Drosophila melanogaster

151 known processes

pan (Dmel_CG34403)

pangolin

(Aliases: TCF/LEF1,dTCF,CG32005,dTcf,Tcf/LEF,pan.dTCF,Dmel\CG34403,Lef1,Pan,DTCF,Lef,LEF1/TCF,PAN,CG34403,Dmel_CG17964,IA5,lef1,tcf,TCF,DTcf,TCF/LEF,LEF1,cTCF,Tcf-1,d-TCF,LEF/TCF-1,Dmel_CG32005,LEF-1,l(4)102ABb,CG17964,Tcf,l(4)13,LEF/TCF)

pan biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
transcription from rna polymerase ii promoter GO:0006366 368 1.000
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.999
positive regulation of rna metabolic process GO:0051254 271 0.998
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.997
positive regulation of cellular biosynthetic process GO:0031328 316 0.997
embryonic morphogenesis GO:0048598 206 0.996
Zebrafish Mouse Worm
regionalization GO:0003002 416 0.995
Zebrafish Mouse Worm
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.993
regulation of hemocyte differentiation GO:0045610 22 0.993
positive regulation of transcription dna templated GO:0045893 266 0.992
muscle structure development GO:0061061 224 0.988
Human Zebrafish Mouse Worm
positive regulation of gene expression GO:0010628 290 0.983
regulation of cell differentiation GO:0045595 302 0.983
cell proliferation GO:0008283 299 0.981
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.980
localization of cell GO:0051674 257 0.978
Human Zebrafish Mouse
negative regulation of nucleic acid templated transcription GO:1903507 240 0.978
tissue morphogenesis GO:0048729 297 0.976
Mouse Worm
embryonic hindgut morphogenesis GO:0048619 48 0.974
Mouse
positive regulation of nucleic acid templated transcription GO:1903508 266 0.966
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.964
stem cell differentiation GO:0048863 117 0.961
Human Zebrafish Mouse
positive regulation of rna biosynthetic process GO:1902680 266 0.961
cell motility GO:0048870 251 0.960
Human Zebrafish Mouse
muscle cell differentiation GO:0042692 103 0.960
Human Zebrafish Mouse
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.956
embryonic development via the syncytial blastoderm GO:0001700 148 0.948
epithelial cell differentiation GO:0030855 322 0.947
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.944
axis specification GO:0009798 167 0.935
Mouse Worm
stem cell proliferation GO:0072089 88 0.922
negative regulation of rna biosynthetic process GO:1902679 240 0.920
digestive tract development GO:0048565 149 0.919
Zebrafish Mouse Worm
tube development GO:0035295 244 0.916
Zebrafish Mouse Worm
tube morphogenesis GO:0035239 191 0.915
Zebrafish Mouse Worm
regulation of organ growth GO:0046620 42 0.907
Mouse
negative regulation of response to stimulus GO:0048585 258 0.905
Human Zebrafish Mouse
anterior posterior pattern specification GO:0009952 136 0.902
Zebrafish Mouse
cell migration GO:0016477 238 0.900
Human Zebrafish Mouse
hemocyte differentiation GO:0042386 38 0.888
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.887
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.887
digestive system development GO:0055123 149 0.880
Zebrafish Mouse Worm
positive regulation of macromolecule metabolic process GO:0010604 405 0.873
imaginal disc derived appendage development GO:0048737 399 0.868
imaginal disc derived wing morphogenesis GO:0007476 337 0.868
renal system development GO:0072001 72 0.866
negative regulation of cell communication GO:0010648 223 0.866
Human Zebrafish Mouse
immune system development GO:0002520 57 0.858
Human Mouse
negative regulation of transcription dna templated GO:0045892 237 0.848
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.847
Human Mouse
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.842
regulation of epithelial cell proliferation GO:0050678 4 0.835
Mouse
myotube differentiation GO:0014902 46 0.835
malpighian tubule morphogenesis GO:0007443 44 0.823
negative regulation of cellular biosynthetic process GO:0031327 277 0.822
hindgut development GO:0061525 58 0.815
Mouse
protein modification process GO:0036211 438 0.812
Human
morphogenesis of embryonic epithelium GO:0016331 94 0.808
vesicle mediated transport GO:0016192 381 0.806
regulation of cell death GO:0010941 173 0.770
Human Mouse
segment polarity determination GO:0007367 25 0.762
response to organic substance GO:0010033 284 0.751
Human Mouse
wing disc morphogenesis GO:0007472 344 0.748
positive regulation of biosynthetic process GO:0009891 316 0.747
axon guidance GO:0007411 233 0.746
positive regulation of developmental process GO:0051094 143 0.743
Human Zebrafish Worm
post embryonic appendage morphogenesis GO:0035120 385 0.725
dorsal closure GO:0007391 79 0.723
forebrain development GO:0030900 2 0.718
Zebrafish Mouse
regulation of cell fate specification GO:0042659 27 0.712
Worm
regulation of striated muscle tissue development GO:0016202 5 0.712
Mouse
neuroblast division GO:0055057 35 0.703
Mouse
immune system process GO:0002376 347 0.703
single organism nuclear import GO:1902593 51 0.692
Mouse
cellular response to dna damage stimulus GO:0006974 223 0.683
regulation of immune system process GO:0002682 176 0.676
regulation of growth GO:0040008 233 0.671
Human Mouse
skeletal muscle organ development GO:0060538 48 0.660
Mouse
positive regulation of epithelial cell differentiation GO:0030858 1 0.656
response to alcohol GO:0097305 95 0.655
circulatory system process GO:0003013 37 0.650
cellular response to extracellular stimulus GO:0031668 64 0.649
Mouse
negative regulation of rna metabolic process GO:0051253 251 0.631
response to oxygen containing compound GO:1901700 200 0.631
Mouse
positive regulation of programmed cell death GO:0043068 62 0.613
Mouse
regulation of muscle organ development GO:0048634 13 0.611
Mouse
axonogenesis GO:0007409 290 0.607
neuron projection guidance GO:0097485 241 0.605
response to endogenous stimulus GO:0009719 119 0.601
Human Mouse
chorion containing eggshell formation GO:0007304 105 0.595
regulation of cell proliferation GO:0042127 163 0.594
covalent chromatin modification GO:0016569 106 0.590
Human
regulation of response to stress GO:0080134 200 0.578
protein acetylation GO:0006473 39 0.572
Human
periodic partitioning GO:0007365 29 0.569
cellular catabolic process GO:0044248 372 0.567
internal protein amino acid acetylation GO:0006475 38 0.562
Human
negative regulation of developmental process GO:0051093 201 0.562
Mouse Worm
germarium derived egg chamber formation GO:0007293 101 0.551
taxis GO:0042330 304 0.545
Human
epithelial cell development GO:0002064 274 0.536
heart field specification GO:0003128 0 0.528
urogenital system development GO:0001655 72 0.525
bmp signaling pathway GO:0030509 27 0.522
Mouse
response to abiotic stimulus GO:0009628 341 0.519
intracellular signal transduction GO:0035556 300 0.514
Human
response to organic cyclic compound GO:0014070 89 0.506
Human
positive regulation of signal transduction GO:0009967 223 0.496
Human
regulation of cellular response to stress GO:0080135 89 0.494
axon development GO:0061564 297 0.493
negative regulation of multicellular organismal process GO:0051241 142 0.487
Human Mouse Worm
compound eye retinal cell programmed cell death GO:0046667 23 0.478
malpighian tubule development GO:0072002 64 0.475
skeletal muscle tissue development GO:0007519 13 0.464
Mouse
cytoplasmic transport GO:0016482 130 0.461
Human Mouse
regulation of immune response GO:0050776 118 0.461
positive regulation of cell communication GO:0010647 250 0.459
Human Mouse
cellular response to chemical stimulus GO:0070887 199 0.458
Human Mouse
segmentation GO:0035282 207 0.457
Zebrafish Mouse
eggshell chorion assembly GO:0007306 66 0.456
embryonic organ development GO:0048568 50 0.454
Zebrafish Mouse
nephrocyte differentiation GO:0061319 12 0.454
negative regulation of signal transduction GO:0009968 206 0.452
Human Zebrafish Mouse
epithelial cell migration open tracheal system GO:0007427 32 0.449
regulation of cell cycle GO:0051726 291 0.444
Human
syncytium formation by plasma membrane fusion GO:0000768 43 0.437
histone modification GO:0016570 106 0.434
Human
striated muscle cell differentiation GO:0051146 90 0.431
Zebrafish
motor neuron axon guidance GO:0008045 58 0.430
cellular protein modification process GO:0006464 438 0.429
Human
renal tubule development GO:0061326 64 0.428
positive regulation of lipid metabolic process GO:0045834 4 0.428
Mouse
respiratory system development GO:0060541 213 0.427
regulation of protein import into nucleus GO:0042306 28 0.427
cell fate specification GO:0001708 71 0.427
Worm
muscle organ development GO:0007517 127 0.425
Mouse Worm
renal tubule morphogenesis GO:0061333 44 0.411
regulation of cytoplasmic transport GO:1903649 47 0.409
Human
cardiovascular system development GO:0072358 82 0.408
response to oxidative stress GO:0006979 86 0.407
imaginal disc derived wing margin morphogenesis GO:0008587 41 0.406
regulation of intracellular signal transduction GO:1902531 236 0.404
Human
nephron tubule morphogenesis GO:0072078 3 0.403
regulation of intracellular protein transport GO:0033157 46 0.398
Human
regulation of cell development GO:0060284 215 0.397
Human Zebrafish Mouse
regulation of imaginal disc growth GO:0045570 26 0.397
regulation of muscle cell differentiation GO:0051147 8 0.394
cellular response to external stimulus GO:0071496 66 0.394
Mouse
nuclear import GO:0051170 51 0.393
Mouse
regulation of muscle tissue development GO:1901861 5 0.384
Mouse
muscle tissue development GO:0060537 30 0.381
Mouse
negative regulation of wnt signaling pathway GO:0030178 28 0.380
Human Zebrafish
appendage development GO:0048736 401 0.380
sensory organ morphogenesis GO:0090596 260 0.374
Zebrafish
endocytosis GO:0006897 310 0.371
asymmetric neuroblast division GO:0055059 33 0.371
dorsal appendage formation GO:0046843 47 0.370
dorsal ventral axis specification GO:0009950 66 0.370
hemocyte migration GO:0035099 19 0.368
protein import into nucleus GO:0006606 51 0.366
Mouse
biological adhesion GO:0022610 138 0.361
Human Mouse
negative regulation of immune system process GO:0002683 50 0.356
heart development GO:0007507 82 0.355
regulation of response to dna damage stimulus GO:2001020 23 0.354
open tracheal system development GO:0007424 204 0.353
protein localization to nucleus GO:0034504 55 0.353
Mouse
defense response to bacterium GO:0042742 178 0.352
positive regulation of protein metabolic process GO:0051247 128 0.351
Human
protein targeting to nucleus GO:0044744 51 0.347
Mouse
epithelial cell proliferation involved in malpighian tubule morphogenesis GO:0061331 11 0.346
camera type eye development GO:0043010 4 0.344
Zebrafish
protein import GO:0017038 55 0.344
Mouse
chemotaxis GO:0006935 249 0.344
Human
positive regulation of locomotion GO:0040017 8 0.341
Human
asymmetric stem cell division GO:0098722 49 0.340
blastoderm segmentation GO:0007350 159 0.340
Mouse
gastrulation involving germ band extension GO:0010004 36 0.336
regulation of wnt signaling pathway GO:0030111 68 0.329
regulation of epithelial cell differentiation GO:0030856 4 0.325
response to growth factor GO:0070848 31 0.324
Mouse
branching involved in open tracheal system development GO:0060446 45 0.321
small molecule metabolic process GO:0044281 305 0.317
Human Zebrafish Mouse
histone acetylation GO:0016573 38 0.316
Human
regulation of stem cell proliferation GO:0072091 40 0.313
smoothened signaling pathway GO:0007224 49 0.313
programmed cell death GO:0012501 257 0.311
Human Mouse Worm
developmental induction GO:0031128 3 0.301
positive regulation of r7 cell differentiation GO:0045678 7 0.294
regulation of innate immune response GO:0045088 71 0.292
homeostatic process GO:0042592 199 0.290
Human Zebrafish Mouse
cellular response to endogenous stimulus GO:0071495 80 0.290
Human Mouse
negative regulation of biosynthetic process GO:0009890 277 0.285
embryonic pattern specification GO:0009880 174 0.283
cellular response to growth factor stimulus GO:0071363 30 0.282
Mouse
somatic muscle development GO:0007525 66 0.282
ectodermal placode morphogenesis GO:0071697 4 0.280
regulation of cell fate commitment GO:0010453 29 0.280
Worm
negative regulation of growth GO:0045926 84 0.277
Mouse
ovarian follicle cell development GO:0030707 248 0.271
negative regulation of signaling GO:0023057 219 0.268
Human Zebrafish Mouse
negative regulation of smoothened signaling pathway GO:0045879 16 0.265
organ induction GO:0001759 3 0.264
gastrulation GO:0007369 70 0.262
Mouse Worm
immune response activating signal transduction GO:0002757 2 0.262
positive regulation of protein localization to nucleus GO:1900182 21 0.260
regulation of developmental growth GO:0048638 174 0.259
Mouse
epithelial cell type specification open tracheal system GO:0035153 11 0.258
head involution GO:0008258 35 0.256
epithelial tube morphogenesis GO:0060562 88 0.254
Mouse
response to bacterium GO:0009617 198 0.254
myotube cell development GO:0014904 3 0.254
positive regulation of lipid catabolic process GO:0050996 1 0.252
establishment of protein localization to organelle GO:0072594 62 0.251
Mouse
positive regulation of molecular function GO:0044093 136 0.247
Human
columnar cuboidal epithelial cell development GO:0002066 249 0.233
response to external biotic stimulus GO:0043207 293 0.230
negative regulation of cell proliferation GO:0008285 69 0.230
regulation of canonical wnt signaling pathway GO:0060828 15 0.230
Human
regulation of protein localization to nucleus GO:1900180 29 0.229
catabolic process GO:0009056 409 0.228
asymmetric cell division GO:0008356 37 0.227
Worm
positive regulation of defense response GO:0031349 59 0.226
cell cell junction assembly GO:0007043 38 0.225
striated muscle adaptation GO:0014888 1 0.223
positive regulation of response to stimulus GO:0048584 323 0.220
Human
regulation of protein metabolic process GO:0051246 256 0.219
Human
positive regulation of i kappab kinase nf kappab signaling GO:0043123 1 0.219
negative regulation of cellular metabolic process GO:0031324 382 0.216
chromatin organization GO:0006325 207 0.215
Human
morphogenesis of a polarized epithelium GO:0001738 93 0.215
protein localization to organelle GO:0033365 82 0.214
Mouse
nephron tubule development GO:0072080 3 0.213
regulation of nucleocytoplasmic transport GO:0046822 35 0.213
Human
imaginal disc derived appendage morphogenesis GO:0035114 395 0.212
determination of genital disc primordium GO:0035225 10 0.208
spinal cord development GO:0021510 1 0.208
Zebrafish
regulation of heart contraction GO:0008016 21 0.208
internal peptidyl lysine acetylation GO:0018393 38 0.207
Human
chromosome organization GO:0051276 360 0.205
Human
digestive tract morphogenesis GO:0048546 127 0.201
Zebrafish Mouse Worm
telencephalon development GO:0021537 2 0.200
Mouse
positive regulation of cell cycle GO:0045787 43 0.200
Human
male gamete generation GO:0048232 201 0.198
response to nitrogen compound GO:1901698 90 0.198
cell cell signaling involved in cell fate commitment GO:0045168 210 0.198
cardiac cell fate commitment GO:0060911 17 0.197
response to biotic stimulus GO:0009607 294 0.196
extracellular structure organization GO:0043062 46 0.195
cuticle pattern formation GO:0035017 27 0.194
response to extracellular stimulus GO:0009991 116 0.193
Mouse
single organism cellular localization GO:1902580 180 0.193
Mouse
growth GO:0040007 359 0.192
Human Zebrafish Mouse
establishment of localization in cell GO:0051649 402 0.189
Human Mouse
limb development GO:0060173 1 0.189
Mouse
negative regulation of cell death GO:0060548 81 0.187
Human Mouse
positive regulation of cell adhesion GO:0045785 10 0.187
Human
cell fate commitment involved in formation of primary germ layer GO:0060795 10 0.186
Worm
regulation of multi organism process GO:0043900 131 0.185
Human
regulation of system process GO:0044057 36 0.184
Worm
retina development in camera type eye GO:0060041 4 0.183
negative regulation of epithelial cell proliferation GO:0050680 4 0.182
myoblast fusion GO:0007520 43 0.181
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.181
Mouse
regulation of developmental pigmentation GO:0048070 24 0.181
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.174
dorsal ventral pattern formation GO:0009953 133 0.173
Zebrafish
regulation of dna templated transcription elongation GO:0032784 17 0.172
positive regulation of protein phosphorylation GO:0001934 34 0.171
nucleocytoplasmic transport GO:0006913 72 0.171
Human Mouse
immune response GO:0006955 246 0.170
Mouse
neuroblast proliferation GO:0007405 74 0.170
Mouse
organic acid metabolic process GO:0006082 103 0.170
Human Zebrafish
fusion cell fate specification GO:0035156 4 0.168
cardiocyte differentiation GO:0035051 29 0.167
regulation of defense response GO:0031347 102 0.167
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 11 0.165
mesoderm development GO:0007498 78 0.164
Mouse Worm
regulation of protein modification process GO:0031399 112 0.164
regulation of bmp signaling pathway GO:0030510 23 0.164
Mouse
appendage morphogenesis GO:0035107 397 0.163
cell maturation GO:0048469 144 0.162
cell death GO:0008219 279 0.162
Human Mouse Worm
positive regulation of catalytic activity GO:0043085 118 0.161
regulation of organ morphogenesis GO:2000027 78 0.161
specification of organ identity GO:0010092 3 0.160
regulation of cellular protein metabolic process GO:0032268 243 0.160
Human
salivary gland development GO:0007431 162 0.159
peptidyl lysine acetylation GO:0018394 39 0.159
Human
gastrulation with mouth forming first GO:0001703 36 0.159
regulation of phosphorus metabolic process GO:0051174 210 0.157
regulation of actin filament based process GO:0032970 42 0.157
wnt signaling pathway GO:0016055 98 0.155
hematopoietic or lymphoid organ development GO:0048534 57 0.155
Human Mouse
regulation of cellular response to growth factor stimulus GO:0090287 13 0.155
Mouse
positive regulation of cell motility GO:2000147 3 0.154
Human
developmental growth GO:0048589 280 0.154
Zebrafish Mouse
anterior posterior axis specification GO:0009948 109 0.154
Mouse
developmental programmed cell death GO:0010623 138 0.154
Mouse
innate immune response GO:0045087 144 0.151
positive regulation of phosphorus metabolic process GO:0010562 139 0.148
positive regulation of phosphate metabolic process GO:0045937 139 0.147
germ cell migration GO:0008354 43 0.146
epithelial cell proliferation involved in renal tubule morphogenesis GO:2001013 11 0.146
neurological system process GO:0050877 358 0.145
Mouse
regulation of phosphate metabolic process GO:0019220 210 0.144
pigmentation GO:0043473 75 0.143
neuroblast differentiation GO:0014016 29 0.143
regulation of protein localization GO:0032880 76 0.142
Human
photoreceptor cell differentiation GO:0046530 170 0.142
positive regulation of cell development GO:0010720 61 0.141
Human Zebrafish
regulation of transport GO:0051049 181 0.140
Human Mouse Worm
negative regulation of cell differentiation GO:0045596 143 0.139
Mouse
morphogenesis of an epithelium GO:0002009 276 0.138
Mouse
cellular response to nutrient levels GO:0031669 62 0.136
Mouse
single organism carbohydrate metabolic process GO:0044723 72 0.136
Mouse
protein modification by small protein conjugation or removal GO:0070647 106 0.136
positive regulation of protein import into nucleus GO:0042307 21 0.134
negative regulation of neuron death GO:1901215 18 0.134
blood circulation GO:0008015 26 0.132
mesenchymal cell differentiation GO:0048762 1 0.132
Human Zebrafish Mouse
cardioblast differentiation GO:0010002 20 0.131
regulation of protein transport GO:0051223 57 0.131
Human
immune response regulating signaling pathway GO:0002764 2 0.131
phosphorylation GO:0016310 294 0.131
organ growth GO:0035265 56 0.130
Mouse
retinal cell programmed cell death GO:0046666 25 0.130
cellular component assembly involved in morphogenesis GO:0010927 151 0.129
cell fate specification involved in pattern specification GO:0060573 8 0.129
heart induction GO:0003129 3 0.128
regulation of compound eye retinal cell programmed cell death GO:0046669 18 0.128
regulation of smoothened signaling pathway GO:0008589 28 0.126
heart process GO:0003015 37 0.126
eye morphogenesis GO:0048592 260 0.125
Zebrafish
positive regulation of multicellular organismal process GO:0051240 143 0.125
Human Zebrafish Worm
regulation of multicellular organismal development GO:2000026 414 0.124
Human Zebrafish Mouse Worm
regulation of tube diameter open tracheal system GO:0035158 11 0.123
cell projection assembly GO:0030031 94 0.121
positive regulation of signaling GO:0023056 243 0.121
Human Mouse
ameboidal type cell migration GO:0001667 151 0.121
Zebrafish
compound eye morphogenesis GO:0001745 249 0.121
negative regulation of heart induction GO:1901320 3 0.120
convergent extension GO:0060026 2 0.118
cell fate determination GO:0001709 91 0.117
Worm
embryonic hemopoiesis GO:0035162 26 0.117
synapse assembly GO:0007416 143 0.117
negative regulation of cell adhesion GO:0007162 9 0.115
Human
positive regulation of cell differentiation GO:0045597 64 0.113
Human Zebrafish
hindgut morphogenesis GO:0007442 58 0.113
Mouse
cellular response to oxygen containing compound GO:1901701 79 0.111
Mouse
negative regulation of intracellular signal transduction GO:1902532 57 0.110
hindbrain development GO:0030902 2 0.110
Zebrafish Mouse
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.109
negative regulation of cell fate specification GO:0009996 15 0.107
regulation of dna repair GO:0006282 5 0.106
cellular protein catabolic process GO:0044257 83 0.105
meiotic nuclear division GO:0007126 151 0.105
positive regulation of intracellular signal transduction GO:1902533 116 0.105
Human
positive regulation of cellular protein metabolic process GO:0032270 118 0.105
signal transduction in response to dna damage GO:0042770 3 0.104
negative regulation of programmed cell death GO:0043069 72 0.104
Human Mouse
pattern recognition receptor signaling pathway GO:0002221 2 0.102
oocyte differentiation GO:0009994 145 0.102
positive regulation of phosphorylation GO:0042327 87 0.101
multicellular organism growth GO:0035264 46 0.100
Mouse
regulation of neuron apoptotic process GO:0043523 16 0.100
negative regulation of gene expression GO:0010629 387 0.100
positive regulation of intracellular transport GO:0032388 42 0.100
Human
dna metabolic process GO:0006259 227 0.100
Human Mouse
genital disc anterior posterior pattern formation GO:0035224 8 0.099
cuticle development GO:0042335 86 0.099
central nervous system development GO:0007417 201 0.099
Zebrafish Mouse
jak stat cascade GO:0007259 49 0.099
phagocytosis GO:0006909 215 0.097
genital disc pattern formation GO:0035221 8 0.095
modification dependent protein catabolic process GO:0019941 78 0.095
skeletal muscle fiber development GO:0048741 3 0.095
positive regulation of cell migration GO:0030335 2 0.094
Human
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 6 0.092
visceral muscle development GO:0007522 14 0.092
response to monosaccharide GO:0034284 4 0.092
Mouse
imaginal disc growth GO:0007446 37 0.092
protein phosphorylation GO:0006468 169 0.090
canonical wnt signaling pathway GO:0060070 21 0.089
Human Zebrafish Mouse
protein acylation GO:0043543 42 0.089
Human
eye photoreceptor cell differentiation GO:0001754 145 0.088
single organism intracellular transport GO:1902582 207 0.088
Human Mouse
tripartite regional subdivision GO:0007351 103 0.088
Mouse
regulation of cell cycle process GO:0010564 181 0.086
Human
chromatin modification GO:0016568 147 0.086
Human
cellular response to molecule of bacterial origin GO:0071219 3 0.085
activation of protein kinase activity GO:0032147 12 0.085
cellular ketone metabolic process GO:0042180 24 0.084
Zebrafish Mouse
cellular response to lipid GO:0071396 20 0.084
Human
ion transmembrane transport GO:0034220 122 0.084
sensory perception of mechanical stimulus GO:0050954 72 0.084
labial disc development GO:0035217 4 0.083
cellular response to organic substance GO:0071310 132 0.083
Human Mouse
macromolecule catabolic process GO:0009057 161 0.082
formation of anatomical boundary GO:0048859 37 0.082
compound eye photoreceptor cell differentiation GO:0001751 140 0.081
negative regulation of heart induction by canonical wnt signaling pathway GO:0003136 3 0.080
signal transduction by p53 class mediator GO:0072331 6 0.080
cell activation GO:0001775 9 0.080
Mouse
neural precursor cell proliferation GO:0061351 75 0.079
Zebrafish Mouse
imaginal disc derived wing hair organization GO:0035317 45 0.078
dna integrity checkpoint GO:0031570 81 0.078
nephron epithelium development GO:0072009 3 0.076
syncytium formation GO:0006949 43 0.075
regeneration GO:0031099 16 0.074
Zebrafish
salivary gland morphogenesis GO:0007435 145 0.074
regulation of cytoskeleton organization GO:0051493 89 0.073
response to lipid GO:0033993 38 0.072
Human
mapk cascade GO:0000165 107 0.072
muscle cell development GO:0055001 50 0.070
Zebrafish
response to ethanol GO:0045471 59 0.070
generation of precursor metabolites and energy GO:0006091 42 0.070
Mouse
protein catabolic process GO:0030163 101 0.070
proteolysis GO:0006508 192 0.069
Human
ubiquitin dependent protein catabolic process GO:0006511 78 0.069
regulation of cell cell adhesion GO:0022407 21 0.068
Human Mouse
death GO:0016265 284 0.066
Human Mouse Worm
posttranscriptional regulation of gene expression GO:0010608 145 0.066
Worm
kidney development GO:0001822 3 0.066
protein transport GO:0015031 155 0.066
Human Mouse
actin cytoskeleton organization GO:0030036 206 0.065
regulation of programmed cell death GO:0043067 152 0.065
Human Mouse
hemopoiesis GO:0030097 46 0.065
Human Mouse
organonitrogen compound metabolic process GO:1901564 318 0.065
response to wounding GO:0009611 94 0.064
Zebrafish
skin development GO:0043588 65 0.064
Mouse
positive regulation of stem cell differentiation GO:2000738 3 0.064
Human
regulation of catabolic process GO:0009894 170 0.063
regulation of heart morphogenesis GO:2000826 3 0.063
g protein coupled receptor signaling pathway GO:0007186 136 0.063
transforming growth factor beta receptor signaling pathway GO:0007179 16 0.063
imaginal disc pattern formation GO:0007447 91 0.062
regulation of retinal cell programmed cell death GO:0046668 18 0.062
regulation of localization GO:0032879 275 0.062
Human Zebrafish Mouse Worm
cellular macromolecule catabolic process GO:0044265 136 0.062
positive regulation of cell death GO:0010942 69 0.061
Mouse
spiracle morphogenesis open tracheal system GO:0035277 22 0.061
non canonical wnt signaling pathway GO:0035567 8 0.060
regulation of kinase activity GO:0043549 53 0.060
regulation of protein serine threonine kinase activity GO:0071900 25 0.060
regulation of apoptotic process GO:0042981 130 0.059
Human Mouse
actin filament bundle organization GO:0061572 28 0.059
compound eye development GO:0048749 307 0.059
regulation of blood circulation GO:1903522 21 0.059
positive regulation of response to external stimulus GO:0032103 44 0.059
semaphorin plexin signaling pathway GO:0071526 4 0.058
neuronal stem cell division GO:0036445 35 0.058
Mouse
intracellular receptor signaling pathway GO:0030522 19 0.058
mitotic spindle organization GO:0007052 220 0.058
Worm
embryonic organ morphogenesis GO:0048562 5 0.058
Zebrafish Mouse
positive regulation of cellular component organization GO:0051130 156 0.057
Human
hippo signaling GO:0035329 20 0.057
protein targeting GO:0006605 64 0.057
Mouse
nuclear transport GO:0051169 72 0.056
Human Mouse
ventral midline development GO:0007418 9 0.056
regulation of response to external stimulus GO:0032101 115 0.055
positive regulation of cellular catabolic process GO:0031331 95 0.055
morphogenesis of an epithelial bud GO:0060572 3 0.055
cellular amino acid metabolic process GO:0006520 61 0.054
maintenance of gastrointestinal epithelium GO:0030277 3 0.054
Zebrafish
regulation of establishment of protein localization GO:0070201 61 0.054
Human
germarium derived female germ line cyst formation GO:0030727 42 0.053
stem cell maintenance GO:0019827 67 0.053
Mouse
embryonic axis specification GO:0000578 107 0.053
Mouse
pigment cell differentiation GO:0050931 3 0.053
regulation of sequence specific dna binding transcription factor activity GO:0051090 12 0.053
Human
initiation of dorsal closure GO:0007392 12 0.052
branching morphogenesis of an epithelial tube GO:0048754 45 0.052
Mouse
heart contraction GO:0060047 26 0.052
gliogenesis GO:0042063 80 0.052
Mouse
establishment of proximal distal cell polarity GO:0022606 4 0.052
regulation of organ formation GO:0003156 3 0.052
response to metal ion GO:0010038 23 0.052
positive regulation of proteolysis GO:0045862 52 0.051
regulation of proteolysis GO:0030162 87 0.051
Human
positive regulation of antifungal peptide production GO:0002804 6 0.050
tissue migration GO:0090130 155 0.050
chitin based cuticle development GO:0040003 49 0.050
positive regulation of immune response GO:0050778 63 0.049
regulation of protein targeting GO:1903533 29 0.049
neuron death GO:0070997 27 0.049
cortical cytoskeleton organization GO:0030865 29 0.049
regulation of reproductive process GO:2000241 54 0.049
cell adhesion GO:0007155 136 0.049
Human Mouse
cell cell junction organization GO:0045216 55 0.049
larval visceral muscle development GO:0007523 9 0.048
negative regulation of dna endoreduplication GO:0032876 2 0.048
positive regulation of nucleocytoplasmic transport GO:0046824 24 0.048
Human
positive regulation of mitotic cell cycle GO:0045931 34 0.048
cell cycle g1 s phase transition GO:0044843 31 0.048
positive regulation of transport GO:0051050 92 0.047
Human Mouse

pan disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.114
disease of cellular proliferation DOID:14566 0 0.114
organ system cancer DOID:0050686 0 0.069