104 0.015
ribonucleoprotein complex subunit organization GO:0071826 28 0.015
small gtpase mediated signal transduction GO:0007264 88 0.015
dorsal ventral pattern formation GO:0009953 133 0.015
organelle assembly GO:0070925 198 0.015
regulation of multicellular organismal development GO:2000026 414 0.015
Fly
centrosome organization GO:0051297 163 0.015
protein localization to organelle GO:0033365 82 0.015
response to wounding GO:0009611 94 0.014
retinal ganglion cell axon guidance GO:0031290 12 0.014
negative regulation of apoptotic process GO:0043066 63 0.014
chemosensory behavior GO:0007635 106 0.014
morphogenesis of a branching epithelium GO:0061138 45 0.014
sperm individualization GO:0007291 48 0.014
positive regulation of mapk cascade GO:0043410 63 0.014
positive regulation of phosphate metabolic process GO:0045937 139 0.014
rho protein signal transduction GO:0007266 14 0.014
mesenchymal cell development GO:0014031 1 0.014
peripheral nervous system development GO:0007422 52 0.014
renal tubule development GO:0061326 64 0.014
muscle structure development GO:0061061 224 0.014
nuclear import GO:0051170 51 0.014
regulation of cellular amine metabolic process GO:0033238 3 0.014
morphogenesis of follicular epithelium GO:0016333 36 0.014
cellular lipid metabolic process GO:0044255 83 0.014
peptidyl amino acid modification GO:0018193 105 0.013
response to nutrient levels GO:0031667 114 0.013
positive regulation of apoptotic signaling pathway GO:2001235 4 0.013
antimicrobial humoral response GO:0019730 99 0.013
multicellular organismal aging GO:0010259 140 0.013
regulation of neuron apoptotic process GO:0043523 16 0.013
peptidyl tyrosine modification GO:0018212 24 0.013
mrna processing GO:0006397 104 0.013
negative regulation of defense response GO:0031348 35 0.013
actin cytoskeleton organization GO:0030036 206 0.013
response to radiation GO:0009314 155 0.013
Fly
telencephalon development GO:0021537 2 0.013
cellularization GO:0007349 90 0.013
nuclear transcribed mrna catabolic process GO:0000956 24 0.013
response to nitrogen compound GO:1901698 90 0.013
dorsal ventral axis specification GO:0009950 66 0.013
protein import into nucleus GO:0006606 51 0.013
digestive tract development GO:0048565 149 0.013
meiotic cell cycle process GO:1903046 132 0.013
positive regulation of developmental growth GO:0048639 62 0.013
salivary gland morphogenesis GO:0007435 145 0.012
eggshell formation GO:0030703 105 0.012
positive regulation of protein complex assembly GO:0031334 22 0.012
regulation of nucleocytoplasmic transport GO:0046822 35 0.012
regulation of cellular ketone metabolic process GO:0010565 3 0.012
centrosome cycle GO:0007098 137 0.012
positive regulation of synapse assembly GO:0051965 29 0.012
dorsal closure GO:0007391 79 0.012
regulation of catalytic activity GO:0050790 185 0.012
neuromuscular junction development GO:0007528 149 0.012
epithelial cell differentiation GO:0030855 322 0.012
synaptic growth at neuromuscular junction GO:0051124 119 0.012
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 18 0.012
regulation of cell cycle GO:0051726 291 0.012
regulation of notch signaling pathway GO:0008593 100 0.012
mrna splicing via spliceosome GO:0000398 73 0.012
pattern recognition receptor signaling pathway GO:0002221 2 0.012
positive regulation of endopeptidase activity GO:0010950 26 0.012
regulation of kinase activity GO:0043549 53 0.012
single organism cell adhesion GO:0098602 47 0.012
multi multicellular organism process GO:0044706 123 0.012
regulation of transferase activity GO:0051338 58 0.012
mating GO:0007618 120 0.012
spermatid development GO:0007286 98 0.012
organic cyclic compound catabolic process GO:1901361 168 0.012
ribonucleoprotein complex assembly GO:0022618 23 0.011
cellular response to growth factor stimulus GO:0071363 30 0.011
regulation of cell size GO:0008361 63 0.011
Fly
axon regeneration GO:0031103 8 0.011
cellular macromolecular complex assembly GO:0034622 153 0.011
establishment of localization in cell GO:0051649 402 0.011
regulation of hemocyte proliferation GO:0035206 37 0.011
positive regulation of i kappab kinase nf kappab signaling GO:0043123 1 0.011
regulation of mitosis GO:0007088 56 0.011
nucleobase containing compound catabolic process GO:0034655 165 0.011
ribonucleoprotein complex biogenesis GO:0022613 31 0.011
hormone metabolic process GO:0042445 33 0.011
sodium ion transport GO:0006814 22 0.011
regulation of cellular amino acid metabolic process GO:0006521 0 0.011
positive regulation of organelle organization GO:0010638 65 0.011
negative regulation of phosphorylation GO:0042326 35 0.011
regulation of tube size open tracheal system GO:0035151 43 0.010
response to fungus GO:0009620 50 0.010
wnt signaling pathway GO:0016055 98 0.010
positive regulation of biosynthetic process GO:0009891 316 0.010
adult behavior GO:0030534 137 0.010
Fly
modification dependent protein catabolic process GO:0019941 78 0.010
regulation of erk1 and erk2 cascade GO:0070372 39 0.010
germline ring canal formation GO:0030725 13 0.010
axon target recognition GO:0007412 16 0.010
carbohydrate derivative metabolic process GO:1901135 217 0.010
protein localization to nucleus GO:0034504 55 0.010
regulation of protein localization to nucleus GO:1900180 29 0.010

Sema-1b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.033
cancer DOID:162 0 0.011
organ system cancer DOID:0050686 0 0.011
disease of cellular proliferation DOID:14566 0 0.011