Drosophila melanogaster

185 known processes

Su(var)205 (Dmel_CG8409)

Suppressor of variegation 205

(Aliases: Suvar2-5,DmHP1,Su(var)2-05,HP1-VS,Su(Var)2-5,dHP-1a,hp1a,HP1,CG8409,E(var)29,Su(var)2-501,Su(var)[205],Su(var)29A,Suvar(2)5,dHP1,Su[Var]205,su(var)205,Hp1,Su(var),HP1alpha,Su-var(2)5,Dmel\CG8409,HP1a,Su[var]205,H3,HP-1,DmHP-1,Su(var)2-5,HP1A,SU(VAR)205,E(var)29A,hp1,Hp1a)

Su(var)205 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
chromatin assembly GO:0031497 48 0.998
negative regulation of rna metabolic process GO:0051253 251 0.998
negative regulation of transcription dna templated GO:0045892 237 0.997
negative regulation of cellular metabolic process GO:0031324 382 0.995
chromatin silencing GO:0006342 76 0.995
negative regulation of gene expression GO:0010629 387 0.992
dna conformation change GO:0071103 105 0.990
chromatin remodeling GO:0006338 72 0.985
chromosome organization GO:0051276 360 0.980
regulation of gene expression epigenetic GO:0040029 128 0.976
negative regulation of gene expression epigenetic GO:0045814 77 0.966
negative regulation of rna biosynthetic process GO:1902679 240 0.964
negative regulation of cellular biosynthetic process GO:0031327 277 0.936
dna packaging GO:0006323 91 0.932
chromosome segregation GO:0007059 157 0.926
cell proliferation GO:0008283 299 0.919
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.912
dna modification GO:0006304 5 0.908
dna metabolic process GO:0006259 227 0.902
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.894
negative regulation of biosynthetic process GO:0009890 277 0.893
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.881
gene silencing GO:0016458 138 0.854
covalent chromatin modification GO:0016569 106 0.828
dna methylation or demethylation GO:0044728 4 0.789
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.774
meiotic cell cycle GO:0051321 171 0.757
Fly
female meiotic division GO:0007143 70 0.679
Fly
negative regulation of nucleic acid templated transcription GO:1903507 240 0.663
histone lysine methylation GO:0034968 32 0.650
chromatin organization GO:0006325 207 0.628
transcription from rna polymerase ii promoter GO:0006366 368 0.602
Fly
negative regulation of chromosome organization GO:2001251 19 0.597
Fly
eye development GO:0001654 323 0.592
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.584
histone h4 k20 methylation GO:0034770 4 0.578
chromatin modification GO:0016568 147 0.570
mitotic spindle organization GO:0007052 220 0.569
mitotic cell cycle phase transition GO:0044772 138 0.545
regulation of neurogenesis GO:0050767 158 0.541
protein complex assembly GO:0006461 200 0.523
programmed cell death GO:0012501 257 0.502
spindle organization GO:0007051 253 0.495
organonitrogen compound metabolic process GO:1901564 318 0.477
mitotic nuclear division GO:0007067 213 0.466
meiotic cell cycle process GO:1903046 132 0.459
macromolecular complex assembly GO:0065003 256 0.449
mitotic sister chromatid segregation GO:0000070 87 0.447
organic substance catabolic process GO:1901575 308 0.438
negative regulation of cellular protein metabolic process GO:0032269 85 0.413
cell death GO:0008219 279 0.412
chromatin silencing at centromere GO:0030702 3 0.401
regulation of cell cycle phase transition GO:1901987 130 0.400
embryo development ending in birth or egg hatching GO:0009792 152 0.370
positive regulation of macromolecule metabolic process GO:0010604 405 0.355
regulation of protein metabolic process GO:0051246 256 0.346
regulation of cellular amine metabolic process GO:0033238 3 0.346
cellular protein modification process GO:0006464 438 0.341
regulation of cell differentiation GO:0045595 302 0.336
Worm
protein modification process GO:0036211 438 0.332
regulation of cellular component biogenesis GO:0044087 201 0.331
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.329
Fly
eye photoreceptor cell differentiation GO:0001754 145 0.328
proteolysis GO:0006508 192 0.321
methylation GO:0032259 47 0.309
positive regulation of protein metabolic process GO:0051247 128 0.306
photoreceptor cell differentiation GO:0046530 170 0.301
small molecule metabolic process GO:0044281 305 0.284
gonad development GO:0008406 50 0.269
Worm
positive regulation of histone h3 k9 methylation GO:0051574 3 0.266
negative regulation of cell cycle GO:0045786 116 0.249
mitotic chromosome condensation GO:0007076 22 0.241
mitotic sister chromatid separation GO:0051306 30 0.240
chromosome condensation GO:0030261 41 0.236
regulation of developmental growth GO:0048638 174 0.235
Worm
regulation of proteolysis GO:0030162 87 0.233
regulation of mitotic cell cycle phase transition GO:1901990 130 0.230
apoptotic process GO:0006915 159 0.226
regulation of cellular protein metabolic process GO:0032268 243 0.223
regulation of protein catabolic process GO:0042176 55 0.220
regulation of heterochromatin assembly GO:0031445 8 0.218
histone modification GO:0016570 106 0.215
cell cycle phase transition GO:0044770 140 0.214
regulation of mitotic cell cycle GO:0007346 190 0.209
dna methylation GO:0006306 4 0.209
regulation of apoptotic process GO:0042981 130 0.203
nuclear division GO:0000280 332 0.195
Fly
body morphogenesis GO:0010171 2 0.191
eye morphogenesis GO:0048592 260 0.181
sister chromatid segregation GO:0000819 92 0.178
heterochromatin assembly GO:0031507 13 0.172
peptidyl amino acid modification GO:0018193 105 0.172
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.163
negative regulation of cell cycle phase transition GO:1901988 103 0.160
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.157
dna replication GO:0006260 48 0.156
regulation of cell development GO:0060284 215 0.147
histone methylation GO:0016571 40 0.140
positive regulation of cellular protein metabolic process GO:0032270 118 0.135
nucleosome organization GO:0034728 59 0.133
stem cell division GO:0017145 69 0.132
organophosphate metabolic process GO:0019637 195 0.128
sensory organ morphogenesis GO:0090596 260 0.122
organelle fission GO:0048285 340 0.121
Fly
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.121
negative regulation of cellular component organization GO:0051129 108 0.120
Fly
cellular catabolic process GO:0044248 372 0.120
synaptonemal complex organization GO:0070193 5 0.117
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.116
Fly
cell division GO:0051301 248 0.113
regulation of cellular amino acid metabolic process GO:0006521 0 0.111
negative regulation of protein processing GO:0010955 31 0.110
regulation of catalytic activity GO:0050790 185 0.109
regulation of multi organism process GO:0043900 131 0.108
negative regulation of proteolysis GO:0045861 31 0.107
positive regulation of rna biosynthetic process GO:1902680 266 0.106
Fly
dna hypermethylation GO:0044026 3 0.105
negative regulation of organelle organization GO:0010639 56 0.101
Fly
cellular macromolecule catabolic process GO:0044265 136 0.101
positive regulation of phosphate metabolic process GO:0045937 139 0.095
histone acetylation GO:0016573 38 0.093
dendrite morphogenesis GO:0048813 199 0.093
negative regulation of neuroblast proliferation GO:0007406 27 0.092
regulation of cell division GO:0051302 72 0.091
death GO:0016265 284 0.090
regulation of neuron differentiation GO:0045664 103 0.090
peptidyl lysine dimethylation GO:0018027 3 0.089
chromosome separation GO:0051304 42 0.088
negative regulation of neurogenesis GO:0050768 53 0.087
positive regulation of response to stimulus GO:0048584 323 0.087
regulation of protein modification process GO:0031399 112 0.081
meiotic nuclear division GO:0007126 151 0.080
Fly
regulation of meiosis GO:0040020 3 0.080
protein maturation GO:0051604 71 0.079
macromolecule methylation GO:0043414 45 0.078
histone exchange GO:0043486 21 0.075
protein complex biogenesis GO:0070271 201 0.075
negative regulation of chromosome segregation GO:0051985 14 0.073
dendrite development GO:0016358 204 0.072
compound eye development GO:0048749 307 0.072
regulation of molecular function GO:0065009 217 0.072
regulation of proteasomal protein catabolic process GO:0061136 39 0.072
positive regulation of cell cycle GO:0045787 43 0.071
positive regulation of cellular component organization GO:0051130 156 0.070
multi multicellular organism process GO:0044706 123 0.067
epithelial cell differentiation GO:0030855 322 0.067
macromolecule catabolic process GO:0009057 161 0.065
protein dna complex subunit organization GO:0071824 86 0.064
regulation of cell cycle GO:0051726 291 0.063
oviposition GO:0018991 19 0.063
negative regulation of cell division GO:0051782 17 0.061
regulation of catabolic process GO:0009894 170 0.060
compound eye morphogenesis GO:0001745 249 0.060
reproductive behavior GO:0019098 122 0.059
neuron projection guidance GO:0097485 241 0.059
gland development GO:0048732 191 0.057
larval development GO:0002164 104 0.057
Worm
regulation of cell death GO:0010941 173 0.056
regulation of cell proliferation GO:0042127 163 0.056
catabolic process GO:0009056 409 0.056
negative regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032435 16 0.055
regulation of nervous system development GO:0051960 248 0.054
development of primary sexual characteristics GO:0045137 50 0.054
Worm
positive regulation of organelle organization GO:0010638 65 0.053
positive regulation of rna metabolic process GO:0051254 271 0.053
Fly
multicellular organismal reproductive behavior GO:0033057 110 0.053
positive regulation of cellular component biogenesis GO:0044089 80 0.053
regulation of cellular protein catabolic process GO:1903362 44 0.052
positive regulation of signal transduction GO:0009967 223 0.052
protein alkylation GO:0008213 43 0.052
response to extracellular stimulus GO:0009991 116 0.052
regulation of sister chromatid segregation GO:0033045 28 0.052
negative regulation of meiotic cell cycle GO:0051447 2 0.051
vesicle mediated transport GO:0016192 381 0.051
regulation of mitotic sister chromatid segregation GO:0033047 28 0.050
peptidyl lysine modification GO:0018205 57 0.050
reproductive system development GO:0061458 74 0.050
Worm
negative regulation of protein maturation GO:1903318 31 0.050
negative regulation of mitotic cell cycle GO:0045930 109 0.049
dna integrity checkpoint GO:0031570 81 0.047
positive regulation of catabolic process GO:0009896 105 0.047
histone h3 k9 methylation GO:0051567 9 0.046
positive regulation of molecular function GO:0044093 136 0.046
regulation of cell cycle process GO:0010564 181 0.046
negative regulation of nervous system development GO:0051961 92 0.045
response to radiation GO:0009314 155 0.045
dorsal vessel heart proper cell fate commitment GO:0035053 2 0.044
negative regulation of multicellular organismal process GO:0051241 142 0.043
Worm
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.042
regulation of chromosome organization GO:0033044 64 0.041
regulation of chromatin silencing GO:0031935 36 0.041
Fly
regulation of phosphate metabolic process GO:0019220 210 0.040
heterochromatin organization GO:0070828 25 0.040
regulation of nuclear division GO:0051783 58 0.039
positive regulation of phosphorus metabolic process GO:0010562 139 0.039
metaphase anaphase transition of cell cycle GO:0044784 28 0.039
purine ribonucleotide metabolic process GO:0009150 145 0.039
developmental growth GO:0048589 280 0.038
Worm
multi organism reproductive behavior GO:0044705 121 0.038
regulation of cellular catabolic process GO:0031329 157 0.037
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.037
modification dependent macromolecule catabolic process GO:0043632 79 0.036
enzyme linked receptor protein signaling pathway GO:0007167 179 0.036
negative regulation of protein metabolic process GO:0051248 85 0.036
aromatic compound catabolic process GO:0019439 166 0.036
positive regulation of multicellular organismal process GO:0051240 143 0.036
Worm
negative regulation of protein catabolic process GO:0042177 17 0.036
multi organism behavior GO:0051705 175 0.034
glial cell migration GO:0008347 31 0.034
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.034
positive regulation of protein modification process GO:0031401 58 0.034
oxoacid metabolic process GO:0043436 103 0.033
regulation of transcription by chromatin organization GO:0034401 3 0.033
phosphorylation GO:0016310 294 0.033
protein catabolic process GO:0030163 101 0.033
nucleus organization GO:0006997 45 0.032
single organism catabolic process GO:0044712 228 0.032
posttranscriptional gene silencing GO:0016441 46 0.032
growth GO:0040007 359 0.031
Worm
negative regulation of cell cycle process GO:0010948 109 0.031
negative regulation of cell proliferation GO:0008285 69 0.030
camera type eye development GO:0043010 4 0.030
nucleoside monophosphate metabolic process GO:0009123 52 0.029
rna processing GO:0006396 147 0.029
rrna processing GO:0006364 3 0.029
gland morphogenesis GO:0022612 145 0.029
positive regulation of catalytic activity GO:0043085 118 0.028
peptidyl lysine acetylation GO:0018394 39 0.028
nucleoside triphosphate metabolic process GO:0009141 120 0.028
protein processing GO:0016485 68 0.028
gliogenesis GO:0042063 80 0.027
axon development GO:0061564 297 0.027
cellular protein catabolic process GO:0044257 83 0.027
compound eye photoreceptor cell differentiation GO:0001751 140 0.026
nucleotide metabolic process GO:0009117 161 0.026
positive regulation of dna metabolic process GO:0051054 12 0.025
negative regulation of cellular catabolic process GO:0031330 34 0.025
regulation of protein processing GO:0070613 32 0.025
establishment or maintenance of polarity of larval imaginal disc epithelium GO:0016336 3 0.025
negative regulation of cell differentiation GO:0045596 143 0.024
positive regulation of cellular biosynthetic process GO:0031328 316 0.024
Fly
positive regulation of cell communication GO:0010647 250 0.024
regulation of protein ubiquitination GO:0031396 22 0.024
positive regulation of protein import into nucleus translocation GO:0033160 2 0.024
ribose phosphate metabolic process GO:0019693 145 0.023
carbohydrate derivative metabolic process GO:1901135 217 0.023
nitric oxide metabolic process GO:0046209 1 0.023
ubiquitin dependent protein catabolic process GO:0006511 78 0.023
establishment or maintenance of cell polarity GO:0007163 167 0.023
regulation of homotypic cell cell adhesion GO:0034110 2 0.023
spindle assembly involved in mitosis GO:0090307 50 0.022
regulation of gene silencing GO:0060968 63 0.021
Fly
modification dependent protein catabolic process GO:0019941 78 0.021
negative regulation of developmental process GO:0051093 201 0.021
Worm
cellular response to nutrient GO:0031670 1 0.021
negative regulation of phosphate metabolic process GO:0045936 45 0.021
regulation of meiotic cell cycle GO:0051445 9 0.021
regulation of hemocyte proliferation GO:0035206 37 0.021
dendrite regeneration GO:0031104 2 0.021
regulation of intracellular signal transduction GO:1902531 236 0.021
Worm
mitotic cell cycle checkpoint GO:0007093 88 0.020
positive regulation of cell cycle process GO:0090068 28 0.020
genitalia development GO:0048806 26 0.020
protein modification by small protein conjugation or removal GO:0070647 106 0.020
regulation of hydrolase activity GO:0051336 97 0.019
chromatin assembly or disassembly GO:0006333 52 0.019
signal transduction by phosphorylation GO:0023014 107 0.019
regulation of cdc42 protein signal transduction GO:0032489 3 0.019
axonogenesis GO:0007409 290 0.019
proteasomal protein catabolic process GO:0010498 59 0.019
regulation of membrane potential in photoreceptor cell GO:0016057 4 0.019
oocyte morphogenesis GO:0048601 3 0.019
protein acetylation GO:0006473 39 0.019
cellular response to chemical stimulus GO:0070887 199 0.018
atp dependent chromatin remodeling GO:0043044 22 0.018
heterocycle catabolic process GO:0046700 166 0.018
regulation of striated muscle contraction GO:0006942 2 0.018
positive regulation of chromatin silencing GO:0031937 16 0.018
Fly
positive regulation of cellular amine metabolic process GO:0033240 0 0.018
dna damage checkpoint GO:0000077 78 0.017
negative regulation of chromatin modification GO:1903309 5 0.017
Fly
regulation of planar cell polarity pathway involved in axis elongation GO:2000040 2 0.017
neuroblast proliferation GO:0007405 74 0.017
maternal determination of dorsal ventral axis ovarian follicular epithelium soma encoded GO:0008071 1 0.017
nucleoside metabolic process GO:0009116 127 0.017
negative regulation of cell communication GO:0010648 223 0.017
Worm
reactive oxygen species biosynthetic process GO:1903409 0 0.016
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 1 0.016
intermediate filament cytoskeleton organization GO:0045104 1 0.016
intermediate filament based process GO:0045103 1 0.016
telomere capping GO:0016233 11 0.016
Fly
regulation of phosphorylation GO:0042325 147 0.016
cellular response to organic substance GO:0071310 132 0.016
response to organic substance GO:0010033 284 0.016
posttranscriptional regulation of gene expression GO:0010608 145 0.016
heterochromatin organization involved in chromatin silencing GO:0070868 9 0.016
regulation of organelle organization GO:0033043 196 0.016
cellular nitrogen compound catabolic process GO:0044270 165 0.016
negative regulation of cell development GO:0010721 62 0.016
regulation of multicellular organismal development GO:2000026 414 0.016
Worm
posttranscriptional gene silencing by rna GO:0035194 45 0.015
positive regulation of mitotic cell cycle GO:0045931 34 0.015
response to red or far red light GO:0009639 2 0.015
immune system development GO:0002520 57 0.015
positive regulation of chromatin silencing at telomere GO:0031940 2 0.015
Fly
cell cycle checkpoint GO:0000075 95 0.015
positive regulation of heterochromatin assembly GO:0031453 5 0.015
regulation of protein modification by small protein conjugation or removal GO:1903320 25 0.015
alpha amino 3 hydroxy 5 methyl 4 isoxazole propionate selective glutamate receptor clustering GO:0097113 2 0.014
purine ribonucleoside catabolic process GO:0046130 112 0.014
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.014
homeostatic process GO:0042592 199 0.014
purine nucleoside metabolic process GO:0042278 127 0.014
regulation of photoreceptor cell differentiation GO:0046532 34 0.013
negative regulation of terminal cell fate specification open tracheal system GO:0035155 2 0.013
regulation of protein maturation GO:1903317 32 0.013
nucleobase containing small molecule metabolic process GO:0055086 174 0.013
regulation of reactive oxygen species biosynthetic process GO:1903426 0 0.013
purine nucleoside catabolic process GO:0006152 112 0.013
intracellular signal transduction GO:0035556 300 0.013
Worm
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.013
convergent extension GO:0060026 2 0.013
imaginal disc derived wing expansion GO:0048526 7 0.013
regulation of phosphorus metabolic process GO:0051174 210 0.013
rna interference GO:0016246 27 0.012
regulation of dna replication GO:0006275 13 0.012
retina development in camera type eye GO:0060041 4 0.012
border follicle cell delamination GO:0030709 3 0.012
pole cell formation GO:0007279 19 0.012
regulation of cellular response to stress GO:0080135 89 0.012
positive regulation of cell maturation GO:1903431 2 0.012
left right axis specification GO:0070986 1 0.012
protein homooligomerization GO:0051260 7 0.012
ribonucleoside triphosphate metabolic process GO:0009199 119 0.012
phospholipid transport GO:0015914 2 0.012
negative regulation of catabolic process GO:0009895 36 0.012
receptor mediated endocytosis GO:0006898 21 0.012
endocytosis GO:0006897 310 0.011
embryonic organ development GO:0048568 50 0.011
negative regulation of purine nucleotide catabolic process GO:0033122 1 0.011
regulation of mapk cascade GO:0043408 92 0.011
regulation of response to stress GO:0080134 200 0.011
positive regulation of neuron projection regeneration GO:0070572 3 0.011
regulation of rap gtpase activity GO:0032317 3 0.011
imaginal disc derived male genitalia morphogenesis GO:0048803 14 0.011
regulation of programmed cell death GO:0043067 152 0.011
reproductive structure development GO:0048608 74 0.011
Worm
regulation of cell proliferation involved in compound eye morphogenesis GO:2000495 2 0.011
purine nucleotide metabolic process GO:0006163 146 0.011
amine metabolic process GO:0009308 12 0.011
negative regulation of mitotic sister chromatid separation GO:2000816 13 0.011
regulation of rna stability GO:0043487 4 0.011
oocyte fate commitment GO:0048600 2 0.011
muscle organ development GO:0007517 127 0.011
regulation of dna methylation GO:0044030 3 0.010
anatomical structure homeostasis GO:0060249 97 0.010
embryonic digestive tract development GO:0048566 5 0.010
mitotic g2 dna damage checkpoint GO:0007095 69 0.010
meiotic nuclear envelope disassembly GO:0051078 2 0.010
appendage morphogenesis GO:0035107 397 0.010
specification of segmental identity antennal segment GO:0007383 2 0.010
purine ribonucleoside monophosphate catabolic process GO:0009169 38 0.010
positive regulation of proteolysis GO:0045862 52 0.010
negative regulation of stem cell proliferation GO:2000647 30 0.010
telomere maintenance GO:0000723 21 0.010
positive regulation of pole plasm oskar mrna localization GO:0045856 2 0.010
purine containing compound metabolic process GO:0072521 155 0.010

Su(var)205 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
brachydactyly DOID:0050581 0 0.038
bone development disease DOID:0080006 0 0.038
bone disease DOID:0080001 0 0.038
disease of anatomical entity DOID:7 0 0.038
dysostosis DOID:1934 0 0.038
musculoskeletal system disease DOID:17 0 0.038
connective tissue disease DOID:65 0 0.038
nervous system benign neoplasm DOID:0060115 0 0.016
organ system benign neoplasm DOID:0060085 0 0.016
neuroma DOID:2001 0 0.016
benign neoplasm DOID:0060072 0 0.016
disease of cellular proliferation DOID:14566 0 0.016
endocrine gland cancer DOID:170 0 0.015
thyroid cancer DOID:1781 0 0.015
cancer DOID:162 0 0.015
organ system cancer DOID:0050686 0 0.015
syndrome DOID:225 0 0.013