Drosophila melanogaster

43 known processes

Gclc (Dmel_CG2259)

Glutamate-cysteine ligase catalytic subunit

(Aliases: Dmel\CG2259,DmGCLC,Gcsh,GCL,CG2259,GCLc,Gcs,DmGCSh,2259,DmGCS,GCSh)

Gclc biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
organophosphate metabolic process GO:0019637 195 0.151
multicellular organismal aging GO:0010259 140 0.127
single organism catabolic process GO:0044712 228 0.109
determination of adult lifespan GO:0008340 137 0.105
small molecule metabolic process GO:0044281 305 0.105
aging GO:0007568 143 0.097
response to organic substance GO:0010033 284 0.094
regulation of intracellular signal transduction GO:1902531 236 0.079
response to oxygen containing compound GO:1901700 200 0.077
organonitrogen compound metabolic process GO:1901564 318 0.076
intracellular signal transduction GO:0035556 300 0.074
behavioral response to ethanol GO:0048149 49 0.073
response to alcohol GO:0097305 95 0.071
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.070
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.070
metal ion transport GO:0030001 74 0.069
catabolic process GO:0009056 409 0.068
cation transport GO:0006812 110 0.063
organonitrogen compound catabolic process GO:1901565 128 0.062
purine nucleotide catabolic process GO:0006195 109 0.061
phosphorylation GO:0016310 294 0.061
organic substance catabolic process GO:1901575 308 0.059
ribonucleoside metabolic process GO:0009119 127 0.058
cellular amino acid metabolic process GO:0006520 61 0.057
adult behavior GO:0030534 137 0.057
regulation of phosphate metabolic process GO:0019220 210 0.056
response to lipopolysaccharide GO:0032496 4 0.052
regulation of phosphorus metabolic process GO:0051174 210 0.051
response to mercury ion GO:0046689 3 0.051
anion homeostasis GO:0055081 3 0.051
cellular lipid metabolic process GO:0044255 83 0.050
ribose phosphate metabolic process GO:0019693 145 0.050
response to abiotic stimulus GO:0009628 341 0.049
ribonucleotide metabolic process GO:0009259 145 0.049
purine ribonucleoside metabolic process GO:0046128 127 0.048
purine containing compound metabolic process GO:0072521 155 0.047
negative regulation of cellular metabolic process GO:0031324 382 0.046
carbohydrate derivative catabolic process GO:1901136 118 0.046
response to oxidative stress GO:0006979 86 0.046
steroid catabolic process GO:0006706 1 0.046
purine ribonucleotide catabolic process GO:0009154 109 0.045
nucleotide metabolic process GO:0009117 161 0.044
glycosyl compound metabolic process GO:1901657 127 0.044
carbohydrate derivative metabolic process GO:1901135 217 0.043
ion transport GO:0006811 145 0.043
negative regulation of cell communication GO:0010648 223 0.043
vesicle mediated transport GO:0016192 381 0.043
nucleoside catabolic process GO:0009164 112 0.043
positive regulation of response to stimulus GO:0048584 323 0.043
ribonucleoside triphosphate catabolic process GO:0009203 108 0.043
cellular catabolic process GO:0044248 372 0.042
nucleobase containing compound catabolic process GO:0034655 165 0.042
lipid metabolic process GO:0006629 121 0.041
purine nucleoside metabolic process GO:0042278 127 0.041
nucleobase containing small molecule metabolic process GO:0055086 174 0.040
single organism behavior GO:0044708 391 0.040
insecticide metabolic process GO:0017143 2 0.040
ribonucleoside triphosphate metabolic process GO:0009199 119 0.040
negative regulation of response to stimulus GO:0048585 258 0.039
regulation of phosphorylation GO:0042325 147 0.039
ras protein signal transduction GO:0007265 88 0.038
response to insulin GO:0032868 29 0.038
signal transduction by phosphorylation GO:0023014 107 0.038
activation of innate immune response GO:0002218 4 0.037
defense response GO:0006952 300 0.037
wing disc morphogenesis GO:0007472 344 0.037
transcription from rna polymerase ii promoter GO:0006366 368 0.037
immune response regulating signaling pathway GO:0002764 2 0.037
response to organonitrogen compound GO:0010243 75 0.036
regulation of catalytic activity GO:0050790 185 0.036
peptide metabolic process GO:0006518 80 0.035
regionalization GO:0003002 416 0.035
lipopolysaccharide mediated signaling pathway GO:0031663 1 0.035
organic acid metabolic process GO:0006082 103 0.035
establishment of localization in cell GO:0051649 402 0.035
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.035
regulation of cellular catabolic process GO:0031329 157 0.035
jnk cascade GO:0007254 50 0.035
aromatic compound catabolic process GO:0019439 166 0.035
nucleoside triphosphate catabolic process GO:0009143 108 0.035
regulation of ras protein signal transduction GO:0046578 93 0.034
purine nucleoside triphosphate catabolic process GO:0009146 108 0.034
organic cyclic compound catabolic process GO:1901361 168 0.033
purine ribonucleotide metabolic process GO:0009150 145 0.033
response to bacterium GO:0009617 198 0.033
purine nucleoside catabolic process GO:0006152 112 0.033
purine nucleoside triphosphate metabolic process GO:0009144 119 0.033
regulation of catabolic process GO:0009894 170 0.032
ion transmembrane transport GO:0034220 122 0.032
death GO:0016265 284 0.032
sulfur compound biosynthetic process GO:0044272 16 0.032
transmembrane transport GO:0055085 139 0.032
purine containing compound catabolic process GO:0072523 112 0.032
endocytosis GO:0006897 310 0.032
cellular nitrogen compound catabolic process GO:0044270 165 0.032
positive regulation of signaling GO:0023056 243 0.032
small gtpase mediated signal transduction GO:0007264 88 0.032
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.032
fat soluble vitamin metabolic process GO:0006775 1 0.031
nucleoside triphosphate metabolic process GO:0009141 120 0.031
positive regulation of signal transduction GO:0009967 223 0.031
response to other organism GO:0051707 293 0.030
regulation of molecular function GO:0065009 217 0.030
positive regulation of jun kinase activity GO:0043507 4 0.030
response to nitrogen compound GO:1901698 90 0.030
nucleoside phosphate metabolic process GO:0006753 162 0.030
nucleoside metabolic process GO:0009116 127 0.029
phagocytosis GO:0006909 215 0.029
polyol biosynthetic process GO:0046173 3 0.029
response to external biotic stimulus GO:0043207 293 0.029
regulation of cellular ketone metabolic process GO:0010565 3 0.029
appendage development GO:0048736 401 0.029
cellular response to molecule of bacterial origin GO:0071219 3 0.028
positive regulation of catalytic activity GO:0043085 118 0.028
nucleotide catabolic process GO:0009166 109 0.028
purine ribonucleoside catabolic process GO:0046130 112 0.028
appendage morphogenesis GO:0035107 397 0.028
hormone catabolic process GO:0042447 3 0.028
organic substance transport GO:0071702 257 0.028
response to ethanol GO:0045471 59 0.027
cell death GO:0008219 279 0.027
neurological system process GO:0050877 358 0.027
macromolecule catabolic process GO:0009057 161 0.027
positive regulation of cell communication GO:0010647 250 0.027
post embryonic appendage morphogenesis GO:0035120 385 0.027
regulation of mapk cascade GO:0043408 92 0.027
immune response activating signal transduction GO:0002757 2 0.027
cellular response to peptide hormone stimulus GO:0071375 28 0.027
cellular response to chemical stimulus GO:0070887 199 0.027
positive regulation of molecular function GO:0044093 136 0.027
regulation of transport GO:0051049 181 0.027
response to biotic stimulus GO:0009607 294 0.027
secondary metabolic process GO:0019748 75 0.027
negative regulation of signal transduction GO:0009968 206 0.026
stress activated mapk cascade GO:0051403 52 0.026
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.026
carboxylic acid metabolic process GO:0019752 92 0.026
oxoacid metabolic process GO:0043436 103 0.026
regulation of cellular component biogenesis GO:0044087 201 0.026
heterocycle catabolic process GO:0046700 166 0.026
negative regulation of nucleic acid templated transcription GO:1903507 240 0.025
cellular amine metabolic process GO:0044106 12 0.025
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.025
positive regulation of phosphate metabolic process GO:0045937 139 0.025
xenobiotic catabolic process GO:0042178 1 0.025
vitamin biosynthetic process GO:0009110 1 0.025
immune response GO:0006955 246 0.025
regulation of immune system process GO:0002682 176 0.024
cellular protein modification process GO:0006464 438 0.024
defense response to bacterium GO:0042742 178 0.024
growth GO:0040007 359 0.024
organophosphate catabolic process GO:0046434 112 0.024
defense response to other organism GO:0098542 225 0.024
cellular response to organic substance GO:0071310 132 0.024
actin cytoskeleton organization GO:0030036 206 0.024
gtp catabolic process GO:0006184 72 0.024
homeostatic process GO:0042592 199 0.023
imaginal disc derived wing morphogenesis GO:0007476 337 0.023
positive regulation of phosphorus metabolic process GO:0010562 139 0.023
telencephalon development GO:0021537 2 0.023
nucleoside phosphate catabolic process GO:1901292 110 0.023
mapk cascade GO:0000165 107 0.023
purine nucleotide metabolic process GO:0006163 146 0.023
regulation of cellular response to stress GO:0080135 89 0.023
single organism biosynthetic process GO:0044711 206 0.023
ribonucleoside catabolic process GO:0042454 112 0.023
enzyme linked receptor protein signaling pathway GO:0007167 179 0.023
response to glucose GO:0009749 2 0.023
organonitrogen compound biosynthetic process GO:1901566 117 0.023
regulation of cell cycle GO:0051726 291 0.022
response to nutrient levels GO:0031667 114 0.022
response to hexose GO:0009746 3 0.022
divalent inorganic cation transport GO:0072511 30 0.022
toxin metabolic process GO:0009404 2 0.022
transition metal ion homeostasis GO:0055076 17 0.022
chemical homeostasis GO:0048878 92 0.022
regulation of cellular localization GO:0060341 136 0.022
glycosyl compound catabolic process GO:1901658 112 0.022
regulation of small gtpase mediated signal transduction GO:0051056 93 0.022
positive regulation of biosynthetic process GO:0009891 316 0.022
cellular ketone metabolic process GO:0042180 24 0.022
regulation of localization GO:0032879 275 0.022
cellular response to lipopolysaccharide GO:0071222 3 0.022
imaginal disc derived appendage development GO:0048737 399 0.021
cation transmembrane transport GO:0098655 88 0.021
negative regulation of gene expression GO:0010629 387 0.021
cellular response to biotic stimulus GO:0071216 4 0.021
ribonucleotide catabolic process GO:0009261 109 0.021
protein modification process GO:0036211 438 0.021
programmed cell death GO:0012501 257 0.021
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.021
fat soluble vitamin biosynthetic process GO:0042362 1 0.021
phosphatidic acid metabolic process GO:0046473 1 0.021
regulation of developmental growth GO:0048638 174 0.021
negative regulation of signaling GO:0023057 219 0.021
amine metabolic process GO:0009308 12 0.020
response to endogenous stimulus GO:0009719 119 0.020
regulation of jnk cascade GO:0046328 40 0.020
lauric acid metabolic process GO:0048252 1 0.020
positive regulation of macromolecule metabolic process GO:0010604 405 0.020
apoptotic process GO:0006915 159 0.020
amide biosynthetic process GO:0043604 42 0.020
regulation of response to stress GO:0080134 200 0.019
negative regulation of biosynthetic process GO:0009890 277 0.019
regulation of organelle organization GO:0033043 196 0.019
cellular response to oxygen containing compound GO:1901701 79 0.019
glutathione metabolic process GO:0006749 37 0.019
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.019
actin filament based process GO:0030029 220 0.019
positive regulation of intracellular signal transduction GO:1902533 116 0.019
response to starvation GO:0042594 97 0.019
cellular homeostasis GO:0019725 80 0.019
regulation of epithelial cell proliferation GO:0050678 4 0.019
single organism carbohydrate metabolic process GO:0044723 72 0.019
regulation of apoptotic process GO:0042981 130 0.019
pattern recognition receptor signaling pathway GO:0002221 2 0.018
leg disc development GO:0035218 92 0.018
body morphogenesis GO:0010171 2 0.018
ameboidal type cell migration GO:0001667 151 0.018
regulation of anatomical structure size GO:0090066 163 0.018
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.018
regulation of programmed cell death GO:0043067 152 0.018
response to radiation GO:0009314 155 0.018
regulation of nucleotide catabolic process GO:0030811 48 0.018
monocarboxylic acid transport GO:0015718 3 0.018
lipid biosynthetic process GO:0008610 46 0.017
cellular modified amino acid metabolic process GO:0006575 45 0.017
gtp metabolic process GO:0046039 72 0.017
guanosine containing compound catabolic process GO:1901069 74 0.017
camera type eye development GO:0043010 4 0.017
retina development in camera type eye GO:0060041 4 0.017
regulation of immune response GO:0050776 118 0.017
carbohydrate metabolic process GO:0005975 82 0.017
localization of cell GO:0051674 257 0.017
sensory perception of smell GO:0007608 80 0.017
atp metabolic process GO:0046034 49 0.017
positive regulation of rna metabolic process GO:0051254 271 0.017
immune system process GO:0002376 347 0.017
regulation of insulin receptor signaling pathway GO:0046626 17 0.017
innate immune response activating signal transduction GO:0002758 2 0.017
regulation of cell differentiation GO:0045595 302 0.017
metal ion homeostasis GO:0055065 44 0.017
oxidation reduction process GO:0055114 123 0.017
response to monosaccharide GO:0034284 4 0.017
forebrain development GO:0030900 2 0.017
positive regulation of gtpase activity GO:0043547 43 0.017
positive regulation of purine nucleotide catabolic process GO:0033123 46 0.017
cellular response to insulin stimulus GO:0032869 28 0.016
positive regulation of catabolic process GO:0009896 105 0.016
organelle assembly GO:0070925 198 0.016
response to heat GO:0009408 63 0.016
regulation of hydrolase activity GO:0051336 97 0.016
ribonucleoside monophosphate metabolic process GO:0009161 51 0.016
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.016
cellular macromolecule localization GO:0070727 220 0.016
nucleoside monophosphate metabolic process GO:0009123 52 0.016
immune effector process GO:0002252 98 0.016
organophosphate biosynthetic process GO:0090407 46 0.016
regulation of cellular response to insulin stimulus GO:1900076 17 0.016
positive regulation of cellular catabolic process GO:0031331 95 0.015
compound eye morphogenesis GO:0001745 249 0.015
negative regulation of rna metabolic process GO:0051253 251 0.015
imaginal disc derived leg morphogenesis GO:0007480 80 0.015
stress activated protein kinase signaling cascade GO:0031098 55 0.015
multi organism behavior GO:0051705 175 0.015
regulation of cellular amine metabolic process GO:0033238 3 0.015
regulation of nucleoside metabolic process GO:0009118 50 0.015
response to copper ion GO:0046688 4 0.015
sterol homeostasis GO:0055092 4 0.015
response to organic cyclic compound GO:0014070 89 0.015
glycerolipid catabolic process GO:0046503 3 0.015
regulation of cellular amino acid metabolic process GO:0006521 0 0.015
regulation of steroid metabolic process GO:0019218 2 0.015
purine nucleoside monophosphate metabolic process GO:0009126 50 0.015
regulation of protein metabolic process GO:0051246 256 0.015
insulin receptor signaling pathway GO:0008286 25 0.015
response to organophosphorus GO:0046683 2 0.015
epithelial cell development GO:0002064 274 0.015
spermatogenesis GO:0007283 200 0.015
positive regulation of lipid metabolic process GO:0045834 4 0.015
sensory perception GO:0007600 196 0.015
positive regulation of cellular biosynthetic process GO:0031328 316 0.014
regulation of growth GO:0040008 233 0.014
central nervous system development GO:0007417 201 0.014
mitotic nuclear division GO:0007067 213 0.014
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.014
defense response to gram negative bacterium GO:0050829 94 0.014
protein phosphorylation GO:0006468 169 0.014
regulation of multi organism process GO:0043900 131 0.014
developmental growth GO:0048589 280 0.014
learning GO:0007612 75 0.014
guanosine containing compound metabolic process GO:1901068 74 0.014
regulation of defense response GO:0031347 102 0.014
negative regulation of protein metabolic process GO:0051248 85 0.014
insecticide catabolic process GO:0046701 1 0.014
cellular response to dna damage stimulus GO:0006974 223 0.014
regulation of cytoplasmic transport GO:1903649 47 0.014
thioester metabolic process GO:0035383 3 0.014
response to temperature stimulus GO:0009266 106 0.014
regulation of cellular protein metabolic process GO:0032268 243 0.014
sulfur compound metabolic process GO:0006790 59 0.014
negative regulation of phosphate metabolic process GO:0045936 45 0.014
compound eye development GO:0048749 307 0.014
negative regulation of immune system process GO:0002683 50 0.014
medium chain fatty acid metabolic process GO:0051791 1 0.014
embryonic morphogenesis GO:0048598 206 0.013
positive regulation of immune response GO:0050778 63 0.013
mrna metabolic process GO:0016071 124 0.013
response to extracellular stimulus GO:0009991 116 0.013
peptidyl amino acid modification GO:0018193 105 0.013
regulation of cell proliferation GO:0042127 163 0.013
positive regulation of nucleoside metabolic process GO:0045979 47 0.013
eye morphogenesis GO:0048592 260 0.013
regulation of cell death GO:0010941 173 0.013
dephosphorylation GO:0016311 51 0.013
organic hydroxy compound metabolic process GO:1901615 83 0.013
negative regulation of developmental process GO:0051093 201 0.013
connective tissue development GO:0061448 3 0.013
positive regulation of gene expression GO:0010628 290 0.013
positive regulation of hydrolase activity GO:0051345 78 0.013
cell proliferation GO:0008283 299 0.012
ion homeostasis GO:0050801 55 0.012
humoral immune response GO:0006959 117 0.012
protein catabolic process GO:0030163 101 0.012
nitrogen compound transport GO:0071705 85 0.012
long term memory GO:0007616 62 0.012
cell migration GO:0016477 238 0.012
intracellular transport GO:0046907 228 0.012
regulation of ras gtpase activity GO:0032318 38 0.012
single organism intracellular transport GO:1902582 207 0.012
rho protein signal transduction GO:0007266 14 0.012
tube development GO:0035295 244 0.012
secondary metabolite catabolic process GO:0090487 1 0.012
endomembrane system organization GO:0010256 119 0.012
regulation of purine nucleotide catabolic process GO:0033121 48 0.012
skin development GO:0043588 65 0.012
atp catabolic process GO:0006200 38 0.012
inorganic ion transmembrane transport GO:0098660 73 0.012
positive regulation of defense response GO:0031349 59 0.012
cellular metal ion homeostasis GO:0006875 31 0.012
positive regulation of transcription dna templated GO:0045893 266 0.012
kidney development GO:0001822 3 0.012
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.012
negative regulation of phosphorus metabolic process GO:0010563 45 0.012
positive regulation of nucleotide catabolic process GO:0030813 46 0.012
eye development GO:0001654 323 0.012
protein localization GO:0008104 284 0.012
positive regulation of cell migration GO:0030335 2 0.012
biological adhesion GO:0022610 138 0.012
regulation of stress activated mapk cascade GO:0032872 41 0.012
negative regulation of transcription dna templated GO:0045892 237 0.011
imaginal disc derived appendage morphogenesis GO:0035114 395 0.011
extrinsic apoptotic signaling pathway GO:0097191 1 0.011
rna processing GO:0006396 147 0.011
cell motility GO:0048870 251 0.011
regulation of neuron projection development GO:0010975 69 0.011
regulation of gtpase activity GO:0043087 44 0.011
cellular response to starvation GO:0009267 61 0.011
xenobiotic transport GO:0042908 1 0.011
nuclear division GO:0000280 332 0.011
gland development GO:0048732 191 0.011
positive regulation of phosphorylation GO:0042327 87 0.011
lipid modification GO:0030258 24 0.011
negative regulation of cellular protein metabolic process GO:0032269 85 0.011
phosphatidylinositol mediated signaling GO:0048015 4 0.011
innate immune response GO:0045087 144 0.011
regulation of multicellular organismal development GO:2000026 414 0.011
proteolysis GO:0006508 192 0.011
protein transport GO:0015031 155 0.011
release of sequestered calcium ion into cytosol GO:0051209 1 0.011
peptidyl threonine phosphorylation GO:0018107 2 0.011
regulation of nucleotide metabolic process GO:0006140 62 0.011
positive regulation of nucleotide metabolic process GO:0045981 55 0.011
establishment of protein localization GO:0045184 163 0.011
negative regulation of homeostatic process GO:0032845 2 0.011
cellular response to nutrient levels GO:0031669 62 0.011
divalent metal ion transport GO:0070838 26 0.011
antimicrobial humoral response GO:0019730 99 0.011
regulation of innate immune response GO:0045088 71 0.011
regulation of protein modification process GO:0031399 112 0.011
negative regulation of cell death GO:0060548 81 0.011
acyl coa metabolic process GO:0006637 3 0.011
negative regulation of phosphorylation GO:0042326 35 0.011
cation homeostasis GO:0055080 51 0.010
peptidyl threonine modification GO:0018210 3 0.010
positive regulation of cell motility GO:2000147 3 0.010
protein import into nucleus GO:0006606 51 0.010
spindle organization GO:0007051 253 0.010
cellular amide metabolic process GO:0043603 80 0.010
glycerophospholipid metabolic process GO:0006650 23 0.010
organic hydroxy compound biosynthetic process GO:1901617 21 0.010
brain development GO:0007420 120 0.010
purine nucleoside biosynthetic process GO:0042451 3 0.010
regulation of cellular component size GO:0032535 98 0.010
mitochondrion organization GO:0007005 65 0.010
response to toxic substance GO:0009636 22 0.010
negative regulation of organelle organization GO:0010639 56 0.010
regulation of sequestering of calcium ion GO:0051282 3 0.010
acid secretion GO:0046717 1 0.010
negative regulation of intracellular signal transduction GO:1902532 57 0.010
regulation of intracellular transport GO:0032386 64 0.010
negative regulation of growth GO:0045926 84 0.010
myotube cell development GO:0014904 3 0.010
spinal cord development GO:0021510 1 0.010
organelle fission GO:0048285 340 0.010

Gclc disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.116
cardiovascular system disease DOID:1287 0 0.044
musculoskeletal system disease DOID:17 0 0.022
nervous system disease DOID:863 0 0.022
vascular disease DOID:178 0 0.020
central nervous system disease DOID:331 0 0.012
neurodegenerative disease DOID:1289 0 0.012
integumentary system disease DOID:16 0 0.012
sensory system disease DOID:0050155 0 0.011
disease of cellular proliferation DOID:14566 0 0.011
disease of metabolism DOID:0014667 0 0.010