Drosophila melanogaster

42 known processes

Actn (Dmel_CG4376)

alpha actinin

(Aliases: l(1)EA82,CT14163,alpha-actinin,CT14232,HM-29,CG4376,actn,EG:133E12.1,y,GA17,fliA,l(1)2Cb,Dmel\CG4376)

Actn biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
myofibril assembly GO:0030239 36 0.998
sarcomere organization GO:0045214 26 0.997
striated muscle cell differentiation GO:0051146 90 0.994
muscle structure development GO:0061061 224 0.988
actomyosin structure organization GO:0031032 56 0.970
striated muscle cell development GO:0055002 50 0.964
muscle cell development GO:0055001 50 0.936
striated muscle myosin thick filament assembly GO:0071688 3 0.902
adult somatic muscle development GO:0007527 14 0.868
cellular component assembly involved in morphogenesis GO:0010927 151 0.810
actin cytoskeleton organization GO:0030036 206 0.783
muscle cell differentiation GO:0042692 103 0.771
striated muscle tissue development GO:0014706 27 0.675
Zebrafish
myosin filament assembly GO:0031034 5 0.663
organelle assembly GO:0070925 198 0.634
actin filament based process GO:0030029 220 0.502
muscle thin filament assembly GO:0071689 5 0.460
cellular protein complex assembly GO:0043623 71 0.447
skeletal muscle organ development GO:0060538 48 0.380
Zebrafish
cellular macromolecular complex assembly GO:0034622 153 0.373
skeletal myofibril assembly GO:0014866 6 0.309
protein complex biogenesis GO:0070271 201 0.297
Human
locomotory behavior GO:0007626 176 0.290
protein polymerization GO:0051258 42 0.268
regulation of cytoskeleton organization GO:0051493 89 0.262
cell death GO:0008219 279 0.260
Rat
regulation of actin filament depolymerization GO:0030834 3 0.256
muscle organ development GO:0007517 127 0.230
Zebrafish
tube development GO:0035295 244 0.226
somatic muscle development GO:0007525 66 0.217
regulation of actin cytoskeleton organization GO:0032956 42 0.201
regulation of actin filament length GO:0030832 27 0.195
small molecule metabolic process GO:0044281 305 0.190
actin polymerization or depolymerization GO:0008154 31 0.185
protein complex assembly GO:0006461 200 0.160
Human
skeletal muscle fiber development GO:0048741 3 0.156
Zebrafish
regulation of protein complex disassembly GO:0043244 29 0.151
actin filament organization GO:0007015 126 0.146
Mouse
molting cycle GO:0042303 56 0.144
oxidation reduction process GO:0055114 123 0.143
cell proliferation GO:0008283 299 0.140
molting cycle chitin based cuticle GO:0007591 56 0.139
macromolecule catabolic process GO:0009057 161 0.137
Worm
body morphogenesis GO:0010171 2 0.131
myosin filament organization GO:0031033 5 0.128
regulation of multicellular organismal development GO:2000026 414 0.126
regulation of actin polymerization or depolymerization GO:0008064 27 0.123
larval development GO:0002164 104 0.123
cellular homeostasis GO:0019725 80 0.118
muscle tissue morphogenesis GO:0060415 2 0.115
skeletal muscle myosin thick filament assembly GO:0030241 3 0.115
regulation of actin filament based process GO:0032970 42 0.114
muscle tissue development GO:0060537 30 0.112
Zebrafish
endocytosis GO:0006897 310 0.112
Mouse
imaginal disc derived wing hair organization GO:0035317 45 0.106
regulation of cellular component biogenesis GO:0044087 201 0.102
nuclear migration GO:0007097 20 0.100
skeletal muscle adaptation GO:0043501 1 0.094
negative regulation of gene expression GO:0010629 387 0.091
cell cycle arrest GO:0007050 4 0.086
regulation of actin filament polymerization GO:0030833 25 0.079
macromolecular complex assembly GO:0065003 256 0.074
Human
protein catabolic process GO:0030163 101 0.072
Worm
reactive oxygen species metabolic process GO:0072593 22 0.070
oxoacid metabolic process GO:0043436 103 0.070
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.070
multicellular organism growth GO:0035264 46 0.064
response to abiotic stimulus GO:0009628 341 0.062
Rat
carboxylic acid metabolic process GO:0019752 92 0.061
negative regulation of protein complex disassembly GO:0043242 23 0.060
cardiac muscle tissue development GO:0048738 9 0.060
growth GO:0040007 359 0.057
regulation of protein complex assembly GO:0043254 42 0.057
striated muscle adaptation GO:0014888 1 0.056
single organism cellular localization GO:1902580 180 0.055
programmed cell death GO:0012501 257 0.053
Rat
myotube cell development GO:0014904 3 0.046
Zebrafish
nucleus localization GO:0051647 34 0.046
intracellular protein transport GO:0006886 104 0.046
negative regulation of neural precursor cell proliferation GO:2000178 27 0.045
regulation of ion transport GO:0043269 39 0.042
Human
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.042
divalent inorganic cation homeostasis GO:0072507 29 0.042
receptor mediated endocytosis GO:0006898 21 0.041
intracellular transport GO:0046907 228 0.041
tube morphogenesis GO:0035239 191 0.040
regulation of multicellular organism growth GO:0040014 40 0.040
positive regulation of protein transport GO:0051222 37 0.040
regulation of protein polymerization GO:0032271 28 0.040
positive regulation of transport GO:0051050 92 0.038
Human Mouse
organelle localization GO:0051640 148 0.038
multi multicellular organism process GO:0044706 123 0.037
cell migration GO:0016477 238 0.037
establishment of organelle localization GO:0051656 122 0.037
establishment of protein localization GO:0045184 163 0.037
tissue morphogenesis GO:0048729 297 0.037
camera type eye development GO:0043010 4 0.036
carbohydrate biosynthetic process GO:0016051 17 0.036
response to hexose GO:0009746 3 0.036
establishment of oocyte nucleus localization involved in oocyte dorsal ventral axis specification GO:0030722 6 0.035
energy derivation by oxidation of organic compounds GO:0015980 32 0.035
regulation of transmembrane transport GO:0034762 27 0.034
Human
transmembrane transport GO:0055085 139 0.034
Human
reproductive system development GO:0061458 74 0.034
actin filament polymerization GO:0030041 27 0.033
establishment of localization in cell GO:0051649 402 0.032
regulation of cell death GO:0010941 173 0.032
Rat
regulation of membrane potential GO:0042391 35 0.032
Human
regulation of cell differentiation GO:0045595 302 0.032
establishment of synaptic vesicle localization GO:0097480 50 0.031
nucleotide metabolic process GO:0009117 161 0.031
organic substance catabolic process GO:1901575 308 0.031
Worm
positive regulation of cellular component organization GO:0051130 156 0.030
Mouse
regulation of growth GO:0040008 233 0.029
multi organism reproductive behavior GO:0044705 121 0.029
regulation of developmental growth GO:0048638 174 0.029
nucleobase containing compound catabolic process GO:0034655 165 0.029
nucleobase containing small molecule metabolic process GO:0055086 174 0.029
positive regulation of cellular biosynthetic process GO:0031328 316 0.029
neurotransmitter gated ion channel clustering GO:0072578 2 0.028
single organism intracellular transport GO:1902582 207 0.028
cellular macromolecule localization GO:0070727 220 0.028
Human
apoptotic process GO:0006915 159 0.027
Rat
peptidyl amino acid modification GO:0018193 105 0.027
skeletal muscle tissue development GO:0007519 13 0.027
Zebrafish
single organism biosynthetic process GO:0044711 206 0.027
regulation of programmed cell death GO:0043067 152 0.027
Rat
multicellular organismal reproductive behavior GO:0033057 110 0.027
regulation of localization GO:0032879 275 0.027
Human Mouse
cytoplasmic transport nurse cell to oocyte GO:0007303 12 0.027
gliogenesis GO:0042063 80 0.027
death GO:0016265 284 0.026
Rat
regulation of anatomical structure morphogenesis GO:0022603 242 0.025
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.025
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.025
establishment of nucleus localization GO:0040023 26 0.025
cellular respiration GO:0045333 26 0.025
muscle contraction GO:0006936 13 0.025
Mouse
regulation of sarcomere organization GO:0060297 2 0.024
atp biosynthetic process GO:0006754 2 0.024
phagocytosis GO:0006909 215 0.024
positive regulation of molecular function GO:0044093 136 0.024
Human Mouse
reproductive structure development GO:0048608 74 0.023
open tracheal system development GO:0007424 204 0.023
cell motility GO:0048870 251 0.023
male mating behavior GO:0060179 70 0.023
cytoplasmic transport GO:0016482 130 0.023
metal ion homeostasis GO:0055065 44 0.022
digestive tract development GO:0048565 149 0.022
germarium derived egg chamber formation GO:0007293 101 0.022
regulation of protein depolymerization GO:1901879 27 0.022
carbohydrate metabolic process GO:0005975 82 0.022
positive regulation of actin filament polymerization GO:0030838 11 0.022
protein modification process GO:0036211 438 0.022
regulation of establishment of protein localization GO:0070201 61 0.021
mating GO:0007618 120 0.021
protein targeting GO:0006605 64 0.020
chemical homeostasis GO:0048878 92 0.020
neuron recognition GO:0008038 101 0.020
muscle organ morphogenesis GO:0048644 7 0.019
regulation of catabolic process GO:0009894 170 0.019
protein localization to organelle GO:0033365 82 0.019
regulation of necrotic cell death GO:0010939 1 0.019
regulation of cellular localization GO:0060341 136 0.019
Human
sequestering of calcium ion GO:0051208 5 0.019
positive regulation of multicellular organismal process GO:0051240 143 0.019
positive regulation of nucleoside metabolic process GO:0045979 47 0.019
gonad development GO:0008406 50 0.019
embryo development ending in birth or egg hatching GO:0009792 152 0.019
Worm
cardiovascular system development GO:0072358 82 0.019
Zebrafish
regulation of nucleotide catabolic process GO:0030811 48 0.019
organonitrogen compound metabolic process GO:1901564 318 0.019
positive regulation of cellular component biogenesis GO:0044089 80 0.019
positive regulation of macromolecule metabolic process GO:0010604 405 0.019
nucleoside phosphate metabolic process GO:0006753 162 0.018
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.018
protein transport GO:0015031 155 0.018
cell cycle phase transition GO:0044770 140 0.018
heart development GO:0007507 82 0.018
Zebrafish
hematopoietic progenitor cell differentiation GO:0002244 1 0.018
nad metabolic process GO:0019674 1 0.018
striated muscle contraction GO:0006941 5 0.018
heart process GO:0003015 37 0.018
localization of cell GO:0051674 257 0.018
sex differentiation GO:0007548 81 0.018
imaginal disc derived appendage morphogenesis GO:0035114 395 0.017
aging GO:0007568 143 0.017
regulation of cytoplasmic transport GO:1903649 47 0.017
axon development GO:0061564 297 0.017
organic acid metabolic process GO:0006082 103 0.017
positive regulation of biosynthetic process GO:0009891 316 0.017
cellular nitrogen compound catabolic process GO:0044270 165 0.016
negative regulation of organelle organization GO:0010639 56 0.016
negative regulation of cell cycle phase transition GO:1901988 103 0.016
nuclear transport GO:0051169 72 0.016
oviposition GO:0018991 19 0.016
response to monosaccharide GO:0034284 4 0.016
regulation of protein transport GO:0051223 57 0.016
positive regulation of protein import into nucleus GO:0042307 21 0.016
negative regulation of cytoskeleton organization GO:0051494 30 0.016
maintenance of location GO:0051235 73 0.016
adult behavior GO:0030534 137 0.015
regulation of immune system process GO:0002682 176 0.015
cell recognition GO:0008037 102 0.015
vesicle mediated transport GO:0016192 381 0.015
Mouse
glycosyl compound metabolic process GO:1901657 127 0.015
regulation of cellular amine metabolic process GO:0033238 3 0.015
regulation of protein localization GO:0032880 76 0.015
Human
purine nucleoside metabolic process GO:0042278 127 0.015
nucleoside triphosphate metabolic process GO:0009141 120 0.014
immune system process GO:0002376 347 0.014
negative regulation of cell cycle GO:0045786 116 0.014
multicellular organismal aging GO:0010259 140 0.014
positive regulation of developmental process GO:0051094 143 0.014
stem cell differentiation GO:0048863 117 0.014
cellular carbohydrate catabolic process GO:0044275 2 0.014
ribonucleotide catabolic process GO:0009261 109 0.014
reproductive behavior GO:0019098 122 0.014
cardiac muscle cell differentiation GO:0055007 4 0.014
cell adhesion GO:0007155 136 0.014
Human
cellular metal ion homeostasis GO:0006875 31 0.014
cellular catabolic process GO:0044248 372 0.014
negative regulation of protein depolymerization GO:1901880 23 0.014
regulation of post embryonic development GO:0048580 10 0.014
regulation of cell proliferation GO:0042127 163 0.014
protein targeting to nucleus GO:0044744 51 0.013
regulation of nucleoside metabolic process GO:0009118 50 0.013
skin development GO:0043588 65 0.013
negative regulation of homeostatic process GO:0032845 2 0.013
heterocycle catabolic process GO:0046700 166 0.013
microtubule polymerization or depolymerization GO:0031109 39 0.013
regulation of cell development GO:0060284 215 0.013
negative regulation of cellular protein metabolic process GO:0032269 85 0.013
regulation of sequestering of calcium ion GO:0051282 3 0.013
single organism nuclear import GO:1902593 51 0.013
circulatory system development GO:0072359 82 0.012
Zebrafish
inorganic ion transmembrane transport GO:0098660 73 0.012
Human
atp metabolic process GO:0046034 49 0.012
generation of precursor metabolites and energy GO:0006091 42 0.012
negative regulation of actin filament depolymerization GO:0030835 2 0.012
dna metabolic process GO:0006259 227 0.012
regulation of phosphatase activity GO:0010921 3 0.012
ovulation GO:0030728 4 0.012
axonogenesis GO:0007409 290 0.012
cellular chemical homeostasis GO:0055082 40 0.012
cell substrate adhesion GO:0031589 10 0.012
Human
regulation of hydrolase activity GO:0051336 97 0.012
regulation of intracellular transport GO:0032386 64 0.012
cellular component disassembly GO:0022411 46 0.012
epithelial cell differentiation GO:0030855 322 0.012
positive regulation of intracellular transport GO:0032388 42 0.011
nicotinamide nucleotide metabolic process GO:0046496 2 0.011
cardiocyte differentiation GO:0035051 29 0.011
response to endogenous stimulus GO:0009719 119 0.011
anatomical structure homeostasis GO:0060249 97 0.011
catabolic process GO:0009056 409 0.011
Worm
lipid localization GO:0010876 54 0.011
regulation of nervous system development GO:0051960 248 0.011
purine ribonucleoside metabolic process GO:0046128 127 0.011
negative regulation of cell death GO:0060548 81 0.011
positive regulation of protein complex assembly GO:0031334 22 0.011
negative regulation of cell cycle process GO:0010948 109 0.011
single organism carbohydrate metabolic process GO:0044723 72 0.011
intercellular transport GO:0010496 2 0.011
positive regulation of cell motility GO:2000147 3 0.010
ribonucleoside catabolic process GO:0042454 112 0.010
neuroblast differentiation GO:0014016 29 0.010
establishment of protein localization to organelle GO:0072594 62 0.010
regionalization GO:0003002 416 0.010

Actn disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
myopathy DOID:423 0 0.527
muscular disease DOID:0080000 0 0.527
heart disease DOID:114 0 0.527
cardiomyopathy DOID:0050700 0 0.527
disease of anatomical entity DOID:7 0 0.527
Human
cardiovascular system disease DOID:1287 0 0.527
musculoskeletal system disease DOID:17 0 0.527
muscle tissue disease DOID:66 0 0.527
intrinsic cardiomyopathy DOID:0060036 0 0.266
dilated cardiomyopathy DOID:12930 0 0.178
bone disease DOID:0080001 0 0.024
connective tissue disease DOID:65 0 0.024