Drosophila melanogaster

141 known processes

slik (Dmel_CG4527)

Sterile20-like kinase

(Aliases: slk,Dmel\CG4527,PLKK1,Plkk/Slik,Slk,CG4527,Slik,Slik1,DPlkk1,Plkk1,SLK,dPlkk/Slik)

slik biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
growth GO:0040007 359 0.714
compound eye photoreceptor development GO:0042051 78 0.648
compound eye photoreceptor cell differentiation GO:0001751 140 0.630
tor signaling GO:0031929 32 0.596
imaginal disc derived wing morphogenesis GO:0007476 337 0.454
regulation of growth GO:0040008 233 0.448
eye photoreceptor cell development GO:0042462 81 0.396
imaginal disc derived appendage development GO:0048737 399 0.392
photoreceptor cell differentiation GO:0046530 170 0.331
compound eye development GO:0048749 307 0.306
imaginal disc derived appendage morphogenesis GO:0035114 395 0.254
homeostatic process GO:0042592 199 0.235
regulation of tor signaling GO:0032006 21 0.225
regulation of cell size GO:0008361 63 0.219
imaginal disc derived leg morphogenesis GO:0007480 80 0.216
wing disc morphogenesis GO:0007472 344 0.212
eye photoreceptor cell differentiation GO:0001754 145 0.188
eye development GO:0001654 323 0.185
post embryonic appendage morphogenesis GO:0035120 385 0.184
multi organism behavior GO:0051705 175 0.183
regulation of developmental growth GO:0048638 174 0.169
aging GO:0007568 143 0.168
programmed cell death GO:0012501 257 0.153
Rat
developmental pigmentation GO:0048066 68 0.144
endosome transport via multivesicular body sorting pathway GO:0032509 12 0.142
ras protein signal transduction GO:0007265 88 0.137
negative regulation of cell communication GO:0010648 223 0.127
positive regulation of tor signaling GO:0032008 13 0.125
regulation of notch signaling pathway GO:0008593 100 0.125
long chain fatty acid biosynthetic process GO:0042759 1 0.118
apoptotic process GO:0006915 159 0.117
Rat
appendage development GO:0048736 401 0.114
leg disc morphogenesis GO:0007478 80 0.111
photoreceptor cell development GO:0042461 96 0.110
cell motility GO:0048870 251 0.103
Human Mouse
positive regulation of developmental growth GO:0048639 62 0.102
sensory organ morphogenesis GO:0090596 260 0.101
regulation of cell differentiation GO:0045595 302 0.100
protein complex assembly GO:0006461 200 0.093
regulation of epidermal growth factor receptor signaling pathway GO:0042058 42 0.087
columnar cuboidal epithelial cell development GO:0002066 249 0.087
response to oxygen containing compound GO:1901700 200 0.086
eye morphogenesis GO:0048592 260 0.084
positive regulation of phosphate metabolic process GO:0045937 139 0.082
nuclear division GO:0000280 332 0.076
regulation of phosphorylation GO:0042325 147 0.075
ocellus pigmentation GO:0033060 19 0.075
negative regulation of signal transduction GO:0009968 206 0.073
chemical homeostasis GO:0048878 92 0.073
cholesterol homeostasis GO:0042632 3 0.071
guanosine containing compound metabolic process GO:1901068 74 0.070
negative regulation of signaling GO:0023057 219 0.069
cell death GO:0008219 279 0.069
Rat
positive regulation of multicellular organism growth GO:0040018 21 0.068
appendage morphogenesis GO:0035107 397 0.067
regulation of ras protein signal transduction GO:0046578 93 0.066
regulation of mitotic cell cycle GO:0007346 190 0.065
positive regulation of growth GO:0045927 75 0.065
regulation of multi organism process GO:0043900 131 0.064
compound eye morphogenesis GO:0001745 249 0.063
regulation of phosphatase activity GO:0010921 3 0.061
positive regulation of protein metabolic process GO:0051247 128 0.061
positive regulation of phosphorus metabolic process GO:0010562 139 0.061
carboxylic acid metabolic process GO:0019752 92 0.061
developmental programmed cell death GO:0010623 138 0.060
epithelial cell development GO:0002064 274 0.060
cardiovascular system development GO:0072358 82 0.060
protein complex biogenesis GO:0070271 201 0.059
rho protein signal transduction GO:0007266 14 0.059
vesicle mediated transport GO:0016192 381 0.059
regulation of protein transport GO:0051223 57 0.058
cellular macromolecular complex assembly GO:0034622 153 0.057
regulation of intracellular signal transduction GO:1902531 236 0.057
small gtpase mediated signal transduction GO:0007264 88 0.057
developmental growth GO:0048589 280 0.056
embryonic development via the syncytial blastoderm GO:0001700 148 0.055
erbb signaling pathway GO:0038127 58 0.055
regulation of cellular component size GO:0032535 98 0.054
regulation of organ growth GO:0046620 42 0.054
positive regulation of cell communication GO:0010647 250 0.053
regulation of multicellular organism growth GO:0040014 40 0.052
actin cytoskeleton organization GO:0030036 206 0.051
small molecule metabolic process GO:0044281 305 0.051
lipid homeostasis GO:0055088 33 0.050
positive regulation of signal transduction GO:0009967 223 0.050
dna packaging GO:0006323 91 0.050
regulation of localization GO:0032879 275 0.050
positive regulation of phosphorylation GO:0042327 87 0.049
rhabdomere development GO:0042052 38 0.049
stress activated protein kinase signaling cascade GO:0031098 55 0.048
regulation of imaginal disc growth GO:0045570 26 0.048
positive regulation of macromolecule metabolic process GO:0010604 405 0.047
organic acid metabolic process GO:0006082 103 0.047
ribonucleoside triphosphate catabolic process GO:0009203 108 0.046
negative regulation of intracellular signal transduction GO:1902532 57 0.046
determination of adult lifespan GO:0008340 137 0.045
oxoacid metabolic process GO:0043436 103 0.045
tissue homeostasis GO:0001894 36 0.045
cellular response to peptide GO:1901653 28 0.045
regulation of rho protein signal transduction GO:0035023 20 0.044
regulation of multicellular organismal development GO:2000026 414 0.043
organic substance catabolic process GO:1901575 308 0.042
imaginal disc derived wing margin morphogenesis GO:0008587 41 0.042
membrane biogenesis GO:0044091 8 0.042
positive regulation of nucleotide metabolic process GO:0045981 55 0.042
regulation of anatomical structure size GO:0090066 163 0.040
immune response regulating signaling pathway GO:0002764 2 0.040
transcription from rna polymerase ii promoter GO:0006366 368 0.039
intracellular protein transport GO:0006886 104 0.039
organic substance transport GO:0071702 257 0.038
organic cyclic compound catabolic process GO:1901361 168 0.038
regulation of erbb signaling pathway GO:1901184 42 0.038
regulation of molecular function GO:0065009 217 0.038
regulation of anatomical structure morphogenesis GO:0022603 242 0.038
regulation of ras gtpase activity GO:0032318 38 0.037
positive regulation of purine nucleotide catabolic process GO:0033123 46 0.036
actin filament organization GO:0007015 126 0.035
negative regulation of small gtpase mediated signal transduction GO:0051058 13 0.035
lateral inhibition GO:0046331 206 0.034
positive regulation of response to stimulus GO:0048584 323 0.034
notch signaling pathway GO:0007219 120 0.033
protein phosphorylation GO:0006468 169 0.033
embryonic morphogenesis GO:0048598 206 0.032
response to extracellular stimulus GO:0009991 116 0.032
cell migration GO:0016477 238 0.032
Human Mouse
nucleoside phosphate catabolic process GO:1901292 110 0.032
nucleoside catabolic process GO:0009164 112 0.032
regulation of gtpase activity GO:0043087 44 0.032
regulation of epithelial cell proliferation GO:0050678 4 0.031
endocytosis GO:0006897 310 0.031
triglyceride homeostasis GO:0070328 18 0.030
positive regulation of signaling GO:0023056 243 0.030
positive regulation of developmental process GO:0051094 143 0.030
reproductive behavior GO:0019098 122 0.030
cellular homeostasis GO:0019725 80 0.029
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.029
positive regulation of rna metabolic process GO:0051254 271 0.029
cellular response to organonitrogen compound GO:0071417 36 0.029
positive regulation of intracellular signal transduction GO:1902533 116 0.028
regulation of nucleotide catabolic process GO:0030811 48 0.028
eye pigmentation GO:0048069 43 0.028
multicellular organism growth GO:0035264 46 0.028
positive regulation of kinase activity GO:0033674 25 0.028
chorion containing eggshell formation GO:0007304 105 0.027
positive regulation of jun kinase activity GO:0043507 4 0.027
rubidium ion transport GO:0035826 1 0.027
death GO:0016265 284 0.027
Rat
negative regulation of developmental process GO:0051093 201 0.027
positive regulation of nucleic acid templated transcription GO:1903508 266 0.026
regulation of catalytic activity GO:0050790 185 0.026
activation of jun kinase activity GO:0007257 3 0.026
immune response activating signal transduction GO:0002757 2 0.026
membrane organization GO:0061024 112 0.026
response to sterol GO:0036314 34 0.026
single organism intracellular transport GO:1902582 207 0.026
positive regulation of protein modification process GO:0031401 58 0.026
jak stat cascade GO:0007259 49 0.025
regulation of protein kinase activity GO:0045859 51 0.025
post golgi vesicle mediated transport GO:0006892 11 0.025
positive regulation of mapk cascade GO:0043410 63 0.025
regulation of small gtpase mediated signal transduction GO:0051056 93 0.025
enzyme linked receptor protein signaling pathway GO:0007167 179 0.025
positive regulation of mitotic cell cycle GO:0045931 34 0.025
intracellular transport GO:0046907 228 0.025
negative regulation of growth GO:0045926 84 0.024
rac protein signal transduction GO:0016601 3 0.024
positive regulation of cellular response to insulin stimulus GO:1900078 4 0.024
protein localization GO:0008104 284 0.023
taxis GO:0042330 304 0.023
histolysis GO:0007559 102 0.023
establishment of localization in cell GO:0051649 402 0.023
negative regulation of response to stimulus GO:0048585 258 0.023
negative regulation of tor signaling GO:0032007 5 0.022
actin filament based process GO:0030029 220 0.022
salivary gland development GO:0007431 162 0.022
insulin receptor signaling pathway GO:0008286 25 0.022
regulation of synapse organization GO:0050807 110 0.022
activation of mapk activity GO:0000187 9 0.022
positive regulation of cellular biosynthetic process GO:0031328 316 0.022
regulation of kinase activity GO:0043549 53 0.022
negative regulation of insulin receptor signaling pathway GO:0046627 11 0.022
phagocytosis GO:0006909 215 0.022
ribonucleoside metabolic process GO:0009119 127 0.022
positive regulation of nucleotide catabolic process GO:0030813 46 0.021
embryo development ending in birth or egg hatching GO:0009792 152 0.021
cellular response to oxygen containing compound GO:1901701 79 0.021
cellular protein complex assembly GO:0043623 71 0.021
immune response GO:0006955 246 0.021
lipid metabolic process GO:0006629 121 0.021
ocellus pigment metabolic process GO:0046158 19 0.021
membrane budding GO:0006900 4 0.021
response to organonitrogen compound GO:0010243 75 0.021
aromatic compound catabolic process GO:0019439 166 0.021
purine nucleoside triphosphate metabolic process GO:0009144 119 0.021
larval development GO:0002164 104 0.020
Worm
negative regulation of phosphorylation GO:0042326 35 0.020
regulation of nucleoside metabolic process GO:0009118 50 0.020
cytokinesis GO:0000910 90 0.020
steroid metabolic process GO:0008202 20 0.020
regulation of cell death GO:0010941 173 0.020
Rat
epithelial cell differentiation GO:0030855 322 0.020
salivary gland histolysis GO:0035070 88 0.020
nucleotide catabolic process GO:0009166 109 0.020
golgi vesicle transport GO:0048193 27 0.019
regulation of cell development GO:0060284 215 0.019
regulation of transport GO:0051049 181 0.019
cellular protein modification process GO:0006464 438 0.019
regulation of establishment of protein localization GO:0070201 61 0.019
regulation of protein localization GO:0032880 76 0.019
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.019
phosphorylation GO:0016310 294 0.019
hormone metabolic process GO:0042445 33 0.019
regulation of cell growth GO:0001558 43 0.019
regionalization GO:0003002 416 0.018
ion homeostasis GO:0050801 55 0.018
regulation of hippo signaling GO:0035330 14 0.018
localization of cell GO:0051674 257 0.018
Human Mouse
signal transduction by phosphorylation GO:0023014 107 0.018
cell proliferation GO:0008283 299 0.018
mitotic cell cycle phase transition GO:0044772 138 0.017
regulation of transferase activity GO:0051338 58 0.017
cellular response to insulin stimulus GO:0032869 28 0.017
regulation of cellular localization GO:0060341 136 0.017
cytoplasmic transport GO:0016482 130 0.017
positive regulation of multicellular organismal process GO:0051240 143 0.017
cellular protein localization GO:0034613 160 0.017
negative regulation of catalytic activity GO:0043086 42 0.017
regulation of rho gtpase activity GO:0032319 20 0.017
ovarian follicle cell development GO:0030707 248 0.017
developmental cell growth GO:0048588 52 0.017
multicellular organismal homeostasis GO:0048871 41 0.017
regulation of vesicle mediated transport GO:0060627 59 0.016
ribonucleoside triphosphate metabolic process GO:0009199 119 0.016
salivary gland cell autophagic cell death GO:0035071 83 0.016
response to nitrogen compound GO:1901698 90 0.016
catabolic process GO:0009056 409 0.016
single organism catabolic process GO:0044712 228 0.016
molting cycle GO:0042303 56 0.016
glycosyl compound catabolic process GO:1901658 112 0.016
regulation of phosphate metabolic process GO:0019220 210 0.016
organonitrogen compound metabolic process GO:1901564 318 0.016
dorsal ventral axis specification GO:0009950 66 0.016
secondary metabolite biosynthetic process GO:0044550 24 0.016
regulation of cellular response to insulin stimulus GO:1900076 17 0.016
protein transport GO:0015031 155 0.015
regulation of protein metabolic process GO:0051246 256 0.015
nucleoside metabolic process GO:0009116 127 0.015
regulation of stress activated mapk cascade GO:0032872 41 0.015
macromolecular complex assembly GO:0065003 256 0.015
purine containing compound catabolic process GO:0072523 112 0.015
negative regulation of organ growth GO:0046621 15 0.015
cellular carbohydrate metabolic process GO:0044262 22 0.015
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.015
anatomical structure homeostasis GO:0060249 97 0.015
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.015
epidermal growth factor receptor signaling pathway GO:0007173 58 0.015
organ growth GO:0035265 56 0.015
regulation of hormone levels GO:0010817 40 0.014
regulation of gtp catabolic process GO:0033124 44 0.014
instar larval development GO:0002168 55 0.014
tissue death GO:0016271 102 0.014
establishment of organelle localization GO:0051656 122 0.014
positive regulation of gtpase activity GO:0043547 43 0.014
chemotaxis GO:0006935 249 0.014
metal ion homeostasis GO:0055065 44 0.014
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.014
purine ribonucleoside metabolic process GO:0046128 127 0.014
long chain fatty acid metabolic process GO:0001676 3 0.014
positive regulation of cellular component organization GO:0051130 156 0.014
Rat
imaginal disc derived wing vein morphogenesis GO:0008586 44 0.013
cell growth GO:0016049 108 0.013
cellular ketone metabolic process GO:0042180 24 0.013
establishment of protein localization GO:0045184 163 0.013
sex differentiation GO:0007548 81 0.013
hormone biosynthetic process GO:0042446 20 0.013
intracellular signal transduction GO:0035556 300 0.013
erk1 and erk2 cascade GO:0070371 39 0.013
locomotory behavior GO:0007626 176 0.013
single organism cellular localization GO:1902580 180 0.013
regulation of protein modification process GO:0031399 112 0.013
cation transport GO:0006812 110 0.013
negative regulation of phosphatidylinositol 3 kinase signaling GO:0014067 4 0.013
negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 29 0.013
organophosphate catabolic process GO:0046434 112 0.013
pigment metabolic process involved in developmental pigmentation GO:0043324 33 0.013
regulation of apoptotic process GO:0042981 130 0.013
Rat
regulation of cellular catabolic process GO:0031329 157 0.013
negative regulation of protein metabolic process GO:0051248 85 0.013
response to abiotic stimulus GO:0009628 341 0.012
dna metabolic process GO:0006259 227 0.012
regulation of cellular protein metabolic process GO:0032268 243 0.012
monocarboxylic acid transport GO:0015718 3 0.012
positive regulation of lipid biosynthetic process GO:0046889 3 0.012
positive regulation of cellular protein metabolic process GO:0032270 118 0.012
regulation of phospholipase activity GO:0010517 2 0.012
cellular response to hypoxia GO:0071456 28 0.012
regulation of reproductive process GO:2000241 54 0.012
vacuolar transport GO:0007034 13 0.012
cellular response to decreased oxygen levels GO:0036294 30 0.012
stress activated mapk cascade GO:0051403 52 0.012
single organism biosynthetic process GO:0044711 206 0.012
positive regulation of biosynthetic process GO:0009891 316 0.012
protein modification process GO:0036211 438 0.012
cell cycle g2 m phase transition GO:0044839 22 0.012
regulation of neuron differentiation GO:0045664 103 0.012
receptor clustering GO:0043113 3 0.012
oocyte differentiation GO:0009994 145 0.012
positive regulation of cell size GO:0045793 21 0.012
purine nucleoside catabolic process GO:0006152 112 0.012
adult behavior GO:0030534 137 0.012
negative regulation of notch signaling pathway GO:0045746 41 0.012
regulation of wnt signaling pathway GO:0030111 68 0.012
negative regulation of cytoskeleton organization GO:0051494 30 0.011
multicellular organismal aging GO:0010259 140 0.011
regulation of establishment of protein localization to plasma membrane GO:0090003 7 0.011
response to alcohol GO:0097305 95 0.011
response to endogenous stimulus GO:0009719 119 0.011
carbohydrate derivative catabolic process GO:1901136 118 0.011
regulation of insulin receptor signaling pathway GO:0046626 17 0.011
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.011
negative regulation of epithelial cell proliferation GO:0050680 4 0.011
regulation of intracellular protein transport GO:0033157 46 0.011
response to peptide GO:1901652 29 0.011
immune system process GO:0002376 347 0.011
Human Mouse
nucleobase containing compound catabolic process GO:0034655 165 0.011
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 4 0.011
regulation of neurogenesis GO:0050767 158 0.011
response to unfolded protein GO:0006986 9 0.011
compound eye photoreceptor fate commitment GO:0001752 36 0.011
inter male aggressive behavior GO:0002121 60 0.011
regulation of stress activated protein kinase signaling cascade GO:0070302 42 0.011
response to organic substance GO:0010033 284 0.011
Rat
regulation of phosphorus metabolic process GO:0051174 210 0.010
positive regulation of binding GO:0051099 4 0.010
response to nutrient levels GO:0031667 114 0.010
eggshell formation GO:0030703 105 0.010
imaginal disc growth GO:0007446 37 0.010
blastoderm segmentation GO:0007350 159 0.010
regulation of intracellular transport GO:0032386 64 0.010
cellular response to nitrogen compound GO:1901699 51 0.010
pigmentation GO:0043473 75 0.010
hippo signaling GO:0035329 20 0.010
regulation of cell cycle GO:0051726 291 0.010
regulation of jnk cascade GO:0046328 40 0.010
positive regulation of cell growth GO:0030307 19 0.010
regulation of rac protein signal transduction GO:0035020 3 0.010
peptidyl threonine modification GO:0018210 3 0.010

slik disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.030
disease of cellular proliferation DOID:14566 0 0.030
organ system cancer DOID:0050686 0 0.030