Drosophila melanogaster

30 known processes

Pgk (Dmel_CG3127)

Phosphoglycerate kinase

(Aliases: pgk,CG3127,l(2)23AB3,PGK,Dmel\CG3127,ESTS:169C9S,l(2)23Ac,169C9S,anon-sts18)

Pgk biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
synaptic transmission GO:0007268 288 0.925
generation of precursor metabolites and energy GO:0006091 42 0.876
oxidation reduction process GO:0055114 123 0.846
nad metabolic process GO:0019674 1 0.780
synapse organization GO:0050808 196 0.748
establishment of localization in cell GO:0051649 402 0.745
carbohydrate catabolic process GO:0016052 7 0.641
transmembrane transport GO:0055085 139 0.618
mitochondrion organization GO:0007005 65 0.613
single organism biosynthetic process GO:0044711 206 0.586
organic acid metabolic process GO:0006082 103 0.529
organonitrogen compound metabolic process GO:1901564 318 0.480
pyruvate metabolic process GO:0006090 7 0.452
carbohydrate metabolic process GO:0005975 82 0.445
single organism carbohydrate metabolic process GO:0044723 72 0.415
myotube differentiation GO:0014902 46 0.405
striated muscle cell differentiation GO:0051146 90 0.394
ion transport GO:0006811 145 0.390
energy derivation by oxidation of organic compounds GO:0015980 32 0.388
carbohydrate biosynthetic process GO:0016051 17 0.382
oxoacid metabolic process GO:0043436 103 0.381
secretion by cell GO:0032940 101 0.380
carboxylic acid metabolic process GO:0019752 92 0.349
ribonucleoside biosynthetic process GO:0042455 3 0.342
single organism carbohydrate catabolic process GO:0044724 7 0.332
actomyosin structure organization GO:0031032 56 0.330
enzyme linked receptor protein signaling pathway GO:0007167 179 0.313
glycolytic process GO:0006096 6 0.310
muscle cell differentiation GO:0042692 103 0.306
nucleoside metabolic process GO:0009116 127 0.301
myoblast fusion GO:0007520 43 0.282
cellular component assembly involved in morphogenesis GO:0010927 151 0.266
cellular response to chemical stimulus GO:0070887 199 0.265
negative regulation of signaling GO:0023057 219 0.262
lipid localization GO:0010876 54 0.253
cation transmembrane transport GO:0098655 88 0.241
nicotinamide nucleotide metabolic process GO:0046496 2 0.238
cellular amino acid metabolic process GO:0006520 61 0.236
neuron neuron synaptic transmission GO:0007270 14 0.225
organophosphate metabolic process GO:0019637 195 0.221
negative regulation of response to stimulus GO:0048585 258 0.209
syncytium formation GO:0006949 43 0.198
regulation of localization GO:0032879 275 0.196
homeostatic process GO:0042592 199 0.189
syncytium formation by plasma membrane fusion GO:0000768 43 0.186
muscle structure development GO:0061061 224 0.183
atp biosynthetic process GO:0006754 2 0.183
cellular response to reactive oxygen species GO:0034614 14 0.179
defense response GO:0006952 300 0.175
small molecule metabolic process GO:0044281 305 0.174
secretion GO:0046903 109 0.174
monocarboxylic acid metabolic process GO:0032787 29 0.169
programmed cell death GO:0012501 257 0.165
regulation of transport GO:0051049 181 0.164
cellular lipid metabolic process GO:0044255 83 0.157
oxidoreduction coenzyme metabolic process GO:0006733 2 0.155
regulation of synaptic transmission GO:0050804 69 0.150
ion transmembrane transport GO:0034220 122 0.148
signal release GO:0023061 49 0.144
organic substance catabolic process GO:1901575 308 0.143
response to organic substance GO:0010033 284 0.142
single organism catabolic process GO:0044712 228 0.138
catabolic process GO:0009056 409 0.138
lipid storage GO:0019915 38 0.137
synapse assembly GO:0007416 143 0.134
negative regulation of protein metabolic process GO:0051248 85 0.134
cellular ketone metabolic process GO:0042180 24 0.132
inorganic cation transmembrane transport GO:0098662 61 0.129
response to oxygen containing compound GO:1901700 200 0.125
protein complex assembly GO:0006461 200 0.122
appendage morphogenesis GO:0035107 397 0.120
metal ion transport GO:0030001 74 0.113
cellular macromolecular complex assembly GO:0034622 153 0.110
regulation of cellular localization GO:0060341 136 0.110
purine nucleoside metabolic process GO:0042278 127 0.107
neurotransmitter transport GO:0006836 37 0.104
regulation of response to stress GO:0080134 200 0.099
negative regulation of signal transduction GO:0009968 206 0.098
pyridine containing compound metabolic process GO:0072524 3 0.097
response to organonitrogen compound GO:0010243 75 0.095
single organism membrane organization GO:0044802 93 0.094
cellular protein modification process GO:0006464 438 0.094
cellular protein complex assembly GO:0043623 71 0.091
regulation of cell death GO:0010941 173 0.091
cellular respiration GO:0045333 26 0.088
purine nucleoside biosynthetic process GO:0042451 3 0.087
posttranscriptional regulation of gene expression GO:0010608 145 0.086
nucleotide metabolic process GO:0009117 161 0.085
negative regulation of cell communication GO:0010648 223 0.084
response to abiotic stimulus GO:0009628 341 0.084
neuromuscular synaptic transmission GO:0007274 67 0.083
protein localization GO:0008104 284 0.083
lipid metabolic process GO:0006629 121 0.083
hexose metabolic process GO:0019318 8 0.082
response to glucose GO:0009749 2 0.082
locomotory behavior GO:0007626 176 0.081
somatic muscle development GO:0007525 66 0.080
cation transport GO:0006812 110 0.080
death GO:0016265 284 0.077
cellular polysaccharide metabolic process GO:0044264 11 0.077
g protein coupled receptor signaling pathway GO:0007186 136 0.076
atp metabolic process GO:0046034 49 0.074
lipid catabolic process GO:0016042 21 0.073
regulation of secretion by cell GO:1903530 39 0.073
cell death GO:0008219 279 0.073
phosphorylation GO:0016310 294 0.070
membrane organization GO:0061024 112 0.069
response to monosaccharide GO:0034284 4 0.068
aging GO:0007568 143 0.068
ribonucleoside triphosphate biosynthetic process GO:0009201 2 0.067
synaptic transmission glutamatergic GO:0035249 7 0.067
regulation of membrane potential GO:0042391 35 0.067
myofibril assembly GO:0030239 36 0.065
actin filament based process GO:0030029 220 0.063
purine ribonucleoside metabolic process GO:0046128 127 0.062
glucose metabolic process GO:0006006 5 0.062
positive regulation of cell communication GO:0010647 250 0.061
response to mechanical stimulus GO:0009612 28 0.061
regulation of secretion GO:0051046 44 0.061
regulation of programmed cell death GO:0043067 152 0.059
polysaccharide metabolic process GO:0005976 11 0.059
myosin filament organization GO:0031033 5 0.058
negative regulation of cellular protein metabolic process GO:0032269 85 0.057
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.055
response to extracellular stimulus GO:0009991 116 0.052
neurotransmitter secretion GO:0007269 35 0.052
response to oxidative stress GO:0006979 86 0.050
regulation of mitochondrion organization GO:0010821 12 0.050
inorganic ion transmembrane transport GO:0098660 73 0.049
regulation of neurotransmitter levels GO:0001505 38 0.046
response to endogenous stimulus GO:0009719 119 0.046
purine nucleotide biosynthetic process GO:0006164 29 0.045
response to temperature stimulus GO:0009266 106 0.045
response to nitrogen compound GO:1901698 90 0.045
oxidative phosphorylation GO:0006119 9 0.044
actin cytoskeleton organization GO:0030036 206 0.044
neuron death GO:0070997 27 0.043
cellular carbohydrate metabolic process GO:0044262 22 0.042
organelle assembly GO:0070925 198 0.042
positive regulation of signaling GO:0023056 243 0.042
adult behavior GO:0030534 137 0.041
ribonucleoside triphosphate metabolic process GO:0009199 119 0.041
translation GO:0006412 69 0.041
purine containing compound metabolic process GO:0072521 155 0.041
striated muscle myosin thick filament assembly GO:0071688 3 0.040
regulation of response to oxidative stress GO:1902882 4 0.039
adult locomotory behavior GO:0008344 76 0.038
regulation of cellular component biogenesis GO:0044087 201 0.038
glucan biosynthetic process GO:0009250 2 0.038
nucleoside biosynthetic process GO:0009163 3 0.037
regulation of ion transport GO:0043269 39 0.037
monosaccharide metabolic process GO:0005996 9 0.037
regulation of developmental growth GO:0048638 174 0.037
glycosyl compound metabolic process GO:1901657 127 0.036
macromolecular complex assembly GO:0065003 256 0.036
response to organic cyclic compound GO:0014070 89 0.035
mechanosensory behavior GO:0007638 12 0.035
regulation of protein metabolic process GO:0051246 256 0.035
lipid modification GO:0030258 24 0.035
nucleobase containing small molecule metabolic process GO:0055086 174 0.035
response to peptide hormone GO:0043434 29 0.034
regulation of neurotransmitter secretion GO:0046928 14 0.034
neurological system process GO:0050877 358 0.033
cellular macromolecule localization GO:0070727 220 0.032
male gamete generation GO:0048232 201 0.031
carbohydrate derivative metabolic process GO:1901135 217 0.031
potassium ion transport GO:0006813 20 0.031
regulation of catalytic activity GO:0050790 185 0.031
purine ribonucleoside monophosphate biosynthetic process GO:0009168 3 0.031
protein complex biogenesis GO:0070271 201 0.030
cellular response to growth factor stimulus GO:0071363 30 0.030
organonitrogen compound biosynthetic process GO:1901566 117 0.029
regulation of cellular amine metabolic process GO:0033238 3 0.029
single organism behavior GO:0044708 391 0.028
regulation of cellular protein metabolic process GO:0032268 243 0.028
striated muscle cell development GO:0055002 50 0.028
response to reactive oxygen species GO:0000302 24 0.028
regulation of apoptotic process GO:0042981 130 0.028
columnar cuboidal epithelial cell development GO:0002066 249 0.027
maintenance of location GO:0051235 73 0.027
establishment of protein localization GO:0045184 163 0.027
response to organophosphorus GO:0046683 2 0.026
protein phosphorylation GO:0006468 169 0.026
eggshell chorion assembly GO:0007306 66 0.026
purine nucleoside triphosphate metabolic process GO:0009144 119 0.026
camera type eye development GO:0043010 4 0.025
negative regulation of organelle organization GO:0010639 56 0.025
positive regulation of macromolecule metabolic process GO:0010604 405 0.025
negative regulation of multicellular organismal process GO:0051241 142 0.025
innate immune response GO:0045087 144 0.024
purine nucleoside monophosphate biosynthetic process GO:0009127 3 0.024
axon guidance GO:0007411 233 0.024
determination of adult lifespan GO:0008340 137 0.024
polysaccharide biosynthetic process GO:0000271 7 0.023
electron transport chain GO:0022900 14 0.023
intracellular protein transmembrane transport GO:0065002 4 0.023
larval development GO:0002164 104 0.023
negative regulation of biosynthetic process GO:0009890 277 0.023
organic hydroxy compound metabolic process GO:1901615 83 0.022
myosin filament assembly GO:0031034 5 0.022
substrate adhesion dependent cell spreading GO:0034446 2 0.022
muscle contraction GO:0006936 13 0.022
cellular response to organic substance GO:0071310 132 0.022
embryo development ending in birth or egg hatching GO:0009792 152 0.022
synaptic vesicle recycling GO:0036465 28 0.022
vesicle mediated transport GO:0016192 381 0.022
response to heat GO:0009408 63 0.022
organic substance transport GO:0071702 257 0.021
response to decreased oxygen levels GO:0036293 58 0.021
monovalent inorganic cation transport GO:0015672 40 0.021
regulation of molecular function GO:0065009 217 0.021
respiratory electron transport chain GO:0022904 11 0.021
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.021
protein modification process GO:0036211 438 0.020
cellular response to oxygen containing compound GO:1901701 79 0.020
macromolecule catabolic process GO:0009057 161 0.020
regulation of ion transmembrane transport GO:0034765 27 0.020
appendage development GO:0048736 401 0.020
glycogen biosynthetic process GO:0005978 2 0.020
cellular homeostasis GO:0019725 80 0.020
cell motility GO:0048870 251 0.020
regionalization GO:0003002 416 0.020
negative regulation of cell cycle GO:0045786 116 0.019
proteolysis GO:0006508 192 0.019
rna localization GO:0006403 115 0.019
regulation of organelle organization GO:0033043 196 0.019
cellular carbohydrate biosynthetic process GO:0034637 7 0.019
cellular amine metabolic process GO:0044106 12 0.019
cell type specific apoptotic process GO:0097285 38 0.019
nucleoside monophosphate metabolic process GO:0009123 52 0.019
spermatogenesis GO:0007283 200 0.019
negative regulation of programmed cell death GO:0043069 72 0.018
neuromuscular junction development GO:0007528 149 0.018
immune system process GO:0002376 347 0.018
activation of mapk activity GO:0000187 9 0.018
negative regulation of cell death GO:0060548 81 0.018
axon development GO:0061564 297 0.017
apoptotic process GO:0006915 159 0.017
cellular response to endogenous stimulus GO:0071495 80 0.017
positive regulation of developmental process GO:0051094 143 0.017
regulation of cellular amino acid metabolic process GO:0006521 0 0.017
positive regulation of molecular function GO:0044093 136 0.017
positive regulation of cellular biosynthetic process GO:0031328 316 0.017
divalent inorganic cation transport GO:0072511 30 0.017
tube development GO:0035295 244 0.017
carbohydrate derivative biosynthetic process GO:1901137 85 0.016
pyridine nucleotide metabolic process GO:0019362 2 0.016
forebrain development GO:0030900 2 0.016
muscle system process GO:0003012 21 0.016
cellular response to organonitrogen compound GO:0071417 36 0.016
nucleoside phosphate metabolic process GO:0006753 162 0.016
regulation of cell substrate adhesion GO:0010810 2 0.016
imaginal disc derived wing morphogenesis GO:0007476 337 0.016
nuclear division GO:0000280 332 0.016
integrin mediated signaling pathway GO:0007229 3 0.016
ribonucleoside metabolic process GO:0009119 127 0.016
immune response GO:0006955 246 0.015
single organism cellular localization GO:1902580 180 0.015
endomembrane system organization GO:0010256 119 0.015
cell migration GO:0016477 238 0.015
developmental growth GO:0048589 280 0.015
cellular catabolic process GO:0044248 372 0.015
positive regulation of phosphorus metabolic process GO:0010562 139 0.015
purine ribonucleotide metabolic process GO:0009150 145 0.015
anion homeostasis GO:0055081 3 0.015
intracellular mrna localization involved in pattern specification process GO:0060810 56 0.015
purine nucleoside triphosphate biosynthetic process GO:0009145 2 0.015
isoprenoid metabolic process GO:0006720 8 0.014
protein catabolic process GO:0030163 101 0.014
multi organism reproductive behavior GO:0044705 121 0.014
morphogenesis of an epithelium GO:0002009 276 0.014
cellular protein localization GO:0034613 160 0.014
chemotaxis GO:0006935 249 0.014
lateral inhibition GO:0046331 206 0.014
response to starvation GO:0042594 97 0.014
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.014
regulation of multicellular organism growth GO:0040014 40 0.014
ribose phosphate biosynthetic process GO:0046390 28 0.014
pigment metabolic process GO:0042440 84 0.013
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 4 0.013
ribonucleotide metabolic process GO:0009259 145 0.013
cellular response to peptide hormone stimulus GO:0071375 28 0.013
positive regulation of phosphate metabolic process GO:0045937 139 0.013
intracellular transport GO:0046907 228 0.013
cellular carbohydrate catabolic process GO:0044275 2 0.013
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.013
regeneration GO:0031099 16 0.013
purine nucleotide metabolic process GO:0006163 146 0.013
regulation of phosphate metabolic process GO:0019220 210 0.013
positive regulation of nucleotide metabolic process GO:0045981 55 0.013
meiotic cell cycle GO:0051321 171 0.013
nucleotide biosynthetic process GO:0009165 34 0.013
spinal cord development GO:0021510 1 0.012
organic hydroxy compound catabolic process GO:1901616 4 0.012
negative regulation of cellular component organization GO:0051129 108 0.012
cellular response to nutrient levels GO:0031669 62 0.012
anatomical structure homeostasis GO:0060249 97 0.012
cell adhesion GO:0007155 136 0.012
skeletal muscle fiber development GO:0048741 3 0.012
regulation of hormone levels GO:0010817 40 0.012
cell aging GO:0007569 2 0.012
regulation of cellular ketone metabolic process GO:0010565 3 0.012
sperm mitochondrion organization GO:0030382 7 0.012
negative regulation of cellular biosynthetic process GO:0031327 277 0.012
negative regulation of developmental process GO:0051093 201 0.012
eggshell formation GO:0030703 105 0.012
regulation of purine nucleotide metabolic process GO:1900542 62 0.012
regulation of cytoskeleton organization GO:0051493 89 0.012
endocytosis GO:0006897 310 0.012
response to hypoxia GO:0001666 53 0.012
response to hexose GO:0009746 3 0.012
oocyte differentiation GO:0009994 145 0.012
nucleoside triphosphate metabolic process GO:0009141 120 0.011
retina development in camera type eye GO:0060041 4 0.011
regulation of nucleotide catabolic process GO:0030811 48 0.011
sex differentiation GO:0007548 81 0.011
regulation of cell cycle phase transition GO:1901987 130 0.011
positive regulation of synaptic transmission GO:0050806 15 0.011
epithelial cell differentiation GO:0030855 322 0.011
myotube cell development GO:0014904 3 0.011
response to calcium ion GO:0051592 1 0.011
purine ribonucleoside triphosphate biosynthetic process GO:0009206 2 0.011
alcohol catabolic process GO:0046164 4 0.011
positive regulation of cellular amine metabolic process GO:0033240 0 0.011
neuron projection guidance GO:0097485 241 0.011
nitrogen compound transport GO:0071705 85 0.011
regulation of intracellular signal transduction GO:1902531 236 0.011
response to oxygen levels GO:0070482 59 0.011
peptidyl amino acid modification GO:0018193 105 0.011
intracellular signal transduction GO:0035556 300 0.011
chromosome organization GO:0051276 360 0.011
taxis GO:0042330 304 0.011
negative regulation of molecular function GO:0044092 51 0.011
cellular response to decreased oxygen levels GO:0036294 30 0.011
nucleoside catabolic process GO:0009164 112 0.011
cellular response to oxidative stress GO:0034599 28 0.011
negative regulation of neuron apoptotic process GO:0043524 14 0.010
apoptotic signaling pathway GO:0097190 27 0.010
negative regulation of cell development GO:0010721 62 0.010
mitochondrial transport GO:0006839 8 0.010
regulation of hemocyte proliferation GO:0035206 37 0.010
positive regulation of response to stimulus GO:0048584 323 0.010
epithelial tube morphogenesis GO:0060562 88 0.010
ribose phosphate metabolic process GO:0019693 145 0.010
imaginal disc derived appendage morphogenesis GO:0035114 395 0.010
regulation of mitotic cell cycle phase transition GO:1901990 130 0.010
regulation of cell adhesion GO:0030155 27 0.010

Pgk disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.843
carbohydrate metabolism disease DOID:0050013 0 0.843
glucose metabolism disease DOID:4194 0 0.843
acquired metabolic disease DOID:0060158 0 0.843
disease of anatomical entity DOID:7 0 0.068
inherited metabolic disorder DOID:655 0 0.051
kidney disease DOID:557 0 0.035
urinary system disease DOID:18 0 0.035
synucleinopathy DOID:0050890 0 0.010
central nervous system disease DOID:331 0 0.010
neurodegenerative disease DOID:1289 0 0.010
nervous system disease DOID:863 0 0.010