Drosophila melanogaster

56 known processes

SMC2 (Dmel_CG10212)

CG10212 gene product from transcript CG10212-RA

(Aliases: DmSMC2,Dmel\CG10212,CG10212,dSMC2)

SMC2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
chromosome organization GO:0051276 360 0.969
mitotic spindle organization GO:0007052 220 0.962
dna conformation change GO:0071103 105 0.918
sister chromatid segregation GO:0000819 92 0.913
mitotic sister chromatid segregation GO:0000070 87 0.876
spindle organization GO:0007051 253 0.864
chromatin modification GO:0016568 147 0.852
dna packaging GO:0006323 91 0.836
mitotic sister chromatid separation GO:0051306 30 0.801
meiotic chromosome segregation GO:0045132 59 0.749
Mouse
chromosome segregation GO:0007059 157 0.698
negative regulation of cellular biosynthetic process GO:0031327 277 0.673
assembly of actomyosin apparatus involved in cytokinesis GO:0000912 11 0.608
chromatin silencing GO:0006342 76 0.597
dna metabolic process GO:0006259 227 0.490
organelle fission GO:0048285 340 0.474
mitotic nuclear division GO:0007067 213 0.469
negative regulation of nucleic acid templated transcription GO:1903507 240 0.463
mitotic chromosome condensation GO:0007076 22 0.394
metaphase plate congression GO:0051310 19 0.389
spindle assembly involved in mitosis GO:0090307 50 0.357
negative regulation of rna metabolic process GO:0051253 251 0.357
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.355
cellular component disassembly GO:0022411 46 0.353
negative regulation of rna biosynthetic process GO:1902679 240 0.352
establishment of organelle localization GO:0051656 122 0.339
chromosome separation GO:0051304 42 0.338
nuclear division GO:0000280 332 0.336
negative regulation of gene expression GO:0010629 387 0.319
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.312
covalent chromatin modification GO:0016569 106 0.311
meiotic cell cycle process GO:1903046 132 0.302
Yeast Mouse
regulation of mitotic sister chromatid segregation GO:0033047 28 0.280
negative regulation of biosynthetic process GO:0009890 277 0.276
negative regulation of transcription dna templated GO:0045892 237 0.270
organelle assembly GO:0070925 198 0.264
metaphase anaphase transition of cell cycle GO:0044784 28 0.264
regulation of mitotic sister chromatid separation GO:0010965 28 0.256
negative regulation of chromosome organization GO:2001251 19 0.239
chromosome condensation GO:0030261 41 0.222
histone modification GO:0016570 106 0.222
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.214
Yeast
regulation of mitotic cell cycle phase transition GO:1901990 130 0.197
organonitrogen compound metabolic process GO:1901564 318 0.193
Yeast
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.193
negative regulation of gene expression epigenetic GO:0045814 77 0.190
body morphogenesis GO:0010171 2 0.187
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.183
cytokinesis GO:0000910 90 0.178
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.162
regulation of mitotic cell cycle GO:0007346 190 0.160
eggshell chorion gene amplification GO:0007307 9 0.156
negative regulation of cell cycle phase transition GO:1901988 103 0.147
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.145
Yeast
protein complex assembly GO:0006461 200 0.145
centrosome cycle GO:0007098 137 0.138
regulation of microtubule cytoskeleton organization GO:0070507 41 0.137
chromatin organization GO:0006325 207 0.134
neuroblast proliferation GO:0007405 74 0.127
female meiotic division GO:0007143 70 0.124
defense response GO:0006952 300 0.123
negative regulation of mitotic sister chromatid separation GO:2000816 13 0.122
spindle midzone assembly GO:0051255 4 0.122
regulation of mitotic spindle organization GO:0060236 9 0.118
negative regulation of cell cycle GO:0045786 116 0.114
Yeast
organelle localization GO:0051640 148 0.113
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.107
mitotic cell cycle phase transition GO:0044772 138 0.105
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.102
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.095
g2 dna damage checkpoint GO:0031572 69 0.094
mitotic spindle elongation GO:0000022 81 0.094
neuron recognition GO:0008038 101 0.090
negative regulation of mitotic cell cycle GO:0045930 109 0.089
embryo development ending in birth or egg hatching GO:0009792 152 0.086
Worm
gene silencing GO:0016458 138 0.084
cell cycle checkpoint GO:0000075 95 0.082
dendrite morphogenesis GO:0048813 199 0.079
regulation of cell cycle phase transition GO:1901987 130 0.079
meiotic nuclear division GO:0007126 151 0.078
Yeast Mouse
macromolecular complex assembly GO:0065003 256 0.075
chromatin remodeling GO:0006338 72 0.075
dendrite development GO:0016358 204 0.075
metaphase anaphase transition of mitotic cell cycle GO:0007091 28 0.074
cellular macromolecular complex assembly GO:0034622 153 0.072
vesicle mediated transport GO:0016192 381 0.072
cellular protein modification process GO:0006464 438 0.072
lateral inhibition GO:0046331 206 0.070
peptidyl amino acid modification GO:0018193 105 0.070
negative regulation of cellular metabolic process GO:0031324 382 0.070
Yeast
protein modification process GO:0036211 438 0.069
regulation of cell cycle GO:0051726 291 0.067
Yeast
negative regulation of cellular component organization GO:0051129 108 0.066
Yeast
regulation of chromosome organization GO:0033044 64 0.066
axon development GO:0061564 297 0.065
regulation of organelle organization GO:0033043 196 0.065
Yeast
endocytosis GO:0006897 310 0.063
axonogenesis GO:0007409 290 0.062
meiotic cell cycle GO:0051321 171 0.062
Yeast Mouse
cellular catabolic process GO:0044248 372 0.061
Yeast
negative regulation of organelle organization GO:0010639 56 0.060
Yeast
female meiosis chromosome segregation GO:0016321 33 0.059
regulation of microtubule polymerization or depolymerization GO:0031110 27 0.058
positive regulation of mitotic cell cycle GO:0045931 34 0.058
cell proliferation GO:0008283 299 0.057
small molecule metabolic process GO:0044281 305 0.055
Yeast
gland development GO:0048732 191 0.055
microtubule cytoskeleton organization involved in mitosis GO:1902850 52 0.054
response to biotic stimulus GO:0009607 294 0.053
mitotic cell cycle checkpoint GO:0007093 88 0.052
spindle assembly GO:0051225 80 0.052
maintenance of location GO:0051235 73 0.051
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 30 0.050
regulation of gene expression epigenetic GO:0040029 128 0.050
Worm
telomere capping GO:0016233 11 0.050
negative regulation of cell cycle process GO:0010948 109 0.049
Yeast
nuclear dna replication GO:0033260 1 0.049
chromosome localization GO:0050000 20 0.049
dna replication GO:0006260 48 0.048
regulation of microtubule based process GO:0032886 49 0.047
chromatin assembly or disassembly GO:0006333 52 0.047
mitotic cytokinesis GO:0000281 50 0.046
regulation of spindle organization GO:0090224 17 0.046
dna repair GO:0006281 54 0.046
cell division GO:0051301 248 0.046
Yeast
regulation of sister chromatid segregation GO:0033045 28 0.046
death GO:0016265 284 0.045
dna damage checkpoint GO:0000077 78 0.044
muscle organ development GO:0007517 127 0.043
regulation of neurogenesis GO:0050767 158 0.043
negative regulation of microtubule depolymerization GO:0007026 21 0.043
multi multicellular organism process GO:0044706 123 0.042
negative regulation of neuroblast proliferation GO:0007406 27 0.041
regulation of cellular protein metabolic process GO:0032268 243 0.041
hematopoietic stem cell differentiation GO:0060218 1 0.041
sex differentiation GO:0007548 81 0.040
organic substance catabolic process GO:1901575 308 0.040
Yeast
meiotic spindle organization GO:0000212 36 0.040
macromolecular complex disassembly GO:0032984 37 0.039
regulation of protein metabolic process GO:0051246 256 0.039
heterocycle catabolic process GO:0046700 166 0.038
Yeast
protein complex biogenesis GO:0070271 201 0.037
regulation of chromatin silencing GO:0031935 36 0.037
positive regulation of phosphorus metabolic process GO:0010562 139 0.037
establishment of localization in cell GO:0051649 402 0.036
regulation of cytoskeleton organization GO:0051493 89 0.036
dna biosynthetic process GO:0071897 24 0.036
regulation of molecular function GO:0065009 217 0.036
dna integrity checkpoint GO:0031570 81 0.035
cell cell signaling involved in cell fate commitment GO:0045168 210 0.034
aromatic compound catabolic process GO:0019439 166 0.034
Yeast
cell cycle phase transition GO:0044770 140 0.034
regulation of phosphate metabolic process GO:0019220 210 0.034
response to external biotic stimulus GO:0043207 293 0.033
regulation of catalytic activity GO:0050790 185 0.033
rna polyadenylation GO:0043631 12 0.032
dna replication initiation GO:0006270 6 0.032
cell death GO:0008219 279 0.031
lipid storage GO:0019915 38 0.031
mitotic spindle assembly checkpoint GO:0007094 11 0.030
single organism biosynthetic process GO:0044711 206 0.030
positive regulation of catalytic activity GO:0043085 118 0.030
organic cyclic compound catabolic process GO:1901361 168 0.029
Yeast
positive regulation of metaphase anaphase transition of cell cycle GO:1902101 10 0.029
double strand break repair GO:0006302 26 0.028
mitotic spindle stabilization GO:0043148 6 0.028
regulation of gene silencing GO:0060968 63 0.028
nucleobase containing compound catabolic process GO:0034655 165 0.027
Yeast
imaginal disc derived appendage morphogenesis GO:0035114 395 0.027
regulation of protein complex disassembly GO:0043244 29 0.027
regulation of proteasomal protein catabolic process GO:0061136 39 0.027
protein complex disassembly GO:0043241 36 0.027
cytoskeleton dependent cytokinesis GO:0061640 81 0.026
eggshell formation GO:0030703 105 0.026
positive regulation of cell cycle GO:0045787 43 0.025
cellular protein complex assembly GO:0043623 71 0.025
chromosome organization involved in meiosis GO:0070192 10 0.025
Mouse
multi organism behavior GO:0051705 175 0.024
histone exchange GO:0043486 21 0.024
regulation of phosphorus metabolic process GO:0051174 210 0.024
gonad development GO:0008406 50 0.024
single organism catabolic process GO:0044712 228 0.023
Yeast
carboxylic acid metabolic process GO:0019752 92 0.023
nucleoside phosphate metabolic process GO:0006753 162 0.023
Yeast
positive regulation of macromolecule metabolic process GO:0010604 405 0.023
negative regulation of microtubule polymerization or depolymerization GO:0031111 21 0.022
negative regulation of mitotic metaphase anaphase transition GO:0045841 13 0.022
oxoacid metabolic process GO:0043436 103 0.022
mitotic spindle checkpoint GO:0071174 11 0.021
negative regulation of sister chromatid segregation GO:0033046 13 0.021
response to organic substance GO:0010033 284 0.021
spermatogenesis GO:0007283 200 0.021
neuron projection guidance GO:0097485 241 0.021
negative regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032435 16 0.021
reproductive behavior GO:0019098 122 0.020
regulation of protein modification process GO:0031399 112 0.020
regulation of heterochromatin assembly GO:0031445 8 0.020
regulation of chromatin binding GO:0035561 3 0.020
reproductive system development GO:0061458 74 0.020
chorion containing eggshell formation GO:0007304 105 0.019
catabolic process GO:0009056 409 0.019
Yeast
nucleotide metabolic process GO:0009117 161 0.019
Yeast
regulation of chromosome segregation GO:0051983 32 0.019
protein dna complex subunit organization GO:0071824 86 0.019
phagocytosis GO:0006909 215 0.019
negative regulation of mitotic sister chromatid segregation GO:0033048 13 0.018
immune response GO:0006955 246 0.018
chitin based larval cuticle pattern formation GO:0035293 11 0.018
negative regulation of developmental process GO:0051093 201 0.018
positive regulation of hydrolase activity GO:0051345 78 0.018
nuclear migration GO:0007097 20 0.018
purine nucleotide catabolic process GO:0006195 109 0.018
Yeast
imaginal disc derived appendage development GO:0048737 399 0.018
gliogenesis GO:0042063 80 0.018
protein localization GO:0008104 284 0.017
establishment of chromosome localization GO:0051303 20 0.017
response to other organism GO:0051707 293 0.017
establishment of spindle orientation GO:0051294 18 0.017
regulation of cytokinesis GO:0032465 3 0.017
dna replication checkpoint GO:0000076 8 0.017
peptidyl threonine modification GO:0018210 3 0.016
appendage development GO:0048736 401 0.016
apoptotic process GO:0006915 159 0.016
nucleoside metabolic process GO:0009116 127 0.016
Yeast
protein processing GO:0016485 68 0.016
programmed cell death GO:0012501 257 0.016
multi organism reproductive behavior GO:0044705 121 0.016
centrosome organization GO:0051297 163 0.016
regulation of proteolysis GO:0030162 87 0.016
purine nucleoside triphosphate metabolic process GO:0009144 119 0.015
Yeast
negative regulation of metaphase anaphase transition of cell cycle GO:1902100 13 0.015
protein maturation GO:0051604 71 0.015
negative regulation of protein metabolic process GO:0051248 85 0.015
regulation of transcription by chromatin organization GO:0034401 3 0.015
regulation of cellular amine metabolic process GO:0033238 3 0.015
positive regulation of mitotic metaphase anaphase transition GO:0045842 10 0.015
reproductive structure development GO:0048608 74 0.015
axon guidance GO:0007411 233 0.014
spindle checkpoint GO:0031577 11 0.014
organic acid metabolic process GO:0006082 103 0.014
negative regulation of chromosome segregation GO:0051985 14 0.014
cellular response to dna damage stimulus GO:0006974 223 0.014
cellular amine metabolic process GO:0044106 12 0.014
digestive tract development GO:0048565 149 0.014
protein localization to nucleus GO:0034504 55 0.014
small gtpase mediated signal transduction GO:0007264 88 0.014
response to alcohol GO:0097305 95 0.014
positive regulation of cellular component biogenesis GO:0044089 80 0.014
cellular nitrogen compound catabolic process GO:0044270 165 0.014
Yeast
regulation of cellular amino acid metabolic process GO:0006521 0 0.014
negative regulation of nucleotide metabolic process GO:0045980 4 0.013
male meiosis GO:0007140 52 0.013
purine nucleoside triphosphate catabolic process GO:0009146 108 0.013
Yeast
renal tubule development GO:0061326 64 0.013
actin filament based process GO:0030029 220 0.013
nucleotide catabolic process GO:0009166 109 0.013
Yeast
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.013
neural precursor cell proliferation GO:0061351 75 0.013
protein dna complex assembly GO:0065004 63 0.013
spindle assembly checkpoint GO:0071173 11 0.013
protein depolymerization GO:0051261 31 0.013
regulation of mitotic spindle elongation GO:0032888 1 0.013
negative regulation of protein export from nucleus GO:0046826 2 0.013
regulation of cellular component biogenesis GO:0044087 201 0.013
positive regulation of molecular function GO:0044093 136 0.013
response to heat GO:0009408 63 0.013
carbohydrate derivative metabolic process GO:1901135 217 0.013
Yeast
ribonucleoside metabolic process GO:0009119 127 0.013
Yeast
cellular protein localization GO:0034613 160 0.013
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.012
intracellular signal transduction GO:0035556 300 0.012
cellular ketone metabolic process GO:0042180 24 0.012
spliceosomal snrnp assembly GO:0000387 2 0.012
hindgut morphogenesis GO:0007442 58 0.012
nucleoside triphosphate catabolic process GO:0009143 108 0.012
Yeast
rna 3 end processing GO:0031123 45 0.012
positive regulation of cellular component organization GO:0051130 156 0.012
cell cycle dna replication GO:0044786 23 0.012
nucleobase containing small molecule metabolic process GO:0055086 174 0.012
Yeast
nucleoside triphosphate metabolic process GO:0009141 120 0.012
Yeast
response to bacterium GO:0009617 198 0.012
regulation of cell death GO:0010941 173 0.012
positive regulation of phosphate metabolic process GO:0045937 139 0.011
stem cell differentiation GO:0048863 117 0.011
regulation of dna metabolic process GO:0051052 34 0.011
amine metabolic process GO:0009308 12 0.011
organophosphate catabolic process GO:0046434 112 0.011
Yeast
head development GO:0060322 135 0.011
positive regulation of organelle organization GO:0010638 65 0.011
positive regulation of chromosome segregation GO:0051984 10 0.011
purine ribonucleoside metabolic process GO:0046128 127 0.011
Yeast
purine nucleoside metabolic process GO:0042278 127 0.011
Yeast
organic substance transport GO:0071702 257 0.011
actomyosin contractile ring assembly GO:0000915 10 0.011
nucleoside phosphate catabolic process GO:1901292 110 0.011
Yeast
taxis GO:0042330 304 0.011
ras protein signal transduction GO:0007265 88 0.011
response to sterol GO:0036314 34 0.011
spindle elongation GO:0051231 83 0.010
regulation of chromatin organization GO:1902275 32 0.010
regulation of mitosis GO:0007088 56 0.010
histone lysine methylation GO:0034968 32 0.010
mitotic g2 dna damage checkpoint GO:0007095 69 0.010
glycosyl compound catabolic process GO:1901658 112 0.010
Yeast
organophosphate metabolic process GO:0019637 195 0.010
Yeast
postreplication repair GO:0006301 2 0.010
cellular protein complex disassembly GO:0043624 35 0.010

SMC2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.021