Drosophila melanogaster

51 known processes

Six4 (Dmel_CG3871)

CG3871 gene product from transcript CG3871-RA

(Aliases: Dmel\CG3871,D-six4,six4,D-Six4,CG3871,six4/5,Dsix4,DSix4)

Six4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
tube development GO:0035295 244 0.897
Mouse Worm
regulation of cell differentiation GO:0045595 302 0.777
Mouse
regulation of multicellular organismal development GO:2000026 414 0.626
Mouse
tissue morphogenesis GO:0048729 297 0.577
Mouse Worm
ovarian follicle cell development GO:0030707 248 0.533
biological adhesion GO:0022610 138 0.525
muscle structure development GO:0061061 224 0.520
germ cell migration GO:0008354 43 0.473
salivary gland development GO:0007431 162 0.458
columnar cuboidal epithelial cell development GO:0002066 249 0.421
negative regulation of cellular metabolic process GO:0031324 382 0.393
Mouse
positive regulation of macromolecule metabolic process GO:0010604 405 0.384
Mouse Fly
negative regulation of transcription dna templated GO:0045892 237 0.344
Mouse
heart development GO:0007507 82 0.335
regulation of muscle organ development GO:0048634 13 0.331
Mouse
exocrine system development GO:0035272 162 0.313
immune system process GO:0002376 347 0.313
Mouse
salivary gland morphogenesis GO:0007435 145 0.307
muscle organ development GO:0007517 127 0.298
Mouse
open tracheal system development GO:0007424 204 0.279
regulation of response to external stimulus GO:0032101 115 0.279
sensory organ morphogenesis GO:0090596 260 0.268
Mouse Fly
positive regulation of biosynthetic process GO:0009891 316 0.265
Mouse Fly
negative regulation of developmental process GO:0051093 201 0.262
Mouse
gland development GO:0048732 191 0.259
Mouse Fly
single organism cell adhesion GO:0098602 47 0.256
positive regulation of rna biosynthetic process GO:1902680 266 0.254
Mouse Fly
regulation of cell development GO:0060284 215 0.252
establishment of localization in cell GO:0051649 402 0.247
morphogenesis of an epithelium GO:0002009 276 0.239
Mouse
circulatory system development GO:0072359 82 0.238
gland morphogenesis GO:0022612 145 0.237
ameboidal type cell migration GO:0001667 151 0.234
renal system development GO:0072001 72 0.230
Mouse
regionalization GO:0003002 416 0.228
chemotaxis GO:0006935 249 0.228
eye development GO:0001654 323 0.226
Mouse Fly
cell motility GO:0048870 251 0.226
Mouse Fly
positive regulation of rna metabolic process GO:0051254 271 0.225
Mouse Fly
regulation of protein metabolic process GO:0051246 256 0.220
eye morphogenesis GO:0048592 260 0.219
Fly
negative regulation of signaling GO:0023057 219 0.209
cardiovascular system development GO:0072358 82 0.207
epithelial cell development GO:0002064 274 0.196
cell projection assembly GO:0030031 94 0.195
cell migration GO:0016477 238 0.190
Mouse Fly
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.182
Mouse Fly
negative regulation of response to stimulus GO:0048585 258 0.181
post embryonic appendage morphogenesis GO:0035120 385 0.178
organonitrogen compound metabolic process GO:1901564 318 0.173
positive regulation of phosphate metabolic process GO:0045937 139 0.165
compound eye development GO:0048749 307 0.163
Fly
positive regulation of signaling GO:0023056 243 0.161
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.159
stem cell differentiation GO:0048863 117 0.159
Mouse
glial cell migration GO:0008347 31 0.157
Fly
negative regulation of cell differentiation GO:0045596 143 0.156
Mouse
respiratory system development GO:0060541 213 0.150
Mouse
negative regulation of gene expression GO:0010629 387 0.150
Mouse
neuron projection guidance GO:0097485 241 0.144
negative regulation of protein phosphorylation GO:0001933 17 0.143
mesoderm development GO:0007498 78 0.142
taxis GO:0042330 304 0.141
synapse assembly GO:0007416 143 0.141
Mouse
larval visceral muscle development GO:0007523 9 0.140
regulation of phosphate metabolic process GO:0019220 210 0.139
imaginal disc derived appendage morphogenesis GO:0035114 395 0.138
kidney development GO:0001822 3 0.137
Mouse
regulation of phosphorylation GO:0042325 147 0.136
urogenital system development GO:0001655 72 0.135
Mouse
embryonic organ development GO:0048568 50 0.134
Mouse
digestive tract morphogenesis GO:0048546 127 0.133
Worm
negative regulation of rna metabolic process GO:0051253 251 0.132
Mouse
camera type eye morphogenesis GO:0048593 2 0.132
regulation of cellular ketone metabolic process GO:0010565 3 0.132
localization of cell GO:0051674 257 0.132
Mouse Fly
axon guidance GO:0007411 233 0.131
cellular catabolic process GO:0044248 372 0.128
negative regulation of multicellular organismal process GO:0051241 142 0.125
Mouse
regulation of protein modification process GO:0031399 112 0.125
chorion containing eggshell formation GO:0007304 105 0.124
gliogenesis GO:0042063 80 0.123
Fly
compound eye morphogenesis GO:0001745 249 0.123
Fly
axon development GO:0061564 297 0.123
epithelial cell differentiation GO:0030855 322 0.121
negative regulation of cellular biosynthetic process GO:0031327 277 0.120
Mouse
protein modification process GO:0036211 438 0.118
regulation of cellular protein metabolic process GO:0032268 243 0.115
epithelial tube morphogenesis GO:0060562 88 0.115
Mouse
maintenance of gastrointestinal epithelium GO:0030277 3 0.114
positive regulation of signal transduction GO:0009967 223 0.111
imaginal disc derived appendage development GO:0048737 399 0.110
protein phosphorylation GO:0006468 169 0.109
phosphorylation GO:0016310 294 0.108
cellular protein modification process GO:0006464 438 0.108
regulation of phosphorus metabolic process GO:0051174 210 0.108
tube morphogenesis GO:0035239 191 0.106
Mouse Worm
actomyosin structure organization GO:0031032 56 0.104
Mouse
nephrocyte differentiation GO:0061319 12 0.103
transcription from rna polymerase ii promoter GO:0006366 368 0.102
Mouse Fly
single organismal cell cell adhesion GO:0016337 45 0.102
negative regulation of cell communication GO:0010648 223 0.100
embryonic morphogenesis GO:0048598 206 0.100
Mouse Worm Fly
defense response to other organism GO:0098542 225 0.100
positive regulation of developmental process GO:0051094 143 0.100
Mouse
embryonic pattern specification GO:0009880 174 0.099
oxoacid metabolic process GO:0043436 103 0.099
regulation of catalytic activity GO:0050790 185 0.098
mesodermal cell migration GO:0008078 7 0.094
stem cell development GO:0048864 79 0.094
regulation of molecular function GO:0065009 217 0.093
defense response GO:0006952 300 0.093
negative regulation of nervous system development GO:0051961 92 0.092
negative regulation of cellular protein metabolic process GO:0032269 85 0.092
embryonic heart tube development GO:0035050 22 0.092
regulation of transport GO:0051049 181 0.091
wing disc morphogenesis GO:0007472 344 0.090
negative regulation of phosphorylation GO:0042326 35 0.088
immune response GO:0006955 246 0.088
death GO:0016265 284 0.088
Mouse Worm
cardioblast differentiation GO:0010002 20 0.087
regulation of intracellular signal transduction GO:1902531 236 0.086
morphogenesis of embryonic epithelium GO:0016331 94 0.086
Mouse
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.086
Mouse
epithelium migration GO:0090132 148 0.085
cellular amine metabolic process GO:0044106 12 0.085
organic substance catabolic process GO:1901575 308 0.084
axonogenesis GO:0007409 290 0.083
negative regulation of nucleic acid templated transcription GO:1903507 240 0.083
Mouse
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.083
Mouse
cell adhesion GO:0007155 136 0.082
apoptotic process GO:0006915 159 0.082
Mouse Worm
positive regulation of cellular catabolic process GO:0031331 95 0.082
positive regulation of response to stimulus GO:0048584 323 0.081
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.081
Mouse Fly
negative regulation of cell development GO:0010721 62 0.081
regulation of localization GO:0032879 275 0.078
Mouse
photoreceptor cell differentiation GO:0046530 170 0.078
Fly
cell proliferation GO:0008283 299 0.077
Mouse
appendage morphogenesis GO:0035107 397 0.077
synapse organization GO:0050808 196 0.076
Mouse
cell death GO:0008219 279 0.076
Mouse Worm
positive regulation of protein metabolic process GO:0051247 128 0.075
blastoderm segmentation GO:0007350 159 0.074
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.074
Mouse Fly
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.074
Mouse Fly
regulation of defense response GO:0031347 102 0.073
regulation of cellular component biogenesis GO:0044087 201 0.073
Mouse
regulation of cellular amino acid metabolic process GO:0006521 0 0.073
establishment of organelle localization GO:0051656 122 0.073
positive regulation of cell communication GO:0010647 250 0.072
wnt signaling pathway GO:0016055 98 0.072
renal filtration cell differentiation GO:0061318 12 0.071
positive regulation of nucleic acid templated transcription GO:1903508 266 0.071
Mouse Fly
male gamete generation GO:0048232 201 0.070
Mouse Fly
purine ribonucleoside metabolic process GO:0046128 127 0.068
catabolic process GO:0009056 409 0.068
striated muscle cell differentiation GO:0051146 90 0.068
appendage development GO:0048736 401 0.068
regulation of cellular amine metabolic process GO:0033238 3 0.066
neuron recognition GO:0008038 101 0.066
enzyme linked receptor protein signaling pathway GO:0007167 179 0.065
negative regulation of signal transduction GO:0009968 206 0.065
larval development GO:0002164 104 0.065
regulation of immune system process GO:0002682 176 0.065
kidney morphogenesis GO:0060993 3 0.064
Mouse
developmental programmed cell death GO:0010623 138 0.064
positive regulation of phosphorus metabolic process GO:0010562 139 0.064
regulation of protein phosphorylation GO:0001932 64 0.063
intracellular signal transduction GO:0035556 300 0.063
negative regulation of phosphate metabolic process GO:0045936 45 0.062
gonadal mesoderm development GO:0007506 8 0.061
epithelial cell migration GO:0010631 148 0.061
cellular ketone metabolic process GO:0042180 24 0.060
positive regulation of transcription dna templated GO:0045893 266 0.060
Mouse Fly
organic acid metabolic process GO:0006082 103 0.060
cellular amino acid metabolic process GO:0006520 61 0.060
protein localization GO:0008104 284 0.059
Mouse
epithelial cell migration open tracheal system GO:0007427 32 0.059
aging GO:0007568 143 0.058
positive regulation of response to external stimulus GO:0032103 44 0.058
visceral muscle development GO:0007522 14 0.058
negative regulation of protein metabolic process GO:0051248 85 0.057
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 38 0.057
amine metabolic process GO:0009308 12 0.057
carboxylic acid metabolic process GO:0019752 92 0.057
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.056
malpighian tubule development GO:0072002 64 0.056
digestive system development GO:0055123 149 0.055
Worm
malpighian tubule morphogenesis GO:0007443 44 0.054
small molecule metabolic process GO:0044281 305 0.054
regulation of anatomical structure morphogenesis GO:0022603 242 0.054
Mouse
negative regulation of phosphorus metabolic process GO:0010563 45 0.053
actin cytoskeleton organization GO:0030036 206 0.052
Mouse
female sex differentiation GO:0046660 20 0.052
growth GO:0040007 359 0.052
Mouse
signal transduction by phosphorylation GO:0023014 107 0.051
regulation of immune response GO:0050776 118 0.051
response to other organism GO:0051707 293 0.051
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.051
cuticle development GO:0042335 86 0.051
positive regulation of phosphorylation GO:0042327 87 0.050
cuticle pattern formation GO:0035017 27 0.050
embryonic development via the syncytial blastoderm GO:0001700 148 0.050
gonad development GO:0008406 50 0.050
outflow tract morphogenesis GO:0003151 4 0.050
heart morphogenesis GO:0003007 32 0.049
positive regulation of cellular biosynthetic process GO:0031328 316 0.049
Mouse Fly
development of primary sexual characteristics GO:0045137 50 0.049
positive regulation of gene expression GO:0010628 290 0.048
Mouse Fly
segmentation GO:0035282 207 0.048
single organism behavior GO:0044708 391 0.048
positive regulation of cell differentiation GO:0045597 64 0.048
response to external biotic stimulus GO:0043207 293 0.047
response to wounding GO:0009611 94 0.046
stem cell maintenance GO:0019827 67 0.046
regulation of innate immune response GO:0045088 71 0.046
regulation of neurogenesis GO:0050767 158 0.045
single organism intracellular transport GO:1902582 207 0.045
regulation of growth GO:0040008 233 0.045
Mouse
cellular nitrogen compound catabolic process GO:0044270 165 0.045
secretion by cell GO:0032940 101 0.044
positive regulation of molecular function GO:0044093 136 0.044
regulation of nervous system development GO:0051960 248 0.044
Mouse
imaginal disc derived wing morphogenesis GO:0007476 337 0.044
epidermal growth factor receptor signaling pathway GO:0007173 58 0.044
regulation of cytoskeleton organization GO:0051493 89 0.044
anterior posterior pattern specification GO:0009952 136 0.044
response to extracellular stimulus GO:0009991 116 0.044
kidney epithelium development GO:0072073 3 0.044
Mouse
cell cell junction assembly GO:0007043 38 0.044
genital disc development GO:0035215 44 0.043
regulation of epithelial cell proliferation GO:0050678 4 0.043
Mouse
imaginal disc pattern formation GO:0007447 91 0.043
response to abiotic stimulus GO:0009628 341 0.043
carbohydrate derivative metabolic process GO:1901135 217 0.043
cytoplasmic transport GO:0016482 130 0.042
organ formation GO:0048645 39 0.042
purine containing compound metabolic process GO:0072521 155 0.042
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.041
establishment of protein localization GO:0045184 163 0.041
pericardial nephrocyte differentiation GO:0061320 9 0.041
hindgut morphogenesis GO:0007442 58 0.041
negative regulation of growth GO:0045926 84 0.041
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.041
glial cell differentiation GO:0010001 35 0.041
positive regulation of programmed cell death GO:0043068 62 0.040
developmental growth GO:0048589 280 0.040
Mouse
defense response to bacterium GO:0042742 178 0.040
dna metabolic process GO:0006259 227 0.040
regulation of protein kinase activity GO:0045859 51 0.039
organelle localization GO:0051640 148 0.039
skin development GO:0043588 65 0.039
regulation of cell proliferation GO:0042127 163 0.039
Mouse
single organism cellular localization GO:1902580 180 0.038
negative regulation of neurogenesis GO:0050768 53 0.038
anterior posterior pattern specification imaginal disc GO:0007448 16 0.037
negative regulation of protein modification process GO:0031400 29 0.037
negative regulation of biosynthetic process GO:0009890 277 0.037
Mouse
nucleobase containing compound catabolic process GO:0034655 165 0.037
response to bacterium GO:0009617 198 0.036
rhythmic process GO:0048511 106 0.036
Fly
nucleoside metabolic process GO:0009116 127 0.036
regulation of cellular catabolic process GO:0031329 157 0.036
regulation of catabolic process GO:0009894 170 0.036
response to organic substance GO:0010033 284 0.036
response to biotic stimulus GO:0009607 294 0.036
digestive tract development GO:0048565 149 0.036
Worm
positive regulation of nucleotide metabolic process GO:0045981 55 0.035
intracellular transport GO:0046907 228 0.035
branching involved in open tracheal system development GO:0060446 45 0.035
response to nutrient levels GO:0031667 114 0.035
determination of adult lifespan GO:0008340 137 0.035
cytoskeleton dependent cytokinesis GO:0061640 81 0.035
ribonucleotide metabolic process GO:0009259 145 0.035
regulation of transferase activity GO:0051338 58 0.035
embryonic hindgut morphogenesis GO:0048619 48 0.034
nucleobase containing small molecule metabolic process GO:0055086 174 0.034
response to oxygen containing compound GO:1901700 200 0.034
cell migration involved in gastrulation GO:0042074 9 0.034
posttranscriptional regulation of gene expression GO:0010608 145 0.034
regulation of cell division GO:0051302 72 0.034
regulation of organ morphogenesis GO:2000027 78 0.033
Mouse
regulation of reproductive process GO:2000241 54 0.033
muscle attachment GO:0016203 36 0.033
spermatid differentiation GO:0048515 114 0.033
Mouse
regulation of cell cycle GO:0051726 291 0.033
positive regulation of cellular component biogenesis GO:0044089 80 0.032
aromatic compound catabolic process GO:0019439 166 0.032
positive regulation of catalytic activity GO:0043085 118 0.032
central nervous system development GO:0007417 201 0.032
microtubule organizing center organization GO:0031023 168 0.032
germ line stem cell maintenance GO:0030718 50 0.031
mesoderm morphogenesis GO:0048332 22 0.031
Worm
positive regulation of multicellular organismal process GO:0051240 143 0.031
Mouse
regulation of programmed cell death GO:0043067 152 0.031
Mouse
cellular response to chemical stimulus GO:0070887 199 0.031
erbb signaling pathway GO:0038127 58 0.030
lamellipodium assembly GO:0030032 21 0.030
regulation of embryonic development GO:0045995 68 0.030
Mouse
regulation of synapse assembly GO:0051963 94 0.030
Mouse
regulation of wnt signaling pathway GO:0030111 68 0.030
regulation of cell death GO:0010941 173 0.030
Mouse
lipid metabolic process GO:0006629 121 0.030
positive regulation of epithelial cell differentiation GO:0030858 1 0.030
mesenchyme development GO:0060485 9 0.029
Mouse
dorsal closure GO:0007391 79 0.029
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 4 0.029
peptidyl amino acid modification GO:0018193 105 0.029
regulation of locomotion GO:0040012 42 0.029
organic substance transport GO:0071702 257 0.029
branching morphogenesis of an epithelial tube GO:0048754 45 0.029
Mouse
positive regulation of cell development GO:0010720 61 0.029
negative regulation of molecular function GO:0044092 51 0.028
regulation of erbb signaling pathway GO:1901184 42 0.028
negative regulation of cell cycle GO:0045786 116 0.028
purine nucleotide metabolic process GO:0006163 146 0.028
regulation of behavior GO:0050795 75 0.028
organelle assembly GO:0070925 198 0.028
Mouse
digestive tract mesoderm development GO:0007502 5 0.028
sex differentiation GO:0007548 81 0.028
positive regulation of cell migration GO:0030335 2 0.027
innate immune response GO:0045087 144 0.027
programmed cell death GO:0012501 257 0.027
Mouse Worm
actin filament organization GO:0007015 126 0.027
positive regulation of immune response GO:0050778 63 0.027
eye photoreceptor cell development GO:0042462 81 0.027
muscle cell differentiation GO:0042692 103 0.027
response to hexose GO:0009746 3 0.027
regulation of epithelial cell migration open tracheal system GO:2000274 11 0.027
regulation of mapk cascade GO:0043408 92 0.026
positive regulation of lipid metabolic process GO:0045834 4 0.026
negative regulation of cell cycle process GO:0010948 109 0.026
organic cyclic compound catabolic process GO:1901361 168 0.026
heterocycle catabolic process GO:0046700 166 0.026
negative regulation of epithelial cell proliferation GO:0050680 4 0.026
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.026
Mouse Fly
ribonucleoside catabolic process GO:0042454 112 0.026
dorsal ventral pattern formation GO:0009953 133 0.026
negative regulation of catalytic activity GO:0043086 42 0.026
organonitrogen compound catabolic process GO:1901565 128 0.026
positive regulation of defense response GO:0031349 59 0.026
embryo development ending in birth or egg hatching GO:0009792 152 0.025
Mouse
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.025
defense response to gram negative bacterium GO:0050829 94 0.025
endocytosis GO:0006897 310 0.025
positive regulation of cell motility GO:2000147 3 0.025
hindgut development GO:0061525 58 0.024
extrinsic apoptotic signaling pathway GO:0097191 1 0.024
actin filament based process GO:0030029 220 0.024
Mouse
positive regulation of catabolic process GO:0009896 105 0.024
negative regulation of cell death GO:0060548 81 0.024
Mouse
hematopoietic or lymphoid organ development GO:0048534 57 0.024
Mouse
regulation of cellular localization GO:0060341 136 0.024
spermatid development GO:0007286 98 0.024
Mouse
gastrulation GO:0007369 70 0.024
Worm
carbohydrate derivative catabolic process GO:1901136 118 0.023
anterior posterior axis specification GO:0009948 109 0.023
response to alcohol GO:0097305 95 0.023
peptidyl tyrosine phosphorylation GO:0018108 24 0.023
g protein coupled receptor signaling pathway GO:0007186 136 0.023
cellular component assembly involved in morphogenesis GO:0010927 151 0.023
Mouse
nuclear import GO:0051170 51 0.023
response to glucose GO:0009749 2 0.023
regulation of stem cell proliferation GO:0072091 40 0.023
organelle fission GO:0048285 340 0.022
positive regulation of cell death GO:0010942 69 0.022
nephron morphogenesis GO:0072028 3 0.022
Mouse
somatic muscle development GO:0007525 66 0.022
nucleoside phosphate metabolic process GO:0006753 162 0.022
positive regulation of intracellular signal transduction GO:1902533 116 0.022
nephron epithelium development GO:0072009 3 0.022
Mouse
establishment of tissue polarity GO:0007164 87 0.022
synaptic target recognition GO:0008039 45 0.022
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.022
Mouse
cellular macromolecule localization GO:0070727 220 0.022
Mouse
photoreceptor cell development GO:0042461 96 0.022
macromolecule catabolic process GO:0009057 161 0.022
positive regulation of cellular protein metabolic process GO:0032270 118 0.022
epidermis development GO:0008544 65 0.022
cellular macromolecular complex assembly GO:0034622 153 0.021
muscle cell development GO:0055001 50 0.021
Mouse
renal tubule development GO:0061326 64 0.021
Mouse
response to organic cyclic compound GO:0014070 89 0.021
cell growth GO:0016049 108 0.021
morphogenesis of a polarized epithelium GO:0001738 93 0.021
eye photoreceptor cell differentiation GO:0001754 145 0.021
Fly
positive regulation of cellular component organization GO:0051130 156 0.021
purine ribonucleoside catabolic process GO:0046130 112 0.021
organophosphate metabolic process GO:0019637 195 0.021
epithelial cell proliferation GO:0050673 15 0.021
Mouse
reproductive structure development GO:0048608 74 0.020
motor neuron axon guidance GO:0008045 58 0.020
sensory perception GO:0007600 196 0.020
adult behavior GO:0030534 137 0.020
positive regulation of protein modification process GO:0031401 58 0.020
regulation of imaginal disc derived wing size GO:0044719 20 0.020
cellular response to external stimulus GO:0071496 66 0.020
multicellular organismal homeostasis GO:0048871 41 0.020
ribonucleoside triphosphate catabolic process GO:0009203 108 0.020
cardiocyte differentiation GO:0035051 29 0.020
larval somatic muscle development GO:0007526 19 0.020
cell cycle phase transition GO:0044770 140 0.020
regulation of cell fate commitment GO:0010453 29 0.020
establishment of planar polarity GO:0001736 87 0.020
regulation of protein transport GO:0051223 57 0.020
regulation of cell cell adhesion GO:0022407 21 0.020
compound eye retinal cell programmed cell death GO:0046667 23 0.020
negative regulation of mitotic cell cycle GO:0045930 109 0.019
peptidyl tyrosine modification GO:0018212 24 0.019
organ growth GO:0035265 56 0.019
purine nucleoside catabolic process GO:0006152 112 0.019
canonical wnt signaling pathway GO:0060070 21 0.019
instar larval development GO:0002168 55 0.019
compound eye photoreceptor cell differentiation GO:0001751 140 0.019
Fly
vesicle mediated transport GO:0016192 381 0.019
lymph gland development GO:0048542 28 0.019
purine ribonucleotide catabolic process GO:0009154 109 0.019
regulation of anatomical structure size GO:0090066 163 0.019
cellular protein localization GO:0034613 160 0.019
Mouse
anatomical structure homeostasis GO:0060249 97 0.019
glycosyl compound catabolic process GO:1901658 112 0.019
mesodermal cell fate specification GO:0007501 2 0.019
Worm
cell surface receptor signaling pathway involved in heart development GO:0061311 3 0.018
embryonic axis specification GO:0000578 107 0.018
positive regulation of protein transport GO:0051222 37 0.018
nephron development GO:0072006 3 0.018
Mouse
positive regulation of cellular amine metabolic process GO:0033240 0 0.018
retinal cell programmed cell death GO:0046666 25 0.018
regulation of cell motility GO:2000145 23 0.018
cellular response to nitrogen compound GO:1901699 51 0.018
negative regulation of cell proliferation GO:0008285 69 0.018
Mouse
oocyte maturation GO:0001556 3 0.018
nucleoside triphosphate catabolic process GO:0009143 108 0.018
regulation of response to wounding GO:1903034 19 0.018
compound eye photoreceptor development GO:0042051 78 0.018
response to monosaccharide GO:0034284 4 0.018
nucleoside triphosphate metabolic process GO:0009141 120 0.018
bmp signaling pathway GO:0030509 27 0.018
positive regulation of apoptotic process GO:0043065 47 0.018
regulation of intracellular transport GO:0032386 64 0.018
endodermal cell differentiation GO:0035987 3 0.018
regulation of organelle organization GO:0033043 196 0.018
nucleoside catabolic process GO:0009164 112 0.018
protein transport GO:0015031 155 0.018
male courtship behavior veined wing extension GO:0048065 22 0.018
regulation of purine nucleotide catabolic process GO:0033121 48 0.017
negative regulation of organelle organization GO:0010639 56 0.017
regulation of developmental pigmentation GO:0048070 24 0.017
substrate dependent cell migration GO:0006929 3 0.017
filopodium assembly GO:0046847 33 0.017
positive regulation of multi organism process GO:0043902 40 0.017
eggshell formation GO:0030703 105 0.017
regulation of response to stress GO:0080134 200 0.017
positive regulation of cell projection organization GO:0031346 29 0.017
regulation of steroid metabolic process GO:0019218 2 0.017
regulation of nucleocytoplasmic transport GO:0046822 35 0.017
regulation of protein import into nucleus GO:0042306 28 0.017
regulation of cell cycle process GO:0010564 181 0.017
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.017
regulation of nucleotide metabolic process GO:0006140 62 0.017
border follicle cell migration GO:0007298 113 0.017
development of primary female sexual characteristics GO:0046545 12 0.017
regulation of cellular component movement GO:0051270 42 0.017
steroid biosynthetic process GO:0006694 16 0.017
mating GO:0007618 120 0.017
jnk cascade GO:0007254 50 0.017
positive regulation of nervous system development GO:0051962 69 0.016
regulation of epithelial cell differentiation GO:0030856 4 0.016
skeletal muscle organ development GO:0060538 48 0.016
Mouse
cell fate specification GO:0001708 71 0.016
Worm
secretion GO:0046903 109 0.016
positive regulation of mapk cascade GO:0043410 63 0.016
endodermal cell fate commitment GO:0001711 3 0.016
cellular response to organic substance GO:0071310 132 0.016
protein complex biogenesis GO:0070271 201 0.016
axis specification GO:0009798 167 0.016
axis elongation GO:0003401 3 0.016
Mouse
proteolysis GO:0006508 192 0.016
neurological system process GO:0050877 358 0.016
leg disc development GO:0035218 92 0.016
limb development GO:0060173 1 0.016
regulation of establishment of protein localization GO:0070201 61 0.016
ribonucleoside metabolic process GO:0009119 127 0.016
negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 29 0.016
mitotic cytokinesis GO:0000281 50 0.016
developmental growth involved in morphogenesis GO:0060560 65 0.015
Mouse
ribonucleoside triphosphate metabolic process GO:0009199 119 0.015
regulation of hydrolase activity GO:0051336 97 0.015
regulation of organ formation GO:0003156 3 0.015
mapk cascade GO:0000165 107 0.015

Six4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.051
cancer DOID:162 0 0.026
disease of cellular proliferation DOID:14566 0 0.026
organ system cancer DOID:0050686 0 0.026
cardiovascular system disease DOID:1287 0 0.020